Balancing cadherin-actin cooperation: the key regulatory role of Ena/VASP proteins (2006-2008)
Abstract
Cell-cell interactions are fundamental determinants of tissue organization in health and disease. Cadherin cell-cell adhesion molecule cooperate with the actin cytoskeleton to control tissue patterning, yet the fundamental cellular and molecular mechanisms responsible for these actions are ill-understood. This project studies how different states of the actin cytoskeleton may be regulated by specific (Ena/VASP) proteins at cadherin contacts. It will probe how the balance between these different states may be regulated to control tissue pattterning.
