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2024

Journal Article

Dynamin independent endocytosis is an alternative cell entry mechanism for multiple animal viruses

Ojha, Ravi, Jiang, Anmin, Mantylae, Elina, Quirin, Tania, Modhira, Naphak, Witte, Robert, Gaudin, Arnaud, De Zanetti, Lisa, Gormal, Rachel Sarah, Vihinen-Ranta, Maija, Mercer, Jason, Suomalainen, Maarit, Greber, Urs F., Yamauchi, Yohei, Lozach, Pierre-Yves, Helenius, Ari, Vapalahti, Olli, Young, Paul, Watterson, Daniel, Meunier, Frederic A., Joensuu, Merja and Balistreri, Giuseppe (2024). Dynamin independent endocytosis is an alternative cell entry mechanism for multiple animal viruses. Plos Pathogens, 20 (11) e1012690, e1012690. doi: 10.1371/journal.ppat.1012690

Dynamin independent endocytosis is an alternative cell entry mechanism for multiple animal viruses

2024

Journal Article

Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein

McMillan, Christopher L. D., Wijesundara, Danushka K., Choo, Jovin J. Y., Amarilla, Alberto A., Modhiran, Naphak, Fernando, Germain J. P., Khromykh, Alexander A., Watterson, Daniel, Young, Paul R. and Muller, David A. (2024). Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein. Journal of General Virology, 105 (1) 001947, 1-6. doi: 10.1099/jgv.0.001947

Enhancement of cellular immunity following needle-free vaccination of mice with SARS-CoV-2 spike protein

2023

Journal Article

Superior efficacy of a skin-applied microprojection device for delivering a novel Zika DNA vaccine

Wijesundara, Danushka K., Yeow, Arthur, McMillan, Christopher L. D., Choo, Jovin J. Y., Todorovic, Aleksandra, Mekonnen, Zelalem A., Masavuli, Makutiro G., Young, Paul R., Gowans, Eric J., Grubor-Bauk, Branka and Muller, David A. (2023). Superior efficacy of a skin-applied microprojection device for delivering a novel Zika DNA vaccine. Molecular Therapy Nucleic Acids, 34 102056. doi: 10.1016/j.omtn.2023.102056

Superior efficacy of a skin-applied microprojection device for delivering a novel Zika DNA vaccine

2023

Journal Article

The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 gamma variant

Pegg, Cassandra L., Modhiran, Naphak, Parry, Rhys H., Liang, Benjamin, Amarilla, Alberto A., Khromykh, Alexander A., Burr, Lucy, Young, Paul R., Chappell, Keith, Schulz, Benjamin L. and Watterson, Daniel (2023). The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 gamma variant. Glycobiology, 34 (2) cwad097, 1-13. doi: 10.1093/glycob/cwad097

The role of N-glycosylation in spike antigenicity for the SARS-CoV-2 gamma variant

2023

Journal Article

Safety, tolerability, and immunogenicity of measles and rubella vaccine delivered with a high-density microarray patch: results from a randomized, partially double-blinded, placebo-controlled phase I clinical trial

Baker, Ben, Bermingham, Imogen M., Leelasena, Indika, Hickling, Julian, Young, Paul R., Muller, David A. and Forster, Angus H. (2023). Safety, tolerability, and immunogenicity of measles and rubella vaccine delivered with a high-density microarray patch: results from a randomized, partially double-blinded, placebo-controlled phase I clinical trial. Vaccines, 11 (11) 1725, 1-17. doi: 10.3390/vaccines11111725

Safety, tolerability, and immunogenicity of measles and rubella vaccine delivered with a high-density microarray patch: results from a randomized, partially double-blinded, placebo-controlled phase I clinical trial

2023

Journal Article

Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial

Chappell, Keith J., Mordant, Francesca L., Amarilla, Alberto A., Modhiran, Naphak, Liang, Benjamin, Li, Zheyi, Wijesundara, Danushka K., Lackenby, Julia A., Griffin, Paul, Bennet, Jillian K., Hensen, Luca, Zhang, Wuji, Nguyen, Thi H.O., Tran, Mai H., Tapley, Peter, Barnes, James, Reading, Patrick C., Kedzierska, Katherine, Ranasinghe, Charani, Subbarao, Kanta, Watterson, Daniel, Young, Paul R. and Munro, Trent P. (2023). Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial. eBioMedicine, 97 104842. doi: 10.1016/j.ebiom.2023.104842

Long-term safety and immunogenicity of an MF59-adjuvanted spike glycoprotein-clamp vaccine for SARS-CoV-2 in adults aged 18–55 years or ≥56 years: 12-month results from a randomised, double-blind, placebo-controlled, phase 1 trial

2023

Journal Article

Microarray patches: scratching the surface of vaccine delivery

Choo, Jovin J. Y., McMillan, Christopher L. D., Young, Paul R. and Muller, David A. (2023). Microarray patches: scratching the surface of vaccine delivery. Expert Review of Vaccines, 22 (1), 937-955. doi: 10.1080/14760584.2023.2270598

Microarray patches: scratching the surface of vaccine delivery

2023

Journal Article

A nanobody recognizes a unique conserved epitope and potently neutralizes against the SARS-CoV-2 omicron variants

Modhiran, Naphak, Lauer, Simon Malte, Amarilla, Alberto A., Hewins, Peter, Lopes van den Broek, Sara Irene, Low, Yu Shang, Thakur, Nazia, Liang, Benjamin, Nieto, Guillermo Valenzuela, Jung, James, Paramitha, Devina, Isaacs, Ariel, Sng, Julian D. J., Song, David, Jørgensen, Jesper Tranekjær, Cheuquemilla, Yorka, Bürger, Jörg, Andersen, Ida Vang, Himelreichs, Johanna, Jara, Ronald, MacLoughlin, Ronan, Miranda-Chacon, Zaray, Chana-Cuevas, Pedro, Kramer, Vasko, Spahn, Christian M. T., Mielke, Thorsten, Khromykh, Alexander A., Munro, Trent, Jones, Martina L. ... Watterson, Daniel (2023). A nanobody recognizes a unique conserved epitope and potently neutralizes against the SARS-CoV-2 omicron variants. iScience, 26 (7) 107085, 107085. doi: 10.1016/j.isci.2023.107085

A nanobody recognizes a unique conserved epitope and potently neutralizes against the SARS-CoV-2 omicron variants

2023

Journal Article

Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”

Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”. mBio, 14 (3), e0081523. doi: 10.1128/mbio.00815-23

Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”

2023

Journal Article

Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”

Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”. mSphere, 8 (3), e0016523. doi: 10.1128/msphere.00165-23

Statement in Support of: “Virology under the Microscope—a Call for Rational Discourse”

2023

Journal Article

Save the microbes to save the planet. A call to action of the International Union of the Microbiological Societies (IUMS)

Rappuoli, Rino, Young, Paul, Ron, Eliora, Pecetta, Simone and Pizza, Mariagrazia (2023). Save the microbes to save the planet. A call to action of the International Union of the Microbiological Societies (IUMS). One Health Outlook, 5 (1) 5, 5. doi: 10.1186/s42522-023-00077-2

Save the microbes to save the planet. A call to action of the International Union of the Microbiological Societies (IUMS)

2023

Journal Article

Erratum: Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions (Proc. Natl. Acad. Sci. U.S.A. (2022) 119 (e2122680119) DOI: 10.1073/pnas.2122680119)

Blyton, Michaela D. J., Young, Paul R., Moore, Ben D. and Chappell, Keith J. (2023). Erratum: Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions (Proc. Natl. Acad. Sci. U.S.A. (2022) 119 (e2122680119) DOI: 10.1073/pnas.2122680119). Proceedings of the National Academy of Sciences of the United States of America, 120 (1) e2220541120. doi: 10.1073/pnas.2220541120

Erratum: Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions (Proc. Natl. Acad. Sci. U.S.A. (2022) 119 (e2122680119) DOI: 10.1073/pnas.2122680119)

2023

Journal Article

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

Albornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0

SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein

2023

Journal Article

Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”

Speck, Peter, Mackenzie, Jason, Bull, Rowena A., Slobedman, Barry, Drummer, Heidi, Fraser, Johanna, Herrero, Lara, Helbig, Karla, Londrigan, Sarah, Moseley, Gregory, Prow, Natalie, Hansman, Grant, Edwards, Robert, Ahlenstiel, Chantelle, Abendroth, Allison, Tscharke, David, Hobson-Peters, Jody, Kriiger-Loterio, Robson, Parry, Rhys, Marsh, Glenn, Harding, Emma, Jacques, David A., Gartner, Matthew J., Lee, Wen Shi, McAuley, Julie, Vaz, Paola, Sainsbury, Frank, Tate, Michelle D., Sinclair, Jane ... Young, Paul (2023). Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”. Journal of Virology, 97 (5). doi: 10.1128/jvi.00451-23

Statement in Support of: “Virology under the Microscope-a Call for Rational Discourse”

2022

Journal Article

Diversity and transmission of koala retrovirus: a case study in three captive koala populations

Joyce, Briony A., Blyton, Michaela D. J., Johnston, Stephen D., Meikle, William D., Vinette Herrin, Kimberly, Madden, Claire, Young, Paul R. and Chappell, Keith J. (2022). Diversity and transmission of koala retrovirus: a case study in three captive koala populations. Scientific Reports, 12 (1) 15787, 1-8. doi: 10.1038/s41598-022-18939-6

Diversity and transmission of koala retrovirus: a case study in three captive koala populations

2022

Journal Article

Characterization and comparison of novel adjuvants for a prefusion clamped MERS vaccine

O’Donnell, Jake S., Isaacs, Ariel, Jakob, Virginie, Lebas, Celia, Barnes, James B., Reading, Patrick C., Young, Paul R., Watterson, Daniel, Dubois, Patrice M., Collin, Nicolas and Chappell, Keith J. (2022). Characterization and comparison of novel adjuvants for a prefusion clamped MERS vaccine. Frontiers in Immunology, 13 976968, 976968. doi: 10.3389/fimmu.2022.976968

Characterization and comparison of novel adjuvants for a prefusion clamped MERS vaccine

2022

Journal Article

A platform technology for generating subunit vaccines against diverse viral pathogens

Young, Andrew, Isaacs, Ariel, Scott, Connor A. P., Modhiran, Naphak, McMillan, Christopher L. D., Cheung, Stacey T. M., Barr, Jennifer, Marsh, Glenn, Thakur, Nazia, Bailey, Dalan, Li, Kenneth S. M., Luk, Hayes K. H., Kok, Kin-Hang, Lau, Susanna K. P., Woo, Patrick C. Y., Furuyama, Wakako, Marzi, Andrea, Young, Paul R., Chappell, Keith J. and Watterson, Daniel (2022). A platform technology for generating subunit vaccines against diverse viral pathogens. Frontiers in Immunology, 13 963023, 1-16. doi: 10.3389/fimmu.2022.963023

A platform technology for generating subunit vaccines against diverse viral pathogens

2022

Journal Article

Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern

McMillan, Christopher L.D., Amarilla, Alberto A., Modhiran, Naphak, Choo, Jovin J.Y., Azuar, Armira, Honeyman, Kate E., Khromykh, Alexander A., Young, Paul R., Watterson, Daniel and Muller, David A. (2022). Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern. Vaccine, 40 (34), 4929-4932. doi: 10.1016/j.vaccine.2022.07.013

Skin-patch delivered subunit vaccine induces broadly neutralising antibodies against SARS-CoV-2 variants of concern

2022

Journal Article

Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions

Blyton, Michaela D. J., Young, Paul R., Moore, Ben D., Chappell, Keith J. and Goff, Stephen (2022). Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions. Proceedings of the National Academy of Sciences of the United States of America, 119 (33) e2122680119, 1-11. doi: 10.1073/pnas.2122680119

Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions

2022

Journal Article

Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions

Blyton, Michaela D. J., Young, Paul R., Moore, Ben D. and Chappell, Keith J. (2022). Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions. Proceedings of the National Academy of Sciences, 119 (33) e2122680119, 1-11. doi: 10.1073/pnas.2122680119

Geographic patterns of koala retrovirus genetic diversity, endogenization, and subtype distributions