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2024 Journal Article Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cellsHolley, Caroline L., Monteleone, Mercedes, Fisch, Daniel, Libert, Alexandre E. S., Ju, Robert J., Choi, Joon H., Condon, Nicholas D., Emming, Stefan, Crawford, Joanna, Lawrence, Grace M. E. P., Coombs, Jared R., Lefevre, James G., Bajracharya, Rinie, Lahoud, Mireille H., Yap, Alpha S., Hamilton, Nicholas, Stehbens, Samantha J., Kagan, Jonathan C., Ariotti, Nicholas, Burgener, Sabrina S. and Schroder, Kate (2024). Pyroptotic cell corpses are crowned with F-actin-rich filopodia that engage CLEC9A signaling in incoming dendritic cells. Nature Immunology, 1-35. doi: 10.1038/s41590-024-02024-3 |
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2024 Journal Article The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axisHolley, Caroline L., Emming, Stefan, Monteleone, Mercedes M., Mellacheruvu, Manasa, Kenney, Kirsten M., Lawrence, Grace M.E.P., Coombs, Jared R., Burgener, Sabrina S. and Schroder, Kate (2024). The septin modifier, forchlorfenuron, activates NLRP3 via a potassium-independent mitochondrial axis. Cell Chemical Biology, 31 (5), 962-972.e4. doi: 10.1016/j.chembiol.2024.04.012 |
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2024 Journal Article Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophagesThygesen, Sara J., Burgener, Sabrina S., Mudai, Prerna, Monteleone, Mercedes, Boucher, Dave, Sagulenko, Vitaliya, Schroder, Kate and Stacey, Katryn J. (2024). Fluorochrome‐labeled inhibitors of caspase‐1 require membrane permeabilization to efficiently access caspase‐1 in macrophages. European Journal of Immunology, 54 (5) 2350515. doi: 10.1002/eji.202350515 |
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2024 Journal Article NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasomeCoombs, Jared R., Zamoshnikova, Alina, Holley, Caroline L., Maddugoda, Madhavi P., Teo, Daniel Eng Thiam, Chauvin, Camille, Poulin, Lionel F, Vitak, Nazarii, Ross, Connie M., Mellacheruvu, Manasa, Coll, Rebecca C., Heinz, Leonhard X., Burgener, Sabrina S., Emming, Stefan, Chamaillard, Mathias, Boucher, Dave and Schroder, Kate (2024). NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome. Science Signaling, 17 (820) abg8145, eabg8145. doi: 10.1126/scisignal.abg8145 |
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2023 Journal Article Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzymeChan, Amy H., Burgener, Sabrina S., Vezyrgiannis, Kassandra, Wang, Xiaohui, Acklam, Jadie, Von Pein, Jessica B., Pizzuto, Malvina, Labzin, Larisa I., Boucher, Dave and Schroder, Kate (2023). Caspase-4 dimerisation and D289 auto-processing elicit an interleukin-1β-converting enzyme. Life Science Alliance, 6 (10) e202301908, 1-11. doi: 10.26508/lsa.202301908 |
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2022 Journal Article Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analysesMilner, Mark T., Lawrence, Grace M. E. P., Holley, Caroline L., Bodea, Liviu-Gabriel, Götz, Jürgen, Burgener, Sabrina S. and Schroder, Kate (2022). Isolation and culture of pure adult mouse microglia and astrocytes for in vitro characterization and analyses. STAR Protocols, 3 (2) 101295, 1-16. doi: 10.1016/j.xpro.2022.101295 |
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2021 Journal Article Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast CellsBurgener, Sabrina Sofia, Brügger, Melanie, Leborgne, Nathan Georges François, Sollberger, Sophia, Basilico, Paola, Kaufmann, Thomas, Bird, Phillip Ian and Benarafa, Charaf (2021). Granule Leakage Induces Cell-Intrinsic, Granzyme B-Mediated Apoptosis in Mast Cells. Frontiers in Cell and Developmental Biology, 9 630166, 1-12. doi: 10.3389/fcell.2021.630166 |
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2021 Journal Article SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophagesLucas, Richard M., Liu, Liping, Curson, James E. B., Koh, Yvette W. H., Tuladhar, Neeraj, Condon, Nicholas D., Das Gupta, Kaustav, Burgener, Sabrina S., Schroder, Kate, Ingley, Evan, Sweet, Matthew J., Stow, Jennifer L. and Luo, Lin (2021). SCIMP is a spatiotemporal transmembrane scaffold for Erk1/2 to direct pro-inflammatory signaling in TLR-activated macrophages. Cell Reports, 36 (10) 109662, 1-20. doi: 10.1016/j.celrep.2021.109662 |
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2021 Journal Article The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer’s diseaseMilner, Mark T, Maddugoda, Madhavi, Götz, Jürgen, Burgener, Sabrina S and Schroder, Kate (2021). The NLRP3 inflammasome triggers sterile neuroinflammation and Alzheimer’s disease. Current Opinion in Immunology, 68, 116-124. doi: 10.1016/j.coi.2020.10.011 |
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2021 Journal Article Placental inflammasome signaling: protection for mother and babyBurgener, Sabrina Sofia and Schroder, Kate (2021). Placental inflammasome signaling: protection for mother and baby. The Journal of Experimental Medicine, 218 (1) e20201738. doi: 10.1084/jem.20201738 |
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2020 Journal Article Chronic cigarette smoke exposure and pneumococcal infection induce oropharyngeal microbiota dysbiosis and contribute to long-lasting lung damage in miceHilty, Markus, Wüthrich, Tsering M., Godel, Aurélie, Adelfio, Roberto, Aebi, Susanne, Burgener, Sabrina S., Illgen-Wilcke, Brunhilde and Benarafa, Charaf (2020). Chronic cigarette smoke exposure and pneumococcal infection induce oropharyngeal microbiota dysbiosis and contribute to long-lasting lung damage in mice. Microbial genomics, 6 (12) 000485, 1-14. doi: 10.1099/mgen.0.000485 |
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2020 Journal Article Neutrophil extracellular traps in host defenseBurgener, Sabrina Sofia and Schroder, Kate (2020). Neutrophil extracellular traps in host defense. Cold Spring Harbor Perspectives in Biology, 12 (7) a037028, a037028-15. doi: 10.1101/cshperspect.a037028 |
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2019 Journal Article Erratum: Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils (Journal of Experimental Medicine (2019) 261:11 DOI: 10.1084/jem.20180371)Ohayon, Delphine, De Chiara, Alessia, Dang, Pham My-Chan, Thieblemont, Nathalie, Chatfield, Simon, Marzaioli, Viviana, Burgener, Sabrina Sofia, Mocek, Julie, Candalh, Céline, Pintard, Coralie, Tacnet-Delorme, Pascale, Renault, Gilles, Lagoutte, Isabelle, Favier, Maryline, Walker, Francine, Hurtado-Nedelec, Margarita, Desplancq, Dominique, Weiss, Etienne, Benarafa, Charaf, Housset, Dominique, Marie, Jean-Claude, Frachet, Philippe, El-Benna, Jamel and Witko-Sarsat, Véronique (2019). Erratum: Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils (Journal of Experimental Medicine (2019) 261:11 DOI: 10.1084/jem.20180371). Journal of Experimental Medicine, 216 (12), 2900-2900. doi: 10.1084/jem.2018037111082019c |
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2019 Journal Article Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophilsOhayon, Delphine, De Chiara, Alessia, Pham My-Chan Dang,, Thieblemont, Nathalie, Chatfield, Simon, Marzaioli, Viviana, Burgener, Sabrina Sofia, Mocek, Julie, Candalh, Celine, Pintard, Coralie, Tacnet-Delorme, Pascale, Renault, Gilles, Lagoutte, Isabelle, Favier, Maryline, Walker, Francine, Hurtado-Nedelec, Margarita, Desplancq, Dominique, Weiss, Etienne, Benarafa, Charaf, Housset, Dominique, Marie, Jean-Claude, Frachet, Philippe, El-Benna, Jamel and Witko-Sarsat, Veronique (2019). Cytosolic PCNA interacts with p47phox and controls NADPH oxidase NOX2 activation in neutrophils. Journal of Experimental Medicine, 216 (11), 2669-2687. doi: 10.1084/jem.20180371 |
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2019 Journal Article Cathepsin G inhibition by Serpinb1 and Serpinb6 prevents programmed necrosis in neutrophils and monocytes and reduces GSDMD-driven inflammationBurgener, Sabrina Sofia, Leborgne, Nathan Georges François, Snipas, Scott J., Salvesen, Guy S., Bird, Phillip Ian and Benarafa, Charaf (2019). Cathepsin G inhibition by Serpinb1 and Serpinb6 prevents programmed necrosis in neutrophils and monocytes and reduces GSDMD-driven inflammation. Cell Reports, 27 (12), 3646-3656.e5. doi: 10.1016/j.celrep.2019.05.065 |
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2019 Journal Article The Genetic Background of Mice Influences the Effects of Cigarette Smoke on Onset and Severity of Experimental Autoimmune EncephalomyelitisEnzmann, Gaby, Adelfio, Roberto, Godel, Aurélie, Haghayegh Jahromi, Neda, Tietz, Silvia, Burgener, Sabrina, Deutsch, Urban, Wekerle, Hartmut, Benarafa, Charaf and Engelhardt, Britta (2019). The Genetic Background of Mice Influences the Effects of Cigarette Smoke on Onset and Severity of Experimental Autoimmune Encephalomyelitis. International Journal of Molecular Sciences, 20 (6) 1433, 1433. doi: 10.3390/ijms20061433 |
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2018 Journal Article miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancerBaumgartner, Ulrich, Berger, Fabienne, Gheinani, Ali Hashemi, Burgener, Sabrina Sofia, Monastyrskaya, Katia and Vassella, Erik (2018). miR-19b enhances proliferation and apoptosis resistance via the EGFR signaling pathway by targeting PP2A and BIM in non-small cell lung cancer. Molecular Cancer, 17 (1) 44, 44. doi: 10.1186/s12943-018-0781-5 |
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2017 Journal Article Transgenic mice expressing human proteinase 3 exhibit sustained neutrophil-associated peritonitisMartin, Katherine R., Pederzoli-Ribeil, Magali, Pacreau, Emeline, Burgener, Sabrina S., Dahdah, Albert, Candalh, Céline, Lauret, Evelyne, Foretz, Marc, Mouthon, Luc, Lucas, Bruno, Thieblemont, Nathalie, Benarafa, Charaf, Launay, Pierre and Witko-Sarsat, Véronique (2017). Transgenic mice expressing human proteinase 3 exhibit sustained neutrophil-associated peritonitis. The Journal of Immunology, 199 (11), 3914-3924. doi: 10.4049/jimmunol.1601522 |
