Forces in Nature: Tissue mechanics and cell sociology (2024-2028)
Abstract
Epithelial cells cover surfaces in the body, forming a shield to protect us from the environment. Despite their importance, we understand poorly how the cells communicate. This project aims to test the novel concept that epithelial cells communicate via transmission and detection of mechanical forces, using an innovative combination of cellular and biophysical experiments and physical theory. The expected outcomes are new knowledge, interdisciplinary training for young scientists, new national research capacity and growing international collaborations. Benefits include enhancing Australia¿s scientific linkages and research capacity and providing fundamental knowledge that could lead to future advances in bioengineering and drug discovery.
