Skip to menu Skip to content Skip to footer

A novel signalling effector of ASC pyroptosomes (2025-2027)

Abstract

The life of an organism relies on the timely birth and death of its cells. Importantly, it is crucial for cells to die not only at the right time, but also in an appropriate manner. This proposal investigates a cell death pathway that triggers potent immune responses. This proposal seeks to validate a new signal effector that induces cell death. Expected outcomes include new insights into how cells die, and how they instruct immune responses from beyond the grave. Project benefits include new fundamental understanding of cell death mechanisms and how this sculpts tissue immune responses, and new knowledge of how to manipulate cell death responses for future basic research and commercial applications beyond this project.

Experts

Professor Kate Schroder

Affiliate of The Centre for Cell Biology of Chronic Disease
Centre for Cell Biology of Chronic Disease
Institute for Molecular Bioscience
Affiliate Professor of Queensland Brain Institute
Queensland Brain Institute
Faculty of Health, Medicine and Behavioural Sciences
NHMRC Leadership Fellow - Group Leader
Institute for Molecular Bioscience
Kate Schroder
Kate Schroder

Dr Sabrina Sofia Burgener

SNF Research Fellow
Institute for Molecular Bioscience
Sabrina Sofia Burgener
Sabrina Sofia Burgener