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2024 Conference Publication GERMLINEELP1 DEFICIENCY SENSITIZES CEREBELLAR GRANULE NEURON PROGENITORS TO SHH MEDULLOBLASTOMATanveer Ahmad, Shiekh, Garcia-Lopez, Jesus, Li, Yiran, Hadley, Jennifer, Paul, Leena, Gudenas, Brian, Batts, Melissa, Soliman, Taha, Pitre, Aaron, Kojic, Marija, Manz, Frederik, Zindy, Frederique, Jones, Alun, Mayasundari, Anand, Bianski, Brandon, Tinkle, Christopher, Shirinifard, Abbas, Janke, Laura Janke, Lu, Meifen, Onar-Thomas, Arzu, Pfister, Stefan, Gajjar, Amar, Baker, Suzanne, Roussel, Martine, Rankovic, Zoran, Robinson, Giles, Orr, Brent, Wainwright, Brandon, Kutscher, Lena ... Northcott, Paul (2024). GERMLINEELP1 DEFICIENCY SENSITIZES CEREBELLAR GRANULE NEURON PROGENITORS TO SHH MEDULLOBLASTOMA. 29th Annual Meeting and Education Day of the Society-for-Neuro-Oncology (SNO), Houston Tx, Nov 21-24, 2024. CARY: OXFORD UNIV PRESS INC. doi: 10.1093/neuonc/noae165.1283 |
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2024 Conference Publication Germline ELP1 deficiency sensitizes cerebellar granule neuron progenitors to SHH medulloblastomaAhmad, Shiekh Tanveer, Garcia-Lopez, Jesus, Li, Yiran, Gudenas, Brian, Hadley, Jennifer, Paul, Leena, Batts, Melissa, Soliman, Taha, Kojic, Marija, Pitre, Aaron, Manz, Frederik, Zindy, Frederique, Jones, Alun, Mayasundari, Anand, Bianski, Brandon, Tinkle, Christopher, Shirinifard, Abbas, Janke, Laura, Lu, Meifen, Pfister, Stefan M., Gajjar, Amar, Baker, Suzanne J., Roussel, Martine F., Rankovic, Zoran, Waszak, Sebastian M., Robinson, Giles W., Orr, Brent A., Wainwright, Brandon, Kutscher, Lena M. ... Northcott, Paul A. (2024). Germline ELP1 deficiency sensitizes cerebellar granule neuron progenitors to SHH medulloblastoma. International Symposium on Pediatric Neuro-Oncology (ISPNO), Philadelphia, PA, United States, 29 June - 2 July 2024. Cary, NC, United States: Oxford University Press. doi: 10.1093/neuonc/noae064.462 |
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2023 Journal Article Efficient detection and monitoring of pediatric brain malignancies with liquid biopsy based on patient-specific somatic mutation screeningKojic, Marija, Maybury, Mellissa K., Waddell, Nicola, Koufariotis, Lambros T., Addala, Venkateswar, Millar, Amanda, Wood, Scott, Pearson, John V., Hansford, Jordan R., Hassall, Tim and Wainwright, Brandon J. (2023). Efficient detection and monitoring of pediatric brain malignancies with liquid biopsy based on patient-specific somatic mutation screening. Neuro-Oncology, 25 (8), 1507-1517. doi: 10.1093/neuonc/noad032 |
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2023 Conference Publication ELP1 Germline Deficiency Sensitizes The Granule Neuron Lineage To SHH Medulloblastoma And Exposes Novel Therapeutic VulnerabilitiesGarcia-Lopez, Jesus, Ahmad, Shiekh Tanveer, Li, Yiran, Gudenas, Brian, Kojic, Marija, Manz, Friedrik, Jonchere, Barbara, Mayasundari, Anand, Pitre, Aaron, Hadley, Jennifer, Paul, Leena, Batts, Melissa, Pfister, Stefan, Waszak, Sebastian, Bianski, Brandon, Tinkle, Christopher, Orr, Brent, Rankovic, Zoran, Robinson, Giles, Wainwright, Brandon, Kutscher, Lena, Lin, Hong and Northcott, Paul (2023). ELP1 Germline Deficiency Sensitizes The Granule Neuron Lineage To SHH Medulloblastoma And Exposes Novel Therapeutic Vulnerabilities. 2023 Pediatric Neuro-Oncology Research Conference, Washington, DC United States, 22-24 June 2023. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/neuonc/noad073.255 |
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2023 Conference Publication ELP1 GERMLINE DEFICIENCY SENSITIZES THE GRANULE NEURON LINEAGE TO SHH MEDULLOBLASTOMA AND EXPOSES NOVEL THERAPEUTIC VULNERABILITIESGarcia-Lopez, Jesus, Ahmad, Shiekh Tanveer, Li, Yiran, Gudenas, Brian, Kojic, Marija, Manz, Friedrik, Jonchere, Barbara, Mayasundari, Anand, Pitre, Aaron, Hadley, Jennifer, Paul, Leena, Batts, Melissa, Pfister, Stefan, Waszak, Sebastian, Bianski, Brandon, Tinkle, Christopher, Orr, Brent, Rankovic, Zoran, Robinson, Giles, Wainwright, Brandon, Kutscher, Lena, Lin, Hong and Northcott, Paul (2023). ELP1 GERMLINE DEFICIENCY SENSITIZES THE GRANULE NEURON LINEAGE TO SHH MEDULLOBLASTOMA AND EXPOSES NOVEL THERAPEUTIC VULNERABILITIES. CARY: OXFORD UNIV PRESS INC. |
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2023 Journal Article Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibitionVo, Tuan, Balderson, Brad, Jones, Kahli, Ni, Guiyan, Crawford, Joanna, Millar, Amanda, Tolson, Elissa, Singleton, Matthew, Kojic, Marija, Robertson, Thomas, Walters, Shaun, Mulay, Onkar, Bhuva, Dharmesh D., Davis, Melissa J., Wainwright, Brandon J., Nguyen, Quan and Genovesi, Laura A. (2023). Spatial transcriptomic analysis of Sonic hedgehog medulloblastoma identifies that the loss of heterogeneity and promotion of differentiation underlies the response to CDK4/6 inhibition. Genome Medicine, 15 (1) 29, 29. doi: 10.1186/s13073-023-01185-4 |
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2023 Journal Article A novel ELP1 mutation impairs the function of the Elongator complex and causes a severe neurodevelopmental phenotypeKojic, Marija, Abbassi, Nour E. H., Lin, Ting-Yu, Jones, Alun, Wakeling, Emma L., Clement, Emma, Nakou, Vasiliki, Singleton, Matthew, Dobosz, Dominika, Kaliakatsos, Marios, Glatt, Sebastian and Wainwright, Brandon J. (2023). A novel ELP1 mutation impairs the function of the Elongator complex and causes a severe neurodevelopmental phenotype. Journal of Human Genetics, 68 (7), 445-453. doi: 10.1038/s10038-023-01135-3 |
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2023 Journal Article Elongator and the role of its subcomplexes in human diseasesGaik, Monika, Kojic, Marija, Wainwright, Brandon J and Glatt, Sebastian (2023). Elongator and the role of its subcomplexes in human diseases. EMBO Molecular Medicine, 15 (2) e16418, e16418. doi: 10.15252/emmm.202216418 |
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2022 Journal Article Functional divergence of the two Elongator subcomplexes during neurodevelopmentGaik, Monika, Kojic, Marija, Stegeman, Megan R., Öncü‐Öner, Tülay, Kościelniak, Anna, Jones, Alun, Mohamed, Ahmed, Chau, Pak Yan Stefanie, Sharmin, Sazia, Chramiec‐Głąbik, Andrzej, Indyka, Paulina, Rawski, Michał, Biela, Anna, Dobosz, Dominika, Millar, Amanda, Chau, Vann, Ünalp, Aycan, Piper, Michael, Bellingham, Mark C., Eichler, Evan E., Nickerson, Deborah A., Güleryüz, Handan, Abbassi, Nour El Hana, Jazgar, Konrad, Davis, Melissa J., Mercimek‐Andrews, Saadet, Cingöz, Sultan, Wainwright, Brandon J. and Glatt, Sebastian (2022). Functional divergence of the two Elongator subcomplexes during neurodevelopment. EMBO Molecular Medicine, 14 (7) e15608, e15608. doi: 10.15252/emmm.202115608 |
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2021 Journal Article SOX9 defines distinct populations of cells in SHH medulloblastoma but is not required for Math1-driven tumour formationAdolphe, Christelle, Millar, Amanda, Kojic, Marija, Barkauskas, Deborah S., Sundstrom, Anders, Swartling, Fredrik J., Hediyeh-zadeh, Soroor, Tan, Chin Wee, Davis, Melissa J., Genovesi, Laura A. and Wainwright, Brandon J. (2021). SOX9 defines distinct populations of cells in SHH medulloblastoma but is not required for Math1-driven tumour formation. Molecular Cancer Research, 19 (11), 1831-1839. doi: 10.1158/1541-7786.mcr-21-0117 |
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2021 Conference Publication MOMC-5. Systems pharmacogenomics identifies novel targets and clinically actionable therapeutics for medulloblastomaGenovesi, Laura, Millar, Amanda, Tolson, Elissa, Singleton, Matthew, Hassall, Emily, Kojic, Marija, Brighi, Caterina, Girald, Emily, Andradas, Clara, Kuchibhotla, Mani, Endersby, Raelene, Gottardo, Nicholas, Bernard, Anne, Adolphe, Christelle, Olson, James, Davis, Melissa and Wainwright, Brandon (2021). MOMC-5. Systems pharmacogenomics identifies novel targets and clinically actionable therapeutics for medulloblastoma. Society for Neuro-Oncology’s Basic and Translational Omics of Brain Tumors and Their Microenvironment Conference, Virtual, 15 - 16 July 2021. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/noajnl/vdab070.015 |
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2021 Journal Article Systems pharmacogenomics identifies novel targets and clinically actionable therapeutics for medulloblastomaGenovesi, Laura A., Millar, Amanda, Tolson, Elissa, Singleton, Matthew, Hassall, Emily, Kojic, Marija, Brighi, Caterina, Girard, Emily, Andradas, Clara, Kuchibhotla, Mani, Bhuva, Dharmesh D., Endersby, Raelene, Gottardo, Nicholas G., Bernard, Anne, Adolphe, Christelle, Olson, James M., Taylor, Michael D., Davis, Melissa J. and Wainwright, Brandon J. (2021). Systems pharmacogenomics identifies novel targets and clinically actionable therapeutics for medulloblastoma. Genome Medicine, 13 (1) 103, 103. doi: 10.1186/s13073-021-00920-z |
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2021 Journal Article Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotypeKojic, Marija, Gawda, Tomasz, Gaik, Monika, Begg, Alexander, Salerno-Kochan, Anna, Kurniawan, Nyoman D., Jones, Alun, Drożdżyk, Katarzyna, Kościelniak, Anna, Chramiec-Głąbik, Andrzej, Hediyeh-Zadeh, Soroor, Kasherman, Maria, Shim, Woo Jun, Sinniah, Enakshi, Genovesi, Laura A., Abrahamsen, Rannvá K., Fenger, Christina D., Madsen, Camilla G., Cohen, Julie S., Fatemi, Ali, Stark, Zornitza, Lunke, Sebastian, Lee, Joy, Hansen, Jonas K., Boxill, Martin F., Keren, Boris, Marey, Isabelle, Saenz, Margarita S., Brown, Kathleen ... Wainwright, Brandon J. (2021). Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype. Nature Communications, 12 (1) 2678, 2678. doi: 10.1038/s41467-021-22888-5 |
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2020 Journal Article Patient derived orthotopic xenograft models of Medulloblastoma lack a functional blood brain barrierGenovesi, Laura A., Puttick, Simon, Millar, Amanda, Kojic, Marija, Ji, Pengxiang, Lagendijk, Anne K., Brighi, Caterina, Bonder, Claudine S, Adolphe, Christelle and Wainwright, Brandon J. (2020). Patient derived orthotopic xenograft models of Medulloblastoma lack a functional blood brain barrier. Neuro-Oncology, 23 (5), 732-742. doi: 10.1093/neuonc/noaa266 |
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2020 Journal Article Germline elongator mutations in Sonic Hedgehog medulloblastomaWaszak, Sebastian M., Robinson, Giles W,, Gudenas, Brian L., Smith, Kyle S., Forget, Antoine, Kojic, Marija, Garcia-Lopez, Jesus, Hadley, Jennifer, Hamilton, Kayla V., Indersie, Emilie, Buchhalter, Ivo, Kerssemakers, Jules, Jäger, Natalie, Sharma, Tanvi, Rausch, Tobias, Kool, Marcel, Sturm, Dominik, Jones, David T. W., Vasilyeva, Aksana, Tatevossian, Ruth G., Neale, Geoffrey, Lombard, Bérangère, Loew, Damarys, Nakitandwe, Joy, Rusch, Michael, Bowers, Daniel C., Bendel, Anne, Partap, Sonia, Chintagumpala, Murali ... Pfister, Stefan M. (2020). Germline elongator mutations in Sonic Hedgehog medulloblastoma. Nature, 580 (7803), 396-401. doi: 10.1038/s41586-020-2164-5 |
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2020 Journal Article Comparative study of preclinical mouse models of high-grade glioma for nanomedicine research: the importance of reproducing blood-brain barrier heterogeneityBrighi, Caterina, Reid, Lee, Genovesi, Laura A., Kojic, Marija, Millar, Amanda, Bruce, Zara, White, Alison L., Day, Bryan W., Rose, Stephen, Whittaker, Andrew K. and Puttick, Simon (2020). Comparative study of preclinical mouse models of high-grade glioma for nanomedicine research: the importance of reproducing blood-brain barrier heterogeneity. Theranostics, 10 (14), 6361-6371. doi: 10.7150/thno.46468 |
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2020 Journal Article MR-guided focused ultrasound increases antibody delivery to nonenhancing high-grade gliomaBrighi, Caterina, Reid, Lee, White, Alison L., Genovesi, Laura A., Kojic, Marija, Millar, Amanda, Bruce, Zara, Day, Bryan W., Rose, Stephen, Whittaker, Andrew K. and Puttick, Simon (2020). MR-guided focused ultrasound increases antibody delivery to nonenhancing high-grade glioma. Neuro-Oncology Advances, 2 (1) vdaa030, 1-12. doi: 10.1093/noajnl/vdaa030 |
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2018 Journal Article Elongator mutation in mice induces neurodegeneration and ataxia-like behaviorKojic, Marija, Gaik, Monika, Kiska, Bence, Salerno-Kochan, Anna, Hunt, Sarah, Tedoldi, Angelo, Mureev, Sergey, Jones, Alun, Whittle, Belinda, Genovesi, Laura A., Adolphe, Christelle, Brown, Darren L., Stow, Jennifer L., Alexandrov, Kirill, Sah, Pankaj, Glatt, Sebastian and Wainwright, Brandon J. (2018). Elongator mutation in mice induces neurodegeneration and ataxia-like behavior. Nature Communications, 9 (1) 3195, 3195. doi: 10.1038/s41467-018-05765-6 |
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2016 Journal Article The many faces of elongator in neurodevelopment and diseaseKojic, Marija and Wainwright, Brandon (2016). The many faces of elongator in neurodevelopment and disease. Frontiers in Molecular Neuroscience, 9 (NOV2016) 115, 115. doi: 10.3389/fnmol.2016.00115 |
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2016 Other Outputs Genetic Regulation of Development and Disorders of the CerebellumKojic, Marija (2016). Genetic Regulation of Development and Disorders of the Cerebellum. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/uql.2016.808 |
