Deep brain neurovascular coupling analysis using multimode fibre endoscopes (2025-2027)
Abstract
This project aims to unravel the hidden rules governing blood flow regulation in the brain, focusing specifically on the intricate interactions between neurons and blood vessels within the thalamus. These interactions are essential for supplying neurons with glucose and oxygen, but their underlying mechanisms remain elusive due to the depth of the thalamus. The project seeks to address this challenge by creating a hair-thin endoscope capable of stimulating activity in neurons and observing the effects on nearby blood vessels using advanced imaging techniques. The anticipated outcome is a suite of tools empowering neuroscientists, with future discoveries facilitated by the technology positioning Australia as a nexus of global brain research.
