Precision Functional Dissection of a Cellular Stress Sensing Organelle (2026-2028)
Abstract
Cells must protect themselves from stress and sense their environment. This depends on the ability of the cell surface, or plasma membrane, to detect changes and translate them into a cellular signal. The project aims to use powerful new methods to study the structure of the plasma membrane and precise protein engineering tools to control and dissect how the plasma membrane responds to external signals. The expected outcomes of this Project include a new understanding of how cells respond to their environment and novel techniques for studying cell function. This will provide significant benefits by generating new knowledge in fundamental cell biology and through the development of powerful innovative systems to understand cellular function.
