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2021 Journal Article Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disordersNabais, Marta F., Laws, Simon M., Lin, Tian, Vallerga, Costanza L., Armstrong, Nicola J., Blair, Ian P., Kwok, John B., Mather, Karen A., Mellick, George D., Sachdev, Perminder S., Wallace, Leanne, Henders, Anjali K., Zwamborn, Ramona A. J., Hop, Paul J., Lunnon, Katie, Pishva, Ehsan, Roubroeks, Janou A. Y., Soininen, Hilkka, Tsolaki, Magda, Mecocci, Patrizia, Lovestone, Simon, Kloszewska, Iwona, Vellas, Bruno, Furlong, Sarah, Garton, Fleur C., Henderson, Robert D., Mathers, Susan, McCombe, Pamela A., Needham, Merrilee ... McRae, Allan F. (2021). Meta-analysis of genome-wide DNA methylation identifies shared associations across neurodegenerative disorders. Genome Biology, 22 (1) 90, 1-30. doi: 10.1186/s13059-021-02275-5 |
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2021 Journal Article Ghrelin as a treatment for amyotrophic lateral sclerosisNgo, Shyuan T., Wang, Hao, Henderson, Robert D., Bowers, Cyril and Steyn, Frederik J. (2021). Ghrelin as a treatment for amyotrophic lateral sclerosis. Journal of Neuroendocrinology, 33 (7) e12938, 1-10. doi: 10.1111/jne.12938 |
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2021 Journal Article CNS glucose metabolism in amyotrophic lateral sclerosis: a therapeutic target?Tefera, Tesfaye Wolde, Steyn, Frederik J., Ngo, Shyuan T. and Borges, Karin (2021). CNS glucose metabolism in amyotrophic lateral sclerosis: a therapeutic target?. Cell & Bioscience, 11 (1) 14, 14. doi: 10.1186/s13578-020-00511-2 |
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2021 Book Chapter Hypothalamus and weight loss in amyotrophic lateral sclerosisAhmed, Rebekah M., Steyn, Frederik and Dupuis, Luc (2021). Hypothalamus and weight loss in amyotrophic lateral sclerosis. Handbook of clinical neurology. (pp. 327-338) Amsterdam, Netherlands: Elsevier. doi: 10.1016/B978-0-12-820107-7.00020-3 |
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2020 Journal Article Genome-wide meta-analysis finds the ACSL5-ZDHHC6 locus is associated with ALS and links weight loss to the disease geneticsIacoangeli, Alfredo, Lin, Tian, Al Khleifat, Ahmad, Jones, Ashley R., Opie-Martin, Sarah, Coleman, Jonathan R.I., Shatunov, Aleksey, Sproviero, William, Williams, Kelly L., Garton, Fleur, Restuadi, Restuadi, Henders, Anjali K., Mather, Karen A., Needham, Merilee, Mathers, Susan, Nicholson, Garth A., Rowe, Dominic B., Henderson, Robert, McCombe, Pamela A., Pamphlett, Roger, Blair, Ian P., Schultz, David, Sachdev, Perminder S., Newhouse, Stephen J., Proitsi, Petroula, Fogh, Isabella, Ngo, Shyuan T., Dobson, Richard J.B., Wray, Naomi R. ... Al-Chalabi, Ammar (2020). Genome-wide meta-analysis finds the ACSL5-ZDHHC6 locus is associated with ALS and links weight loss to the disease genetics. Cell Reports, 33 (4) 108323, 1-9. doi: 10.1016/j.celrep.2020.108323 |
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2020 Journal Article Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosisSteyn, Frederik J., Li, Rui, Kirk, Siobhan E., Tefera, Tesfaye W, Xie, Teresa Y., Tracey, Timothy J., Kelk, Dean, Wimberger, Elyse, Garton, Fleur C., Roberts, Llion, Chapman, Sarah E., Coombes, Jeff S., Leevy, W. Matthew, Ferri, Alberto, Valle, Cristiana, René, Frédérique, Loeffler, Jean-Philippe, McCombe, Pamela A., Henderson, Robert D. and Ngo, Shyuan T. (2020). Altered skeletal muscle glucose-fatty acid flux in amyotrophic lateral sclerosis. Brain Communications, 2 (2) fcaa154, fcaa154. doi: 10.1093/braincomms/fcaa154 |
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2020 Journal Article The role of lipids in the central nervous system and their pathological implications in amyotrophic lateral sclerosisTracey, T. J., Kirk, S. E., Steyn, F. J. and Ngo, S. T. (2020). The role of lipids in the central nervous system and their pathological implications in amyotrophic lateral sclerosis. Seminars in Cell and Developmental Biology, 112, 69-81. doi: 10.1016/j.semcdb.2020.08.012 |
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2020 Journal Article Prognostic value of weight loss in patients with amyotrophic lateral sclerosisSteyn, Frederik J and Ngo, Shyuan T (2020). Prognostic value of weight loss in patients with amyotrophic lateral sclerosis. Journal of Neurology, Neurosurgery and Psychiatry, 91 (8), 813-813. doi: 10.1136/jnnp-2020-323440 |
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2020 Journal Article Response to Letter to the Editor: "IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction"Joustra, Sjoerd D., Roelfsema, Ferdinand, van Trotsenburg, A. S. Paul, Schneider, Harald J., Kosilek, Robert P., Kroon, Herman M., Logan, John G., Butterfield, Natalie C., Zhou, Xiang, Toufaily, Chirine, Bak, Beata, Turgeon, Marc-Olivier, Brule, Emilie, Steyn, Frederik J., Gurnell, Mark, Koulouri, Olympia, Le Tissier, Paul, Fontanaud, Pierre, Bassett, J. H. Duncan, Williams, Graham R., Oostdijk, Wilma, Wit, Jan M., Pereira, Alberto M., Biermasz, Nienke R., Bernard, Daniel J. and Schoenmakers, Nadia (2020). Response to Letter to the Editor: "IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction". Journal of Clinical Endocrinology and Metabolism, 105 (6), E2315-E2316. doi: 10.1210/clinem/dgaa147 |
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2020 Journal Article Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1G93A Mice Predates Disease Onset and Is A Promising Therapeutic TargetScaricamazza, Silvia, Salvatori, Illari, Giacovazzo, Giacomo, Loeffler, Jean Philippe, Renè, Frederique, Rosina, Marco, Quessada, Cyril, Proietti, Daisy, Heil, Constantin, Rossi, Simona, Battistini, Stefania, Giannini, Fabio, Volpi, Nila, Steyn, Frederik J., Ngo, Shyuan T., Ferraro, Elisabetta, Madaro, Luca, Coccurello, Roberto, Valle, Cristiana and Ferri, Alberto (2020). Skeletal-Muscle Metabolic Reprogramming in ALS-SOD1G93A Mice Predates Disease Onset and Is A Promising Therapeutic Target. iScience, 23 (5) 101087, 101087. doi: 10.1016/j.isci.2020.101087 |
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2020 Journal Article Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosisNabais, Marta F., Lin, Tian, Benyamin, Beben, Williams, Kelly L., Garton, Fleur C., Vinkhuyzen, Anna A. E., Zhang, Futao, Vallerga, Costanza L., Restuadi, Restuadi, Freydenzon, Anna, Zwamborn, Ramona A. J., Hop, Paul J., Robinson, Matthew R., Gratten, Jacob, Visscher, Peter M., Hannon, Eilis, Mill, Jonathan, Brown, Matthew A., Laing, Nigel G., Mather, Karen A., Sachdev, Perminder S., Ngo, Shyuan T., Steyn, Frederik J., Wallace, Leanne, Henders, Anjali K., Needham, Merrilee, Veldink, Jan H., Mathers, Susan, Nicholson, Garth ... Wray, Naomi R. (2020). Significant out-of-sample classification from methylation profile scoring for amyotrophic lateral sclerosis. npj Genomic Medicine, 5 (1) 10, 1-9. doi: 10.1038/s41525-020-0118-3 |
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2020 Journal Article Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosisMcGill, Raquel B., Steyn, Frederik J., Ngo, Shyuan T., Thorpe, Kathryn A., Heggie, Susan, Ruitenberg, Marc J., Henderson, Robert D., McCombe, Pamela A. and Woodruff, Trent M. (2020). Monocytes and neutrophils are associated with clinical features in amyotrophic lateral sclerosis. Brain Communications, 2 (1) fcaa013, fcaa013. doi: 10.1093/braincomms/fcaa013 |
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2020 Journal Article Progression and survival of patients with motor neuron disease relative to their fecal microbiotaNgo, Shyuan T., Restuadi, Restuadi, McCrea, Allan F., Van Eijk, Ruben P., Garton, Fleur, Henderson, Robert D., Wray, Naomi R., McCombe, Pamela A. and Steyn, Frederik J. (2020). Progression and survival of patients with motor neuron disease relative to their fecal microbiota. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 21 (7-8), 1-14. doi: 10.1080/21678421.2020.1772825 |
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2019 Journal Article IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory HyperfunctionJoustra, Sjoerd D., Roelfsema, Ferdinand, van Trotsenburg, A. S. Paul, Schneider, Harald J., Kosilek, Robert P., Kroon, Herman M., Logan, John G., Butterfield, Natalie C., Zhou, Xiang, Toufaily, Chirine, Bak, Beata, Turgeon, Marc-Olivier, Brûlé, Emilie, Steyn, Frederik J., Gurnell, Mark, Koulouri, Olympia, Le Tissier, Paul, Fontanaud, Pierre, Duncan Bassett, J. H., Williams, Graham R., Oostdijk, Wilma, Wit, Jan M., Pereira, Alberto M., Biermasz, Nienke R., Bernard, Daniel J. and Schoenmakers, Nadia (2019). IGSF1 Deficiency Results in Human and Murine Somatotrope Neurosecretory Hyperfunction. The Journal of Clinical Endocrinology & Metabolism, 105 (3) dgz093, e70-e84. doi: 10.1210/clinem/dgz093 |
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2019 Journal Article C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanomaNabizadeh, Jamileh A., Manthey, Helga D., Panagides, Nadya, Steyn, Frederik J., Lee, John D., Li, Xaria X., Akhir, Fazrena N. M., Chen, Weiyu, Boyle, Glen M., Taylor, Stephen M., Woodruff, Trent M. and Rolfe, Barbara E. (2019). C5a receptors C5aR1 and C5aR2 mediate opposing pathologies in a mouse model of melanoma. FASEB Journal, 33 (10), fj201800980RR-11071. doi: 10.1096/fj.201800980rr |
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2019 Journal Article Gut microbiota in ALS: possible role in pathogenesis?McCombe, Pamela A., Henderson, Robert D., Lee, Aven, Lee, John D., Woodruff, Trent M., Restuadi, Restuadi, McRae, Allan, Wray, Naomi R., Ngo, Shyuan and Steyn, Frederik J. (2019). Gut microbiota in ALS: possible role in pathogenesis?. Expert Review of Neurotherapeutics, 19 (9), 1-21. doi: 10.1080/14737175.2019.1623026 |
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2019 Journal Article Loss of appetite is associated with a loss of weight and fat mass in patients with amyotrophic lateral sclerosisNgo, Shyuan T., Van Eijk, Ruben P. A., Chachay, V. , Van Den Berg, Leonard H., Mccombe, Pamela A., Henderson, Robert D. and Steyn, Frederik J. (2019). Loss of appetite is associated with a loss of weight and fat mass in patients with amyotrophic lateral sclerosis. Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration, 20 (7-8), 1-9. doi: 10.1080/21678421.2019.1621346 |
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2019 Journal Article Biomarkers of metabolism in amyotrophic lateral sclerosisKirk, Siobhan E., Tracey, Timothy J., Steyn, Frederik J. and Ngo, Shyuan T. (2019). Biomarkers of metabolism in amyotrophic lateral sclerosis. Frontiers in Neurology, 10 191, 191. doi: 10.3389/fneur.2019.00191 |
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2019 Conference Publication Complement C5a receptors, C5aR1 and C5aR2, mediate opposing pathologies in a mouse model of melanomaNabizadeh, J., Manthey, H., Panagides, N., Steyn, F., Lee, J., Li, X., Woodruff, T. and Rolfe, B. (2019). Complement C5a receptors, C5aR1 and C5aR2, mediate opposing pathologies in a mouse model of melanoma. 17th International Congress of Immunology (IUIS), Beijing, China, 19-23 October 2019. Weinheim, Germany: Wiley. |
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2018 Journal Article Hypermetabolism in ALS is associated with greater functional decline and shorter survivalSteyn, Frederik J., Ioannides, Zara A., van Eijk, Ruben P. A., Heggie, Susan, Thorpe, Kathryn A., Ceslis, Amelia, Heshmat, Saman, Henders, Anjali K., Wray, Naomi R., van den Berg, Leonard H., Henderson, Robert D., McCombe, Pamela A. and Ngo, Shyuan T. (2018). Hypermetabolism in ALS is associated with greater functional decline and shorter survival. Journal of Neurology, Neurosurgery, and Psychiatry, 89 (10), jnnp-2017. doi: 10.1136/jnnp-2017-317887 |
