Rewiring enzymes for direct electrochemistry (2026-2029)

This project aims to overcome existing barriers to activating nature's catalysts (enzymes) with an electrical current instead of chemical reagents. Electrochemical methods applied to new modified hybrid enzymes, comprising natural and synthetic components, will provide improved electrical connections allowing direct electron exchange between the enzyme and an electrode. Applications of enzymes in chemical analysis, small molecule activation, bioremediation, sensing and synthesis are currently limited by poor electrode-enzyme communication. The expected outcome of this project comprises a generally applicable electrochemical platform technology that may be applied in all fields that utilise redox enzymes.