Biodegradable magnesium alloy scaffolds for bone tissue engineering (ARC Discovery Project administered by RMIT University) (2017-2020)
Abstract
The present project is aimed at developing a novel class of porous, biocompatible, biofunctional and biodegradable magnesium (Mg) alloy scaffolds with designed pore architecture and mechanical properties mimicking those of natural bone for bone tissue engineering applications. The Mg alloy scaffolds possess advantages of new bone-tissue ingrowth ability and vascular invasion, suitability for load-bearing applications, biofunction of osteoinduction and suitable in vivo biodegradation, whereby, the Mg alloy scaffolds are gradually replaced by natural bone. The outcomes of the project are of considerable significance for the ageing population, and individuals adversely affected by bone abnormalities.
