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2024

Journal Article

The quest for evidence on time to antibiotics in children with sepsis—finding the sweet spot

Luethi, Nora, Schlapbach, Luregn J. and Baumann, Philipp (2024). The quest for evidence on time to antibiotics in children with sepsis—finding the sweet spot. JAMA Network Open, 7 (6) e2413926. doi: 10.1001/jamanetworkopen.2024.13926

The quest for evidence on time to antibiotics in children with sepsis—finding the sweet spot

2024

Journal Article

Pediatric Phoenix Sepsis Score validation challenges in low-resource settings and in the ED—Reply

Watson, R. Scott, Schlapbach, Luregn J., Sorce, Lauren R. and for the Society of Critical Care Medicine Pediatric Sepsis Definitions Task Force (2024). Pediatric Phoenix Sepsis Score validation challenges in low-resource settings and in the ED—Reply. JAMA, 331 (24), E1-E1. doi: 10.1001/jama.2024.8447

Pediatric Phoenix Sepsis Score validation challenges in low-resource settings and in the ED—Reply

2024

Journal Article

Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study

Schlapbach, Luregn J., Ganesamoorthy, Devika, Wilson, Clare, Raman, Sainath, George, Shane, Snelling, Peter J., Phillips, Natalie, Irwin, Adam, Sharp, Natalie, Le Marsney, Renate, Chavan, Arjun, Hempenstall, Allison, Bialasiewicz, Seweryn, MacDonald, Anna D., Grimwood, Keith, Cling, Jessica C., McPherson, Stephen J., Blumenthal, Antje, Kaforou, Myrsini, Levin, Michael, Herberg, Jethro A., Gibbons, Kristen S., Coin, Lachlan J. M., EUCLIDS consortium and RAPIDS Study Group (2024). Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study. The Lancet Child and Adolescent Health, 8 (5), 325-338. doi: 10.1016/S2352-4642(24)00017-8

Host gene expression signatures to identify infection type and organ dysfunction in children evaluated for sepsis: a multicentre cohort study

2024

Journal Article

Plasma protein biomarkers distinguish multisystem inflammatory syndrome in children from other pediatric infectious and inflammatory diseases

Yeoh, Sophya, Estrada-Rivadeneyra, Diego, Jackson, Heather, Keren, Ilana, Galassini, Rachel, Cooray, Samantha, Shah, Priyen, Agyeman, Philipp, Basmaci, Romain, Carrol, Enitan, Emonts, Marieke, Fink, Colin, Kuijpers, Taco, Martinon-Torres, Federico, Mommert-Tripon, Marine, Paulus, Stephane, Pokorn, Marko, Rojo, Pablo, Romani, Lorenza, Schlapbach, Luregn, Schweintzger, Nina, Shen, Ching-Fen, Tsolia, Maria, Usuf, Effua, van der Flier, Michiel, Vermont, Clementien, von Both, Ulrich, Yeung, Shunmay, Zavadska, Dace ... DIAMONDS and UK KD Genetic Consortia (2024). Plasma protein biomarkers distinguish multisystem inflammatory syndrome in children from other pediatric infectious and inflammatory diseases. Pediatric Infectious Disease Journal, 43 (5), 444-53. doi: 10.1097/inf.0000000000004267

Plasma protein biomarkers distinguish multisystem inflammatory syndrome in children from other pediatric infectious and inflammatory diseases

2024

Journal Article

Swissped-RECOVERY: masked independent adjudication for the interpretation of non-randomised treatment in a two-arm open-label randomised controlled trial (methylprednisolone vs immunoglobulins) in Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) involving 10 secondary and tertiary paediatric hospitals in Switzerland

Schöbi, Nina, Sanchez, Carlos, Welzel, Tatjana, Bamford, Alasdair, Webb, Kate, Rojo, Pablo, Tremoulet, Adriana, Atkinson, Andrew, Schlapbach, Luregn J. and Bielicki, Julia Anna (2024). Swissped-RECOVERY: masked independent adjudication for the interpretation of non-randomised treatment in a two-arm open-label randomised controlled trial (methylprednisolone vs immunoglobulins) in Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) involving 10 secondary and tertiary paediatric hospitals in Switzerland. BMJ Open, 14 (4) e078137, 1-8. doi: 10.1136/bmjopen-2023-078137

Swissped-RECOVERY: masked independent adjudication for the interpretation of non-randomised treatment in a two-arm open-label randomised controlled trial (methylprednisolone vs immunoglobulins) in Paediatric Inflammatory Multisystem Syndrome Temporally Associated with SARS-CoV-2 (PIMS-TS) involving 10 secondary and tertiary paediatric hospitals in Switzerland

2024

Journal Article

Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis

Khan, Nemat, Kumar, Vinod, Li, Pengcheng, RAPIDS Study Group, Raman, Sainath (RSG member), Sharp, Natalie (RSG member), Phillips, Natalie (RSG member), Irwin, Adam (RSG member), George, Shane (RSG member), Grimwood, Keith (RSG member), Snelling, Peter (RSG member), Chavan, Arjun (RSG member), Hempenstall, Allison (RSG member), Gibbons, Kristen (RSG member), Le Marsney, Renate (RSG member), Blumenthal, Antje (RSG member), Ganesamoorthy, Devika (RSG member), Coin, Lachlan (RSG member), Schlapbach, Luregn J., Boyd, Andrew W., Coulthard, Mark G. and Woodruff, Trent M. (2024). Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis. Science Translational Medicine, 16 (744) eadg5768, 1-15. doi: 10.1126/scitranslmed.adg5768

Inhibiting Eph/ephrin signaling reduces vascular leak and endothelial cell dysfunction in mice with sepsis

2024

Journal Article

Fluid management and active fluid removal practices: a global survey of paediatric critical care physicians

Aramburo, Angela, Raman, Sainath, Silversides, Jonathan A., Schlapbach, Luregn J., Gibbons, Kristen S., Ramnarayan, Padmanabhan, on behalf of the Australian, New Zealand Intensive Care Society Paediatric Study Group (ANZICS PSG), the United Kingdom Paediatric Critical Care Society Study Group (PCCS-SG), Pellegrini, Breanna, George, Shane, Balit, Corrine, Oberender, Felix, Erickson, Simon, Flores, Jenipher Chumbes, Charles, Karina, Waak, Michaela, Long, Debbie, Butt, Warwick, Delzoppo, Carmel, Gelbart, Ben, Masterson, Kate, Millar, Johnny, Ganeshalingam, Anusha, Sherring, Claire, Singh, Puneet, Smith, Vicky, Schults, Jessica, Darvas, Jennifer and Festa, Marino (2024). Fluid management and active fluid removal practices: a global survey of paediatric critical care physicians. Intensive Care Medicine – Paediatric and Neonatal, 2 (1) 16, 1-16. doi: 10.1007/s44253-024-00038-1

Fluid management and active fluid removal practices: a global survey of paediatric critical care physicians

2024

Journal Article

A Critique of the “Conservative Versus Liberal Oxygenation Targets in Critically Ill Children” Multicenter, Randomized Clinical Trial Published in the Lancet 2024—More on “Less Is More?”

Mozun, Rebeca and Schlapbach, Luregn J. (2024). A Critique of the “Conservative Versus Liberal Oxygenation Targets in Critically Ill Children” Multicenter, Randomized Clinical Trial Published in the Lancet 2024—More on “Less Is More?”. Pediatric Critical Care Medicine, 25 (7), e338-e342. doi: 10.1097/pcc.0000000000003519

A Critique of the “Conservative Versus Liberal Oxygenation Targets in Critically Ill Children” Multicenter, Randomized Clinical Trial Published in the Lancet 2024—More on “Less Is More?”

2024

Journal Article

Correction: achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis

Chai, Ming G., Tu, Quyen, Cotta, Menino O., Bauer, Michelle J., Balch, Ross, Okafor, Charles, Comans, Tracy, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Ungerer, Jacobus P. J., Mcwhinney, Brett C., Farkas, Andras, Paterson, David L., Clark, Julia E., Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Forde, Brian M., Harris, Patrick N. A., Schlapbach, Luregn J., Coin, Lachlan, Roberts, Jason A. and Irwin, Adam D. (2024). Correction: achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis. Intensive Care Medicine, 50 (5), 810-810. doi: 10.1007/s00134-024-07393-9

Correction: achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis

2024

Journal Article

Platelet reactivity in young children undergoing congenital heart disease surgery: a NITRIC randomized clinical trial substudy

van Loon, Kim, Koomen, Erik, Hiensch, Senna, van Belle- van Haaren, Nicole J. C. W., Koelhuis-Faber, Mizja, Charlier, Jean-Luc, Lammers, Jan, Imhof, Oscar, Nijman, Joppe, van Wijk, Abraham, Breur, Johannes M. P. J., Gibbons, Kristen, Butt, Warwick, Schlapbach, Luregn J., Horton, Stephen, Korporaal, Suzanne and the NITRIC Study Group (2024). Platelet reactivity in young children undergoing congenital heart disease surgery: a NITRIC randomized clinical trial substudy. Intensive Care Medicine – Paediatric and Neonatal, 2 (1) 13. doi: 10.1007/s44253-024-00037-2

Platelet reactivity in young children undergoing congenital heart disease surgery: a NITRIC randomized clinical trial substudy

2024

Journal Article

Raising AWaRe-ness of antimicrobial stewardship challenges in pediatric emergency care: results from the PERFORM study assessing consistency and appropriateness of antibiotic prescribing across Europe

Kolberg, Laura, Khanijau, Aakash, van der Velden, Fabian J S, Herberg, Jethro, De, Tisham, Galassini, Rachel, Cunnington, Aubrey J, Wright, Victoria, Shah, Priyen, Kaforou, Myrsini, Wilson, Clare, Kuijpers, Taco, Martinón-Torres, Federico, Rivero-Calle, Irene, Moll, Henriette, Vermont, Clementien, Pokorn, Marko, Kolnik, Mojca, Pollard, Andrew J, Agyeman, Philipp K A, Schlapbach, Luregn J, Tsolia, Maria N, Yeung, Shunmay, Zavadska, Dace, Zenz, Werner, Schweintzger, Nina A, van der Flier, Michiel, de Groot, Ronald, Usuf, Effua ... The PERFORM Consortium (2024). Raising AWaRe-ness of antimicrobial stewardship challenges in pediatric emergency care: results from the PERFORM study assessing consistency and appropriateness of antibiotic prescribing across Europe. Clinical Infectious Diseases, 78 (3), 526-534. doi: 10.1093/cid/ciad615

Raising AWaRe-ness of antimicrobial stewardship challenges in pediatric emergency care: results from the PERFORM study assessing consistency and appropriateness of antibiotic prescribing across Europe

2024

Journal Article

Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis

Chai, Gene G., Tu, Quyen, Cotta, Menino O., Bauer, Michelle J., Balch, Ross, Okafor, Charles, Comans, Tracy, Kruger, Peter, Meyer, Jason, Shekar, Kiran, Brady, Kara, Fourie, Cheryl, Sharp, Natalie, Vlad, Luminita, Whiley, David, Ungerer, Jacobus P. J., McWhinney, Brett C., Farkas, Andras, Paterson, David L., Clark, Julia E., Hajkowicz, Krispin, Raman, Sainath, Bialasiewicz, Seweryn, Lipman, Jeffrey, Forde, Brian M., Harris, Patrick N. A., Schlapbach, Luregn J., Coin, Lachlan, Roberts, Jason A. and Irwin, Adam D. (2024). Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis. Intensive Care Medicine, 50 (4), 539-547. doi: 10.1007/s00134-024-07353-3

Achievement of therapeutic antibiotic exposures using Bayesian dosing software in critically unwell children and adults with sepsis

2024

Journal Article

Intravenous maintenance fluid therapy in acutely and critically ill children: state of the evidence

Brossier, David W., Goyer, Isabelle, Verbruggen, Sascha C. A. T., Jotterand Chaparro, Corinne, Rooze, Shancy, Marino, Luise V., Schlapbach, Luregn J., Tume, Lyvonne N. and Valla, Frederic V. (2024). Intravenous maintenance fluid therapy in acutely and critically ill children: state of the evidence. The Lancet Child and Adolescent Health, 8 (3), 236-244. doi: 10.1016/s2352-4642(23)00288-2

Intravenous maintenance fluid therapy in acutely and critically ill children: state of the evidence

2024

Journal Article

International consensus criteria for pediatric sepsis and septic shock

Schlapbach, Luregn J., Watson, R. Scott, Sorce, Lauren R., Argent, Andrew C., Menon, Kusum, Hall, Mark W., Akech, Samuel, Albers, David J., Alpern, Elizabeth R., Balamuth, Fran, Bembea, Melania, Biban, Paolo, Carrol, Enitan D., Chiotos, Kathleen, Chisti, Mohammod Jobayer, Dewitt, Peter E., Evans, Idris, Flauzino De Oliveira, Cláudio, Horvat, Christopher M., Inwald, David, Ishimine, Paul, Jaramillo-Bustamante, Juan Camilo, Levin, Michael, Lodha, Rakesh, Martin, Blake, Nadel, Simon, Nakagawa, Satoshi, Peters, Mark J., Randolph, Adrienne G. ... Bennett, Tellen D. (2024). International consensus criteria for pediatric sepsis and septic shock. JAMA, 331 (8), 665-674. doi: 10.1001/jama.2024.0179

International consensus criteria for pediatric sepsis and septic shock

2024

Journal Article

Serum levels of vitamin C and thiamin in children with suspected sepsis: a prospective observational cohort study

McWhinney, Brett, Ungerer, Jacobus, LeMarsey, Renate, Phillips, Natalie, Raman, Sainath, Gibbons, Kristen, Schlapbach, Luregn J., on behalf of Rapid Acute Paediatric Infection Diagnosis in Suspected Sepsis (RAPIDS) Study Investigators, Irwin, Adam (RAPIDS member) and Bialasiewicz, Seweryn (RAPIDS member) (2024). Serum levels of vitamin C and thiamin in children with suspected sepsis: a prospective observational cohort study. Pediatric Critical Care Medicine, 25 (2), 171-176. doi: 10.1097/PCC.0000000000003349

Serum levels of vitamin C and thiamin in children with suspected sepsis: a prospective observational cohort study

2024

Journal Article

Resuscitation with early adrenaline infusion for children with septic shock: a randomized pilot trial

Harley, Amanda, George, Shane, Phillips, Natalie, King, Megan, Long, Debbie, Keijzers, Gerben, Lister, Paula, Raman, Sainath, Bellomo, Rinaldo, Gibbons, Kristen, Schlapbach, Luregn J. and on behalf of Resuscitation in Paediatric Sepsis Randomized Controlled Pilot Platform Study in the Emergency Department (RESPOND ED) Study Group (2024). Resuscitation with early adrenaline infusion for children with septic shock: a randomized pilot trial. Pediatric Critical Care Medicine, 25 (2), 106-117. doi: 10.1097/PCC.0000000000003351

Resuscitation with early adrenaline infusion for children with septic shock: a randomized pilot trial

2024

Journal Article

Resuscitation with vitamin C, hydrocortisone, and thiamin in children with septic shock: a multicenter randomized pilot study

Schlapbach, Luregn J., Raman, Sainath, Buckley, David, George, Shane, King, Megan, Ridolfi, Roberta, Harley, Amanda, Cree, Michele, Long, Debbie, Erickson, Simon, Singh, Puneet, Festa, Marino, Gibbons, Kristen, Bellomo, Rinaldo and on behalf of Resuscitation in Paediatric Sepsis Randomized Controlled Pilot Platform in the Paediatric Intensive Care Unit (RESPOND PICU) Study Investigators and the Australian and New Zealand Intensive Care Society Paediatric Study Group (2024). Resuscitation with vitamin C, hydrocortisone, and thiamin in children with septic shock: a multicenter randomized pilot study. Pediatric Critical Care Medicine, 25 (2), 159-170. doi: 10.1097/PCC.0000000000003346

Resuscitation with vitamin C, hydrocortisone, and thiamin in children with septic shock: a multicenter randomized pilot study

2024

Journal Article

COVID-19 vaccine acceptance among parents of children with multisystem inflammatory syndrome in children

Blanchard-Rohner, Geraldine, Sanchez, Carlos, Andre, Maya C., Bressieux-Degueldre, Sabrina, Grazioli, Serge, Perez, Marie-Helene, Wütz, Daniela, Schöbi, Nina, Welzel, Tatjana, Atkinson, Andrew, Schlapbach, Luregn J., Bielicki, Julia A., Trück, Johannes and for the Swissped RECOVERY Trial Group (2024). COVID-19 vaccine acceptance among parents of children with multisystem inflammatory syndrome in children. Pediatric Infectious Disease Journal, 43 (4), 361-364. doi: 10.1097/inf.0000000000004206

COVID-19 vaccine acceptance among parents of children with multisystem inflammatory syndrome in children

2024

Journal Article

Rapid nanopore sequencing and predictive susceptibility testing of positive blood cultures from intensive care patients with sepsis

Harris, Patrick N. A., Bauer, Michelle J., Lüftinger, Lukas, Beisken, Stephan, Forde, Brian M., Balch, Ross, Cotta, Menino, Schlapbach, Luregn, Raman, Sainath, Shekar, Kiran, Kruger, Peter, Lipman, Jeff, Bialasiewicz, Seweryn, Coin, Lachlan, Roberts, Jason A., Paterson, David L. and Irwin, Adam D. (2024). Rapid nanopore sequencing and predictive susceptibility testing of positive blood cultures from intensive care patients with sepsis. Microbiology Spectrum, 12 (2) e0306523, 1-16. doi: 10.1128/spectrum.03065-23

Rapid nanopore sequencing and predictive susceptibility testing of positive blood cultures from intensive care patients with sepsis

2024

Journal Article

Correction: Neonatal sepsis definitions from randomised clinical trials (Pediatric Research, (2023), 93, 5, (1141-1148), 10.1038/s41390-021-01749-3)

Hayes, Rían, Hartnett, Jack, Semova, Gergana, Murray, Cian, Murphy, Katherine, Carroll, Leah, Plapp, Helena, Hession, Louise, O’Toole, Jonathan, McCollum, Danielle, Roche, Edna, Jenkins, Elinor, Mockler, David, Hurley, Tim, McGovern, Matthew, Allen, John, Meehan, Judith, Plötz, Frans B., Strunk, Tobias, de Boode, Willem P., Polin, Richard, Wynn, James L., Degtyareva, Marina, Küster, Helmut, Janota, Jan, Giannoni, Eric, Schlapbach, Luregn J., Keij, Fleur M., Reiss, Irwin K. M. ... Molloy, Eleanor J. (2024). Correction: Neonatal sepsis definitions from randomised clinical trials (Pediatric Research, (2023), 93, 5, (1141-1148), 10.1038/s41390-021-01749-3). Pediatric Research, 96 (7), 1882-1882. doi: 10.1038/s41390-024-03416-9

Correction: Neonatal sepsis definitions from randomised clinical trials (Pediatric Research, (2023), 93, 5, (1141-1148), 10.1038/s41390-021-01749-3)