Mathematical modeling of multicellular organization of epithelial tissues (2014-2019)

This project will use mathematical modelling and computer simulations to understand the dynamic organisation of epithelial tissues in close interaction with ongoing laboratory experiments. The key challenge is to develop a multi-scale modelling framework that is capable to bridge the gap between biochemical and biophysical sub-cellular processes, cell-cell interactions and the large scale multicellular properties of tissues composed of large cell populations. This will require the design of novel mathematical approximation techniques and application of high performance parallel computing technology specifically adapted for the description of multicellular systems.