Overview
Background
Dr Asmerom Sengal MD, PhD is a clinician-scientist and holds a senior postdoctoral position at the Tumour Biology and Therapeutics Lab, MRI- University of Queensland (UQ). Dr Sengal has an outstanding experience in preclinical model development including primary cell lines, patient-derived organoids (PDOs) and patient-derived xenografts (PDXs). Dr Sengal has exceptional skills in vitro and in vivo drug screening and has optimised several assays and protocols for biomarker discovery. He also has excellent experience in biostatistical analyses, automated image analysis, digital pathology, and molecular pathology. He pioneered a novel protocol for organoid culture and isolation of cancer-associated fibroblasts (CAFs) and immune cells to develop a co-culture of models that represent the tumour micro-environment, a noble platform for drug testing and biomarker discovery
Availability
- Dr Asmerom Sengal is:
- Available for supervision
Qualifications
- Professional Doctorate of General Medicine, Latin American Schol of Medicine
- Doctoral (Research) of Molecular Medicine, Queensland University of Technology
Research interests
-
Gynaecological cancer
Biomarker discovery, preclinical model development, precision therapy
Works
Search Professor Asmerom Sengal’s works on UQ eSpace
2024
Book Chapter
Development and expansion of patient-derived xenografts for endometrial cancer
Sengal, Asmerom T. and Pollock, Pamela M. (2024). Development and expansion of patient-derived xenografts for endometrial cancer. Patient-derived xenografts: methods and protocols. (pp. 101-115) edited by Mohamed I. Saad. New York, NY USA: Humana Press. doi: 10.1007/978-1-0716-3858-3_9
2023
Journal Article
Endometrial cancer PDX-derived organoids (PDXOs) and PDXs with FGFR2c isoform expression are sensitive to FGFR inhibition
Sengal, Asmerom T., Bonazzi, Vanessa, Smith, Deborah, Moiola, Cristian P., Lourie, Rohan, Rogers, Rebecca, Colas, Eva, Gil-Moreno, Antonio, Frentzas, Sophia, Chetty, Naven, Perrin, Lewis and Pollock, Pamela M. (2023). Endometrial cancer PDX-derived organoids (PDXOs) and PDXs with FGFR2c isoform expression are sensitive to FGFR inhibition. npj Precision Oncology, 7 (1) 127, 127. doi: 10.1038/s41698-023-00478-6
2022
Journal Article
Spatial expression of the FGFR2b splice isoform and its prognostic significance in endometrioid endometrial carcinoma
Sengal, Asmerom T., Smith, Deborah, Snell, Cameron E., Leung, Samuel, Talhouk, Aline, Williams, Elizabeth D., McAlpine, Jessica N. and Pollock, Pamela M. (2022). Spatial expression of the FGFR2b splice isoform and its prognostic significance in endometrioid endometrial carcinoma. Journal of Pathology: Clinical Research, 8 (6), 521-537. doi: 10.1002/cjp2.286
2022
Journal Article
Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer
Bonazzi, Vanessa F., Kondrashova, Olga, Smith, Deborah, Nones, Katia, Sengal, Asmerom T., Ju, Robert, Packer, Leisl M., Koufariotis, Lambros T., Kazakoff, Stephen H., Davidson, Aimee L., Ramarao-Milne, Priya, Lakis, Vanessa, Newell, Felicity, Rogers, Rebecca, Davies, Claire, Nicklin, James, Garrett, Andrea, Chetty, Naven, Perrin, Lewis, Pearson, John V., Patch, Ann-Marie, Waddell, Nicola and Pollock, Pamela M. (2022). Patient-derived xenograft models capture genomic heterogeneity in endometrial cancer. Genome Medicine, 14 (1) 3, 1-19. doi: 10.1186/s13073-021-00990-z
2021
Conference Publication
Targeting FGFR2c isoform, a novel therapeutic target with FGFR inhibitor in endometrial cancer
Sengal, Asmerom T., Bonazzi, Vanessa, Kondrashova, Olga, Perrin, Lewis, Chetty, Naven, Smith, Deborah, Gil-Moreno, Antonio, Colas, Eva and Pollock, Pamela M. (2021). Targeting FGFR2c isoform, a novel therapeutic target with FGFR inhibitor in endometrial cancer. PHILADELPHIA: AMER ASSOC CANCER RESEARCH. doi: 10.1158/1535-7163.TARG-21-LBA020
2021
Journal Article
Fibroblast growth factor receptor 2 isoforms detected via novel RNA ISH as predictive biomarkers for progestin therapy in atypical hyperplasia and low-grade endometrial cancer
Sengal, Asmerom T., Smith, Deborah, Rogers, Rebecca, Snell, Cameron E., Williams, Elizabeth D. and Pollock, Pamela M. (2021). Fibroblast growth factor receptor 2 isoforms detected via novel RNA ISH as predictive biomarkers for progestin therapy in atypical hyperplasia and low-grade endometrial cancer. Cancers, 13 (7) 1703, 1-17. doi: 10.3390/cancers13071703
2021
Conference Publication
FGFR2 isoform switching strongly associates with progestin treatment failure in atypical hyperplasia and well-differentiated endometrial cancer
Sengal, Asmerom, Smith, Deborah, Rogers, Rebecca, Snell, Cameron, Williams, Elizabeth and Pollock, Pamela (2021). FGFR2 isoform switching strongly associates with progestin treatment failure in atypical hyperplasia and well-differentiated endometrial cancer. AACR Virtual Special Conference: Endometrial Cancer: New Biology Driving Research and Treatment, Virtual, 9-10 November 2020. Philadelphia, PA USA: American Association for Cancer Research. doi: 10.1158/1557-3265.endomet20-po033
2021
Conference Publication
Genomic characterization of endometrial cancer patient-derived xenografts reveals intratumor heterogeneity
Kondrashova, Olga, Bonazzi, Vanessa F., Smith, Deborah, Nones, Katia, Sengal, Asmerom, Ju, Robert, Packer, Leisl M., Koufariotis, Lambros T., Kazakoff, Stephen H., Davidson, Aimee L., Ramarao-Milne, Priya, Lakis, Vanessa, Newell, Felicity, Rogers, Rebecca, Davies, Claire, Chetty, Naven, Perrin, Lewis, Pearson, John, Patch, Ann-Marie, Garrett, Andrea, Waddell, Nicola, Pollock, Pamela and Nicklin, James (2021). Genomic characterization of endometrial cancer patient-derived xenografts reveals intratumor heterogeneity. AACR Special Conference on Endometrial Cancer - New Biology Driving Research and Treatment, Electr Network, Nov 09-10, 2020. PHILADELPHIA: AMER ASSOC CANCER RESEARCH.
2021
Conference Publication
FGFR2 isoform switching strongly associates with progestin treatment failure in atypical hyperplasia and well-differentiated endometrial cancer
Sengal, Asmerom, Smith, Deborah, Rogers, Rebecca, Snell, Cameron, Williams, Elizabeth and Pollock, Pamela (2021). FGFR2 isoform switching strongly associates with progestin treatment failure in atypical hyperplasia and well-differentiated endometrial cancer. AACR Special Conference on Endometrial Cancer - New Biology Driving Research and Treatment, Electr Network, Nov 09-10, 2020. PHILADELPHIA: AMER ASSOC CANCER RESEARCH.
2020
Journal Article
FGFR2c mesenchymal isoform expression is associated with poor prognosis and further refines risk stratification within endometrial cancer molecular subtypes
Sengal, Asmerom T., Patch, Ann-Marie, Snell, Cameron E., Smith, Deborah S., Leung, Samuel, Talhouk, Aline, Williams, Elizabeth D., McAlpine, Jessica N. and Pollock, Pamela M. (2020). FGFR2c mesenchymal isoform expression is associated with poor prognosis and further refines risk stratification within endometrial cancer molecular subtypes. Clinical Cancer Research, 26 (17), 4569-4580. doi: 10.1158/1078-0432.ccr-19-4088
2017
Journal Article
Immunohistochemistry defined subtypes of breast cancer in 678 Sudanese and Eritrean women; hospitals based case series
Sengal, Asmerom Tesfamariam, Haj-Mukhtar, Nada Suliman, Elhaj, Ahmed Mohammed, Bedri, Shahinaz, Kantelhardt, Eva Johanna and Mohamedani, Ahmed A. (2017). Immunohistochemistry defined subtypes of breast cancer in 678 Sudanese and Eritrean women; hospitals based case series. BMC Cancer, 17 (1) 804, 1-9. doi: 10.1186/s12885-017-3805-4
2017
Journal Article
Comparison of Receptor-Defined Breast Cancer Subtypes Between German and Sudanese Women: A Facility-Based Cohort Study
Sengal, Asmerom Tesfamariam, Mukhtar, Nada Suliman Haj, Vetter, Martina, Elhaj, Ahmed Mohammed, Bedri, Shahinaz, Hauptmann, Steffen, Thomssen, Christoph, Mohamedani, Ahmed Abdalla, Wickenhauser, Claudia and Kantelhardt, Eva Johanna (2017). Comparison of Receptor-Defined Breast Cancer Subtypes Between German and Sudanese Women: A Facility-Based Cohort Study. Journal of Global Oncology, 4. doi: 10.1200/JGO.2017.010082
2016
Journal Article
The Role of PCR in Diagnosis of a Rare Appendicular Tuberculosis and Mini Literature Review
Sengal, Asmerom Tesfamariam, Mohamedani, Ahmed Abdalla, Hussein, Hanan Hasaan and Kamal, Alaa (2016). The Role of PCR in Diagnosis of a Rare Appendicular Tuberculosis and Mini Literature Review. Case Reports in Gastrointestinal Medicine, 2016 8356708. doi: 10.1155/2016/8356708
2013
Journal Article
Breast cancer clinicopathological presentation, gravity and challenges in Eritrea, East Africa: management practice in a resource-poor setting
Tesfamariam, A., Gebremichael, A. and Mufunda, J. (2013). Breast cancer clinicopathological presentation, gravity and challenges in Eritrea, East Africa: management practice in a resource-poor setting. South African Medical Journal, 103 (8), 526-528. doi: 10.7196/SAMJ.6829
2013
Journal Article
Molecular biology of breast cancer in the Horn of Africa: case series—a pilot study of breast cancer from Eritrea
Tesfamariam, Asmerom and Roy, Indrojit (2013). Molecular biology of breast cancer in the Horn of Africa: case series—a pilot study of breast cancer from Eritrea. ISRN Pathology, 2013, 1-7. doi: 10.1155/2013/787495
Supervision
Availability
- Dr Asmerom Sengal is:
- Available for supervision
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