Investigating A novel generic Approach to Anti-Infective Agents (2008-2010)
Abstract
Alpha helical regions on proteins mediate infection by viruses and bacteria. Short peptides corresponding to these helical segments are unstructured in water. We will (a) test new technology for its generic capacity to stabalize 1-4 turns of alpha helical viral and bacterial peptides, (b) test small molecules for helical structure, & (c) test for antiviral, antibacterial or immunogenecity activeity in cell assays. Proof of the technology may benefit many fiels of medicine and health prevention
