Overview
Background
Daniel S. Nielsen is a Post Doctoral Research Fellow at the Australian Institute for Bioengineering and Nanotechnology (AIBN), The University of Queensland (UQ). As an academic early career researcher (ECR) and expert in the field of biomolecular drug discovery, he has received multiple academic awards, and holds a decorated publication record. He received his Ph.D. in 2016 from the Institute of Molecular Bioscience (IMB) at UQ and dedicated the following three years of his post graduate career to academic research as post doctoral researcher in David P. Fairlie's (IMB, UQ) and Morten Meldal's (Science, University of Copenhagen) laboratories before venturing into the biotech start-up industry. While holding a position as Head of Peptide Chemistry at San Francisco based start-up, SyntheX (www.synthexlabs.com), he managed pre-clinical cross-team collaborative drug discovery projects in the oncology space and helped secure over $750 million in funding. In 2024, he returned to academia with a focus to foster and drive mRNA drug discovery and development programs.
Availability
- Dr Daniel Nielsen is:
- Available for supervision
Qualifications
- Doctor of Philosophy of Pharmacology and Pharmaceutical Sciences, The University of Queensland
Works
Search Professor Daniel Nielsen’s works on UQ eSpace
2021
Journal Article
C-Terminal lactamization of peptides
Fischer, Niklas H., Nielsen, Daniel S., Palmer, Daniel, Meldal, Morten and Diness, Frederik (2021). C-Terminal lactamization of peptides. Chemical Communications, 57 (7), 895-898. doi: 10.1039/d0cc06018f
2020
Journal Article
High cell permeability does not predict oral bioavailability for analogues of cyclic heptapeptide sanguinamide A
Nielsen, Daniel S., Lohman, Rink-Jan, Hoang, Huy N., Fairlie, David P. and Hill, Timothy A. (2020). High cell permeability does not predict oral bioavailability for analogues of cyclic heptapeptide sanguinamide A. Australian Journal of Chemistry, 73 (4), 344-351. doi: 10.1071/ch19479
2019
Journal Article
Mirror image pairs of cyclic hexapeptides have different oral bioavailabilities and metabolic stabilities
Lohman, Rink-Jan, Nielsen, Daniel S., Kok, W. Mei, Hoang, Huy N., Hill, Timothy A. and Fairlie, David P. (2019). Mirror image pairs of cyclic hexapeptides have different oral bioavailabilities and metabolic stabilities. Chemical Communications, 55 (89), 13362-13365. doi: 10.1039/c9cc06234c
2019
Journal Article
Azotides as modular peptide-based ligands for asymmetric Lewis acid catalysis
Jacobsen, Christian Borch, Nielsen, Daniel Steen, Meldal, Morten and Diness, Frederik (2019). Azotides as modular peptide-based ligands for asymmetric Lewis acid catalysis. The Journal of Organic Chemistry, 84 (11), 6940-6945. doi: 10.1021/acs.joc.9b00732
2019
Other Outputs
Supplementary Data tables for: Orally absorbed cyclic peptides
Nielsen, Daniel S., Shepherd, Nicholas E., Xu, Weijun, Lucke, Andrew J., Stoermer, Martin J. and Fairlie, David P. (2019). Supplementary Data tables for: Orally absorbed cyclic peptides. The University of Queensland. (Dataset) doi: 10.14264/uql.2019.213
2017
Journal Article
Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a
Lohman, Rink-Jan, Hamidon, Johan K., Reid, Robert C., Rowley, Jessica A., Yau, Mei-Kwan, Halili, Maria A., Nielsen, Daniel S., Lim, Junxian, Wu, Kai-Chen, Loh, Zhixuan, Do, Anh, Suen, Jacky Y., Iyer, Abishek and Fairlie, David P. (2017). Exploiting a novel conformational switch to control innate immunity mediated by complement protein C3a. Nature Communications, 8 (1) 351, 351. doi: 10.1038/s41467-017-00414-w
2017
Journal Article
Orally absorbed cyclic peptides
Nielsen, Daniel S., Shepherd, Nicholas E., Xu, Weijun, Lucke, Andrew J., Stoermer, Martin J. and Fairlie, David P. (2017). Orally absorbed cyclic peptides. Chemical Reviews, 117 (12), 8094-8128. doi: 10.1021/acs.chemrev.6b00838
2016
Other Outputs
Structural features in orally bioavailable cyclic peptides
Nielsen, Daniel Steen (2016). Structural features in orally bioavailable cyclic peptides. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/uql.2016.659
2015
Journal Article
Flexibility versus rigidity for orally bioavailable cyclic hexapeptides
Nielsen, Daniel S., Lohman, Rink-Jan, Hoang, Huy Ngoc, Hill, Timothy A., Jones, Alun, Lucke, Andrew J. and Fairlie, David P. (2015). Flexibility versus rigidity for orally bioavailable cyclic hexapeptides. Chembiochem, 16 (16), 2289-2293. doi: 10.1002/cbic.201500441
2015
Conference Publication
Cyclic penta- and hexa leucine peptides without N-methylation are orally absorbed
Kok, Woan Mei, Hill, Timothy A., Lohman, Rink-Jan, Hoang, Huy N., Nielsen, Daniel S., Scully, Conor G., Schroeder, Christina I., Colless, Barbara, Bernhardt, Paul V., Edmonds, David, Griffith, David, Rotter, Charles, Ruggeri, Roger, Price, David, Liras, Spiros, Craik, David and Fairlie, David (2015). Cyclic penta- and hexa leucine peptides without N-methylation are orally absorbed. American Chemical Society Meeting, x, 2015. Washington, DC United States: American Chemical Society.
2014
Journal Article
Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficients
Wang, Conan K., Northfield, Susan E., Colless, Barbara, Chaousis, Stephanie, Hamernig, Ingrid, Lohman, Rink-Jan, Nielsen, Daniel S., Schroeder, Christina I., Liras, Spiros, Price, David, A., Fairlie, David and Craik, David J. (2014). Rational design and synthesis of orally bioavailable peptides guided by NMR amide temperature coefficients. Proceedings of the National Academy of Sciences of the United States of America (PNAS), 111 (49), 17504-17509. doi: 10.1073/pnas.1417611111
2014
Journal Article
Improving on nature: making a cyclic heptapeptide orally bioavailable
Nielsen, Daniel S., Hoang, Huy N., Lohman, Rink-Jan, Hill, Timothy A., Lucke, Andrew J., Craik, David J., Edmonds, David J., Griffith, David A., Rotter, Charles J., Ruggeri, Roger B., Price, David A., Liras, Spiros and Fairlie, David P. (2014). Improving on nature: making a cyclic heptapeptide orally bioavailable. Angewandte Chemie - International Edition, 53 (45), 12059-12063. doi: 10.1002/anie.201405364
2014
Journal Article
Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbed
Hill, Timothy A., Lohman, Rink-Jan, Hoang, Huy N., Nielsen, Daniel S., Scully, Conor C. G., Kok, W. Mei, Liu, Ligong, Lucke, Andrew J., Stoermer, Martin J., Schroeder, Christina I., Chaousis, Stephanie, Colless, Barbara, Bernhardt, Paul V., Edmonds, David J., Griffith, David A., Rotter, Charles J., Ruggeri, Roger B., Price, David A., Liras, Spiros, Craik, David J. and Fairlie, David P. (2014). Cyclic penta- and hexaleucine peptides without N-methylation are orally absorbed. ACS Medicinal Chemistry Letters, 5 (10), 1148-1151. doi: 10.1021/ml5002823
2013
Journal Article
Total synthesis, structure, and oral absorption of a thiazole cyclic peptide, sanguinamide A
Nielsen, Daniel S., Hoang, Huy N., Lohman, Rink-Jan, Diness, Frederik and Fairlie, David P. (2013). Total synthesis, structure, and oral absorption of a thiazole cyclic peptide, sanguinamide A. Organic Letters, 14 (22), 5720-5723. doi: 10.1021/ol3027347
2011
Journal Article
Synthesis of the Thiazole-Thiazoline Fragment of Largazole Analogues
Diness, Frederik, Nielsen, Daniel S. and Fairlie, David P. (2011). Synthesis of the Thiazole-Thiazoline Fragment of Largazole Analogues. Journal of Organic Chemistry, 76 (23), 9845-9851. doi: 10.1021/jo201675r
Supervision
Availability
- Dr Daniel Nielsen is:
- Available for supervision
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Media
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