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2024 Journal Article Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killingLi, Xaria X., Fung, Jenny N., Clark, Richard J., Lee, John D. and Woodruff, Trent M. (2024). Cell-intrinsic C5a synergizes with Dectin-1 in macrophages to mediate fungal killing. Proceedings of the National Academy of Sciences, 121 (5) e2314627121, 1-10. doi: 10.1073/pnas.2314627121 |
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2024 Journal Article A panel of miRNA biomarkers common to serum and brain-derived extracellular vesicles identified in mouse model of amyotrophic lateral sclerosisVassileff, Natasha, Spiers, Jereme G., Lee, John D., Woodruff, Trent M., Ebrahimie, Esmaeil, Mohammadi Dehcheshmeh, Manijeh, Hill, Andrew F. and Cheng, Lesley (2024). A panel of miRNA biomarkers common to serum and brain-derived extracellular vesicles identified in mouse model of amyotrophic lateral sclerosis. Molecular Neurobiology, 61 (8), 5901-5915. doi: 10.1007/s12035-023-03857-z |
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2023 Journal Article The concise guide to PHARMACOLOGY 2023/24: G protein-coupled receptorsAlexander, Stephen P. H., Christopoulos, Arthur, Davenport, Anthony P., Kelly, Eamonn, Mathie, Alistair A., Peters, John A., Veale, Emma L., Armstrong, Jane F., Faccenda, Elena, Harding, Simon D., Davies, Jamie A., Abbracchio, Maria Pia, Abraham, George, Agoulnik, Alexander, Alexander, Wayne, Al‐hosaini, Khaled, Bäck, Magnus, Baker, Jillian G., Barnes, Nicholas M., Bathgate, Ross, Beaulieu, Jean‐Martin, Beck‐Sickinger, Annette G., Behrens, Maik, Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J. M., Blaho, Victoria, Boulay, Francois, Bousquet, Corinne ... Ye, Richard D. (2023). The concise guide to PHARMACOLOGY 2023/24: G protein-coupled receptors. British Journal of Pharmacology, 180 (S2), S23-S144. doi: 10.1111/bph.16177 |
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2023 Journal Article Complement peptide receptors in GtoPdb v.2023.1Cianciulli, Antonia, Coulthard, Liam, Hawksworth, Owen, Lee, John D., Li, Xaria X., Mitolo, Vincenzo, Monk, Peter, Panaro, Maria A. and Woodruff, Trent M. (2023). Complement peptide receptors in GtoPdb v.2023.1. IUPHAR/BPS Guide to Pharmacology CITE, 2023 (1). doi: 10.2218/gtopdb/f5/2023.1 |
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2023 Journal Article TLQP-21 is a low potency partial C3aR activator on human primary macrophagesLi, Xaria X., Lee, John D., Lee, Han S., Clark, Richard J. and Woodruff, Trent M. (2023). TLQP-21 is a low potency partial C3aR activator on human primary macrophages. Frontiers in Immunology, 14 1086673, 1-10. doi: 10.3389/fimmu.2023.1086673 |
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2023 Journal Article SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike proteinAlbornoz, Eduardo A., Amarilla, Alberto A., Modhiran, Naphak, Parker, Sandra, Li, Xaria X., Wijesundara, Danushka K., Aguado, Julio, Zamora, Adriana Pliego, McMillan, Christopher L. D., Liang, Benjamin, Peng, Nias Y. G., Sng, Julian D. J., Saima, Fatema Tuj, Fung, Jenny N., Lee, John D., Paramitha, Devina, Parry, Rhys, Avumegah, Michael S., Isaacs, Ariel, Lo, Martin W., Miranda-Chacon, Zaray, Bradshaw, Daniella, Salinas-Rebolledo, Constanza, Rajapakse, Niwanthi W., Wolvetang, Ernst J., Munro, Trent P., Rojas-Fernandez, Alejandro, Young, Paul R., Stacey, Katryn J. ... Woodruff, Trent M. (2023). SARS-CoV-2 drives NLRP3 inflammasome activation in human microglia through spike protein. Molecular Psychiatry, 28 (7), 2878-2893. doi: 10.1038/s41380-022-01831-0 |
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2022 Journal Article Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disordersMcDonald, Tanya S., Lerskiatiphanich, Titaya, Woodruff, Trent M., McCombe, Pamela A. and Lee, John D. (2022). Potential mechanisms to modify impaired glucose metabolism in neurodegenerative disorders. Journal of Cerebral Blood Flow and Metabolism, 43 (1), 26-43. doi: 10.1177/0271678x221135061 |
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2022 Journal Article Glucose metabolism in amyotrophic lateral sclerosis: It is bitter-sweetLerskiatiphanich, Titaya, Marallag, Jianina and Lee, John D. (2022). Glucose metabolism in amyotrophic lateral sclerosis: It is bitter-sweet. Neural Regeneration Research, 17 (9), 1975-1977. doi: 10.4103/1673-5374.335154 |
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2022 Journal Article SARS-CoV-2 triggers complement activation through interactions with heparan sulfateLo, Martin W., Amarilla, Alberto A., Lee, John D., Albornoz, Eduardo A., Modhiran, Naphak, Clark, Richard J., Ferro, Vito, Chhabra, Mohit, Khromykh, Alexander A., Watterson, Daniel and Woodruff, Trent M. (2022). SARS-CoV-2 triggers complement activation through interactions with heparan sulfate. Clinical and Translational Immunology, 11 (8) e1413, e1413. doi: 10.1002/cti2.1413 |
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2021 Journal Article In vivo pharmacodynamic method to assess complement C5a receptor antagonist efficacyCui, Cedric S., Kumar, Vinod, Gorman, Declan M., Clark, Richard J., Lee, John D. and Woodruff, Trent M. (2021). In vivo pharmacodynamic method to assess complement C5a receptor antagonist efficacy. ACS Pharmacology and Translational Science, 5 (1) acsptsci.1c00227, 41-51. doi: 10.1021/acsptsci.1c00227 |
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2021 Journal Article Unexpected off-target activities for recombinant C5a in human macrophagesLi, Xaria X., Gorman, Declan M., Lee, John D., Clark, Richard J. and Woodruff, Trent M. (2021). Unexpected off-target activities for recombinant C5a in human macrophages. Journal of Immunology, 208 (1), 133-142. doi: 10.4049/jimmunol.2100444 |
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2021 Journal Article Development of synthetic human and mouse C5a: application to binding and functional assays in vitro and in vivoGorman, Declan M., Li, Xaria X., Payne, Colton D., Cui, Cedric S., Lee, John D., Rosengren, K. Johan, Woodruff, Trent M. and Clark, Richard J. (2021). Development of synthetic human and mouse C5a: application to binding and functional assays in vitro and in vivo. ACS Pharmacology and Translational Science, 4 (6) acsptsci.1c00199, 1808-1817. doi: 10.1021/acsptsci.1c00199 |
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2021 Journal Article Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo ActivityGorman, Declan M., Li, Xaria X., Lee, John D., Fung, Jenny N., Cui, Cedric S., Lee, Han Siean, Rolfe, Barbara E., Woodruff, Trent M. and Clark, Richard J. (2021). Development of Potent and Selective Agonists for Complement C5a Receptor 1 with In Vivo Activity. Journal of Medicinal Chemistry, 64 (22) acs.jmedchem.1c01174, 16598-16608. doi: 10.1021/acs.jmedchem.1c01174 |
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2021 Journal Article Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptorsPandey, Shubhi, Kumari, Punita, Baidya, Mithu, Kise, Ryoji, Cao, Yubo, Dwivedi-Agnihotri, Hemlata, Banerjee, Ramanuj, Li, Xaria X., Cui, Cedric S., Lee, John D., Kawakami, Kouki, Maharana, Jagannath, Ranjan, Ashutosh, Chaturvedi, Madhu, Jhingan, Gagan Deep, Laporte, Stéphane A., Woodruff, Trent M., Inoue, Asuka and Shukla, Arun K. (2021). Intrinsic bias at non-canonical, β-arrestin-coupled seven transmembrane receptors. Molecular Cell, 81 (22), 4605-4621.e11. doi: 10.1016/j.molcel.2021.09.007 |
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2021 Journal Article The emerging role of complement in neuromuscular disordersLee, John D. and Woodruff, Trent M. (2021). The emerging role of complement in neuromuscular disorders. Seminars in Immunopathology, 43 (6), 817-828. doi: 10.1007/s00281-021-00895-4 |
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2021 Journal Article The concise guide to pharmacology 2021/22: G protein‐coupled receptorsAlexander, Stephen PH, Christopoulos, Arthur, Davenport, Anthony P, Kelly, Eamonn, Mathie, Alistair, Peters, John A, Veale, Emma L, Armstrong, Jane F, Faccenda, Elena, Harding, Simon D, Pawson, Adam J, Southan, Christopher, Davies, Jamie A, Abbracchio, Maria Pia, Alexander, Wayne, Al‐hosaini, Khaled, Bäck, Magnus, Barnes, Nicholas M., Bathgate, Ross, Beaulieu, Jean‐Martin, Bernstein, Kenneth E., Bettler, Bernhard, Birdsall, Nigel J.M., Blaho, Victoria, Boulay, Francois, Bousquet, Corinne, Bräuner‐Osborne, Hans, Burnstock, Geoffrey, Caló, Girolamo ... Ye, Richard D. (2021). The concise guide to pharmacology 2021/22: G protein‐coupled receptors. British Journal of Pharmacology, 178 (S1), S27-S156. doi: 10.1111/bph.15538 |
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2021 Journal Article Complement peptide receptors in GtoPdb v.2021.3Cianciulli, Antonia, Coulthard, Liam, Hawksworth, Owen, Lee, John D., Li, Xaria X., Mitolo, Vincenzo, Monk, Peter, Panaro, Maria A. and Woodruff, Trent M. (2021). Complement peptide receptors in GtoPdb v.2021.3. IUPHAR/BPS Guide to Pharmacology CITE, 2021 (3), 1-13. doi: 10.2218/gtopdb/f5/2021.3 |
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2021 Journal Article Glucose clearance and uptake is increased in the SOD1 G93A mouse model of amyotrophic lateral sclerosis through an insulin‐independent mechanismMcDonald, Tanya S., Kumar, Vinod, Fung, Jenny N., Woodruff, Trent M. and Lee, John D. (2021). Glucose clearance and uptake is increased in the SOD1 G93A mouse model of amyotrophic lateral sclerosis through an insulin‐independent mechanism. The FASEB Journal, 35 (7) e21707, e21707. doi: 10.1096/fj.202002450r |
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2021 Journal Article Complement: a global immunometabolic regulator in amyotrophic lateral sclerosisLo, Martin W. and Lee, John D. (2021). Complement: a global immunometabolic regulator in amyotrophic lateral sclerosis. Neural Regeneration Research, 16 (6), 1210-1211. doi: 10.4103/1673-5374.300441 |
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2021 Journal Article The “C3aR Antagonist” SB290157 is a partial C5aR2 agonistLi, Xaria X., Kumar, Vinod, Clark, Richard J., Lee, John D. and Woodruff, Trent M. (2021). The “C3aR Antagonist” SB290157 is a partial C5aR2 agonist. Frontiers in Pharmacology, 11 591398, 591398. doi: 10.3389/fphar.2020.591398 |
