How Adherens junctions coordinate cell signaling for epithelial homeostasis (2026-2029)
Abstract
Epithelial tissues are the fundamental barriers of the body. During life, healthy epithelial cells constantly monitor their locale for cell injury and engage homeostatic responses to preserve tissue integrity. This application probes how the junctions that hold epithelial cells together control signaling networks within the cells to regulate homeostasis. The expected outcomes are fundamental new knowledge using an innovative combination of quantitative cell biological and biophysical experiments, interdisciplinary training for young scientists, new national research capacity and growing international collaborations. It will benefit Australia by enhancing its scientific world linkage, status in scientific leadership and research capacity.
