Intelligent scaffolds and methods for repair of osteochondral defects (2009-2012)

This project will develop an intelligent biphasic scaffold capable of instructing mesenchymal precursor cells (MPCs) to become a functional osteochondral graft for the resurfacing of joints in osteoarthritis patients. Biaxial strain will be imposed on MPCs cultured on engineered osteo- and chondro-conductive substrates in order to assess the ability of mechanical stimulation to invoke control over lineage fate. These outcomes will inform the fabrication of a novel 3D biphasic scaffold which will direct MPCs in adjacent layers to develop into bone and cartilage upon the application of mechanical load, realizing the current unmet potential of these cells to regenerate functional osteochondral defects.'',