|
2026 Journal Article Depletion and replacement of tissue resident macrophages in mice with germ-line deletion of a conserved enhancer in the <i>Csf1r</i> locusLiu, Yajun, Jacquelin, Sebastien, Taylor, Isis, Green, Emma K., Patkar, Omkar L., Keshvari, Sahar, Ranpura, Ginell, O'Brien, Conan J. O., Jessen, Eline, Maxwell, Emma, Allavena, Rachel, Gallerand, Alexandre, Ivanov, Stoyan, Adamson, Antony, Humphreys, Neil E., Summers, Kim M., Irvine, Katharine M. and Hume, David A. (2026). Depletion and replacement of tissue resident macrophages in mice with germ-line deletion of a conserved enhancer in the Csf1r locus. Development dev.205655. doi: 10.1242/dev.205655 |
|
2026 Journal Article Homozygous kinase-dead <i>Csf1r</i> mutation in outbred mice reveals essential and redundant functions of tissue resident macrophagesJacquelin, Sebastien, Maxwell, Emma, Taylor, Isis, Green, Emma, O’Brien, Conan J O, Jessen, Eline E, Ranpura, Ginell, Guo, Jintao, Nooru-Mohamed, Fathima, Liu, Yajun, Keshvari, Sahar, Huang, Stephen, Cooper, Emily, Lane, Steven W, Flegg, Cameron, Kasherman, Maria A, Sokolowski, Kamil, Pettit, Allison R, Hume, David A and Irvine, Katharine M (2026). Homozygous kinase-dead Csf1r mutation in outbred mice reveals essential and redundant functions of tissue resident macrophages. Journal of Leukocyte Biology, 118 (6) qiag074. doi: 10.1093/jleuko/qiag074 |
|
2026 Journal Article Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet‐induced obesityWang, Yizhuo, Ramnath, Divya, Das Gupta, Kaustav, Prakrithi, P., Bisht, Kavita, Miller, Gregory C., Xiong, Zherui, Wan, Yujun, Tejo, Ellen N., Curson, James E. B., Abrol, Rishika, Keshvari, Sahar, Gunther, Kimberley S., Atkinson, Jordan D., Loh, Zhixuan, Engel, Jessica A., Engwerda, Christian R., Burgener, Sabrina Sofia, Schroder, Kate, Fairlie, David P., Clouston, Andrew D., Powell, Elizabeth E., Irvine, Katharine M., Sullivan, Mitchell A., Lévesque, Jean‐Pierre, Nguyen, Quan, Sweet, Matthew J. and Karunakaran, Denuja (2026). Myeloid HDAC7 drives liver inflammation and systemic glucose dysregulation during diet‐induced obesity. Clinical and Translational Immunology, 15 (6) e70100, 1-20. doi: 10.1002/cti2.70100 |
|
2026 Journal Article THU-526 Macrophage colony stimulating factor (CSF1) induces a proregenerative response in human liver during normothermic machine perfusionKeshvari, Sahar, Schulze, Sarah, Carter-Cusack, Dylan, Butler, Nick and Irvine, Katharine (2026). THU-526 Macrophage colony stimulating factor (CSF1) induces a proregenerative response in human liver during normothermic machine perfusion. Journal of Hepatology, 84, S420. doi: 10.1016/s0168-8278(26)01267-5 |
|
2026 Journal Article FRI-403 Ascites bactericidal capacity in patients with decompensated cirrhosisRatnasekera, Isanka, Phan, Min-Duy, Nguyen, Nhu, Jessen, Eline, Keshvari, Sahar, Ong, Yvette, Kidd, Timothy, Hancock, Steven, Hume, David, Powell, Elizabeth, Sweet, Matthew, Schembri, Mark and Irvine, Katharine (2026). FRI-403 Ascites bactericidal capacity in patients with decompensated cirrhosis. Journal of Hepatology, 84, S170-S171. doi: 10.1016/s0168-8278(26)00664-1 |
|
2025 Journal Article Correction: Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammationHuang, Stephen, Patkar, Omkar L., Schulze, Sarah, Carter-Cusack, Dylan, Millard, Susan, Ranpura, Ginell, Green, Emma K., Maxwell, Emma, Kanesarajah, Jeeva, Cowin, Gary, Stimson, Damion, Kurniawan, Nyoman D, Keshvari, Sahar, Allavena, Rachel, Pettit, Allison R., Irvine, Katharine M. and Hume, David A. (2025). Correction: Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis and inflammation. Life Science Alliance, 8 (10) e202503435, e202503435. doi: 10.26508/lsa.202503435 |
|
2025 Journal Article Perisurgical colony stimulating factor one treatment ameliorates liver ischaemia/reperfusion injury in ratsSchulze, Sarah, Keshvari, Sahar, Miller, Gregory C., Bridle, Kim R., Hume, David A. and Irvine, Katharine M. (2025). Perisurgical colony stimulating factor one treatment ameliorates liver ischaemia/reperfusion injury in rats. World Journal of Gastroenterology, 31 (24) 108234, 1-18. doi: 10.3748/wjg.v31.i24.108234 |
|
2025 Journal Article Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis, and inflammationHuang, Stephen, Patkar, Omkar L., Schulze, Sarah, Carter-Cusack, Dylan, Millard, Susan, Ranpura, Ginell, Green, Emma K., Maxwell, Emma, Kanesarajah, Jeeva, Cowin, Gary, Stimson, Damion, Kurniawan, Nyoman D., Keshvari, Sahar, Allavena, Rachel, Pettit, Allison R., Irvine, Katharine M. and Hume, David A. (2025). Mutation in the rat interleukin 34 gene impacts macrophage development, homeostasis, and inflammation. Life Science Alliance, 8 (9) e202503264, e202503264. doi: 10.26508/lsa.202503264 |
|
2025 Journal Article Barriers to Implementing the Surgical Safety Checklist in Operating Rooms of Educational Hospitals of Dezful University of Medical Sciences: A Qualitative StudyPourzamani, Mohadese, Shamloo, Marzieh Beigom Bigdeli, Rashidi, Neda, Kalani, Leila and Keshvari, Sahar (2025). Barriers to Implementing the Surgical Safety Checklist in Operating Rooms of Educational Hospitals of Dezful University of Medical Sciences: A Qualitative Study. Evidence Based Care Journal, 15 (1), 67-75. doi: 10.22038/EBCJ.2025.85514.3090 |
|
2025 Journal Article Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutationCarter-Cusack, Dylan, Huang, Stephen, Keshvari, Sahar, Patkar, Omkar, Sehgal, Anuj, Allavena, Rachel, Byrne, Robert A. J., Morgan, B. Paul, Bush, Stephen J., Summers, Kim M., Irvine, Katharine M. and Hume, David A. (2025). Wild-type bone marrow cells repopulate tissue resident macrophages and reverse the impacts of homozygous CSF1R mutation. PLoS Genetics, 21 (1) e1011525, 1-40. doi: 10.1371/journal.pgen.1011525 |
|
2024 Journal Article Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasisThierry, Guilhem R., Baudon, Elisa M., Bijnen, Mitchell, Bellomo, Alicia, Lagueyrie, Marine, Mondor, Isabelle, Simonnet, Louise, Carrette, Florent, Fenouil, Romain, Keshvari, Sahar, Hume, David A., Dombrowicz, David and Bajenoff, Marc (2024). Non-classical monocytes scavenge the growth factor CSF1 from endothelial cells in the peripheral vascular tree to ensure survival and homeostasis. Immunity, 57 (9), 2108-2121.e6. doi: 10.1016/j.immuni.2024.07.005 |
|
2024 Journal Article Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasisSajiir, Haressh, Wong, Kuan Yau, Müller, Alexandra, Keshvari, Sahar, Burr, Lucy, Aiello, Elena, Mezza, Teresa, Giaccari, Andrea, Sebastiani, Guido, Dotta, Francesco, Ramm, Grant A., Macdonald, Graeme A., McGuckin, Michael A., Prins, Johannes B. and Hasnain, Sumaira Z. (2024). Pancreatic beta-cell IL-22 receptor deficiency induces age-dependent dysregulation of insulin biosynthesis and systemic glucose homeostasis. Nature Communications, 15 (1) 4527, 1-12. doi: 10.1038/s41467-024-48320-2 |
|
2024 Journal Article Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitisSajiir, Haressh, Keshvari, Sahar, Wong, Kuan Yau, Borg, Danielle J., Steyn, Frederik J., Fercher, Christian, Taylor, Karin, Taylor, Breten, Barnard, Ross T., Müller, Alexandra, Moniruzzaman, Md, Miller, Gregory, Wang, Ran, Fotheringham, Amelia, Schreiber, Veronika, Sheng, Yong Hua, Hancock, Janelle Louise, Loo, Dorothy, Burr, Lucy, Huynh, Tony, Lockett, Jack, Ramm, Grant A., Macdonald, Graeme A., Prins, Johannes B., McGuckin, Michael A. and Hasnain, Sumaira Z. (2024). Liver and pancreatic-targeted interleukin-22 as a therapeutic for metabolic dysfunction-associated steatohepatitis. Nature Communications, 15 (1) 4528, 1-13. doi: 10.1038/s41467-024-48317-x |
|
2024 Journal Article Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transferBatoon, Lena, Keshvari, Sahar, Irvine, Katharine M., Ho, Eileen, Caruso, Melanie, Patkar, Omkar L., Sehgal, Anuj, Millard, Susan M., Hume, David A. and Pettit, Allison R. (2024). Relative contributions of osteal macrophages and osteoclasts to postnatal bone development in CSF1R-deficient rats and phenotype rescue following wild-type bone marrow cell transfer. Journal of Leukocyte Biology, 116 (4), 753-765. doi: 10.1093/jleuko/qiae077 |
|
2024 Journal Article Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolismKeshvari, Sahar, Masson, Jesse J.R., Ferrari-Cestari, Michelle, Bodea, Liviu-Gabriel, Nooru-Mohamed, Fathima, Tse, Brian W.C., Sokolowski, Kamil A., Batoon, Lena, Patkar, Omkar L., Sullivan, Mitchell A., Ebersbach, Hilmar, Stutz, Cian, Parton, Robert G., Summers, Kim M., Pettit, Allison R., Hume, David A. and Irvine, Katharine M. (2024). Reversible expansion of tissue macrophages in response to macrophage colony-stimulating factor (CSF1) transforms systemic lipid and carbohydrate metabolism. American Journal of Physiology-Endocrinology and Metabolism, 326 (2), E149-E165. doi: 10.1152/ajpendo.00347.2023 |
|
2023 Journal Article Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo developmentHume, David A, Teakle, Ngari, Keshvari, Sahar and Irvine, Katharine M (2023). Macrophage deficiency in CSF1R-knockout rat embryos does not compromise placental or embryo development. Journal of Leukocyte Biology, 114 (5), 421-433. doi: 10.1093/jleuko/qiad052 |
|
2023 Journal Article Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesisSehgal, Anuj, Carter‐Cusack, Dylan, Keshvari, Sahar, Patkar, Omkar, Huang, Stephen, Summers, Kim M., Hume, David A. and Irvine, Katharine M. (2023). Intraperitoneal transfer of wild‐type bone marrow repopulates tissue macrophages in the Csf1r knockout rat without contributing to monocytopoiesis. European Journal of Immunology, 53 (8) 2250312, e2250312. doi: 10.1002/eji.202250312 |
|
2023 Journal Article Fibrillin-1 and asprosin, novel players in metabolic syndromeSummers, Kim M., Bush, Stephen J., Davis, Margaret R., Hume, David A., Keshvari, Sahar and West, Jennifer A. (2023). Fibrillin-1 and asprosin, novel players in metabolic syndrome. Molecular Genetics and Metabolism, 138 (1) 106979, 106979. doi: 10.1016/j.ymgme.2022.106979 |
|
2023 Journal Article Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD)Ferrari-Cestari, Michelle, Okano, Satomi, Patel, Preya J., Horsfall, Leigh U., Keshvari, Sahar, Hume, David A., Williams, Suzanne, Russell, Anthony, Powell, Elizabeth E. and Irvine, Katharine M (2023). Serum CCL2 is associated with visceral adiposity but not fibrosis in patients with Non-alcoholic Fatty Liver Disease (NAFLD). Digestive Diseases, 41 (3), 439-446. doi: 10.1159/000527784 |
|
2022 Journal Article CSF1R as a therapeutic target in bone diseases: obvious but not so simpleHume, David A., Batoon, Lena, Sehgal, Anuj, Keshvari, Sahar and Irvine, Katharine M. (2022). CSF1R as a therapeutic target in bone diseases: obvious but not so simple. Current Osteoporosis Reports, 20 (6), 516-531. doi: 10.1007/s11914-022-00757-4 |
