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2024 Journal Article Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibitionVora, Shivam, Andrew, Ariel, Kumar, Ramyashree Prasanna, Nazareth, Deborah, Bonfim-Melo, Alexis, Lim, Yoon, Ong, Xin Yee, Fernando, Madushan, He, Yaowu, Hooper, John D., McMillan, Nigel A. J., Urosevic, Jelena, Travers, Jon, Saeh, Jamal, Kumar, Sharad, Jones, Mathew J. K. and Gabrielli, Brian (2024). Aurora B inhibitors promote RB hypophosphorylation and senescence independent of p53-dependent CDK2/4 inhibition. Cell Death & Disease, 15 (11) 810, 810. doi: 10.1038/s41419-024-07204-5 |
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2024 Journal Article PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4Nguyen-Dien, Giang Thanh, Townsend, Brendan, Kulkarni, Prajakta Gosavi, Kozul, Keri-Lyn, Ooi, Soo Siang, Eldershaw, Denaye N, Weeratunga, Saroja, Liu, Meihan, Jones, Mathew JK, Millard, S Sean, Ng, Dominic CH, Pagano, Michele, Bonfim-Melo, Alexis, Schneider, Tobias, Komander, David, Lazarou, Michael, Collins, Brett M and Pagan, Julia K (2024). PPTC7 antagonizes mitophagy by promoting BNIP3 and NIX degradation via SCFFBXL4. EMBO Reports, 25 (8), 3324-3347. doi: 10.1038/s44319-024-00181-y |
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2024 Journal Article TGF-β signalling limits effector function capacity of NK cell anti-tumour immunity in human bladder cancerWong, Joshua K. M., McCulloch, Timothy R., Alim, Louisa, Omer, Natacha, Mehdi, Ahmed M., Tuong, Zewen Kelvin, Bonfim-Melo, Alexis, Chung, Eric, Nicol, Alice, Simpson, Fiona, Rhee, Handoo, Rossi, Gustavo Rodrigues and Souza-Fonseca-Guimaraes, Fernando (2024). TGF-β signalling limits effector function capacity of NK cell anti-tumour immunity in human bladder cancer. EBioMedicine, 104 105176. doi: 10.1016/j.ebiom.2024.105176 |
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2023 Journal Article An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotionNoordstra, Ivar, Hermoso, Mario Díez, Schimmel, Lilian, Bonfim-Melo, Alexis, Currin-Ross, Denni, Duong, Cao Nguyen, Kalappurakkal, Joseph Mathew, Morris, Richard G., Vestweber, Dietmar, Mayor, Satyajit, Gordon, Emma, Roca-Cusachs, Pere and Yap, Alpha S. (2023). An E-cadherin-actin clutch translates the mechanical force of cortical flow for cell-cell contact to inhibit epithelial cell locomotion. Developmental Cell, 58 (18), 1748-1763.e6. doi: 10.1016/j.devcel.2023.06.011 |
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2022 Journal Article Successful invasion of Trypanosoma cruzi trypomastigotes is dependent on host cell actin cytoskeletonBonifácio, Bruno Souza, Bonfim‐Melo, Alexis, Mortara, Renato Arruda and Ferreira, Éden Ramalho (2022). Successful invasion of Trypanosoma cruzi trypomastigotes is dependent on host cell actin cytoskeleton. Journal of Eukaryotic Microbiology, 69 (3) e12903, e12903. doi: 10.1111/jeu.12903 |
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2022 Journal Article Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell deathBonfim-Melo, Alexis, Noordstra, Ivar, Gupta, Shafali, Chan, Amy H., Jones, Mathew J.K., Schroder, Kate and Yap, Alpha S. (2022). Rapid lamellipodial responses by neighbor cells drive epithelial sealing in response to pyroptotic cell death. Cell Reports, 38 (5) 110316, 110316. doi: 10.1016/j.celrep.2022.110316 |
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2022 Journal Article Regulating life after death: how mechanical communication mediates the epithelial response to apoptosisBonfim-Melo, Alexis, Duszyc, Kinga, Gomez, Guillermo A. and Yap, Alpha S. (2022). Regulating life after death: how mechanical communication mediates the epithelial response to apoptosis. The European Physical Journal E, 45 (1) 9, 9. doi: 10.1140/epje/s10189-022-00163-9 |
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2021 Journal Article Trypanosoma cruzi extracellular amastigotes engage Rac1 and Cdc42 to invade RAW macrophagesMedina, Camila Macedo, Ferreira, Éden Ramalho, Bonifácio, Bruno Souza, Mortara, Renato Arruda and Bonfim-Melo, Alexis (2021). Trypanosoma cruzi extracellular amastigotes engage Rac1 and Cdc42 to invade RAW macrophages. Microbes and Infection, 23 (8) 104837, 104837. doi: 10.1016/j.micinf.2021.104837 |
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2021 Journal Article Parasite-mediated remodeling of the host microfilament cytoskeleton enables rapid egress of Trypanosoma cruzi following membrane ruptureFerreira, Eden R., Bonfim-Melo, Alexis, Burleigh, Barbara A., Costales, Jaime A., Tyler, Kevin M. and Mortara, Renato A. (2021). Parasite-mediated remodeling of the host microfilament cytoskeleton enables rapid egress of Trypanosoma cruzi following membrane rupture. mBio, 12 (3) e00988-21. doi: 10.1128/mbio.00988-21 |
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2020 Journal Article Genomic properties and temporal analysis of the interaction of an invasive Escherichia albertii with epithelial cellsRomão, Fabiano T., Martins, Fernando H., Hernandes, Rodrigo T., Ooka, Tadasuke, Santos, Fernanda F., Yamamoto, Denise, Bonfim-Melo, Alexis, Jones, Nina, Hayashi, Tetsuya, Elias, Waldir P., Sperandio, Vanessa and Gomes, Tânia A. T. (2020). Genomic properties and temporal analysis of the interaction of an invasive Escherichia albertii with epithelial cells. Frontiers in Cellular and Infection Microbiology, 10 571088, 1-14. doi: 10.3389/fcimb.2020.571088 |
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2019 Journal Article Trypanosoma cruzi extracellular amastigotes selectively trigger the PI3K/Akt and Erk pathways during HeLa cell invasionFerreira, Bianca Lima, Ferreira, Éden Ramalho, Bonfim-Melo, Alexis, Mortara, Renato Arruda and Bahia, Diana (2019). Trypanosoma cruzi extracellular amastigotes selectively trigger the PI3K/Akt and Erk pathways during HeLa cell invasion. Microbes and Infection, 21 (10), 485-489. doi: 10.1016/j.micinf.2019.06.003 |
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2019 Journal Article Host cell protein LAMP‐2 is the receptor for Trypanosoma cruzi surface molecule gp82 that mediates invasionRodrigues, João Paulo Ferreira, Souza Onofre, Thiago, Barbosa, Bruno Couto, Ferreira, Éden Ramalho, Bonfim‐Melo, Alexis and Yoshida, Nobuko (2019). Host cell protein LAMP‐2 is the receptor for Trypanosoma cruzi surface molecule gp82 that mediates invasion. Cellular Microbiology, 21 (5) e13003, e13003. doi: 10.1111/cmi.13003 |
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2018 Journal Article Amastigote synapse: the tricks of Trypanosoma cruzi extracellular amastigotesBonfim-Melo, Alexis, Ferreira, Eden R., Florentino, Pilar T.V. and Mortara, Renato A. (2018). Amastigote synapse: the tricks of Trypanosoma cruzi extracellular amastigotes. Frontiers in Microbiology, 9 (JUN) 1341. doi: 10.3389/fmicb.2018.01341 |
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2018 Journal Article Rac1/WAVE2 and Cdc42/N-WASP participation in actin-dependent host cell invasion by extracellular amastigotes of Trypanosoma cruziBonfim-Melo, Alexis, Ferreira, Éden R. and Mortara, Renato A. (2018). Rac1/WAVE2 and Cdc42/N-WASP participation in actin-dependent host cell invasion by extracellular amastigotes of Trypanosoma cruzi. Frontiers in Microbiology, 9 (FEB) 360, 360. doi: 10.3389/fmicb.2018.00360 |
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2017 Journal Article ERM proteins play distinct roles in cell invasion by extracellular amastigotes of Trypanosoma cruziFerreira, Éden R., Bonfim-Melo, Alexis, Cordero, Esteban M. and Mortara, Renato A. (2017). ERM proteins play distinct roles in cell invasion by extracellular amastigotes of Trypanosoma cruzi. Frontiers in Microbiology, 8 (NOV) 2230, 2230. doi: 10.3389/fmicb.2017.02230 |
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2017 Journal Article Candida albicans: the ability to invade epithelial cells and survive under oxidative stress is unlinked to hyphal lengthMaza, Paloma K., Bonfim-Melo, Alexis, Padovan, Ana C.B., Mortara, Renato A., Orikaza, Cristina M., Ramos, Lilian M. Damas, Moura, Tauany R., Soriani, Frederico M., Almeida, Ricardo S., Suzuki, Erika and Bahia, Diana (2017). Candida albicans: the ability to invade epithelial cells and survive under oxidative stress is unlinked to hyphal length. Frontiers in Microbiology, 8 (JUL) 1235, 1235. doi: 10.3389/fmicb.2017.01235 |
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2016 Journal Article Genetic relatedness and virulence properties of enteropathogenic Escherichia coli strains of serotype O119: H6 expressing localized adherence or localized and aggregative adherence-like patterns on HeLa cellsGarcia, Bruna G., Ooka, Tadasuke, Gotoh, Yasuhiro, Vieira, Mônica A.M., Yamamoto, Denise, Ogura, Yoshitoshi, Girão, Dennys M., Sampaio, Suely C.F., Melo, Alexis Bonfim, Irino, Kinue, Hayashi, Tetsuya and Gomes, Tânia A.T. (2016). Genetic relatedness and virulence properties of enteropathogenic Escherichia coli strains of serotype O119: H6 expressing localized adherence or localized and aggregative adherence-like patterns on HeLa cells. International Journal of Medical Microbiology, 306 (3), 152-164. doi: 10.1016/j.ijmm.2016.02.008 |
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2016 Journal Article Unique behavior of Trypanosoma cruzi mevalonate kinase: a conserved glycosomal enzyme involved in host cell invasion and signalingFerreira, Éden Ramalho, Horjales, Eduardo, Bonfim-Melo, Alexis, Cortez, Cristian, Da Silva, Claudio Vieira, De Groote, Michel, Sobreira, Tiago José Paschoal, Cruz, Mário Costa, Lima, Fabio Mitsuo, Cordero, Esteban Mauricio, Yoshida, Nobuko, Da Silveira, José Franco, Mortara, Renato Arruda and Bahia, Diana (2016). Unique behavior of Trypanosoma cruzi mevalonate kinase: a conserved glycosomal enzyme involved in host cell invasion and signaling. Scientific Reports, 6 (1) 24610. doi: 10.1038/srep24610 |
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2015 Journal Article Trypanosoma cruzi extracellular amastigotes trigger the protein kinase D1-cortactin-actin pathway during cell invasionBonfim-Melo, Alexis, Zanetti, Bianca Ferrarini, Ferreira, Éden Ramalho, Vandoninck, Sandy, Han, Sang Won, Van Lint, Johan, Mortara, Renato Arruda and Bahia, Diana (2015). Trypanosoma cruzi extracellular amastigotes trigger the protein kinase D1-cortactin-actin pathway during cell invasion. Cellular Microbiology, 17 (12), 1797-1810. doi: 10.1111/cmi.12472 |
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2014 Journal Article An historical perspective on how advances in microscopic imaging contributed to understanding the Leishmania Spp. and Trypanosoma cruzi host-parasite relationshipFlorentino, P. T.V., Real, F., Bonfim-Melo, A., Orikaza, C. M., Ferreira, E. R., Pessoa, C. C., Lima, B. R., Sasso, G. R.S. and Mortara, R. A. (2014). An historical perspective on how advances in microscopic imaging contributed to understanding the Leishmania Spp. and Trypanosoma cruzi host-parasite relationship. BioMed Research International, 2014 565291, 1-16. doi: 10.1155/2014/565291 |
