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2024 Journal Article Advances in the synthesis and engineering of conotoxinsHo, Thao NT., Tran, Thanh Hoa, Sinh, Le Hoang and Lewis, Richard J. (2024). Advances in the synthesis and engineering of conotoxins. European Journal of Medicinal Chemistry, 282 117038, 117038. doi: 10.1016/j.ejmech.2024.117038 |
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2024 Journal Article Novel scorpion toxin ω-Buthitoxin-Hf1a selectively inhibits calcium influx via CaV3.3 and CaV3.2 and alleviates allodynia in a mouse model of acute postsurgical painWang, Dan, Herzig, Volker, Dekan, Zoltan, Rosengren, K. Johan, Payne, Colton D., Hasan, Md. Mahadhi, Zhuang, Jiajie, Bourinet, Emmanuel, Ragnarsson, Lotten, Alewood, Paul F. and Lewis, Richard J. (2024). Novel scorpion toxin ω-Buthitoxin-Hf1a selectively inhibits calcium influx via CaV3.3 and CaV3.2 and alleviates allodynia in a mouse model of acute postsurgical pain. International Journal of Molecular Sciences, 25 (9) 4745, 4745. doi: 10.3390/ijms25094745 |
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2024 Journal Article HSQC spectra simulation and matching for molecular identificationPriessner, Martin, Lewis, Richard J., Johansson, Magnus J., Goodman, Jonathan M., Janet, Jon Paul and Tomberg, Anna (2024). HSQC spectra simulation and matching for molecular identification. Journal of Chemical Information and Modeling, 64 (8), 3180-3191. doi: 10.1021/acs.jcim.3c01735 |
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2024 Journal Article Inhibition of N-type calcium channels by phenoxyaniline and sulfonamide analoguesBispat, Anjie, Cardoso, Fernanda, Hasan, Md. Mahadhi, Dongol, Yashad, Wilcox, Ricki, Lewis, Richard, Duggan, Peter James and Tuck, Kellie (2024). Inhibition of N-type calcium channels by phenoxyaniline and sulfonamide analogues. RSC Medicinal Chemistry, 15 (3), 916-936. doi: 10.1039/d3md00714f |
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2024 Journal Article Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal LymphopoietinNarjes, Frank, Edfeldt, Fredrik, Petersen, Jens, Oster, Linda, Hamblet, Corinne, Bird, James, Bold, Peter, Rae, Rebecca, Back, Elisabeth, Stomilovic, Stina, Zlatoidsky, Pavol, Svensson, Tor, Hidestal, Lotta, Kunalingam, Lavaniya, Shamovsky, Igor, De Maria, Leonardo, Gordon, Euan, Lewis, Richard J., Watcham, Sophie, van Rietschoten, Katerine, Mudd, Gemma E., Harrison, Helen, Chen, Liuhong and Skynner, Michael J. (2024). Discovery and Characterization of a Bicyclic Peptide (Bicycle) Binder to Thymic Stromal Lymphopoietin. Journal of Medicinal Chemistry, 67 (3), 2220-2235. doi: 10.1021/acs.jmedchem.3c02163 |
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2024 Journal Article N-Sulfonylphenoxazines as neuronal calcium ion channel blockersSchmit, Matthieu, Hasan, Md. Mahadhi, Dongol, Yashad, Cardoso, Fernanda C., Kuiper, Michael J., Lewis, Richard J., Duggan, Peter J. and Tuck, Kellie L. (2024). N-Sulfonylphenoxazines as neuronal calcium ion channel blockers. RSC Medicinal Chemistry, 15 (7), 2400-2412. doi: 10.1039/d4md00336e |
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2023 Journal Article Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypesDongol, Yashad, Wilson, David T., Daly, Norelle L., Cardoso, Fernanda C. and Lewis, Richard J. (2023). Structure-function and rational design of a spider toxin Ssp1a at human voltage-gated sodium channel subtypes. Frontiers in Pharmacology, 14 1277143, 1-13. doi: 10.3389/fphar.2023.1277143 |
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2023 Journal Article Development of a selective peptide κ-opioid receptor antagonist by late-stage functionalization with cysteine staplesMuratspahić, Edin, White, Andrew M., Ciotu, Cosmin I., Hochrainer, Nadine, Tomašević, Nataša, Koehbach, Johannes, Lewis, Richard J., Spetea, Mariana, Fischer, Michael J. M., Craik, David J. and Gruber, Christian W. (2023). Development of a selective peptide κ-opioid receptor antagonist by late-stage functionalization with cysteine staples. Journal of Medicinal Chemistry, 66 (17), 11843-11854. doi: 10.1021/acs.jmedchem.3c00426 |
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2023 Journal Article Ciguatera fish poisoning in the Caribbean Sea and Atlantic Ocean: reconciling the multiplicity of ciguatoxins and analytical chemistry approach for public health safetyPottier, Ivannah, Lewis, Richard J. and Vernoux, Jean-Paul (2023). Ciguatera fish poisoning in the Caribbean Sea and Atlantic Ocean: reconciling the multiplicity of ciguatoxins and analytical chemistry approach for public health safety. Toxins, 15 (7) 453, 1-40. doi: 10.3390/toxins15070453 |
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2023 Journal Article Coordinated adaptations define the ontogenetic shift from worm-to fish-hunting in a venomous cone snailRogalski, Aymeric, Himaya, S. W. A. and Lewis, Richard J. (2023). Coordinated adaptations define the ontogenetic shift from worm-to fish-hunting in a venomous cone snail. Nature Communications, 14 (1) 3287, 1-11. doi: 10.1038/s41467-023-38924-5 |
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2023 Journal Article The T type calcium channel CaV3.2 regulates bladder afferent responses to mechanical stimuliGrundy, Luke, Tay, Cindy, Christie, Stewart, Harrington, Andrea M., Castro, Joel, Cardoso, Fernanda C., Lewis, Richard J., Zagorodnyuk, Vladimir and Brierley, Stuart M. (2023). The T type calcium channel CaV3.2 regulates bladder afferent responses to mechanical stimuli. Pain, 164 (5), 1012-1026. doi: 10.1097/j.pain.0000000000002795 |
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2023 Journal Article Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptorsHo, Thao NT, Abraham, Nikita and Lewis, Richard J. (2023). Unravelling the allosteric binding mode of αD-VxXXB at nicotinic acetylcholine receptors. Frontiers in Pharmacology, 14 1170514, 1170514. doi: 10.3389/fphar.2023.1170514 |
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2023 Journal Article Model of the origin of a ciguatoxic grouper (Plectropomus leopardus)Holmes, Michael J. and Lewis, Richard J. (2023). Model of the origin of a ciguatoxic grouper (Plectropomus leopardus). Toxins, 15 (3) 230, 1-20. doi: 10.3390/toxins15030230 |
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2023 Journal Article "Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction" (vol 65, pg 2204, 2022)Begnini, Fabio, Geschwindner, Stefan, Johansson, Patrik, Wissler, Lisa, Lewis, Richard J., Danelius, Emma, Luttens, Andreas, Matricon, Pierre, Carlsson, Jens, Lenders, Stijn, Koenig, Beate, Friedel, Anna, Sjoe, Peter, Schiesser, Stefan and Kihlberg, Jan (2023). "Importance of Binding Site Hydration and Flexibility Revealed When Optimizing a Macrocyclic Inhibitor of the Keap1-Nrf2 Protein-Protein Interaction" (vol 65, pg 2204, 2022). Journal of Medicinal Chemistry, 66 (3), 2204-2204. doi: 10.1021/acs.jmedchem.3c00037 |
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2022 Journal Article Bimodal cell size and fusing cells observed in a clonal culture of the ciguatoxin-producing benthic dinoflagellate Gambierdiscus (WC1/1)Holmes, Michael J. and Lewis, Richard J. (2022). Bimodal cell size and fusing cells observed in a clonal culture of the ciguatoxin-producing benthic dinoflagellate Gambierdiscus (WC1/1). Toxins, 14 (11) 767, 1-8. doi: 10.3390/toxins14110767 |
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2022 Journal Article The deadly toxin arsenal of the tree-dwelling Australian funnel-web spidersCardoso, Fernanda C., Pineda, Sandy S., Herzig, Volker, Sunagar, Kartik, Shaikh, Naeem Yusuf, Jin, Ai-Hua, King, Glenn F., Alewood, Paul F., Lewis, Richard J. and Dutertre, Sébastien (2022). The deadly toxin arsenal of the tree-dwelling Australian funnel-web spiders. International Journal of Molecular Sciences, 23 (21) 13077, 13077. doi: 10.3390/ijms232113077 |
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2022 Journal Article Synthesis of full-length homodimer αD-VxXXB that targets human α7 nicotinic acetylcholine receptorsHo, Thao N. T., Abraham, Nikita and Lewis, Richard J. (2022). Synthesis of full-length homodimer αD-VxXXB that targets human α7 nicotinic acetylcholine receptors. RSC Medicinal Chemistry, 13 (11), 1410-1419. doi: 10.1039/d2md00188h |
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2022 Journal Article Origin of ciguateric fish: quantitative modelling of the flow of ciguatoxin through a marine food chainHolmes, Michael J. and Lewis, Richard J. (2022). Origin of ciguateric fish: quantitative modelling of the flow of ciguatoxin through a marine food chain. Toxins, 14 (8) 534, 1-11. doi: 10.3390/toxins14080534 |
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2022 Journal Article Diindolylmethane derivatives: new selective blockers for T-type calcium channelsWang, Dan, Neupane, Pratik, Ragnarsson, Lotten, Capon, Robert and Lewis, Richard (2022). Diindolylmethane derivatives: new selective blockers for T-type calcium channels. Membranes, 12 (8) 749, 1-13. doi: 10.3390/membranes12080749 |
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2022 Journal Article The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF <sup>V600E</sup>Moral‐Sanz, Javier, Fernandez‐Rojo, Manuel A., Colmenarejo, Gonzalo, Kurdyukov, Sergey, Brust, Andreas, Ragnarsson, Lotten, Andersson, Åsa, Vila, Sabela F., Cabezas‐Sainz, Pablo, Wilhelm, Patrick, Vela‐Sebastian, Ana, Fernández‐Carrasco, Isabel, Chin, Yanni K. Y., López‐ Mancheño, Yaiza, Smallwood, Taylor B., Clark, Richard J., Fry, Bryan G., King, Glenn F., Ramm, Grant A., Alewood, Paul F., Lewis, Richard J., Mulvenna, Jason P., Boyle, Glen M., Sanchez, Laura E., Neely, G. Gregory, Miles, John J. and Ikonomopoulou, Maria P. (2022). The structural conformation of the tachykinin domain drives the anti‐tumoral activity of an octopus peptide in melanoma BRAF V600E. British Journal of Pharmacology, 179 (20), 4878-4896. doi: 10.1111/bph.15923 |
