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2020

Conference Publication

Metabolic and mitochondrial alterations following brain death and heart transplantation

Hoe, L. E. See, Wells, M. A., Bouquet, M., Hyslop, K., Passmore, M. R., Bartnikowski, N., Obonyo, N. G., Reid, J., O'Neill, H., Shuker, T., McDonald, C., Engkilde-Pedersen, S., Wildi, K., Ainola, C., Skeggs, K., Jung, J., Colombo, S., Sato, K., James, L., He, P., Wood, E. S., Heinser, S., Wang, X., Abbate, G., Livingstone, S., Haymet, A., Walweel, K., Mullins, D., Marasco, S. ... Fraser, J. F. (2020). Metabolic and mitochondrial alterations following brain death and heart transplantation. 40th Annual Meeting and Scientific Sessions of the International Society for Heart and Lung Transplantation (ISHLT), Montreal, Canada, 22-25 April 2020. Philadelphia, PA, United States: Elsevier. doi: 10.1016/j.healun.2020.01.419

Metabolic and mitochondrial alterations following brain death and heart transplantation

2020

Conference Publication

(-)-Noradrenaline sensitivity, contractility and mitochondrial function in an ovine model of brain stem death and transplantation

Wells, Matthew, Molenaar, Peter, Hoe, Louise See, Obonyo, Nchafatso, James, Lynette, Bouquet, Mahe, Bartnikowski, Nicole, Passmore, Margaret, Boone, Connie, Wilde, Karin, Weilan, Mo, Hyslop, Kieran, McDonald, Charles, Pedersen, Sanne, Suen, Jacky, Peart, Jason, McGiffin, David and Fraser, John (2020). (-)-Noradrenaline sensitivity, contractility and mitochondrial function in an ovine model of brain stem death and transplantation. 2019 ISHR World Congress, Beijing, China, 3-6 June 2019. London, United Kingdom: Academic Press. doi: 10.1016/j.yjmcc.2019.11.114

(-)-Noradrenaline sensitivity, contractility and mitochondrial function in an ovine model of brain stem death and transplantation

2019

Journal Article

Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration

Houston, Kirsty A., Gibb, Jack, Olupot-Olupot, Peter, Obonyo, Nchafatso, Mpoya, Ayub, Nakuya, Margaret, Muhindo, Rita, Uyoga, Sophie, Evans, Jennifer A., Connon, Roisin, Gibb, Diana M., George, Elizabeth C. and Maitland, Kathryn (2019). Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration. BMC Medicine, 17 (1) 122. doi: 10.1186/s12916-019-1356-z

Gastroenteritis aggressive versus slow treatment for rehydration (GASTRO): a phase II rehydration trial for severe dehydration: WHO plan C versus slow rehydration

2019

Journal Article

Fluid resuscitation with 0.9% saline alters haemostasis in an ovine model of endotoxemic shock

Passmore, Margaret R., Obonyo, Nchafatso G., Byrne, Liam, Boon, Ai-Ching, Diab, Sara D., Dunster, Kimble R., Fung, Yoke L., Spanevello, Michelle M., Fauzi, Mohd H., Pedersen, Sanne E., Simonova, Gabriela, Anstey, Chris M., Shekar, Kiran, Tung, John-Paul, Maitland, Kathryn and Fraser, John F. (2019). Fluid resuscitation with 0.9% saline alters haemostasis in an ovine model of endotoxemic shock. Thrombosis Research, 176, 39-45. doi: 10.1016/j.thromres.2019.02.015

Fluid resuscitation with 0.9% saline alters haemostasis in an ovine model of endotoxemic shock

2019

Journal Article

Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models

Millar, Jonathan E., Bartnikowski, Nicole, von Bahr, Viktor, Malfertheiner, Maximilian V., Obonyo, Nchafatso G., Belliato, Mirko, Suen, Jacky Y., Combes, Alain, McAuley, Daniel F., Lorusso, Roberto and Fraser, John F. (2019). Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models. Intensive Care Medicine Experimental, 7 (1) 18, 18. doi: 10.1186/s40635-019-0232-7

Extracorporeal membrane oxygenation (ECMO) and the acute respiratory distress syndrome (ARDS): a systematic review of pre-clinical models

2019

Journal Article

Assessment of myocardial function in Kenyan children with severe, acute malnutrition the Cardiac Physiology in Malnutrition (CAPMAL) Study

Brent, Bernadette, Obonyo, Nchafatso, Akech, Samuel, Shebbe, Mohammed, Mpoya, Ayub, Mturi, Neema, Berkley, James A., Tulloh, Robert M. R. and Maitland, Kathryn (2019). Assessment of myocardial function in Kenyan children with severe, acute malnutrition the Cardiac Physiology in Malnutrition (CAPMAL) Study. JAMA Network Open, 2 (3). doi: 10.1001/jamanetworkopen.2019.1054

Assessment of myocardial function in Kenyan children with severe, acute malnutrition the Cardiac Physiology in Malnutrition (CAPMAL) Study

2019

Journal Article

Neuron specific enolase and matrix metalloproteinase 9 signal perioperative silent brain infarction during or after transcatheter aortic valve implantation

Fanning, Jonathon P., Hoe, Louise E. See, Passmore, Margaret R., Barnett, Adrian G., Obonyo, Nchafatso G., Millar, Jonathan E., Wesley, Allan J., Suen, Jacky Y. and Fraser, John F. (2019). Neuron specific enolase and matrix metalloproteinase 9 signal perioperative silent brain infarction during or after transcatheter aortic valve implantation. The American Journal of Cardiology, 123 (3), 434-439. doi: 10.1016/j.amjcard.2018.10.022

Neuron specific enolase and matrix metalloproteinase 9 signal perioperative silent brain infarction during or after transcatheter aortic valve implantation

2019

Journal Article

Sepsis: changing definitions, unchanging treatment

Obonyo, Nchafatso Gikenyi, Schlapbach, Luregn Jan and Fraser, John Francis (2019). Sepsis: changing definitions, unchanging treatment. Frontiers in Pediatrics, 6 (JAN) 425, 425. doi: 10.3389/fped.2018.00425

Sepsis: changing definitions, unchanging treatment

2019

Conference Publication

Characterisation of cardiac neurohormonal and inflammatory changes induced by brain death in a novel ovine heart transplant model

Hoe, L. See, Shuker, T., Bartnikowski, N., Passmore, M., Bouquet, M., Obonyo, N., Engkilde-Pedersen, S., McDonald, C., Wells, M., Boon, A., Hyslop, K., James, L., Wildi, K., Cullen, L., Bassi, G. Li, Suen, J., McGiffin, D. and Fraser, J. (2019). Characterisation of cardiac neurohormonal and inflammatory changes induced by brain death in a novel ovine heart transplant model. 67th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 13th Annual Australia and New Zealand Endovascular Therapies Meeting, Adelaide, Australia, 8-11 August 2019. chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2019.06.074

Characterisation of cardiac neurohormonal and inflammatory changes induced by brain death in a novel ovine heart transplant model

2019

Journal Article

Pre-clinical study protocol: Blood transfusion in endotoxaemic shock

Obonyo, Nchafatso G., Byrne, Liam, Tung, John-Paul, Simonova, Gabriela, Diab, Sara D., Dunster, Kimble R., Passmore, Margaret R., Boon, Ai-Ching, See Hoe, Louise, Engkilde-Pedersen, Sanne, Esguerra-Lallen, Arlanna, Fauzi, Mohd H., Pimenta, Leticia P., Millar, Jonathan E., Fanning, Jonathon P., Van Haren, Frank, Anstey, Chris M., Cullen, Louise, Suen, Jacky, Shekar, Kiran, Maitland, Kathryn and Fraser, John F. (2019). Pre-clinical study protocol: Blood transfusion in endotoxaemic shock. MethodsX, 6, 1124-1132. doi: 10.1016/j.mex.2019.05.005

Pre-clinical study protocol: Blood transfusion in endotoxaemic shock

2018

Journal Article

Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock

Passmore, Margaret R., Byrne, Liam, Obonyo, Nchafatso G., See Hoe, Louise E., Boon, Ai-Ching, Diab, Sara D., Dunster, Kimble R., Bisht, Kavita, Tung, John-Paul, Fauzi, Mohd H., Narula, Monica, Pedersen, Sanne E., Esguerra-Lallen, Arlanna, Simonova, Gabriela, Sultana, Annette, Anstey, Chris M., Shekar, Kiran, Maitland, Kathryn, Suen, Jacky Y. and Fraser, John F. (2018). Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock. Respiratory Research, 19 (1) 231, 231. doi: 10.1186/s12931-018-0935-4

Inflammation and lung injury in an ovine model of fluid resuscitated endotoxemic shock

2018

Conference Publication

Packed Red Cell Age Associated With Adverse Cardiovascular Changes in an Ovine Model of Septic Shock Resuscitation

Fanning, Jonathon P., Obonyo, Nchafatso G., Tung, John-Paul, Byrne, Liam, Simonova, Gabriela, Diab, Sara, Dunster, Kimble, Passmore, Margaret, Boon, Ai-Ching, See Hoe, Louise, Engkilde-Pedersen, Sanne, Esguerra-Lallen, Arlanna, Hashairi Fauzi, Mohd, Pretti Pimenta, Leticia, Millar, Jonathan, Anstey, Christopher, van Haren, Frank, Cullen, Louise, Suen, Jacky, Shekar, Kiran, Maitland, Kathryn and Fraser, John (2018). Packed Red Cell Age Associated With Adverse Cardiovascular Changes in an Ovine Model of Septic Shock Resuscitation. American Heart Association's 2018 Scientific Sessions, Chicago, IL United States, 10-12 November 2018. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1161/circ.138.suppl_1.17116

Packed Red Cell Age Associated With Adverse Cardiovascular Changes in an Ovine Model of Septic Shock Resuscitation

2018

Journal Article

Unintended consequences: fluid resuscitation worsens shock in an ovine model of endotoxemia

Byrne, Liam, Obonyo, Nchafatso G., Diab, Sara D., Dunster, Kimble R., Passmore, Margaret R., Boon, Ai-Ching, See Hoe, Louise, Pedersen, Sanne, Hashairi Fauzi, Mohd, Pretti Pimenta, Leticia, Van Haren, Frank, Anstey, Christopher M., Cullen, Louise, Tung, John-Paul, Shekar, Kiran, Maitland, Kathryn and Fraser, John F. (2018). Unintended consequences: fluid resuscitation worsens shock in an ovine model of endotoxemia. American Journal of Respiratory and Critical Care Medicine, 198 (8), 1043-1054. doi: 10.1164/rccm.201801-0064OC

Unintended consequences: fluid resuscitation worsens shock in an ovine model of endotoxemia

2018

Conference Publication

Fluid resuscitation with 0.9% saline impairs myocardial contractility in an ovine model of endotoxemic shock

Obonyo, N., Byrne, L., Shiino, K., Diab, S., Dunster, K., Passmore, M., Boon, A.C., See Hoe, L., Pedersen, S., Fauzi, M., Pimenta, L., Van Haren, F., Shekar, K., Anstey, C., Tung, J.P., Cullen, L., Platts, D., Chan, J., Maitland, K. and Fraser, J. (2018). Fluid resuscitation with 0.9% saline impairs myocardial contractility in an ovine model of endotoxemic shock. 9th Congress of the World Federation of Pediatric Intensive & Critical Care Societies (WFPICCS 2018), Singapore, 9-13 June 2018. Philadelphia, PA United States: Lippincott Williams & Wilkins. doi: 10.1097/01.pcc.0000538016.15507.8c

Fluid resuscitation with 0.9% saline impairs myocardial contractility in an ovine model of endotoxemic shock

2018

Conference Publication

G265(P) Gastroenteritis aggressive versus slow treatment for rehydration (gastro study): a descriptive analysis

Houston, K., Gibb, J., Mpoya, A., Obonyo, N., Olupot-Olupot, P., George, E., Gibb, D. and Maitland, K. (2018). G265(P) Gastroenteritis aggressive versus slow treatment for rehydration (gastro study): a descriptive analysis. Annual Conference of Royal College of Paediatrics and Child Health, Glasgow, United Kingdom, 13-15 March 2018. London, United Kingdom: BMJ Publishing Group. doi: 10.1136/archdischild-2018-rcpch.258

G265(P) Gastroenteritis aggressive versus slow treatment for rehydration (gastro study): a descriptive analysis

2018

Conference Publication

Inflammatory cytokine profiles in 24-hour brain stem death model

Boon, A. C., Hoe, L. E. See, Pederson, S. E., Obonyo, N. G., Wells, M. A., Bartnikowski, N. J., Passmore, M. R., Marshall, L., James, L., Tung, J., Suen, J. Y., Macdonald, P. S., McGiffin, D. C. and Fraser, J. F. (2018). Inflammatory cytokine profiles in 24-hour brain stem death model. 38th Annual Meeting and Scientific Sessions of the International-Society-for-Heart-and-Lung-Transplantation (ISHLT), Nice, France, 11-14 April 2018. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.healun.2018.01.506

Inflammatory cytokine profiles in 24-hour brain stem death model

2018

Book Chapter

Optimizing the patient and timing of the introduction of mechanical circulatory and extracorporeal respiratory support

Shekar, Kiran, Obonyo, Nchafatso and Fraser, John F. (2018). Optimizing the patient and timing of the introduction of mechanical circulatory and extracorporeal respiratory support. Mechanical circulatory and respiratory support. (pp. 441-468) edited by Shaun D. Gregory, Michael C. Stevens and John F. Fraser. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-810491-0.00014-X

Optimizing the patient and timing of the introduction of mechanical circulatory and extracorporeal respiratory support

2018

Conference Publication

Development of an ovine model of heart transplantation following 24-hour brain stem death

See Hoe, L., Engkilde-Pedersen, S., Obonyo, N., Wells, M., Boon, C., Bartnikowski, N., Passmore, M., McDonald, C., Black, D., Molenaar, P., Diab, S., Suen, J., Marasco, S., McGiffin, D. and Fraser, J. (2018). Development of an ovine model of heart transplantation following 24-hour brain stem death. 66th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 12th Annual Australia and New Zealand Endovascular Therapies Meeting, Brisbane, Australia, 2-5 August 2018. Chatswood, NSW, Australia: Elsevier . doi: 10.1016/j.hlc.2018.06.111

Development of an ovine model of heart transplantation following 24-hour brain stem death

2018

Conference Publication

Development of an ovine model of dilated cardiomyopathy to facilitate clinically translational research

Bartnikowski, N., Obonyo, N., Pedersen, S., Wells, M., Millar, J., Raffel, O., Suen, J., Gregory, S., Haqqani, H. and Fraser, J. (2018). Development of an ovine model of dilated cardiomyopathy to facilitate clinically translational research. 66th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 12th Annual Australia and New Zealand Endovascular Therapies Meeting, Brisbane, QLD Australia, 2 - 5 August 2018. Chatswood, NSW Australia: Elsevier . doi: 10.1016/j.hlc.2018.06.110

Development of an ovine model of dilated cardiomyopathy to facilitate clinically translational research

2018

Conference Publication

Fluid resuscitation with 0.9% saline impairs myocardial contractility in an ovine model of endotoxaemic shock

See Hoe, L., Obonyo, N., Byrne, L., Shiino, K., Diab, S., Dunster, K., Passmore, M., Boon, C., Engkilde-Pedersen, S., Esguerra, A., Fauzi, M., Pretti Pimenta, L., Simonova, G., Van Haren, F., Shekar, K., Anstey, C., Tung, J., Cullen, L., Platts, D., Chan, J., Maitland, K. and Fraser, J. (2018). Fluid resuscitation with 0.9% saline impairs myocardial contractility in an ovine model of endotoxaemic shock. 66th Cardiac Society of Australia and New Zealand Annual Scientific Meeting, the International Society for Heart Research Australasian Section Annual Scientific Meeting and the 12th Annual Australia and New Zealand Endovascular Therapies Meeting, Brisbane, Australia, 2-5 August 2018. Chatswood, NSW, Australia: Elsevier. doi: 10.1016/j.hlc.2018.06.129

Fluid resuscitation with 0.9% saline impairs myocardial contractility in an ovine model of endotoxaemic shock