Overview
Availability
- Dr Hue Tran is:
- Available for supervision
Qualifications
- Bachelor (Honours) of Biotechnology, The University of Queensland
- Doctor of Philosophy of Chemical Sciences, The University of Queensland
Works
Search Professor Hue Tran’s works on UQ eSpace
2024
Journal Article
A venom peptide-induced NaV channel modulation mechanism involving the interplay between fixed channel charges and ionic gradients
Thapa, Ashvriya, Beh, Jia Hao, Robinson, Samuel D., Deuis, Jennifer R., Tran, Hue, Vetter, Irina and Keramidas, Angelo (2024). A venom peptide-induced NaV channel modulation mechanism involving the interplay between fixed channel charges and ionic gradients. Journal of Biological Chemistry, 300 (10) 107757, 107757. doi: 10.1016/j.jbc.2024.107757
2023
Journal Article
Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1a
Tran, Hue N. T., Budusan, Elena, Saez, Natalie J., Norman, Alexander, Tucker, Isaac J., King, Glenn F., Payne, Richard J., Rash, Lachlan D., Vetter, Irina and Schroeder, Christina I. (2023). Evaluation of peptide ligation strategies for the synthesis of the bivalent acid-sensing ion channel inhibitor Hi1a. Organic Letters, 25 (24), 4439-4444. doi: 10.1021/acs.orglett.3c01346
2023
Journal Article
Changes in potency and subtype selectivity of bivalent NaV toxins are knot-specific
Tran, Poanna, Tran, Hue N. T., McMahon, Kirsten L., Deuis, Jennifer R., Ragnarsson, Lotten, Norman, Alexander, Sharpe, Simon J., Payne, Richard J., Vetter, Irina and Schroeder, Christina I. (2023). Changes in potency and subtype selectivity of bivalent NaV toxins are knot-specific. Bioconjugate Chemistry, 34 (6), 1072-1083. doi: 10.1021/acs.bioconjchem.3c00135
2023
Journal Article
Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function
Jami, Sina, Deuis, Jennifer R., Klasfauseweh, Tabea, Cheng, Xiaoyang, Kurdyukov, Sergey, Chung, Felicity, Okorokov, Andrei L., Li, Shengnan, Zhang, Jiangtao, Cristofori-Armstrong, Ben, Israel, Mathilde R., Ju, Robert J., Robinson, Samuel D., Zhao, Peng, Ragnarsson, Lotten, Andersson, Åsa, Tran, Poanna, Schendel, Vanessa, McMahon, Kirsten L., Tran, Hue N. T., Chin, Yanni K.-Y., Zhu, Yifei, Liu, Junyu, Crawford, Theo, Purushothamvasan, Saipriyaa, Habib, Abdella M., Andersson, David A., Rash, Lachlan D., Wood, John N. ... Vetter, Irina (2023). Pain-causing stinging nettle toxins target TMEM233 to modulate NaV1.7 function. Nature Communications, 14 (1) 2442. doi: 10.1038/s41467-023-37963-2
2022
Other Outputs
Novel heterodimeric ion channel modulators derived from conotoxins and spider toxins
Tran, Hue (2022). Novel heterodimeric ion channel modulators derived from conotoxins and spider toxins. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/07b2aae
2022
Journal Article
µ-Conotoxins targeting the human voltage-gated sodium channel subtype NaV1.7
McMahon, Kirsten L., Tran, Hue N. T., Deuis, Jennifer R., Craik, David J., Vetter, Irina and Schroeder, Christina I. (2022). µ-Conotoxins targeting the human voltage-gated sodium channel subtype NaV1.7. Toxins, 14 (9) 600, 1-16. doi: 10.3390/toxins14090600
2022
Journal Article
On the utility of chemical strategies to improve peptide gut stability
Kremsmayr, Thomas, Aljnabi, Aws, Blanco-Canosa, Juan B., Tran, Hue N. T., Emidio, Nayara Braga and Muttenthaler, Markus (2022). On the utility of chemical strategies to improve peptide gut stability. Journal of Medicinal Chemistry, 65 (8), 6191-6206. doi: 10.1021/acs.jmedchem.2c00094
2022
Journal Article
Structural and functional insights into inhibition of human voltage-gated sodium channels by μ‐conotoxin KIIIA disulfide isomers
Tran, Hue N. T., McMahon, Kirsten L., Deuis, Jennifer R., Vetter, Irina and Schroeder, Christina I. (2022). Structural and functional insights into inhibition of human voltage-gated sodium channels by μ‐conotoxin KIIIA disulfide isomers. Journal of Biological Chemistry, 298 (3) 101728, 1-13. doi: 10.1016/j.jbc.2022.101728
2021
Journal Article
Evaluation of efficient non-reducing enzymatic and chemical ligation strategies for complex disulfide-rich peptides
Tran, Hue N. T., Tran, Poanna, Deuis, Jennifer R., McMahon, Kirsten L., Yap, Kuok, Craik, David J., Vetter, Irina and Schroeder, Christina I. (2021). Evaluation of efficient non-reducing enzymatic and chemical ligation strategies for complex disulfide-rich peptides. Bioconjugate Chemistry, 32 (11) acs.bioconjchem.1c00452, 2407-2419. doi: 10.1021/acs.bioconjchem.1c00452
2021
Journal Article
The allosteric activation of α7 nAChR by α-Conotoxin MrIC is modified by mutations at the vestibular site
Gulsevin, Alican , Papke, Roger L., Stokes, Clare, Tran, Hue N. T., Jin, Aihua H., Vetter, Irina and Meiler, Jens (2021). The allosteric activation of α7 nAChR by α-Conotoxin MrIC is modified by mutations at the vestibular site. Toxin, 13 (8) 555, 555. doi: 10.3390/toxins13080555
2021
Journal Article
Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metabolite
Braga Emidio, Nayara, Meli, Rajeshwari, Tran, Hue N. T., Baik, Hayeon, Morisset-Lopez, Séverine, Elliott, Alysha G., Blaskovich, Mark A. T., Spiller, Sabrina, Beck-Sickinger, Annette G., Schroeder, Christina I. and Muttenthaler, Markus (2021). Chemical synthesis of TFF3 reveals novel mechanistic insights and a gut-stable metabolite. Journal of Medicinal Chemistry, 64 (13) acs.jmedchem.1c00767, 9484-9495. doi: 10.1021/acs.jmedchem.1c00767
2021
Journal Article
Improving the gastrointestinal stability of linaclotide
Braga Emidio, Nayara, Tran, Hue N. T., Andersson, Asa, Dawson, Philip E., Albericio, Fernando, Vetter, Irina and Muttenthaler, Markus (2021). Improving the gastrointestinal stability of linaclotide. Journal of Medicinal Chemistry, 64 (12) acs.jmedchem.1c00380, 8384-8390. doi: 10.1021/acs.jmedchem.1c00380
2020
Journal Article
Discovery, pharmacological characterisation and NMR structure of the novel µ-Conotoxin SxIIIC, a potent and irreversible NaV channel inhibitor
McMahon, Kirsten L., Tran, Hue N.T., Deuis, Jennifer R., Lewis, Richard J., Vetter, Irina and Schroeder, Christina I. (2020). Discovery, pharmacological characterisation and NMR structure of the novel µ-Conotoxin SxIIIC, a potent and irreversible NaV channel inhibitor. Biomedicines, 8 (10) 391, 1-15. doi: 10.3390/biomedicines8100391
2020
Journal Article
Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7
Agwa, Akello J., Tran, Poanna, Mueller, Alexander, Tran, Hue N. T., Deuis, Jennifer R., Israel, Mathilde R., McMahon, Kirsten L., Craik, David J., Vetter, Irina and Schroeder, Christina I. (2020). Manipulation of a spider peptide toxin alters its affinity for lipid bilayers and potency and selectivity for voltage-gated sodium channel subtype 1.7. The Journal of Biological Chemistry, 295 (15), 5067-5080. doi: 10.1074/jbc.ra119.012281
2019
Journal Article
Enzymatic ligation of a pore blocker toxin and gating modifier toxin; creating double-knotted peptides with improved sodium channel NaV1.7 inhibition
Tran, Hue, Tran, Poanna, Deuis, Jennifer R., Agwa, Akello Joanna, Zhang, Alan H., Vetter, Irina and Schroeder, Christina I (2019). Enzymatic ligation of a pore blocker toxin and gating modifier toxin; creating double-knotted peptides with improved sodium channel NaV1.7 inhibition. Bioconjugate Chemistry, 31 (1) acs.bioconjchem.9b00744, 64-73. doi: 10.1021/acs.bioconjchem.9b00744
Supervision
Availability
- Dr Hue Tran is:
- Available for supervision
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