Designer Nano-carriers for Targeted Hydrophobic Anticancer Drug Delivery with Enhanced Bioavailability (2011-2013)

This project aims at developing a designable and general platform for site-specific anticancer drug delivery to address a critical challenge, i.e. the low bioavailability of anticancer drugs in cancer therapy. Functionalized nano-carriers with controlled pore and particle size will be synthesized to enhance the bioavailability of water insoluble anticancer drugs, promote endocytosis performance, and achieve targeted delivery in both oral and intravenous administration routes. Completion of this project will advance the knowledge of nano-materials and nano-medicine, and provide innovative technologies for efficient drug delivery and utilization.