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2019 Journal Article Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosisLee, John D., Liu, Ning, Levin, Samantha C., Ottosson, Lars, Andersson, Ulf, Harris, Helena E. and Woodruff, Trent M. (2019). Therapeutic blockade of HMGB1 reduces early motor deficits, but not survival in the SOD1G93A mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 16 (1) 45, 45. doi: 10.1186/s12974-019-1435-2 |
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2019 Conference Publication Deciphering key roles for complement peptide receptors in brain developmentWoodruff, T., Hawksworth, O., Lee, J. and Coulthard, L. (2019). Deciphering key roles for complement peptide receptors in brain development. Joint Meeting of the International Society for Neurochemistry and American Society for Neurochemistry (ISN-ASN), Montreal, Canada, 4-8 August 2019. Chichester, West Sussex, United Kingdom: Wiley-Blackwell. |
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2019 Conference Publication Complement C5a receptors, C5aR1 and C5aR2, mediate opposing pathologies in a mouse model of melanomaNabizadeh, J., Manthey, H., Panagides, N., Steyn, F., Lee, J., Li, X., Woodruff, T. and Rolfe, B. (2019). Complement C5a receptors, C5aR1 and C5aR2, mediate opposing pathologies in a mouse model of melanoma. 17th International Congress of Immunology (IUIS), Beijing, China, 19-23 October 2019. Weinheim, Germany: Wiley. |
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2018 Journal Article Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performanceCoulthard, Liam G., Hawksworth, Owen A., Conroy, Jacinta, Lee, John D. and Woodruff, Trent M. (2018). Complement C3a receptor modulates embryonic neural progenitor cell proliferation and cognitive performance. Molecular Immunology, 101, 176-181. doi: 10.1016/j.molimm.2018.06.271 |
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2018 Journal Article Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in miceKumar, Vinod, Lee, John D., Clark, Richard J. and Woodruff, Trent M. (2018). Development and validation of a LC-MS/MS assay for pharmacokinetic studies of complement C5a receptor antagonists PMX53 and PMX205 in mice. Scientific Reports, 8 (1) 8101, 8101. doi: 10.1038/s41598-018-26387-4 |
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2018 Journal Article Defects in synaptic transmission at the neuromuscular junction precedes motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosisChand, Kirat K., Lee, Kah Meng, Lee, John D., Qiu, Hao, Willis, Emily F., Lavidis, Nickolas A., Hilliard, Massimo A. and Noakes, Peter G. (2018). Defects in synaptic transmission at the neuromuscular junction precedes motor deficits in a TDP-43Q331K transgenic mouse model of amyotrophic lateral sclerosis. FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology, 32 (5), fj201700835R-2689. doi: 10.1096/fj.201700835R |
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2017 Journal Article Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosisWang, Haitao A., Lee, John D., Lee, Kah Meng, Woodruff, Trent M. and Noakes, Peter G. (2017). Complement C5a-C5aR1 signalling drives skeletal muscle macrophage recruitment in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Skeletal Muscle, 7 (1) 10, 10. doi: 10.1186/s13395-017-0128-8 |
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2017 Journal Article Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCζCoulthard, Liam G., Hawksworth, Owen A., Li, Rui, Balachandran, Anushree, Lee, John D., Sepehrband, Farshid, Kurniawan, Nyoman, Jeanes, Angela, Simmons, David G., Wolvetang, Ernst and Woodruff, Trent M. (2017). Complement C5aR1 signaling promotes polarization and proliferation of embryonic neural progenitor cells through PKCζ. Journal of Neuroscience, 37 (22), 5395-5407. doi: 10.1523/JNEUROSCI.0525-17.2017 |
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2017 Journal Article Non-invasive assessment of altered activity following restraint in mice using an automated physiological monitoring systemSpiers, Jereme G., Chen, Hsiao-Jou Cortina, Steyn, Frederik J., Lavidis, Nickolas A., Woodruff, Trent M. and Lee, John D. (2017). Non-invasive assessment of altered activity following restraint in mice using an automated physiological monitoring system. Stress, 20 (1), 59-67. doi: 10.1080/10253890.2016.1276898 |
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2017 Conference Publication Motor neuron disease proteins activate complement and generate C5aDeora, Vandana, Mantovani, Susanna, Yerbury, Justin, Clark, Richard, Atkin, Julie, Lee, John, Gordon, Richard and Woodruff, Trent M. (2017). Motor neuron disease proteins activate complement and generate C5a. 16th European Meeting on Complement in Human Disease (EMCHD), Copenhagen, Denmark, 8-12 September 2017. Kidlington, Oxford, United Kingdom: Pergamon Press. doi: 10.1016/j.molimm.2017.06.144 |
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2016 Journal Article Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosisFogarty, Matthew J., Klenowski, Paul M., Lee, John D., Drieberg-Thompson, Joy R., Bartlett, Selena E., Ngo, Shyuan T., Hilliard, Massimo A., Bellingham, Mark C. and Noakes, Peter G. (2016). Cortical synaptic and dendritic spine abnormalities in a presymptomatic TDP-43 model of amyotrophic lateral sclerosis. Scientific Reports, 6 (1) 37968, 37968. doi: 10.1038/srep37968 |
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2016 Conference Publication A pathogenic role for the C5a receptor, C5aR2, in mouse models of Huntington's and Parkinson's diseaseLi, Rui, Lee, John D., Levin, Samantha, Gordon, Richard and Woodruff, Trent M. (2016). A pathogenic role for the C5a receptor, C5aR2, in mouse models of Huntington's and Parkinson's disease. The XXVI International Complement Workshop (ICW), Kanazawa, Japan, 4-8 September 2016. Muenchen, Germany: Elsevier. doi: 10.1016/j.imbio.2016.06.186 |
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2016 Conference Publication The complement C5a receptor, C5aR2 contributes to motor deficits in mouse models of Huntington's and Parkinson's diseaseLi, R., Levin, S., Lee, J., Gordon, R. and Woodruff, T. (2016). The complement C5a receptor, C5aR2 contributes to motor deficits in mouse models of Huntington's and Parkinson's disease. International Congress of Immunology (ICI), Melbourne, Australia, 21-26 August 2016. Weinheim, Germany: Wiley - VCH. doi: 10.1002/eji.201670200 |
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2016 Journal Article Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditionsBrennan, Faith H., Lee, John D., Ruitenberg, Marc J. and Woodruff, Trent M. (2016). Therapeutic targeting of complement to modify disease course and improve outcomes in neurological conditions. Seminars in Immunology, 28 (3), 292-308. doi: 10.1016/j.smim.2016.03.015 |
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2015 Journal Article Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1<sup>G93A</sup> mouse model of amyotrophic lateral sclerosisLee, Jia Y., Lee, John D., Phipps, Simon, Noakes, Peter G. and Woodruff, Trent M. (2015). Absence of toll-like receptor 4 (TLR4) extends survival in the hSOD1G93A mouse model of amyotrophic lateral sclerosis. Journal of Neuroinflammation, 12 (1) 90, 90. doi: 10.1186/s12974-015-0310-z |
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2015 Conference Publication Blood brain barrier impairment alters the pharmacokinetic properties of the complement C5aR1 antagonist PMX205 in mouse models of neurodegenerationKumar, Vinod, Lee, John, Noakes, Peter and Woodruff, Trent (2015). Blood brain barrier impairment alters the pharmacokinetic properties of the complement C5aR1 antagonist PMX205 in mouse models of neurodegeneration. 8th International Conference on Complement Therapeutics, Chania, Crete, Greece, 1-6 January 2015. |
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2014 Other Outputs The role of complement system in amyotrophic lateral sclerosisLee, John (2014). The role of complement system in amyotrophic lateral sclerosis. PhD Thesis, School of Biomedical Sciences, The University of Queensland. doi: 10.14264/uql.2015.156 |
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2014 Journal Article Role for terminal complement activation in amyotrophic lateral sclerosis disease progressionWoodruff, Trent M., Lee, John D. and Noakes, Peter G. (2014). Role for terminal complement activation in amyotrophic lateral sclerosis disease progression. Proceeding of the National Academy of Sciences of the United States of America, 111 (1), E3-E4. doi: 10.1073/pnas.1321248111 |
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2013 Journal Article Silencing of ghrelin receptor expression inhibits endometrial cancer cell growth in vitro and in vivoFung, Jenny N. T., Jeffery, Penny L., Lee, John D., Seim, Inge, Roche, Deborah, Obermair, Andreas, Chopin, Lisa K. and Chen, Chen (2013). Silencing of ghrelin receptor expression inhibits endometrial cancer cell growth in vitro and in vivo. American Journal of Physiology-Endocrinology and Metabolism, 305 (2), E305-E313. doi: 10.1152/ajpendo.00156.2013 |
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2012 Journal Article Impairments to the GH-IGF-I axis in hSOD1(G93A) mice give insight into possible mechanisms of GH dysregulation in patients with amyotrophic lateral sclerosisSteyn, F. J., Ngo, S. T, Lee, J. D., Leong, J. W., Buckley, A. J., Veldhuis, J. D., McCombe, P. A., Chen, C. and Bellingham, M. C. (2012). Impairments to the GH-IGF-I axis in hSOD1(G93A) mice give insight into possible mechanisms of GH dysregulation in patients with amyotrophic lateral sclerosis. Endocrinology, 153 (8), 3735-3746. doi: 10.1210/en.2011-2171 |
