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2024 Journal Article Co-observation of germline pathogenic variants in breast cancer predisposition genes: Results from analysis of the BRIDGES sequencing datasetDavidson, Aimee L., Michailidou, Kyriaki, Parsons, Michael T., Fortuno, Cristina, Bolla, Manjeet K., Wang, Qin, Dennis, Joe, Naven, Marc, Abubakar, Mustapha, Ahearn, Thomas U., Alonso, M. Rosario, Andrulis, Irene L., Antoniou, Antonis C., Auvinen, Päivi, Behrens, Sabine, Bermisheva, Marina A., Bogdanova, Natalia V., Bojesen, Stig E., Brüning, Thomas, Byers, Helen J., Camp, Nicola J., Campbell, Archie, Castelao, Jose E., Cessna, Melissa H., Chang-Claude, Jenny, Chanock, Stephen J., Chenevix-Trench, Georgia, Sahlberg, Kristine K., Børresen-Dale, Anne-Lise ... Spurdle, Amanda B. (2024). Co-observation of germline pathogenic variants in breast cancer predisposition genes: Results from analysis of the BRIDGES sequencing dataset. The American Journal of Human Genetics, 111 (9), 2059-2069. doi: 10.1016/j.ajhg.2024.07.004 |
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2023 Journal Article A molecular signature for IL-10-producing Th1 cells in protozoan parasitic diseasesEdwards, Chelsea L., Engel, Jessica A., De Labastida Rivera, Fabian, Ng, Susanna S., Corvino, Dillon, Montes de Oca, Marcela, Frame, Teija C.M., Chauhan, Shashi Bhushan, Singh, Siddharth Sanker, Kumar, Awnish, Wang, Yulin, Na, Jinrui, Mukhopadhyay, Pamela, Lee, Jason S., Nylén, Susanne, Sundar, Shyam, Kumar, Rajiv and Engwerda, Christian R. (2023). A molecular signature for IL-10-producing Th1 cells in protozoan parasitic diseases. JCI Insight, 8 (24) e169362, 1-17. doi: 10.1172/jci.insight.169362 |
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2023 Journal Article COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasisHancock, Janelle L., Kalimutho, Murugan, Straube, Jasmin, Lim, Malcolm, Gresshoff, Irma, Saunus, Jodi M., Lee, Jason S., Lakhani, Sunil R., Simpson, Kaylene J., Bush, Ashley I., Anderson, Robin L. and Khanna, Kum Kum (2023). COMMD3 loss drives invasive breast cancer growth by modulating copper homeostasis. Journal of Experimental and Clinical Cancer Research, 42 (1) 90, 1-16. doi: 10.1186/s13046-023-02663-8 |
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2023 Journal Article FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European womenFiglioli, Gisella, Billaud, Amandine, Ahearn, Thomas U., Antonenkova, Natalia N., Becher, Heiko, Beckmann, Matthias W., Behrens, Sabine, Benitez, Javier, Bermisheva, Marina, Blok, Marinus J., Bogdanova, Natalia V., Bonanni, Bernardo, Burwinkel, Barbara, Camp, Nicola J., Campbell, Archie, Castelao, Jose E., Cessna, Melissa H., Chanock, Stephen J., Alnæs, Grethe I. Grenaker, Sørlie, Therese, Skjerven, Helle Kristine, Russnes, Hege G., Mælandsmo, Gunhild Mari, Lingjærde, Ole Christian, Langerød, Anita, Hofvind, Solveig, Geitvik, Gry Aarum, Garred, Øystein, Fritzman, Britt ... Peterlongo, Paolo (2023). FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women. European Journal of Human Genetics, 31 (5), 578-587. doi: 10.1038/s41431-022-01257-w |
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2023 Journal Article IL-10-producing Th1 cells possess a distinct molecular signature in malariaEdwards, Chelsea L., Ng, Susanna S., de Labastida Rivera, Fabian, Corvino, Dillon, Engel, Jessica A., Montes de Oca, Marcela, Bukali, Luzia, Frame, Teija C.M., Bunn, Patrick T., Chauhan, Shashi Bhushan, Singh, Siddharth Sankar, Wang, Yulin, Na, Jinrui, Amante, Fiona H., Loughland, Jessica R., Soon, Megan S.F., Waddell, Nicola, Mukhopadhay, Pamela, Koufariotis, Lambros T., Johnston, Rebecca L., Lee, Jason S., Kuns, Rachel, Zhang, Ping, Boyle, Michelle J., Hill, Geoffrey R., McCarthy, James S., Kumar, Rajiv and Engwerda, Christian R. (2023). IL-10-producing Th1 cells possess a distinct molecular signature in malaria. Journal of Clinical Investigation, 133 (1) e153733. doi: 10.1172/jci153733 |
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2022 Journal Article Combined inhibition of G9a and EZH2 suppresses tumor growth via synergistic induction of IL24-mediated apoptosisCasciello, Francesco, Kelly, Gregory M., Ramarao-Milne, Priya, Kamal, Nabilah, Stewart, Teneale A., Mukhopadhyay, Pamela, Kazakoff, Stephen H., Miranda, Mariska, Kim, Dorim, Davis, Felicity M., Hayward, Nicholas K., Vertino, Paula M., Waddell, Nicola, Gannon, Frank and Lee, Jason S. (2022). Combined inhibition of G9a and EZH2 suppresses tumor growth via synergistic induction of IL24-mediated apoptosis. Cancer Research, 82 (7), 1208-1221. doi: 10.1158/0008-5472.can-21-2218 |
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2021 Journal Article G9a inhibition enhances checkpoint inhibitor blockade response in melanomaKelly, Gregory M., Al-Ejeh, Fares, McCuaig, Robert, Casciello, Francesco, Kamal, Nabilah Ahmad, Ferguson, Blake, Pritchard, Antonia L., Ali, Sayed, Silva, Ines P., Wilmott, James S., Long, Georgina V., Scolyer, Richard A., Rao, Sudha, Hayward, Nicholas K., Gannon, Frank and Lee, Jason S. (2021). G9a inhibition enhances checkpoint inhibitor blockade response in melanoma. Clinical Cancer Research, 27 (9), 2624-2635. doi: 10.1158/1078-0432.CCR-20-3463 |
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2021 Journal Article Genome instability and pressure on non-homologous end joining drives chemotherapy resistance via a DNA repair crisis switch in triple negative breast cancerWiegmans, Adrian P., Ward, Ambber, Ivanova, Ekaterina, Duijf, Pascal H. G., Adams, Mark N., Najib, Idris Mohd, Van Oosterhout, Romy, Sadowski, Martin C., Kelly, Greg, Morrical, Scott W., O’Byrne, Ken, Lee, Jason S. and Richard, Derek J. (2021). Genome instability and pressure on non-homologous end joining drives chemotherapy resistance via a DNA repair crisis switch in triple negative breast cancer. NAR Cancer, 3 (2) zcab041, zcab022. doi: 10.1093/narcan/zcab022 |
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2021 Journal Article Histone modifying enzymes in gynaecological cancersRamarao-Milne, Priya, Kondrashova, Olga, Barry, Sinead, Hooper, John D., Lee, Jason S. and Waddell, Nicola (2021). Histone modifying enzymes in gynaecological cancers. Cancers, 13 (4) 816, 1-21. doi: 10.3390/cancers13040816 |
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2021 Journal Article Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)Klionsky, Daniel J., Abdel-Aziz, Amal Kamal, Abdelfatah, Sara, Abdellatif, Mahmoud, Abdoli, Asghar, Abel, Steffen, Abeliovich, Hagai, Abildgaard, Marie H., Abudu, Yakubu Princely, Acevedo-Arozena, Abraham, Adamopoulos, Iannis E., Adeli, Khosrow, Adolph, Timon E., Adornetto, Annagrazia, Aflaki, Elma, Agam, Galila, Agarwal, Anupam, Aggarwal, Bharat B., Agnello, Maria, Agostinis, Patrizia, Agrewala, Javed N., Agrotis, Alexander, Aguilar, Patricia V., Ahmad, S. Tariq, Ahmed, Zubair M., Ahumada-Castro, Ulises, Aits, Sonja, Aizawa, Shu, Akkoc, Yunus ... Tong, Chun-Kit (2021). Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). Autophagy, 17 (1), 1-382. doi: 10.1080/15548627.2020.1797280 |
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2020 Journal Article ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasomeCheong, Melody, Gartlan, Kate H., Lee, Jason S., Tey, Siok-Keen, Zhang, Ping, Kuns, Rachel D., Andoniou, Christopher E., Martins, Jose Paulo, Chang, Karshing, Sutton, Vivien R., Kelly, Greg, Varelias, Antiopi, Vuckovic, Slavica, Markey, Kate A., Boyle, Glen M., Smyth, Mark J., Engwerda, Christian R., MacDonald, Kelli P.A., Trapani, Joseph A., Degli-Esposti, Mariapia A., Koyama, Motoko and Hill, Geoffrey R. (2020). ASC modulates CTL cytotoxicity and transplant outcome independent of the inflammasome. Cancer Immunology Research, 8 (8), 1085-1098. doi: 10.1158/2326-6066.cir-19-0653 |
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2020 Journal Article Chromatin interactome mapping at 139 independent breast cancer risk signalsBeesley, Jonathan, Sivakumaran, Haran, Moradi Marjaneh, Mahdi, Lima, Luize G., Hillman, Kristine M., Kaufmann, Susanne, Tuano, Natasha, Hussein, Nehal, Ham, Sunyoung, Mukhopadhyay, Pamela, Kazakoff, Stephen, Lee, Jason S., Michailidou, Kyriaki, Barnes, Daniel R., Antoniou, Antonis C., Fachal, Laura, Dunning, Alison M., Easton, Douglas F., Waddell, Nicola, Rosenbluh, Joseph, Möller, Andreas, Chenevix-Trench, Georgia, French, Juliet D. and Edwards, Stacey L. (2020). Chromatin interactome mapping at 139 independent breast cancer risk signals. Genome Biology, 21 (1) 8, 8. doi: 10.1186/s13059-019-1877-y |
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2019 Journal Article Molecular basis of distinct oestrogen responses in endometrial and breast cancerBaxter, Eva, Windloch, Karolina, Kelly, Greg, Lee, Jason S., Gannon, Frank and Brennan, Donal (2019). Molecular basis of distinct oestrogen responses in endometrial and breast cancer. Endocrine-Related Cancer, 26 (1), 31-46. doi: 10.1530/ERC-17-0563 |
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2018 Journal Article Granulocytes are unresponsive to IL-6 due to an absence of gp130Wilkinson, Andrew N., Gartlan, Kate H., Kelly, Greg, Samson, Luke D., Olver, Stuart D., Avery, Judy, Zomerdijk, Nienke, Tey, Siok-Keen, Lee, Jason S., Vuckovic, Slavica and Hill, Geoffrey R. (2018). Granulocytes are unresponsive to IL-6 due to an absence of gp130. Journal of Immunology, 200 (9), 3547-3555. doi: 10.4049/jimmunol.1701191 |
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2018 Journal Article Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasiaBond, Catherine E., Liu, Cheng, Kawamata, Futoshi, McKeone, Diane M., Fernando, Winnie, Jamieson, Saara, Pearson, Sally-Ann, Kane, Alexandra, Woods, Susan L., Lannagan, Tamsin R. M., Somashekar, Roshini, Lee, Young, Dumenil, Troy, Hartel, Gunter, Spring, Kevin J., Borowsky, Jennifer, Fennell, Lochlan, Bettington, Mark, Lee, Jason, Worthley, Daniel L., Leggett, Barbara A. and Whitehall, Vicki L. J. (2018). Oncogenic BRAF mutation induces DNA methylation changes in a murine model for human serrated colorectal neoplasia. Epigenetics, 13 (1), 40-48. doi: 10.1080/15592294.2017.1411446 |
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2017 Journal Article G9a in hypoxia: Linking tumor hypoxia and epigenetic regulationCasciello, Francesco and Lee, Jason S. (2017). G9a in hypoxia: Linking tumor hypoxia and epigenetic regulation. Cell Cycle, 16 (21), 2001-2002. doi: 10.1080/15384101.2017.1377505 |
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2017 Journal Article Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cellsGao, Yulong, Souza-Fonseca-Guimaraes, Fernando, Bald, Tobias, Ng, Susanna S., Young, Arabella, Ngiow, Shin Foong, Rautela, Jai, Straube, Jasmin, Waddell, Nic, Blake, Stephen J., Yan, Juming, Bartholin, Laurent, Lee, Jason S., Vivier, Eric, Takeda, Kazuyoshi, Messaoudene, Meriem, Zitvogel-, Laurence, Teng, Michele W. L., Belz, Gabrielle T., Engwerda, Christian R., Huntington, Nicholas D., Nakamura, Kyohei, Hoelzel, Michael and Smyth, Mark J. (2017). Tumor immunoevasion by the conversion of effector NK cells into type 1 innate lymphoid cells. Nature Immunology, 18 (9), 1004-1015. doi: 10.1038/ni.3800 |
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2017 Journal Article G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesisCasciello, Francesco, Al-Ejeh, Fares, Kelly, Greg, Brennan, Donal J., Ngiow, Shin Foong, Young, Arabella, Stoll, Thomas, Windloch, Karolina, Hill, Michelle M., Smyth, Mark J., Gannon, Frank and Lee, Jason S. (2017). G9a drives hypoxia-mediated gene repression for breast cancer cell survival and tumorigenesis. Proceedings of the National Academy of Sciences, 114 (27), 7077-7082. doi: 10.1073/pnas.1618706114 |
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2017 Journal Article Eomesodermin promotes the development of Type-1 Regulatory T (TR1) cellsZhang, Ping, Lee, Jason S., Gartlan, Kate H., Schuster, Iona S., Comerford, Iain, Varelias, Antiopi, Ullah, Md Ashik, Vuckovic, Slavica, Koyama, Motoko, Kuns, Rachel D., Locke, Kelly R., Beckett, Kirrilee J., Olver, Stuart D., Samson, Luke D., Montes de Oca, Marcela, de Labastida Rivera, Fabian, Clouston, Andrew D., Belz, Gabrielle T., Blazar, Bruce R., MacDonald, Kelli P., McColl, Shaun R., Thomas, Ranjeny, Engwerda, Christian R., Degli-Esposti, Mariapia A., Kallies, Axel, Tey, Siok-Keen and Hill, Geoffrey R. (2017). Eomesodermin promotes the development of Type-1 Regulatory T (TR1) cells. Science Immunology, 2 (10) eaah7152. doi: 10.1126/sciimmunol.aah7152 |
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2016 Journal Article Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 RegulationGhoussaini, Maya, French, Juliet D., Michailidou, Kyriaki, Nord, Silje, Beesley, Jonathan, Canisus, Sander, Hillman, Kristine M., Kaufmann, Susanne, Sivakumaran, Haran, Moradi Marjaneh, Mahdi, Lee, Jason S., Dennis, Joe, Bolla, Manjeet K., Wang, Qin, Dicks, Ed, Milne, Roger L., Hopper, John L., Southey, Melissa C., Schmidt, Marjanka K., Broeks, Annegien, Muir, Kenneth, Lophatananon, Artitaya, Fasching, Peter A., Beckmann, Matthias W., Fletcher, Olivia, Johnson, Nichola, Sawyer, Elinor J., Tomlinson, Ian, Burwinkel, Barbara ... kConFab/AOCS Investigators (2016). Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation. American Journal of Human Genetics, 99 (4), 903-911. doi: 10.1016/j.ajhg.2016.07.017 |
