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2024 Journal Article Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal modelsPietrogrande, Giovanni, Shaker, Mohammed R., Stednitz, Sarah J., Soheilmoghaddam, Farhad, Aguado, Julio, Morrison, Sean D., Zambrano, Samuel, Tabassum, Tahmina, Javed, Ibrahim, Cooper-White, Justin, Davis, Thomas P., O’Brien, Terence J., Scott, Ethan K. and Wolvetang, Ernst J. (2024). Valproic acid-induced teratogenicity is driven by senescence and prevented by Rapamycin in human spinal cord and animal models. Molecular Psychiatry, 1-13. doi: 10.1038/s41380-024-02732-0 |
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2024 Journal Article Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2Shaker, Mohammed R., Slonchak, Andrii, Al-Mhanawi, Bahaa, Morrison, Sean D., Sng, Julian D.J., Cooper-White, Justin, Khromykh, Alexander A. and Wolvetang, Ernst J. (2024). Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2. Science Advances, 10 (23) eadj4735, 1-23. doi: 10.1126/sciadv.adj4735 |
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2024 Journal Article A roadmap for selecting and utilizing optimal features in scRNA sequencing data analysis for stem cell research: a comprehensive reviewAlani, Maath, Altarturih, Hamza, Pars, Selin, Al-Mhanawi, Bahaa, Wolvetang, Ernst J. and Shaker, Mohammed R. (2024). A roadmap for selecting and utilizing optimal features in scRNA sequencing data analysis for stem cell research: a comprehensive review. International Journal of Stem Cells, 17 (4), 1-16. doi: 10.15283/ijsc23170 |
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2023 Journal Article Protocol for generating embedding-free brain organoids enriched with oligodendrocytesAl-mhanawi, Bahaa, Marti, Marta Boira, Morrison, Sean D., Gupta, Pallavi, Alani, Maath, Noakes, Peter G., Wolvetang, Ernst J. and Shaker, Mohammed R. (2023). Protocol for generating embedding-free brain organoids enriched with oligodendrocytes. STAR Protocols, 4 (4) 102725, 1-18. doi: 10.1016/j.xpro.2023.102725 |
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2023 Journal Article Transcriptional signature of valproic acid-induced neural tube defects in human spinal cord organoidsLee, Ju-Hyun, Shaker, Mohammed R., Park, Si-Hyung and Sun, Woong (2023). Transcriptional signature of valproic acid-induced neural tube defects in human spinal cord organoids. International Journal of Stem Cells, 16 (4), 385-393. doi: 10.15283/ijsc23012 |
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2023 Journal Article Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2Shaker, Mohammed R., Slonchak, Andrii, Al-mhanawi, Bahaa, Morrison, Sean D., Sng, Julian D. J., Cooper-White, Justin, Khromykh, Alexander A. and Wolvetang, Ernst J. (2023). Choroid plexus defects in Down syndrome brain organoids enhance neurotropism of SARS-CoV-2. bioRxiv, 10 (23) eadj4735, eadj4735. doi: 10.1101/2023.06.12.544552 |
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2022 Journal Article Robust and highly reproducible generation of cortical brain organoids for modelling brain neuronal senescence in vitroShaker, Mohammed R., Hunter, Zoe L. and Wolvetang, Ernst J. (2022). Robust and highly reproducible generation of cortical brain organoids for modelling brain neuronal senescence in vitro. Journal of Visualized Experiments, 2022 (183) e63714. doi: 10.3791/63714 |
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2022 Journal Article Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screeningHunter, Zoe L., Leeson, Hannah C., Shaker, Mohammed R., Wolvetang, Ernst J. and Vadlamudi, Lata (2022). Human induced pluripotent stem cells generated from epilepsy patients for use as in vitro models for drug screening. Stem Cell Research, 60 102673, 102673. doi: 10.1016/j.scr.2022.102673 |
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2022 Journal Article Production of human spinal-cord organoids recapitulating neural-tube morphogenesisLee, Ju-Hyun, Shin, Hyogeun, Shaker, Mohammed R., Kim, Hyun Jung, Park, Si-Hyung, Kim, June Hoan, Lee, Namwon, Kang, Minjin, Cho, Subin, Kwak, Tae Hwan, Kim, Jong Woon, Song, Mi-Ryoung, Kwon, Seung-Hae, Han, Dong Wook, Lee, Sanghyuk, Choi, Se-Young, Rhyu, Im Joo, Kim, Hyun, Geum, Dongho, Cho, Il-Joo and Sun, Woong (2022). Production of human spinal-cord organoids recapitulating neural-tube morphogenesis. Nature Biomedical Engineering, 6 (4), 435-448. doi: 10.1038/s41551-022-00868-4 |
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2022 Journal Article Neural epidermal growth factor-like like protein 2 is expressed in human oligodendroglial cell typesShaker, Mohammed R., Kahtan, Amna, Prasad, Renuka, Lee, Ju-Hyun, Pietrogrande, Giovanni, Leeson, Hannah C., Sun, Woong, Wolvetang, Ernst J. and Slonchak, Andrii (2022). Neural epidermal growth factor-like like protein 2 is expressed in human oligodendroglial cell types. Frontiers in Cell and Developmental Biology, 10 803061, 803061. doi: 10.3389/fcell.2022.803061 |
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2021 Journal Article Hypermethylation of Mest promoter causes aberrant Wnt signaling in patients with Alzheimer's diseasePrasad, Renuka, Jung, Hwajin, Tan, Anderson, Song, Yonghee, Moon, Sungho, Shaker, Mohammed R., Sun, Woong, Lee, Junghee, Ryu, Hoon, Lim, Hyun Kook and Jho, Eek-hoon (2021). Hypermethylation of Mest promoter causes aberrant Wnt signaling in patients with Alzheimer's disease. Scientific Reports, 11 (1) 20075, 20075. doi: 10.1038/s41598-021-99562-9 |
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2021 Journal Article Spatiotemporal contribution of neuromesodermal progenitor-derived neural cells in the elongation of developing mouse spinal cordShaker, Mohammed R., Lee, Ju-Hyun, Kim, Kyung Hyun, Ban, Saeli, Kim, Veronica Jihyun, Kim, Joo Yeon, Lee, Ji Yeoun and Sun, Woong (2021). Spatiotemporal contribution of neuromesodermal progenitor-derived neural cells in the elongation of developing mouse spinal cord. Life Sciences, 282 119393, 1-11. doi: 10.1016/j.lfs.2021.119393 |
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2021 Journal Article Generation of induced pluripotent stem cell lines from peripheral blood mononuclear cells of three drug resistant and three drug responsive epilepsy patientsHunter, Zoe L., Leeson, Hannah C., Shaker, Mohammed R., Wolvetang, Ernst J. and Vadlamudi, Lata (2021). Generation of induced pluripotent stem cell lines from peripheral blood mononuclear cells of three drug resistant and three drug responsive epilepsy patients. Stem Cell Research, 56 102564, 102564. doi: 10.1016/j.scr.2021.102564 |
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2021 Journal Article Inhibition of the cGAS‐STING pathway ameliorates the premature senescence hallmarks of Ataxia‐Telangiectasia brain organoidsAguado, Julio, Chaggar, Harman K., Gómez‐Inclán, Cecilia, Shaker, Mohammed R., Leeson, Hannah C., Mackay‐Sim, Alan and Wolvetang, Ernst J. (2021). Inhibition of the cGAS‐STING pathway ameliorates the premature senescence hallmarks of Ataxia‐Telangiectasia brain organoids. Aging Cell, 20 (9) e13468, 1-16. doi: 10.1111/acel.13468 |
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2021 Journal Article Klotho inhibits neuronal senescence in human brain organoidsShaker, Mohammed R., Aguado, Julio, Chaggar, Harman Kaur and Wolvetang, Ernst J. (2021). Klotho inhibits neuronal senescence in human brain organoids. npj Aging and Mechanisms of Disease, 7 (1) 18, 1-12. doi: 10.1038/s41514-021-00070-x |
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2021 Journal Article Embryonal neuromesodermal progenitors for caudal central nervous system and tissue developmentShaker, Mohammed R., Lee, Ju-Hyun and Sun, Woong (2021). Embryonal neuromesodermal progenitors for caudal central nervous system and tissue development. Journal of Korean Neurosurgical Society, 64 (3), 359-366. doi: 10.3340/jkns.2020.0359 |
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2021 Journal Article Rapid and efficient generation of myelinating human oligodendrocytes in organoidsShaker, Mohammed R., Pietrogrande, Giovanni, Martin, Sally, Lee, Ju-Hyun, Woong, Sun and Wolvetang, Ernst J. (2021). Rapid and efficient generation of myelinating human oligodendrocytes in organoids. Frontiers in Cellular Neuroscience, 15 631548, 1-11. doi: 10.3389/fncel.2021.631548 |
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2020 Journal Article Human spinal cord organoids exhibiting neural tube morphogenesis for a quantifiable drug screening system of neural tube defectsLee, Ju-Hyun, Shin, Hyogeun, Shaker, Mohammed R., Kim, Hyun Jung, Kim, June Hoan, Lee, Namwon, Kang, Minjin, Cho, Subin, Kwak, Tae Hwan and Sun, Woong (2020). Human spinal cord organoids exhibiting neural tube morphogenesis for a quantifiable drug screening system of neural tube defects. |
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2020 Journal Article Anteroposterior Wnt-RA gradient defines adhesion and migration properties of neural progenitors in developing spinal cordShaker, Mohammed R., Lee, Ju-Hyun, Park, Si-Hyung, Kim, Joo Yeon, Son, Gi Hoon, Son, Jong Wan, Park, Bae Ho, Rhyu, Im Joo, Kim, Hyun and Sun, Woong (2020). Anteroposterior Wnt-RA gradient defines adhesion and migration properties of neural progenitors in developing spinal cord. Stem Cell Reports, 15 (4), 898-911. doi: 10.1016/j.stemcr.2020.08.016 |
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2020 Journal Article Self-organizing 3D human choroid plexus-ventricle-cortical organoidsShaker, Mohammed R. , Cooper-White, Justin and Wolvetang, Ernst J. (2020). Self-organizing 3D human choroid plexus-ventricle-cortical organoids. |
