New mathematical models for brain tissue microstructure imaging (ARC Discovery Project administered by Queensland University of Technology) (2025-2028)

Diffusion MRI is a modern workhorse for neuroscientists to non-invasively study the brain. However, the mechanism underlying diffusion MRI signal formation, due to the movement of water molecules in complex brain tissue, is still unclear. This project aims to develop the next generation mathematical framework to interpret and model diffusion-weighted MRI signals, surpassing the capability of conventional mathematical models. Expected outcomes include novel mathematical and computational approaches enabling more sensitive and specific imaging markers for characterising brain tissue microstructure. The mathematical tools developed will advance the state of the art in diffusion MRI data analysis and benefit both researchers and clinicians.