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2023 Journal Article SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activityMartínez-Mármol, Ramón, Giordano-Santini, Rosina, Kaulich, Eva, Cho, Ann-Na, Przybyla, Magdalena, Riyadh, Md Asrafuzzaman, Robinson, Emilija, Chew, Keng Yih, Amor, Rumelo, Meunier, Frédéric A., Balistreri, Giuseppe, Short, Kirsty R., Ke, Yazi D., Ittner, Lars M. and Hilliard, Massimo A. (2023). SARS-CoV-2 infection and viral fusogens cause neuronal and glial fusion that compromises neuronal activity. Science Advances, 9 (23) eadg2248, 1-15. doi: 10.1126/sciadv.adg2248 |
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2023 Journal Article The dynamin GTPase mediates regenerative axonal fusion in Caenorhabditis elegans by regulating fusogen levelsVijayaraghavan, Tarika, Dhananjay, Samiksha, Ho, Xue Yan, Giordano-Santini, Rosina, Hilliard, Massimo and Neumann, Brent (2023). The dynamin GTPase mediates regenerative axonal fusion in Caenorhabditis elegans by regulating fusogen levels. PNAS Nexus, 2 (5) pgad114, pgad114. doi: 10.1093/pnasnexus/pgad114 |
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2022 Journal Article Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron DiseaseDing, Qiao, Kesavan, Kaamini, Lee, Kah Meng, Wimberger, Elyse, Robertson, Thomas, Gill, Melinder, Power, Dominique, Chang, Jeryn, Fard, Atefeh T., Mar, Jessica C., Henderson, Robert D., Heggie, Susan, McCombe, Pamela A., Jeffree, Rosalind L., Colditz, Michael J., Hilliard, Massimo A., Ng, Dominic C. H., Steyn, Frederik J., Phillips, William D., Wolvetang, Ernst J., Ngo, Shyuan T. and Noakes, Peter G. (2022). Impaired signaling for neuromuscular synaptic maintenance is a feature of Motor Neuron Disease. Acta Neuropathologica Communications, 10 (1) 61, 61. doi: 10.1186/s40478-022-01360-5 |
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2022 Journal Article The metalloprotease ADM-4/ADAM17 promotes axonal repairHo, Xue Yan, Coakley, Sean, Amor, Rumelo, Anggono, Victor and Hilliard, Massimo A. (2022). The metalloprotease ADM-4/ADAM17 promotes axonal repair. Science Advances, 8 (11) eabm2882, eabm2882. doi: 10.1126/sciadv.abm2882 |
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2022 Journal Article Neuron-epidermal attachment protects hyper-fragile axons from mechanical strainBonacossa-Pereira, Igor, Coakley, Sean and Hilliard, Massimo A. (2022). Neuron-epidermal attachment protects hyper-fragile axons from mechanical strain. Cell Reports, 38 (10) 110501, 110501. doi: 10.1016/j.celrep.2022.110501 |
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2021 Journal Article TDP-43 mutation affects stress granule dynamics in differentiated NSC-34 motoneuron-like cellsDing, Qiao, Chaplin, Justin, Morris, Matthew J., Hilliard, Massimo A., Wolvetang, Ernst, Ng, Dominic C. H. and Noakes, Peter G. (2021). TDP-43 mutation affects stress granule dynamics in differentiated NSC-34 motoneuron-like cells. Frontiers in Cell and Developmental Biology, 9 611601, 611601. doi: 10.3389/fcell.2021.611601 |
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2020 Journal Article Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodiesGormal, Rachel S., Padmanabhan, Pranesh, Kasula, Ravikiran, Bademosi, Adekunle T., Coakley, Sean, Giacomotto, Jean, Blum, Ailisa, Joensuu, Merja, Wallis, Tristan P., Lo, Harriet P., Budnar, Srikanth, Rae, James, Ferguson, Charles, Bastiani, Michele, Thomas, Walter G., Pardon, Els, Steyaert, Jan, Yap, Alpha S., Goodhill, Geoffrey J., Hilliard, Massimo A., Parton, Robert G. and Meunier, Frédéric A. (2020). Modular transient nanoclustering of activated β2-adrenergic receptors revealed by single-molecule tracking of conformation-specific nanobodies. Proceedings of the National Academy of Sciences of the United States of America, 117 (48), 30476-30487. doi: 10.1073/pnas.2007443117 |
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2020 Journal Article Fusogen-mediated neuron−neuron fusion disrupts neural circuit connectivity and alters animal behaviorGiordano-Santini, Rosina, Kaulich, Eva, Galbraith, Kate M., Ritchie, Fiona K., Wang, Wei, Li, Zhaoyu and Hilliard, Massimo A. (2020). Fusogen-mediated neuron−neuron fusion disrupts neural circuit connectivity and alters animal behavior. Proceedings of the National Academy of Sciences, 117 (37), 201919063-23065. doi: 10.1073/pnas.1919063117 |
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2020 Journal Article Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degenerationCoakley, Sean, Ritchie, Fiona K., Galbraith, Kate M. and Hilliard, Massimo A. (2020). Epidermal control of axonal attachment via β-spectrin and the GTPase-activating protein TBC-10 prevents axonal degeneration. Nature Communications, 11 (1) 133, 1-12. doi: 10.1038/s41467-019-13795-x |
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2019 Journal Article Axonal repair by fusion: pitfalls, consequences and solutionsNeumann, Brent and Hilliard, Massimo A. (2019). Axonal repair by fusion: pitfalls, consequences and solutions. FASEB Journal, 33 (12), 13071-13074. doi: 10.1096/fj.201901407R |
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2019 Journal Article Disruption of RAB-5 increases EFF-1 fusogen availability at the cell surface and promotes the regenerative axonal fusion capacity of the neuronLinton, Casey, Riyadh, M. Asrafuzzaman, Ho, Xue Yan, Neumann, Brent, Giordano-Santini, Rosina and Hilliard, Massimo A. (2019). Disruption of RAB-5 increases EFF-1 fusogen availability at the cell surface and promotes the regenerative axonal fusion capacity of the neuron. Journal of Neuroscience, 39 (15), 2823-2836. doi: 10.1523/jneurosci.1952-18.2019 |
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2019 Journal Article Axonal fusion: an alternative and efficient mechanism of nerve repairNeumann, Brent, Linton, Casey, Giordano-Santini, Rosina and Hilliard, Massimo A. (2019). Axonal fusion: an alternative and efficient mechanism of nerve repair. Progress in Neurobiology, 173, 88-101. doi: 10.1016/j.pneurobio.2018.11.004 |
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2019 Journal Article Neuronal sub-compartmentalization: a strategy to optimize neuronal functionDonato, Alessandra, Kagias, Konstantinos, Zhang, Yun and Hilliard, Massimo A. (2019). Neuronal sub-compartmentalization: a strategy to optimize neuronal function. Biological Reviews. doi: 10.1111/brv.12487 |
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2018 Journal Article 6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33Offenburger, Sarah-Lena, Ho, Xue Yan, Tachie-Menson, Theresa, Coakley, Sean, Hilliard, Massimo A. and Gartner, Anton (2018). 6-OHDA-induced dopaminergic neurodegeneration in Caenorhabditis elegans is promoted by the engulfment pathway and inhibited by the transthyretin-related protein TTR-33. PLoS Genetics, 14 (1) e1007125, 1-27. doi: 10.1371/journal.pgen.1007125 |
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2018 Journal Article Defects in synaptic transmission at the neuromuscular junction precedes motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosisChand, Kirat K., Lee, Kah Meng, Lee, John D., Qiu, Hao, Willis, Emily F., Lavidis, Nickolas A., Hilliard, Massimo A. and Noakes, Peter G. (2018). Defects in synaptic transmission at the neuromuscular junction precedes motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 32 (5), fj201700835R-2689. doi: 10.1096/fj.201700835R |
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2017 Journal Article The heterochronic gene lin-14 controls axonal degeneration in C. elegans neuronsRitchie, Fiona K., Knable, Rhianna, Chaplin, Justin, Gursanscky, Rhiannon, Gallegos, Maria, Neumann, Brent and Hilliard, Massimo A. (2017). The heterochronic gene lin-14 controls axonal degeneration in C. elegans neurons. Cell Reports, 20 (12), 2955-2965. doi: 10.1016/j.celrep.2017.08.083 |
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2017 Journal Article A multi-trap microfluidic chip enabling longitudinal studies of nerve regeneration in Caenorhabditis elegansGokce, Sertan Kutal, Hegarty, Evan Marley, Mondal, Sudip, Zhao, Peisen, Ghorashian, Navid, Hilliard, Massimo A. and Ben-Yakar, Adela (2017). A multi-trap microfluidic chip enabling longitudinal studies of nerve regeneration in Caenorhabditis elegans. Scientific Reports, 7 (9837) 9837, 9837. doi: 10.1038/s41598-017-10302-4 |
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2017 Journal Article Phosphatidylserine save-me signals drive functional recovery of severed axons in Caenorhabditis elegansAbay, Zehra C, Wong, Michelle Yu-Ying, Teoh, Jean-Sébastien, Vijayaraghavan, Tarika, Hilliard, Massimo A and Neumann, Brent (2017). Phosphatidylserine save-me signals drive functional recovery of severed axons in Caenorhabditis elegans. Proceedings of the National Academy of Sciences of the United States of America, 114 (47), 1-10. doi: 10.1073/pnas.1703807114 |
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2016 Journal Article Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosisFogarty, Matthew J., Klenowski, Paul M., Lee, John D., Drieberg-Thompson, Joy R., Bartlett, Selena E., Ngo, Shyuan T., Hilliard, Massimo A., Bellingham, Mark C. and Noakes, Peter G. (2016). Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis. Scientific Reports, 6 (1) 37968, 37968. doi: 10.1038/srep37968 |
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2016 Journal Article Cell-cell fusion in the nervous system: alternative mechanisms of development, injury and repairGiordano-Santini, Rosina, Linton, Casey and Hilliard, Massimo A. (2016). Cell-cell fusion in the nervous system: alternative mechanisms of development, injury and repair. Seminars in Cell and Developmental Biology, 60, 146-154. doi: 10.1016/j.semcdb.2016.06.019 |
