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2019 Journal Article Cyclotides: from structure to functionde Veer, Simon J., Kan, Meng-Wei and Craik, David J. (2019). Cyclotides: from structure to function. Chemical Reviews, 119 (24) acs.chemrev.9b00402, 12375-12421. doi: 10.1021/acs.chemrev.9b00402 |
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2019 Journal Article Iterative optimization of the cyclic peptide SFTI-1 yields potent inhibitors of neutrophil proteinase 3Tian, Sixin, Swedberg, Joakim E., Li, Choi Yi, Craik, David J. and de Veer, Simon J. (2019). Iterative optimization of the cyclic peptide SFTI-1 yields potent inhibitors of neutrophil proteinase 3. ACS Medicinal Chemistry Letters, 10 (8) acsmedchemlett.9b00253, 1234-1239. doi: 10.1021/acsmedchemlett.9b00253 |
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2019 Journal Article KLK4 inhibition by cyclic and acyclic peptides: structural and dynamical insights into standard-mechanism protease inhibitorsRiley, Blake T., Ilyichova, Olga, de Veer, Simon J., Swedberg, Joakim E., Wilson, Emily, Hoke, David E., Harris, Jonathan M. and Buckle, Ashley M. (2019). KLK4 inhibition by cyclic and acyclic peptides: structural and dynamical insights into standard-mechanism protease inhibitors. Biochemistry, 58 (21), 2524-2533. doi: 10.1021/acs.biochem.9b00191 |
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2019 Journal Article Amino acid scanning at P5′ within the Bowman–Birk inhibitory loop reveals specificity trends for diverse serine proteasesLi, Choi Yi, de Veer, Simon J., White, Andrew M., Chen, Xingchen, Harris, Jonathan M., Swedberg, Joakim E. and Craik, David J. (2019). Amino acid scanning at P5′ within the Bowman–Birk inhibitory loop reveals specificity trends for diverse serine proteases. Journal of Medicinal Chemistry, 62 (7), 3696-3706. doi: 10.1021/acs.jmedchem.9b00211 |
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2019 Journal Article Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motifChen, Xingchen, Riley, Blake T., De Veer, Simon J., Hoke, David E., Van Haeften, Jessica, Leahy, Darren, Swedberg, Joakim E., Brattsand, Maria, Hartfield, Perry J., Buckle, Ashley M. and Harris, Jonathan M. (2019). Potent, multi-target serine protease inhibition achieved by a simplified β-sheet motif. PLoS ONE, 14 (1) e0210842, e0210842. doi: 10.1371/journal.pone.0210842 |
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2019 Journal Article Characterising the subsite specificity of urokinase-type plasminogen activator and tissue-type plasminogen activator using a sequence-defined peptide aldehyde libraryLi, Choi Yi, de Veer, Simon J., Law, Ruby H. P., Whisstock, James C., Craik, David J. and Swedberg, Joakim E. (2019). Characterising the subsite specificity of urokinase-type plasminogen activator and tissue-type plasminogen activator using a sequence-defined peptide aldehyde library. ChemBioChem, 19 (1), 46-50. doi: 10.1002/cbic.201800395 |
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2018 Journal Article Potent, selective, and cell-penetrating inhibitors of Kallikrein-related peptidase 4 based on the cyclic peptide MCoTI-IISwedberg, Joakim E., Ghani, Hafiza Abdul, Harris, Jonathan M., de Veer, Simon J. and Craik, David J. (2018). Potent, selective, and cell-penetrating inhibitors of Kallikrein-related peptidase 4 based on the cyclic peptide MCoTI-II. ACS Medicinal Chemistry Letters, 9 (12) acsmedchemlett.8b00422, 1258-1262. doi: 10.1021/acsmedchemlett.8b00422 |
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2018 Journal Article Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1de Veer, Simon J., Li, Choi Yi, Swedberg, Joakim E., Schroeder, Christina I. and Craik, David J. (2018). Engineering potent mesotrypsin inhibitors based on the plant-derived cyclic peptide, sunflower trypsin inhibitor-1. European Journal of Medicinal Chemistry, 155, 695-704. doi: 10.1016/j.ejmech.2018.06.029 |
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2017 Journal Article Kallikrein-related peptidase 5 contributes to H3N2 influenza virus infection in human lungsMagnen, Melia, Gueugnon, Fabien, Guillon, Antoine, Baranek, Thomas, Thibault, Virginie C., Petit-Courty, Agnes, de Veer, Simon J., Harris, Jonathan, Humbles, Alison A., Si-Tahar, Mustapha and Courty, Yves (2017). Kallikrein-related peptidase 5 contributes to H3N2 influenza virus infection in human lungs. Journal of Virology, 91 (16) e00421-17. doi: 10.1128/JVI.00421-17 |
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2017 Journal Article Cyclotides as tools in chemical biologyde Veer, Simon J., Weidmann, Joachim and Craik, David J. (2017). Cyclotides as tools in chemical biology. Accounts of Chemical Research, 50 (7), 1557-1565. doi: 10.1021/acs.accounts.7b00157 |
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2017 Journal Article Selective substrates and inhibitors for kallikrein-related peptidase 7 (KLK7) shed light on KLK proteolytic activity in the stratum corneumde Veer, Simon J., Furio, Laetitia, Swedberg, Joakim E., Munro, Christopher A., Brattsand, Maria, Clements, Judith A., Hovnanian, Alain and Harris, Jonathan M. (2017). Selective substrates and inhibitors for kallikrein-related peptidase 7 (KLK7) shed light on KLK proteolytic activity in the stratum corneum. The Journal of Investigative Dermatology, 137 (2), 430-439. doi: 10.1016/j.jid.2016.09.017 |
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2017 Journal Article Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffoldSwedberg, Joakim E., Li, Choi Yi, De Veer, Simon J., Wang, Conan K. and Craik, David J. (2017). Design of potent and selective cathepsin G inhibitors based on the sunflower trypsin inhibitor-1 scaffold. Journal of Medicinal Chemistry, 60 (2), 658-667. doi: 10.1021/acs.jmedchem.6b01509 |
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2017 Journal Article Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent modelsMcGovern, J. A., Meinert, C., de Veer, S. J., Hollier, B. G., Parker, T. J. and Upton, Z. (2017). Attenuated kallikrein-related peptidase activity disrupts desquamation and leads to stratum corneum thickening in human skin equivalent models. British Journal of Dermatology, 176 (1), 145-158. doi: 10.1111/bjd.14879 |
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2017 Book Chapter Naturally occurring disulfide-rich cyclic peptides from plants and animals: synthesis and biosynthesisde Veer, Simon J. and Craik, David J. (2017). Naturally occurring disulfide-rich cyclic peptides from plants and animals: synthesis and biosynthesis. Chemical biology of natural products. (pp. 491-528) edited by David J. Newman, Gordon M. Cragg and Paul G. Grothaus. Boca Raton, FL, United States: CRC Press. doi: 10.1201/9781315117089-13 |
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2016 Journal Article Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitorsDe Veer, Simon J., Swedberg, Joakim E., Brattsand, Maria, Clements, Judith A. and Harris, Jonathan M. (2016). Exploring the active site binding specificity of kallikrein-related peptidase 5 (KLK5) guides the design of new peptide substrates and inhibitors. Biological Chemistry, 397 (12), 1237-1249. doi: 10.1515/hsz-2016-0112 |
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2016 Journal Article Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamicsRiley, Blake T., Ilyichova, Olga, Costa, Mauricio G. S., Porebski, Benjamin T., De Veer, Simon J., Swedberg, Joakim E., Kass, Itamar, Harris, Jonathan M., Hoke, David E. and Buckle, Ashley M. (2016). Direct and indirect mechanisms of KLK4 inhibition revealed by structure and dynamics. Scientific Reports, 6 (1) 35385, 35385. doi: 10.1038/srep35385 |
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2016 Journal Article Substrate-guided design of selective FXIIa inhibitors based on the plant-derived Momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffoldSwedberg, Joakim E., Mahatmanto, Tunjung, Ghani, Hafiza Abdul, de Veer, Simon J., Schroeder, Christina I., Harris, Jonathan M. and Craik, David J. (2016). Substrate-guided design of selective FXIIa inhibitors based on the plant-derived Momordica cochinchinensis trypsin inhibitor-II (MCoTI-II) scaffold. Journal of Medicinal Chemistry, 59 (15), 7287-7292. doi: 10.1021/acs.jmedchem.6b00557 |
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2015 Journal Article Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide libraryde Veer, Simon J., Wang, Conan, Harris, Jonathan M., Craik, David J. and Swedberg, Joakim E. (2015). Improving the selectivity of engineered protease inhibitors: optimizing the P2 prime residue using a versatile cyclic peptide library. Journal of Medicinal Chemistry, 58 (20), 8257-8268. doi: 10.1021/acs.jmedchem.5b01148 |
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2015 Journal Article Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibitionde Veer, Simon J., Swedberg, Joakim E., Akcan, Muharrem, Rosengren, K. Johan, Brattsand, Maria, Craik, David J. and Harris, Jonathan M. (2015). Engineered protease inhibitors based on sunflower trypsin inhibitor-1 (SFTI-1) provide insights into the role of sequence and conformation in Laskowski mechanism inhibition. Biochemical Journal, 469 (2), 243-253. doi: 10.1042/BJ20150412 |
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2014 Journal Article Olmsted syndrome with erythromelalgia caused by recessive TRPV3 mutationsDuchatelet, S., Guibbal, L., de Veer, S., Fraitag, S., Nitschké, P., Zarhrate, M., Bodemer, C. and Hovnanian, A. (2014). Olmsted syndrome with erythromelalgia caused by recessive TRPV3 mutations. British Journal of Dermatology, 171 (3), 675-678. doi: 10.1111/bjd.12951 |
