Overview
Background
Dr Henry de Malmanche is a biotechnology researcher specialising in vaccine development, insect cell engineering and bioprocessing. His research combines molecular biology, synthetic biology and bioprocess engineering to develop and translate new vaccine and biotechnology platforms.
A major focus of his work is insect cell biotechnology, including the culture, engineering and optimisation of Sf9 and mosquito cell systems for recombinant protein and virus production. He has expertise in CRISPR-based genome engineering of insect cells, development and characterisation of engineered cell lines, and applying genetic engineering approaches to improve the performance and utility of insect-cell expression systems.
His current research focuses on the development and translation of novel vaccine technologies, including the ISVac platform, which uses insect-specific viruses as a basis for vaccines against medically important viral diseases. His work spans early-stage vaccine development through to manufacturing and translation, including viral vaccine production, suspension cell culture, upstream and downstream bioprocess development, process scale-up, analytical characterisation and vaccine CMC.
His broader research interests include CRISPR genome engineering, synthetic biology, insect cell expression systems, flaviviruses, recombinant vaccines and scalable vaccine manufacturing, with a particular interest in translating laboratory technologies into practical biotechnology products.
Availability
- Dr Henry De Malmanche is:
- Available for supervision
Qualifications
- Masters (Research) of Research, University College London
- Doctor of Philosophy of Biotechnology, The University of Queensland
Research impacts
The impact of Henry’s research lies in translating new vaccine and insect-cell technologies toward practical applications in human health and biotechnology.
His work on insect-specific virus vaccine platforms, including ISVac, is contributing to the development of new approaches for vaccines against mosquito-borne diseases such as Japanese encephalitis. This research spans laboratory discovery through to process development, scale-up and manufacturing, helping bridge the gap between academic research and technologies that can ultimately progress toward clinical use.
His research in insect-cell engineering and CRISPR also aims to improve the performance and versatility of cell-based manufacturing systems used to produce vaccines, viruses and recombinant proteins. By developing more efficient and scalable biological production platforms, this work has potential to reduce manufacturing barriers and support faster development of new biotechnology products.
A central theme of his research is translation: turning advances in molecular biology, cell engineering and virology into technologies that can be manufactured, scaled and applied outside the laboratory.
Works
Search Professor Henry De Malmanche’s works on UQ eSpace
2025
Journal Article
Serum-free suspension culture of the Aedes albopictus C6/36 cell line for chimeric orthoflavivirus vaccine production
Dawurung, Joshua S., Harrison, Jessica J., Modhiran, Naphak, Hall, Roy A., Hobson-Peters, Jody and de Malmanche, Henry (2025). Serum-free suspension culture of the Aedes albopictus C6/36 cell line for chimeric orthoflavivirus vaccine production. Viruses, 17 (2) 250, 250. doi: 10.3390/v17020250
2024
Journal Article
A chimeric vaccine derived from Australian genotype IV Japanese encephalitis virus protects mice from lethal challenge
Harrison, Jessica J., Nguyen, Wilson, Morgan, Mahali S., Tang, Bing, Habarugira, Gervais, de Malmanche, Henry, Freney, Morgan E., Modhiran, Naphak, Watterson, Daniel, Cox, Abigail L., Yan, Kexin, Yuen, Nicholas K. Y., Bowman, Dylan H., Kirkland, Peter D., Bielefeldt-Ohmann, Helle, Suhrbier, Andreas, Hall, Roy A., Rawle, Daniel J. and Hobson-Peters, Jody (2024). A chimeric vaccine derived from Australian genotype IV Japanese encephalitis virus protects mice from lethal challenge. npj Vaccines, 9 (1) 134, 1-14. doi: 10.1038/s41541-024-00903-2
2023
Book Chapter
Production of entomopathogenic viruses
Reid, Steven, De Malmanche, Henry, Chan, Leslie, Popham, Holly and Van Oers, Monique M. (2023). Production of entomopathogenic viruses. Mass production of beneficial organisms: invertebrates and entomopathogens. (pp. 375-406) edited by Juan A. Morales-Ramos, M. Guadalupe Rojas and David I. Shapiro-Ilan. London, United Kingdom: Adademic Press. doi: 10.1016/B978-0-12-822106-8.00020-8
2022
Journal Article
Knockout of Dicer-2 in the Sf9 cell line enhances the replication of Spodoptera frugiperda rhabdovirus and conditionally increases baculovirus replication
de Malmanche, Henry, Hussain, Mazhar, Marcellin, Esteban, Reid, Steve and Asgari, Sassan (2022). Knockout of Dicer-2 in the Sf9 cell line enhances the replication of Spodoptera frugiperda rhabdovirus and conditionally increases baculovirus replication. Journal of General Virology, 103 (8) 001779, 1-18. doi: 10.1099/jgv.0.001779
2022
Journal Article
Knockout of Sf‐Caspase‐1 generates apoptosis‐resistant Sf9 cell lines: implications for baculovirus expression
Malmanche, Henry, Marcellin, Esteban and Reid, Steven (2022). Knockout of Sf‐Caspase‐1 generates apoptosis‐resistant Sf9 cell lines: implications for baculovirus expression. Biotechnology Journal, 17 (7) 2100532, 2100532. doi: 10.1002/biot.202100532
2022
Other Outputs
Sf9 cell line engineering to improve baculovirus expression: generation and characterisation of CRISPR-Cas9 knockout Sf9 cell lines defective in the antiviral pathways of apoptosis and RNA interference
de Malmanche, Henry Frederick (2022). Sf9 cell line engineering to improve baculovirus expression: generation and characterisation of CRISPR-Cas9 knockout Sf9 cell lines defective in the antiviral pathways of apoptosis and RNA interference. PhD Thesis, School of Chemistry and Molecular Biosciences, The University of Queensland. doi: 10.14264/833b19c
2021
Journal Article
Persistent Spodoptera frugiperda rhabdovirus infection in Sf9 cells is not restricted by Wolbachia wMelPop-CLA and wAlbB strains and is targeted by the RNAi machinery
Parry, Rhys, de Malmanche, Henry and Asgari, Sassan (2021). Persistent Spodoptera frugiperda rhabdovirus infection in Sf9 cells is not restricted by Wolbachia wMelPop-CLA and wAlbB strains and is targeted by the RNAi machinery. Virology, 563, 82-87. doi: 10.1016/j.virol.2021.08.013
Supervision
Availability
- Dr Henry De Malmanche is:
- Available for supervision
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Media
Enquiries
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