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2019 Journal Article The DNA modification N6-methyl-2’-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinctionLi, Xiang, Zhao, Qiongyi, Wei, Wei, Lin, Quan, Magnan, Christophe, Emami, Michael R., Wearick-Silva, Luis E., Viola, Thiago W., Marshall, Paul R., Yin, Jiayu, Madugalle, Sachithrani U., Wang, Ziqi, Nainar, Sarah, Vågbø, Cathrine Broberg, Leighton, Laura J., Zajaczkowski, Esmi L., Ke, Ke, Grassi-Oliveira, Rodrigo, Bjørås, Magnar, Baldi, Pierre F., Spitale, Robert C. and Bredy, Timothy W. (2019). The DNA modification N6-methyl-2’-deoxyadenosine (m6dA) drives activity-induced gene expression and is required for fear extinction. Nature Neuroscience, 22 (4), 534-544. doi: 10.1038/s41593-019-0339-x |
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2019 Journal Article The DNA repair-associated protein gadd45γ regulates the temporal coding of immediate early gene expression within the prelimbic prefrontal cortex and is required for the consolidation of associative fear memoryLi, Xiang, Marshall, Paul R., Leighton, Laura J., Zajaczkowski, Esmi L., Wang, Ziqi, Madugalle, Sachithrani U., Yin, Jiayu, Bredy, Timothy W. and Wei, Wei (2019). The DNA repair-associated protein gadd45γ regulates the temporal coding of immediate early gene expression within the prelimbic prefrontal cortex and is required for the consolidation of associative fear memory. The Journal of Neuroscience, 39 (6), 970-983. doi: 10.1523/JNEUROSCI.2024-18.2018 |
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2019 Journal Article Neuroepigenetic mechanisms underlying fear extinction: emerging conceptsMarshall, Paul R. and Bredy, Timothy W. (2019). Neuroepigenetic mechanisms underlying fear extinction: emerging concepts. Psychopharmacology, 236 (1), 133-142. doi: 10.1007/s00213-018-5084-4 |
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2019 Journal Article Postnatal impoverished housing impairs adolescent risk-assessment and increases risk-taking: a sex-specific effect associated with histone epigenetic regulation of Crfr1 in the medial prefrontal cortexViola, Thiago Wendt, Wearick-Silva, Luis Eduardo, Creutzberg, Kerstin C., Kestering-Ferreira, Érika, Orso, Rodrigo, Centeno-Silva, Anderson, Albrechet-Souza, Lucas, Marshall, Paul R., Li, Xiang, Bredy, Timothy W., Riva, Marco A. and Grassi-Oliveira, Rodrigo (2019). Postnatal impoverished housing impairs adolescent risk-assessment and increases risk-taking: a sex-specific effect associated with histone epigenetic regulation of Crfr1 in the medial prefrontal cortex. Psychoneuroendocrinology, 99, 8-19. doi: 10.1016/j.psyneuen.2018.08.032 |
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2018 Journal Article Prolonged-access to cocaine induces distinct Homer2 DNA methylation, hydroxymethylation, and transcriptional profiles in the dorsomedial prefrontal cortex of Male Sprague-Dawley ratsPloense, Kyle L., Li, Xiang, Baker-Andresen, Danay, Carr, Amanda E., Woodward, Nick, Bagley, Jared, Szumlinski, Karen K., Bredy, Timothy W. and Kippin, Tod E. (2018). Prolonged-access to cocaine induces distinct Homer2 DNA methylation, hydroxymethylation, and transcriptional profiles in the dorsomedial prefrontal cortex of Male Sprague-Dawley rats. Neuropharmacology, 143, 299-305. doi: 10.1016/j.neuropharm.2018.09.029 |
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2018 Journal Article Bioorthogonal metabolic labeling of nascent RNA in neurons improves the sensitivity of transcriptome-wide profilingZajaczkowski, Esmi L., Zhao, Qiong-Yi, Zhang, Zong Hong, Li, Xiang, Wei, Wei, Marshall, Paul R., Leighton, Laura J., Nainar, Sarah, Feng, Chao, Spitale, Robert C. and Bredy, Timothy W. (2018). Bioorthogonal metabolic labeling of nascent RNA in neurons improves the sensitivity of transcriptome-wide profiling. ACS Chemical Neuroscience, 9 (7), 1858-1865. doi: 10.1021/acschemneuro.8b00197 |
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2018 Journal Article Functional interplay between small non-coding RNAs and RNA modification in the brainLeighton, Laura J. and Bredy, Timothy W. (2018). Functional interplay between small non-coding RNAs and RNA modification in the brain. Non-Coding RNA, 4 (2) 15, 15. doi: 10.3390/ncrna4020015 |
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2017 Journal Article A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical NeuronsLeighton, Laura J., Zhao, Qiongyi, Li, Xiang, Dai, Chuanyang, Marshall, Paul R., Liu, Sha, Wang, Yi, Zajaczkowski, Esmi L., Khandelwal, Nitin, Kumar, Arvind, Bredy, Timothy W. and Wei, Wei (2017). A Functional Role for the Epigenetic Regulator ING1 in Activity-induced Gene Expression in Primary Cortical Neurons. Neuroscience, 369, 248-260. doi: 10.1016/j.neuroscience.2017.11.018 |
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2017 Journal Article Experience-dependent neural plasticity, learning, and memory in the era of epitranscriptomicsLeighton, L. J., Ke, K., Zajaczkowski, E. L., Edmunds, J., Spitale, R. C. and Bredy, T. W. (2017). Experience-dependent neural plasticity, learning, and memory in the era of epitranscriptomics. Genes, Brain, and Behavior, 17 (3) e12426, e12426. doi: 10.1111/gbb.12426 |
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2017 Journal Article MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in lifeLin, Quan, Ponnusamy, Ravikumar, Widagdo, Jocelyn, Choi, Jung A., Ge, Weihong, Probst, Christine, Buckley, Tyler, Lou, Mimi, Bredy, Timothy W., Fanselow, Michael S., Ye, Keqiang and Sun, Yi E. (2017). MicroRNA-mediated disruption of dendritogenesis during a critical period of development influences cognitive capacity later in life. Proceedings from the National Academy of Sciences of the United States of America, 114 (34), 9188-9193. doi: 10.1073/pnas.1706069114 |
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2017 Journal Article Persistent histone modifications at the BDNF and Cdk-5 promoters following extinction of nicotine-seeking in ratsCastino, M. R., Baker-Andresen, D., Ratnu, V. S., Shevchenko, G., Morris, K. V., Bredy, T. W., Youngson, N. A. and Clemens, K. J. (2017). Persistent histone modifications at the BDNF and Cdk-5 promoters following extinction of nicotine-seeking in rats. Genes, Brain and Behavior, 17 (2), 98-106. doi: 10.1111/gbb.12421 |
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2017 Journal Article MotifMap-RNA: a genome-wide map of RBP binding sitesLiu, Yu, Sun, Sha, Bredy, Timothy, Wood, Marcelo, Spitale, Robert C. and Baldi, Pierre (2017). MotifMap-RNA: a genome-wide map of RBP binding sites. Bioinformatics, 33 (13), 2029-2031. doi: 10.1093/bioinformatics/btx087 |
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2017 Journal Article MicroRNA-mediated rescue of fear extinction memory by miR-144-3p in extinction-impaired miceMurphy, Conor P., Li, Xiang, Maurer, Verena, Oberhauser, Michael, Gstir, Ronald, Wearick-Silva, Luis Eduardo, Viola, Thiago Wendt, Schafferer, Simon, Grassi-Oliverira, Rodrigo, Whittle, Nigel, Huttenhofer, Alexander, Bredy, Timothy W. and Singewald, Nicolas (2017). MicroRNA-mediated rescue of fear extinction memory by miR-144-3p in extinction-impaired mice. Biological Psychiatry, 81 (12), 979-989. doi: 10.1016/j.biopsych.2016.12.021 |
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2017 Journal Article Maternal separation induces hippocampal changes in cadherin-1 (CDH-1) mRNA and recognition memory impairment in adolescent micede Azeredo, Lucas Araujo, Wearick-Silva, Luis Eduardo, Viola, Thiago Wendt, Tractenberg, Saulo Gantes, Centeno-Silva, Anderson, Orso, Rodrigo, Schroder, Nadja, Bredy, Timothy William and Grassi-Oliveira, Rodrigo (2017). Maternal separation induces hippocampal changes in cadherin-1 (CDH-1) mRNA and recognition memory impairment in adolescent mice. Neurobiology of Learning and Memory, 141, 157-167. doi: 10.1016/j.nlm.2017.04.006 |
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2017 Journal Article Transgenerational paternal transmission of acquired traits: stress-induced modification of the sperm regulatory transcriptome and offspring phenotypesPang, Terence Y. C., Short, Annabel K., Bredy, Timothy W. and Hannan, Anthony J. (2017). Transgenerational paternal transmission of acquired traits: stress-induced modification of the sperm regulatory transcriptome and offspring phenotypes. Current Opinion in Behavioral Sciences, 14, 140-147. doi: 10.1016/j.cobeha.2017.02.007 |
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2017 Journal Article Paternal environmental enrichment transgenerationally alters affective behavioral and neuroendocrine phenotypesYeshurun, Shlomo, Short, Annabel K., Bredy, Timothy W., Pang, Terence Y. and Hannan, Anthony J. (2017). Paternal environmental enrichment transgenerationally alters affective behavioral and neuroendocrine phenotypes. Psychoneuroendocrinology, 77, 225-235. doi: 10.1016/j.psyneuen.2016.11.013 |
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2017 Journal Article Running during adolescence rescues a maternal separation-induced memory impairment in female mice: Potential role of differential exon-specific BDNF expressionWearick-Silva, Luis Eduardo, Marshall, Paul, Viola, Thiago Wendt, Centeno-Silva, Anderson, de Azeredo, Lucas Araujo, Orso, Rodrigo, Li, Xiang, Donadio, Marcio V., Bredy, Timothy W. and Grassi-Oliveira, Rodrigo (2017). Running during adolescence rescues a maternal separation-induced memory impairment in female mice: Potential role of differential exon-specific BDNF expression. Developmental Psychobiology, 59 (2), 268-274. doi: 10.1002/dev.21487 |
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2017 Journal Article Cell-selective bioorthogonal metabolic labeling of RNANguyen, Kim, Fazio, Michael, Kubota, Miles, Nainar, Sarah, Feng, Chao, Li, Xiang, Atwood, Scott X., Bredy, Timothy W. and Spitale, Robert C. (2017). Cell-selective bioorthogonal metabolic labeling of RNA. Journal of the American Chemical Society, 139 (6), 2148-2151. doi: 10.1021/jacs.6b11401 |
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2017 Book Chapter What does the future hold for the study of nucleic acid modifications in the brain?Marshall, P. R. and Bredy, T. W. (2017). What does the future hold for the study of nucleic acid modifications in the brain?. DNA modifications in the brain: Neuroepigenetic Regulation of Gene Expression. (pp. 149-159) edited by Timothy W. Bredy. London, United Kingdom: Academic Press. doi: 10.1016/B978-0-12-801596-4.00009-5 |
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2017 Journal Article Genetic and epigenetic factors underlying sex differences in the regulation of gene expression in the brainRatnu, Vikram S., Emami, Michael R. and Bredy, Timothy W. (2017). Genetic and epigenetic factors underlying sex differences in the regulation of gene expression in the brain. Journal of Neuroscience Research, 95 (1-2), 301-310. doi: 10.1002/jnr.23886 |
