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2024 Journal Article A maternal high-fat diet predisposes to infant lung disease via increased neutrophil-mediated IL-6 trans-signalingCurren, Bodie, Ahmed, Tufael, Rashid, Ridwan B., Sebina, Ismail, Al Amin Sikder, Md., Howard, Daniel R., Alorro, Mariah, Ullah, Md. Ashik, Bissell, Alec, Rahman, Muhammed Mahfuzur, Pearen, Michael A., Ramm, Grant A., Varelias, Antiopi, Rose-John, Stefan, MacDonald, Kelli P. A., Hoelzle, Robert, Ó Cuív, Páraic, Spann, Kirsten M., Dennis, Paul G. and Phipps, Simon (2024). A maternal high-fat diet predisposes to infant lung disease via increased neutrophil-mediated IL-6 trans-signaling. Cell Reports, 43 (11) 114974, 114974. doi: 10.1016/j.celrep.2024.114974 |
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2024 Journal Article Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasisSajiir, Haressh, Wong, Kuan Yau, Müller, Alexandra, Keshvari, Sahar, Burr, Lucy, Aiello, Elena, Mezza, Teresa, Giaccari, Andrea, Sebastiani, Guido, Dotta, Francesco, Ramm, Grant A., Macdonald, Graeme A., McGuckin, Michael A., Prins, Johannes B. and Hasnain, Sumaira Z. (2024). Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis. Nature Communications, 15 (1) 4527, 1-12. doi: 10.1038/s41467-024-48320-2 |
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Featured 2024 Journal Article Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitisSajiir, Haressh, Keshvari, Sahar, Wong, Kuan Yau, Borg, Danielle J., Steyn, Frederik J., Fercher, Christian, Taylor, Karin, Taylor, Breten, Barnard, Ross T., Müller, Alexandra, Moniruzzaman, Md, Miller, Gregory, Wang, Ran, Fotheringham, Amelia, Schreiber, Veronika, Sheng, Yong Hua, Hancock, Janelle Louise, Loo, Dorothy, Burr, Lucy, Huynh, Tony, Lockett, Jack, Ramm, Grant A., Macdonald, Graeme A., Prins, Johannes B., McGuckin, Michael A. and Hasnain, Sumaira Z. (2024). Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis. Nature Communications, 15 (1) 4528, 4528. doi: 10.1038/s41467-024-48317-x |
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2024 Journal Article The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammationFernandez-Rojo, Manuel A., Pearen, Michael A., Burgess, Anita G., Ikonomopoulou, Maria P., Hoang-Le, Diem, Genz, Berit, Saggiomo, Silvia L., Nawaratna, Sujeevi S. K., Poli, Maura, Reissmann, Regina, Gobert, Geoffrey N., Deutsch, Urban, Engelhardt, Britta, Brooks, Andrew J., Jones, Alun, Arosio, Paolo and Ramm, Grant A. (2024). The heavy subunit of ferritin stimulates NLRP3 inflammasomes in hepatic stellate cells through ICAM-1 to drive hepatic inflammation. Science Signaling, 17 (830) eade4335, 1-16. doi: 10.1126/scisignal.ade4335 |
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2024 Journal Article Extrahepatic iron loading associates with the propensity to develop advanced hepatic fibrosis in hemochromatosisOlynyk, John K., St. Pierre, Timothy G., Chen, James, Frazer, David M., Ramm, Louise E. and Ramm, Grant A. (2024). Extrahepatic iron loading associates with the propensity to develop advanced hepatic fibrosis in hemochromatosis. Gastro Hep Advances, 3 (4), 454-460. doi: 10.1016/j.gastha.2024.01.011 |
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2023 Journal Article The ancestral haplotype markers HLA -A3 and B7 do not influence the likelihood of advanced hepatic fibrosis or cirrhosis in HFE hemochromatosisOlynyk, John K., Grainger, Richard, Currie, Helen, Ramm, Louise E. and Ramm, Grant A. (2023). The ancestral haplotype markers HLA -A3 and B7 do not influence the likelihood of advanced hepatic fibrosis or cirrhosis in HFE hemochromatosis. Scientific Reports, 13 (1) 7775, 1-6. doi: 10.1038/s41598-023-35028-4 |
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2023 Journal Article Exploring the impact of severity in hepatic fibrosis disease on the intrahepatic distribution of novel biodegradable nanoparticles targeted towards different disease biomarkersBalaji, Arunpandian, Bell, Craig A., Houston, Zachary H., Bridle, Kim R., Genz, Berit, Fletcher, Nicholas L., Ramm, Grant A. and Thurecht, Kristofer J. (2023). Exploring the impact of severity in hepatic fibrosis disease on the intrahepatic distribution of novel biodegradable nanoparticles targeted towards different disease biomarkers. Biomaterials, 302 122318, 1-18. doi: 10.1016/j.biomaterials.2023.122318 |
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2023 Journal Article Risk factors for more rapid progression of severe liver fibrosis in children with cystic fibrosis-related liver disease: A multi-center study validated by liver biopsySakhuja, Shruti, Staples, Heather M., Minard, Charles G., Ramm, Louise E., Lewindon, Peter J., Ramm, Grant A. and Leung, Daniel H. (2023). Risk factors for more rapid progression of severe liver fibrosis in children with cystic fibrosis-related liver disease: A multi-center study validated by liver biopsy. Liver International, 43 (6), 1277-1286. doi: 10.1111/liv.15572 |
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2023 Journal Article Clinical practice guidelines on hemochromatosis: Asian Pacific Association for the Study of the LiverCrawford, Darrell H. G., Ramm, Grant A., Bridle, Kim R., Nicoll, Amanda J., Delatycki, Martin B. and Olynyk, John K. (2023). Clinical practice guidelines on hemochromatosis: Asian Pacific Association for the Study of the Liver. Hepatology International, 17 (3), 522-541. doi: 10.1007/s12072-023-10510-3 |
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2023 Journal Article TWEAK/Fn14 Signalling Regulates the Tissue Microenvironment in Chronic PancreatitisAbu Bakar, N. Dianah B., Carlessi, Rodrigo, Gogoi-Tiwari, Jully, Köhn-Gaone, Julia, Williams, Vincent, Falasca, Marco, Olynyk, John K., Ramm, Grant A. and Tirnitz-Parker, Janina E. E. (2023). TWEAK/Fn14 Signalling Regulates the Tissue Microenvironment in Chronic Pancreatitis. Cancers, 15 (6) 1807, 1-15. doi: 10.3390/cancers15061807 |
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2022 Journal Article Synthetic peptides derived from the Schistosoma mansoni secretory protein Sm16 induce contrasting responses in hepatic stellate cellsCarson, Jack P., Robinson, Mark W., Ramm, Grant A. and Gobert, Geoffrey N. (2022). Synthetic peptides derived from the Schistosoma mansoni secretory protein Sm16 induce contrasting responses in hepatic stellate cells. Experimental Parasitology, 236-237 108255, 108255. doi: 10.1016/j.exppara.2022.108255 |
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2022 Journal Article Gamma-glutamyl transpeptidase-to-platelet ratio as a biomarker of liver disease and hepatic fibrosis severity in paediatric Cystic FibrosisCalvopina, Diego A., Lewindon, Peter J., Ramm, Louise E., Noble, Charlton, Hartel, Gunter F., Leung, Daniel H and Ramm, Grant A. (2022). Gamma-glutamyl transpeptidase-to-platelet ratio as a biomarker of liver disease and hepatic fibrosis severity in paediatric Cystic Fibrosis. Journal of Cystic Fibrosis, 21 (2), 236-242. doi: 10.1016/j.jcf.2021.10.014 |
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2022 Journal Article Advanced but not mild liver disease is a predictor of decreased survival in children with cystic fibrosis, with far greater impact in females: a 27-year real-life cohort studyBaldissera, Marilisa, Lewindon, Peter J., Ramm, Louise E., Hartel, Gunter F., Mattiello, Rita and Ramm, Grant A. (2022). Advanced but not mild liver disease is a predictor of decreased survival in children with cystic fibrosis, with far greater impact in females: a 27-year real-life cohort study. Journal of Cystic Fibrosis, 21 (2), 230-235. doi: 10.1016/j.jcf.2021.11.015 |
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2022 Journal Article Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver diseaseKeshvari, Sahar, Genz, Berit, Teakle, Ngari, Caruso, Melanie, Cestari, Michelle F., Patkar, Omkar L., Tse, Brian W. C., Sokolowski, Kamil A., Ebersbach, Hilmar, Jascur, Julia, MacDonald, Kelli P. A., Miller, Gregory, Ramm, Grant A., Pettit, Allison R., Clouston, Andrew D., Powell, Elizabeth E., Hume, David A. and Irvine, Katharine M. (2022). Therapeutic potential of macrophage colony-stimulating factor (CSF1) in chronic liver disease. Disease Models and Mechanisms, 15 (4) dmm049387, 1-15. doi: 10.1242/dmm.049387 |
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2022 Journal Article Arthritis Prediction of Advanced Hepatic Fibrosis in HFE HemochromatosisAndersson, Lauren, Powell, Lawrie W., Ramm, Louise E., Ramm, Grant A. and Olynyk, John K. (2022). Arthritis Prediction of Advanced Hepatic Fibrosis in HFE Hemochromatosis. Mayo Clinic Proceedings, 97 (9), 1649-1655. doi: 10.1016/j.mayocp.2022.02.017 |
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2021 Journal Article Risk of Liver Cancer in HFE-HemochromatosisOlynyk, John K. and Ramm, Grant A. (2021). Risk of Liver Cancer in HFE-Hemochromatosis. Gastroenterology, 161 (5), 1718-1719. doi: 10.1053/j.gastro.2021.08.025 |
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2021 Journal Article RNA sequencing of LX-2 cells treated with TGF-β1 identifies genes associated with hepatic stellate cell activationCarson, Jack P., Robinson, Mark W., Ramm, Grant A. and Gobert, Geoffrey N. (2021). RNA sequencing of LX-2 cells treated with TGF-β1 identifies genes associated with hepatic stellate cell activation. Molecular Biology Reports, 48 (12), 7677-7688. doi: 10.1007/s11033-021-06774-3 |
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2021 Journal Article Cost-effectiveness of a serum biomarker test for risk-stratified liver ultrasound screening for hepatocellular carcinomaCarter, Hannah E., Jeffrey, Gary P., Ramm, Grant A. and Gordon, Louisa G. (2021). Cost-effectiveness of a serum biomarker test for risk-stratified liver ultrasound screening for hepatocellular carcinoma. Value in Health, 24 (10), 1454-1462. doi: 10.1016/j.jval.2021.04.1286 |
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2021 Journal Article The role of sonic hedgehog in human holoprosencephaly and short-rib polydactyly syndromesLoo, Christine K. C., Pearen, Michael A. and Ramm, Grant A. (2021). The role of sonic hedgehog in human holoprosencephaly and short-rib polydactyly syndromes. International Journal of Molecular Sciences, 22 (18) 9854, 9854. doi: 10.3390/ijms22189854 |
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2021 Journal Article Androgens alter the heterogeneity of small extracellular vesicles and the small RNA cargo in prostate cancerMartens-Uzunova, Elena S., Kusuma, Gina D., Crucitta, Stefania, Lim, Hong Kiat, Cooper, Crystal, Riches, James E., Azad, Arun, Ochiya, Takahiro, Boyle, Glen M., Southey, Melissa C., Del Re, Marzia, Lim, Rebecca, Ramm, Grant A., Jenster, Guido W. and Soekmadji, Carolina (2021). Androgens alter the heterogeneity of small extracellular vesicles and the small RNA cargo in prostate cancer. Journal of Extracellular Vesicles, 10 (10) e12136. doi: 10.1002/jev2.12136 |
