Deconstructing neurotransmission one molecule at a time: Munc13 (2025-2028)
Abstract
Understanding the nanoscale workings of the synapse, the site of neuronal communication, is a holy grail of neuroscience. Munc13-1 prepares synaptic vesicle (SV) for neurotransmitter release. This grant will investigate how Munc13-1 is (1) enriched at the synapse, (2) undergoes translocation and immobilisation at the interface between SVs and the plasma membrane. Using cutting-edge super-resolution techniques, we will test whether Munc13-1 first binds to the membrane, then hooks SVs, thereby contributing to their immobilisation and building a fusogenic interface. The project will harness innovation and EMCR training, propelling Australia to the forefront of neuroscience research, ultimately helping to understand neurological conditions.
