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2020 Journal Article Single-cell transcriptomics of alloreactive CD4+ T cells over time reveals divergent fates during gut graft-versus-host diseaseEngel, Jessica A., Lee, Hyun Jae, Williams, Cameron G., Kuns, Rachel, Olver, Stuart, Lansink, Lianne Im, Soon, Megan Sf, Andersen, Stacey B., Powell, Joseph E., Svensson, Valentine, Teichmann, Sarah A., Hill, Geoffrey R., Varelias, Antiopi, Koyama, Motoko and Haque, Ashraful (2020). Single-cell transcriptomics of alloreactive CD4+ T cells over time reveals divergent fates during gut graft-versus-host disease. JCI Insight, 5 (13) 137990, 1-19. doi: 10.1172/jci.insight.137990 |
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2020 Journal Article ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasomeCheong, Melody, Gartlan, Kate H., Lee, Jason S., Tey, Siok-Keen, Zhang, Ping, Kuns, Rachel D., Andoniou, Christopher E., Martins, Jose Paulo, Chang, Karshing, Sutton, Vivien R., Kelly, Greg, Varelias, Antiopi, Vuckovic, Slavica, Markey, Kate A., Boyle, Glen M., Smyth, Mark J., Engwerda, Christian R., MacDonald, Kelli P.A., Trapani, Joseph A., Degli-Esposti, Mariapia A., Koyama, Motoko and Hill, Geoffrey R. (2020). ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasome. Cancer Immunology Research, 8 (8), 1085-1098. doi: 10.1158/2326-6066.cir-19-0653 |
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2020 Journal Article Experiences and unmet needs of family members requested to donate haematopoietic stem cells to an ill relative: findings from a prospective multi-centre studyZomerdijk, Nienke, Turner, Jane, Hill, Geoffrey R. and Gottlieb, David (2020). Experiences and unmet needs of family members requested to donate haematopoietic stem cells to an ill relative: findings from a prospective multi-centre study. Supportive Care in Cancer, 29 (2), 635-644. doi: 10.1007/s00520-020-05520-y |
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2020 Journal Article Immunotherapy of multiple myelomaMinnie, Simone A. and Hill, Geoffrey R. (2020). Immunotherapy of multiple myeloma. The Journal of Clinical Investigation, 130 (4), 1565-1575. doi: 10.1172/JCI129205 |
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2020 Journal Article Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasisKumar, Rajiv, Bunn, Patrick T., Singh, Siddharth Sankar, Ng, Susanna S., Montes de Oca, Marcela, De Labastida Rivera, Fabian, Chauhan, Shashi Bhushan, Singh, Neetu, Faleiro, Rebecca J., Edwards, Chelsea L., Frame, Teija C.M., Sheel, Meru, Austin, Rebecca J., Lane, Steven W., Bald, Tobias, Smyth, Mark J., Hill, Geoffrey.R., Best, Shannon E., Haque, Ashraful, Corvino, Dillon, Waddell, Nic, Koufariotis, Lambross, Mukhopadhay, Pamela, Rai, Madhukar, Chakravarty, Jaya, Singh, Om Prakash, Sacks, David, Nylen, Susanne, Uzonna, Jude ... Engwerda, Christian R. (2020). Type I interferons suppress anti-parasitic immunity and can be targeted to improve treatment of visceral leishmaniasis. Cell Reports, 30 (8), 2512-2525.e9. doi: 10.1016/j.celrep.2020.01.099 |
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2020 Journal Article Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthmaLynch, Jason P., Werder, Rhiannon B., Curren, Bodie F., Sikder, Md. Al Amin, Ullah, Ashik, Sebina, Ismail, Rashid, Ridwan B., Zhang, Vivian, Upham, John W., Hill, Geoff R., Steptoe, Raymond J. and Phipps, Simon (2020). Long-lived regulatory T cells generated during severe bronchiolitis in infancy influence later progression to asthma. Mucosal Immunology, 13 (4), 652-664. doi: 10.1038/s41385-020-0268-8 |
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2020 Journal Article Continuous pre- and post-transplant exposure to a disease-associated gut microbiome promotes hyper-acute graft-versus-host disease in wild-type miceBowerman, Kate L., Varelias, Antiopi, Lachner, Nancy, Kuns, Rachel D., Hill, Geoffrey R. and Hugenholtz, Philip (2020). Continuous pre- and post-transplant exposure to a disease-associated gut microbiome promotes hyper-acute graft-versus-host disease in wild-type mice. Gut Microbes, 11 (4), 1-17. doi: 10.1080/19490976.2019.1705729 |
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2020 Journal Article Inhibition of inositol kinase B controls acute and chronic graft-versus-host diseaseThangavelu, Govindarajan, Du, Jing, Paz, Katelyn G., Loschi, Michael, Zaiken, Michael C., Flynn, Ryan, Taylor, Patricia A., Kirchmeier, Andrew Kemal, Panoskaltsis-Mortari, Angela, Luznik, Leo, MacDonald, Kelli P., Hill, Geoffrey R., Maillard, Ivan, Munn, David H., Serody, Jonathan S., Murphy, William J., Miklos, David, Cutler, Corey S., Koreth, John, Antin, Joseph H., Soiffer, Robert J., Ritz, Jerome, Dahlberg, Carol, Miller, Andrew T. and Blazar, Bruce R. (2020). Inhibition of inositol kinase B controls acute and chronic graft-versus-host disease. Blood, 135 (1), 28-40. doi: 10.1182/blood.2019000032 |
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2019 Journal Article MHC class II antigen presentation by the intestinal epithelium initiates graft-versus-host disease and is influenced by the microbiotaKoyama, Motoko, Mukhopadhyay, Pamela, Schuster, Iona S., Henden, Andrea S., Hülsdünker, Jan, Varelias, Antiopi, Vetizou, Marie, Kuns, Rachel D., Robb, Renee J., Zhang, Ping, Blazar, Bruce B., Thomas, Ranjeny, Begun, Jakob, Waddell, Nicola, Trinchieri, Giorgio, Zeiser, Robert, Clouston, Andrew D., Degli-Esposti, Mariapia A. and Hill, Geoffrey R. (2019). MHC class II antigen presentation by the intestinal epithelium initiates graft-versus-host disease and is influenced by the microbiota. Immunity, 51 (5), 885-898. doi: 10.1016/j.immuni.2019.08.011 |
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2019 Journal Article Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populationsAustin, Rebecca J., Straube, Jasmin, Bruedigam, Claudia, Pali, Gabor, Jacquelin, Sebastien, Vu, Therese, Green, Joanne, Gräsel, Julius, Lansink, Lianne, Cooper, Leanne, Lee, Shin-Jye, Chen, Nien-Tsu, Lee, Chung-Wei, Haque, Ashraful, Heidel, Florian H., D’Andrea, Richard, Hill, Geoff R., Mullally, Ann, Milsom, Michael D., Bywater, Megan and Lane, Steven W. (2019). Distinct effects of ruxolitinib and interferon-alpha on murine JAK2V617F myeloproliferative neoplasm hematopoietic stem cell populations. Leukemia, 34 (4), 1075-1089. doi: 10.1038/s41375-019-0638-y |
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2019 Journal Article Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHDKoehn, Brent H., Saha, Asim, McDonald-Hyman, Cameron, Loschi, Michael, Thangavelu, Govindarajan, Ma, Lie, Zaiken, Michael, Dysthe, Josh, Krepps, Walker, Panthera, Jamie, Hippen, Keli, Jameson, Stephen C., Miller, Jeffrey S., Cooper, Matthew A., Farady, Christopher J., Iwawaki, Takao, Ting, Jenny P-Y, Serody, Jonathan S., Murphy, William J., Hill, Geoffrey R., Murray, Peter J., Bronte, Vincenzo, Munn, David H., Zeiser, Robert and Blazar, Bruce R. (2019). Danger-associated extracellular ATP counters MDSC therapeutic efficacy in acute GVHD. Blood, 134 (19), 1670-1682. doi: 10.1182/blood.2019001950 |
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2019 Journal Article Pegylated interferon-2 alpha invokes graft-versus-leukemia effects in patients relapsing after allogeneic stem cell transplantationHenden, Andrea S., Varelias, Antiopi, Leach, Justine, Sturgeon, Elise, Avery, Judy, Kelly, Jessica, Olver, Stuart, Samson, Luke, Hartel, Gunter, Durrant, Simon, Butler, Jason, Morton, Anthony J., Misra, Ashish, Tey, Siok-Keen, Subramoniapillai, Elango, Curley, Cameron, Kennedy, Glen and Hill, Geoffrey R. (2019). Pegylated interferon-2 alpha invokes graft-versus-leukemia effects in patients relapsing after allogeneic stem cell transplantation. Blood Advances, 3 (20), 3013-3019. doi: 10.1182/bloodadvances.2019000453 |
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2019 Journal Article Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tractGartlan, Kate H., Koyama, Motoko, Lineburg, Katie E., Chang, Karshing, Ensbey, Kathleen S., Kuns, Rachel D., Henden, Andrea S., Samson, Luke D., Clouston, Andrew D., Lopez, Angel F., MacDonald, Kelli P. A. and Hill, Geoffrey R. (2019). Donor T-cell–derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract. Blood Advances, 3 (19), 2859-2865. doi: 10.1182/bloodadvances.2019000053 |
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2019 Journal Article Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethalitySaha, Asim, Taylor, Patricia A., Lees, Christopher J., Panoskaltsis-Mortari, Angela, Osborn, Mark J., Feser, Colby J., Thangavelu, Govindarajan, Melchinger, Wolfgang, Refaeli, Yosef, Hill, Geoffrey R., Munn, David H., Murphy, William J., Serody, Jonathan S., Maillard, Ivan, Kreymborg, Katharina, van den Brink, Marcel, Dong, Chen, Huang, Shuyu, Zang, Xingxing, Allison, James P., Zeiser, Robert and Blazar, Bruce R. (2019). Donor and host B7-H4 expression negatively regulates acute graft-versus-host disease lethality. JCI insight, 4 (19) e127716. doi: 10.1172/jci.insight.127716 |
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2019 Journal Article IL-6 dysregulation originates in dendritic cells and initiates graft-versus-host disease via classical signalingWilkinson, Andrew N., Chang, Karshing, Kuns, Rachel D., Henden, Andrea S., Minnie, Simone A., Ensbey, Kathleen S., Clouston, Andrew D., Zhang, Ping, Koyama, Motoko, Hidalgo, Juan, Rose-John, Stefan, Varelias, Antiopi, Vuckovic, Slavica, Gartlan, Kate H. and Hill, Geoffrey R. (2019). IL-6 dysregulation originates in dendritic cells and initiates graft-versus-host disease via classical signaling. Blood, 134 (23), 2092-2106. doi: 10.1182/blood.2019000396 |
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2019 Journal Article Inhibition of the cytolytic protein perforin prevents rejection of transplanted bone marrow stem cells in vivoSpicer, Julie A., Miller, Christian K., O'Connor, Patrick D., Jose, Jiney, Giddens, Anna C., Jaiswal, Jagdish K., Jamieson, Stephen M. F., Bull, Matthew R., Denny, William A., Akhlaghi, Hedieh, Trapani, Joseph A., Hill, Geoff R., Chang, Karshing and Gartlan, Kate H. (2019). Inhibition of the cytolytic protein perforin prevents rejection of transplanted bone marrow stem cells in vivo. Journal of Medicinal Chemistry, 63 (5) acs.jmedchem.9b00881, 2229-2239. doi: 10.1021/acs.jmedchem.9b00881 |
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2019 Journal Article Interleukin-10 mediated immune regulation after stem cell transplantation: mechanisms and implications for therapeutic interventionZhang, Ping and Hill, Geoffrey R. (2019). Interleukin-10 mediated immune regulation after stem cell transplantation: mechanisms and implications for therapeutic intervention. Seminars in Immunology, 44 101322, 101322. doi: 10.1016/j.smim.2019.101322 |
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2019 Journal Article Adult related haematopoietic stem cell donor care: views of transplant nursesZomerdijk, Nienke, Turner, Jane, Hill, Geoffrey R. and Gottlieb, David (2019). Adult related haematopoietic stem cell donor care: views of transplant nurses. European Journal of Oncology Nursing, 41, 56-63. doi: 10.1016/j.ejon.2019.05.012 |
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2019 Journal Article Chemotherapy followed by anti-CD137 mAb immunotherapy improves disease control in a mouse myeloma modelGuillerey, Camille, Nakamura, Kyohei, Pichler, Andrea C., Barkauskas, Deborah, Krumeich, Sophie, Stannard, Kimberley, Miles, Kim, Harjunpää, Heidi, Yu, Yuan, Casey, Mika, Doban, Alina I., Lazar, Mircea, Hartel, Gunter, Smith, David, Vuckovic, Slavica, Teng, Michele W.L., Bergsagel, P. Leif, Chesi, Marta, Hill, Geoffrey R., Martinet, Ludovic and Smyth, Mark J. (2019). Chemotherapy followed by anti-CD137 mAb immunotherapy improves disease control in a mouse myeloma model. JCI Insight, 4 (14) :e125932. doi: 10.1172/jci.insight.125932 |
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2019 Journal Article Adult-related haematopoietic stem cell donor experiences and the provision of information and psychosocial support: a systematic literature reviewZomerdijk, Nienke, Turner, Jane M. and Hill, Geoffrey R. (2019). Adult-related haematopoietic stem cell donor experiences and the provision of information and psychosocial support: a systematic literature review. European Journal of Cancer Care, 28 (3) e12932, 1-15. doi: 10.1111/ecc.12932 |
