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2025 Journal Article Assessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissuesVo, Tuan, Prakrithi, P., Jones, Kahli, Yoon, Sohye, Lam, Pui Yeng, Kao, Yung-Ching, Ma, Ning, Tan, Samuel X., Jin, Xinnan, Zhou, Chenhao, Crawford, Joanna, Walters, Shaun, Gupta, Ishaan, Soyer, Peter H., Khosrotehrani, Kiarash, Stark, Mitchell S. and Nguyen, Quan (2025). Assessing spatial sequencing and imaging approaches to capture the molecular and pathological heterogeneity of archived cancer tissues. Journal of Pathology, 265 (3), 274-288. doi: 10.1002/path.6383 |
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2025 Journal Article Enhancement of anti-sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2-targeted CARLam, Pui Yeng, Omer, Natacha, Wong, Josh K. M., Tu, Cui, Alim, Louisa, Rossi, Gustavo R., Victorova, Maria, Tompkins, Hannah, Lin, Cheng-Yu, Mehdi, Ahmed M., Choo, Amos, Elliott, Melissa R., Coleborn, Elaina, Sun, Jane, Mercer, Timothy, Vittorio, Orazio, Dobson, Lachlan J., Mclellan, Alexander D., Brooks, Andrew, Tuong, Zewen Kelvin, Cheetham, Seth W., Nicholls, Wayne and Souza-Fonseca-Guimaraes, Fernando (2025). Enhancement of anti-sarcoma immunity by NK cells engineered with mRNA for expression of a EphA2-targeted CAR. Clinical and Translational Medicine, 15 (1) e70140, 1-21. doi: 10.1002/ctm2.70140 |
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2024 Journal Article Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammationMcCulloch, Timothy R., Rossi, Gustavo R., Alim, Louisa, Lam, Pui Yeng, Wong, Joshua K. M., Coleborn, Elaina, Kumari, Snehlata, Keane, Colm, Kueh, Andrew J., Herold, Marco J., Wilhelm, Christoph, Knolle, Percy A., Kane, Lawrence, Wells, Timothy J. and Souza-Fonseca-Guimaraes, Fernando (2024). Dichotomous outcomes of TNFR1 and TNFR2 signaling in NK cell-mediated immune responses during inflammation. Nature Communications, 15 (1) 9871, 1-16. doi: 10.1038/s41467-024-54232-y |
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2024 Journal Article A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapyRossi, Gustavo R., Sun, Jane, Lin, Cheng‐Yu, Wong, Joshua K.M., Alim, Louisa, Lam, Pui Yeng, Khosrotehrani, Kiarash, Wolvetang, Ernst, Cheetham, Seth W., Derrick, Emily B., Amoako, Akwasi, Lehner, Christoph, Brooks, Andrew J., Beavis, Paul A. and Souza‐Fonseca‐Guimaraes, Fernando (2024). A scalable, spin‐free approach to generate enhanced induced pluripotent stem cell–derived natural killer cells for cancer immunotherapy. Immunology & Cell Biology, 102 (10), 1-11. doi: 10.1111/imcb.12820 |
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2024 Journal Article Highlight of 2023: Unlocking the therapeutic potential of natural killer cells—advances in adaptive functions, cellular engineering and immunotherapyLam, Pui Yeng and Souza‐Fonseca‐Guimaraes, Fernando (2024). Highlight of 2023: Unlocking the therapeutic potential of natural killer cells—advances in adaptive functions, cellular engineering and immunotherapy. Immunology and Cell Biology, 102 (6), 444-447. doi: 10.1111/imcb.12769 |
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2024 Journal Article The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapyMcCulloch, Timothy R., Rossi, Gustavo R., Miranda‐Hernandez, Socorro, Valencia‐Hernandez, Ana Maria, Alim, Louisa, Belle, Clemence J., Krause, Andrew, Zacchi, Lucia F., Lam, Pui Yeng, Nakamura, Kyohei, Kupz, Andreas, Wells, Timothy J. and Souza‐Fonseca‐Guimaraes, Fernando (2024). The immune checkpoint TIGIT is upregulated on T cells during bacterial infection and is a potential target for immunotherapy. Immunology and Cell Biology, 102 (8), 721-733. doi: 10.1111/imcb.12794 |
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2023 Journal Article Robust mapping of spatiotemporal trajectories and cell–cell interactions in healthy and diseased tissuesPham, Duy, Tan, Xiao, Balderson, Brad, Xu, Jun, Grice, Laura F., Yoon, Sohye, Willis, Emily F., Tran, Minh, Lam, Pui Yeng, Raghubar, Arti, Kalita-de Croft, Priyakshi, Lakhani, Sunil, Vukovic, Jana, Ruitenberg, Marc J. and Nguyen, Quan H. (2023). Robust mapping of spatiotemporal trajectories and cell–cell interactions in healthy and diseased tissues. Nature Communications, 14 (1) 7739, 1-25. doi: 10.1038/s41467-023-43120-6 |
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2022 Journal Article A robust experimental and computational analysis framework at multiple resolutions, modalities and coveragesTran, M., Yoon, S., Teoh, M., Andersen, S., Lam, PY., Purdue, B. W., Raghubar, A., Hanson, S.J., Devitt, K., Jones, K., Walters, S., Monkman, J., Kulasinghe, A., Tuong, Z.K., Soyer, H.P., Frazer, I. H. and Nguyen, Q. (2022). A robust experimental and computational analysis framework at multiple resolutions, modalities and coverages. Frontiers in Immunology, 13 911873, 911873. doi: 10.3389/fimmu.2022.911873 |
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2022 Journal Article Spatially resolved transcriptomes of mammalian kidneys illustrate the molecular complexity and interactions of functional nephron segmentsRaghubar, Arti M., Pham, Duy T., Tan, Xiao, Grice, Laura F., Crawford, Joanna, Lam, Pui Yeng, Andersen, Stacey B., Yoon, Sohye, Teoh, Siok Min, Matigian, Nicholas A., Stewart, Anne, Francis, Leo, Ng, Monica S. Y., Healy, Helen G., Combes, Alexander N., Kassianos, Andrew J., Nguyen, Quan and Mallett, Andrew J. (2022). Spatially resolved transcriptomes of mammalian kidneys illustrate the molecular complexity and interactions of functional nephron segments. Frontiers in Medicine, 9 873923, 873923. doi: 10.3389/fmed.2022.873923 |
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2020 Journal Article Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environmentKobayashi, Takumi, Lam, Pui Yeng, Jiang, Hui, Bednarska, Karolina, Gloury, Renee Elyse, Murigneux, Valentine, Tay, Joshua, Jacquelot, Nicolas, Li, Rui, Tuong, Zewen Kelvin, Leggatt, Graham, Gandhi, Maher K., Hill, Michelle M, Belz, Gabrielle T., Ngo, Shyuan, Kallies, Axel and Mattarollo, Stephen R. (2020). Increased lipid metabolism impairs NK cell function and mediates adaptation to the lymphoma environment. Blood, 136 (26), 3004-3017. doi: 10.1182/blood.2020005602 |
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2020 Journal Article stLearn integrating spatial location, tissue morphology and gene expression to find cell types, cell-cell interactions and spatial trajectories within undissociated tissuesPham, Duy, Tan, Xiao, Xu, Jun, Grice, Laura F., Lam, Pui Yeng, Raghubar, Arti, Vukovic, Jana, Ruitenberg, Marc J. and Nguyen, Quan (2020). stLearn integrating spatial location, tissue morphology and gene expression to find cell types, cell-cell interactions and spatial trajectories within undissociated tissues. Biorxiv, 1-18. doi: 10.1101/2020.05.31.125658v1 |
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2019 Journal Article NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsionLam, Pui Yeng, Kobayashi, Takumi, Soon, Megan, Zeng, Bijun, Dolcetti, Riccardo, Leggatt, Graham, Thomas, Ranjeny and Mattarollo, Stephen R. (2019). NKT cell-driven enhancement of antitumor immunity induced by Clec9a-targeted tailorable nanoemulsion. Cancer Immunology Research, 7 (6), 952-962. doi: 10.1158/2326-6066.cir-18-0650 |
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2018 Journal Article Therapeutic vaccination with 4–1BB co-stimulation eradicates mouse acute myeloid leukemiaKerage, Daniel, Soon, Megan S. F., Doff, Brianna L., Kobayashi, Takumi, Nissen, Michael D., Lam, Pui Yeng, Leggatt, Graham R. and Mattarollo, Stephen R. (2018). Therapeutic vaccination with 4–1BB co-stimulation eradicates mouse acute myeloid leukemia. OncoImmunology, 7 (10) e1486952, 1-10. doi: 10.1080/2162402x.2018.1486952 |
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2018 Journal Article Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity articleAchuthan, Adrian, Aslam, Ahmad S. M., Nguyen, Quyen, Lam, Pui-Yeng, Fleetwood, Andrew J., Frye, Ashlee T., Louis, Cynthia, Lee, Ming-Chin, Smith, Julia E., Cook, Andrew D., Olshansky, Moshe, Turner, Stephen J. and Hamilton, John A. (2018). Glucocorticoids promote apoptosis of proinflammatory monocytes by inhibiting ERK activity article. Cell Death and Disease, 9 (3) 267, 1-13. doi: 10.1038/s41419-018-0332-4 |
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2018 Journal Article B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activityMcKee, Sara J., Tuong, Zewen K., Kobayashi, Takumi, Doff, Brianna L., Soon, Megan S. F ., Nissen, Michael, Lam, Pui Yeng, Keane, Colm, Vari, Frank, Moi, Davide, Mazzieri, Roberta, Leggatt, Graham, Gandhi, Maher K. and Mattarollo, Stephen R. (2018). B cell lymphoma progression promotes the accumulation of circulating Ly6Clo monocytes with immunosuppressive activity. OncoImmunology, 7 (2) e1393599, e1393599. doi: 10.1080/2162402X.2017.1393599 |
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2017 Journal Article Invariant natural killer T cell in immune regulation of blood cancers: harnessing their potential in immunotherapiesLam, Pui Yeng, Nissen, Michael D. and Mattarollo, Stephen R. (2017). Invariant natural killer T cell in immune regulation of blood cancers: harnessing their potential in immunotherapies. Frontiers in Immunology, 8 (OCT) 1355, 1355. doi: 10.3389/fimmu.2017.01355 |
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2016 Journal Article Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammationAchuthan, Adrian, Cook, Andrew D., Lee, Ming-Chin, Saleh, Reem, Khiew, Hsu-Wei, Chang, Melody W.N., Louis, Cynthia, Fleetwood, Andrew J., Lacey, Derek C., Christensen, Anne D., Frye, Ashlee T., Lam, Pui Yeng, Kusano, Hitoshi, Nomura, Koji, Steiner, Nancy, Förster, Irmgard, Nutt, Stephen L., Olshansky, Moshe, Turner, Stephen J. and Hamilton, John A. (2016). Granulocyte macrophage colony-stimulating factor induces CCL17 production via IRF4 to mediate inflammation. Journal of Clinical Investigation, 126 (9), 3453-3466. doi: 10.1172/JCI87828 |
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2014 Journal Article Interferon regulatory factor 6 differentially regulates toll-like receptor 2-dependent chemokine gene expression in epithelial cellsKwa, Mei Qi, Nguyen, Thao, Huynh, Jennifer, Ramnath, Divya, De Nardo, Dominic, Lam, Pei Yeng, Reynolds, Eric C., Hamilton, John A., Sweet, Matthew J. and Scholz, Glen M. (2014). Interferon regulatory factor 6 differentially regulates toll-like receptor 2-dependent chemokine gene expression in epithelial cells. Journal of Biological Chemistry, 289 (28), 19758-19768. doi: 10.1074/jbc.M114.584540 |
