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2026 Journal Article Scalable Engineering of Bio-Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient-Derived ModelsGodbole, Nihar, Lai, Andrew, Quinn, Alexander, Gillard, Marianne, Guanzon, Dominic, Scholz-Romero, Katherin, Salas-Burgos, Alexis, Dapremont, Bastián Lillo, Lourie, Rohan, Chetty, Naven, Lobb, Richard, Beecher, Kate, McCart Reed, Amy E., Ferguson, Kaltin, Sun, Biao, He, Yaowu, Hooper, John D. and Salomon, Carlos (2026). Scalable Engineering of Bio-Manufactured Extracellular Vesicles for Selective Delivery in Ovarian Cancer Patient-Derived Models. Advanced Science e75415, 1-28. doi: 10.1002/advs.75415 |
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2026 Journal Article Multifactor authentication in extracellular vesicle analysis: methods and approaches to address the heterogeneity problemZhou, Quan, Lobb, Richard J., Wuethrich, Alain and Trau, Matt (2026). Multifactor authentication in extracellular vesicle analysis: methods and approaches to address the heterogeneity problem. Nature Methods. doi: 10.1038/s41592-026-03068-z |
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2026 Journal Article Early-stage multi-cancer detection through a plasma extracellular vesicle protein signatureLobb, Richard J., Zhou, Quan, Fielding, David, Visan, Kekoolani S., Wuethrich, Alain, Wang, Jing, Hu, Youran, Norris, Emma L., Hastie, Marcus L., Everitt, Sarah, Parris, Brielle, Aoude, Lauren G., Bonazzi, Vanessa F., Nixon, Elizabeth, Mooi, Jennifer, Koo, Kevin M., O'Byrne, Kenneth, Kulasinghe, Arutha, Bowman, Rayleen V., Yang, Ian A., Corcoran, Niall M., Hovens, Christopher M., MacManus, Michael, Gorman, Jeffrey J., Day, Bryan W., Hartel, Gunter, Whiteman, David C., Tebbutt, Niall, Mariadason, John M. ... Möller, Andreas (2026). Early-stage multi-cancer detection through a plasma extracellular vesicle protein signature. Cell Reports Medicine, 7 (4) 102694, 1-20. doi: 10.1016/j.xcrm.2026.102694 |
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2026 Journal Article Monitoring glioblastoma extracellular vesicle evolution using a nanodiagnostic platform to detect glioma stem cells driving recurrent diseaseZhang, Zhen, Lobb, Richard J., Tooney, Paul, Wang, Jing, Lane, Rebecca, Zhou, Quan, Niu, Xueming, Faulkner, Sam, Al-Iedani, Oun, Day, Bryan W., Puttick, Simon, Rose, Stephen, Fay, Mike and Trau, Matt (2026). Monitoring glioblastoma extracellular vesicle evolution using a nanodiagnostic platform to detect glioma stem cells driving recurrent disease. Science Advances, 12 (5) eadt2804, eadt2804. doi: 10.1126/sciadv.adt2804 |
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2025 Journal Article A digital single‐molecule nanocavity assay to monitor phosphoprotein circuits in single‐cellMiao, Xinzhe, Shanmugasundaram, Karthik, Vedelago, Courtney, Naei, Vahid Yaghoubi, Kulasinghe, Arutha, Lobb, Richard, Trau, Matt and Wuethrich, Alain (2025). A digital single‐molecule nanocavity assay to monitor phosphoprotein circuits in single‐cell. Advanced Materials Technologies, 11 (7) e02611. doi: 10.1002/admt.202502611 |
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2025 Journal Article Single extracellular vesicle profiling to define brain specific traumatic brain injury induced neuro‐inflammationZhang, Zhen, Lobb, Richard J., Lane, Rebecca E., To, Xuan Vinh, Niu, Xueming, Antaw, Fiach, Pietrogrande, Giovanni, Winter, Craig, Wuethrich, Alain, Nasrallah, Fatima and Trau, Matt (2025). Single extracellular vesicle profiling to define brain specific traumatic brain injury induced neuro‐inflammation. Small Methods, 9 (7) 2401931, 1-9. doi: 10.1002/smtd.202401931 |
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2024 Journal Article Glycan profiling in small extracellular vesicles with a SERS microfluidic biosensor identifies early malignant development in lung cancerZhou, Quan, Niu, Xueming, Zhang, Zhen, O'Byrne, Kenneth, Kulasinghe, Arutha, Fielding, David, Möller, Andreas, Wuethrich, Alain, Lobb, Richard J. and Trau, Matt (2024). Glycan profiling in small extracellular vesicles with a SERS microfluidic biosensor identifies early malignant development in lung cancer. Advanced Science, 11 (33) 2401818, 1-12. doi: 10.1002/advs.202401818 |
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2024 Journal Article Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro‐ and anti‐inflammatory proteomic profilesNiu, Xueming, Zhang, Zhen, Zhou, Quan, Wuethrich, Alain, Lobb, Richard and Trau, Matt (2024). Analysis of secreted small extracellular vesicles from activated human microglial cell lines reveals distinct pro‐ and anti‐inflammatory proteomic profiles. Proteomics, 24 (11) 2300094, 1-13. doi: 10.1002/pmic.202300094 |
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2024 Journal Article A mesoporous gold biosensor to investigate immune checkpoint protein heterogeneity in single lung cancer cellsAhmed, Emtiaz, Masud, Mostafa Kamal, Komatineni, Prathyusha, Dey, Shuvashis, Lobb, Richard, Hossain, Md Shahriar A., Möller, Andreas, Yamauchi, Yusuke, Sina, Abu Ali Ibn and Trau, Matt (2024). A mesoporous gold biosensor to investigate immune checkpoint protein heterogeneity in single lung cancer cells. Biosensors and Bioelectronics, 249 115984, 1-9. doi: 10.1016/j.bios.2023.115984 |
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2024 Journal Article Tracking the EMT-like phenotype switching during targeted therapy in melanoma by analyzing extracellular vesicle phenotypesZhou, Quan, Wang, Jing, Zhang, Zhen, Wuethrich, Alain, Lobb, Richard J. and Trau, Matt (2024). Tracking the EMT-like phenotype switching during targeted therapy in melanoma by analyzing extracellular vesicle phenotypes. Biosensors and Bioelectronics, 244 115819, 1-10. doi: 10.1016/j.bios.2023.115819 |
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2023 Journal Article A microfluidic liquid biopsy platform to monitor protein biomarker heterogeneity in single circulating therapy‐resistance cancer cellAhmed, Emtiaz, Shanmugasundaram, Karthik Balaji, Li, Junrong, Behren, Andreas, Lobb, Richard, Möller, Andreas, Wuethrich, Alain, Dey, Shuvashis, Sina, Abu Ali Ibn and Trau, Matt (2023). A microfluidic liquid biopsy platform to monitor protein biomarker heterogeneity in single circulating therapy‐resistance cancer cell. Advanced Sensor Research, 2 (12) 2300059. doi: 10.1002/adsr.202300059 |
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2023 Journal Article A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragmentsLi, Junrong, Howard, Christopher B., Dey, Shuvashis, Lowry, Kym, Whiley, David M., Puttick, Simon, Rose, Stephen, Lobb, Richard J., Wuethrich, Alain, Edwardraja, Selvakumar and Trau, Matt (2023). A universal reagent for detection of emerging diseases using bioengineered multifunctional yeast nanofragments. Nature Nanotechnology, 18 (10), 1222-1229. doi: 10.1038/s41565-023-01415-1 |
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2023 Journal Article An epithelial-to-mesenchymal transition induced extracellular vesicle prognostic signature in non-small cell lung cancerLobb, Richard J., Visan, Kekoolani S., Wu, Li-Ying, Norris, Emma L., Hastie, Marcus L., Everitt, Sarah, Yang, Ian A., Bowman, Rayleen V., Siva, Shankar, Larsen, Jill E., Gorman, Jeffrey J., MacManus, Michael, Leimgruber, Antoine, Fong, Kwun M. and Möller, Andreas (2023). An epithelial-to-mesenchymal transition induced extracellular vesicle prognostic signature in non-small cell lung cancer. Communications biology, 6 (1) 68, 68. doi: 10.1038/s42003-022-04350-4 |
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2023 Journal Article Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesionsLi, Junrong, Sina, Abu A. I., Antaw, Fiach, Fielding, David, Möller, Andreas, Lobb, Richard, Wuethrich, Alain and Trau, Matt (2023). Digital decoding of single extracellular vesicle phenotype differentiates early malignant and benign lung lesions. Advanced Science, 10 (1) 2204207, e2204207. doi: 10.1002/advs.202204207 |
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2022 Journal Article Comparative analysis of tangential flow filtration and ultracentrifugation, both combined with subsequent size exclusion chromatography, for the isolation of small extracellular vesiclesVisan, Kekoolani S., Lobb, Richard J., Ham, Sunyoung, Lima, Luize G., Palma, Carlos, Edna, Chai Pei Zhi, Wu, Li-Ying, Gowda, Harsha, Datta, Keshava K., Hartel, Gunter, Salomon, Carlos and Möller, Andreas (2022). Comparative analysis of tangential flow filtration and ultracentrifugation, both combined with subsequent size exclusion chromatography, for the isolation of small extracellular vesicles. Journal of Extracellular Vesicles, 11 (9) 12266, 12266. doi: 10.1002/jev2.12266 |
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2022 Journal Article Blood-derived extracellular vesicle-associated miR-3182 detects non-small cell lung cancer patientsVisan, Kekoolani S., Lobb, Richard J., Wen, Shu Wen, Bedo, Justin, Lima, Luize G., Krumeich, Sophie, Palma, Carlos, Ferguson, Kaltin, Green, Ben, Niland, Colleen, Cloonan, Nicole, Simpson, Peter T., McCart Reed, Amy E., Everitt, Sarah J., MacManus, Michael P., Hartel, Gunter, Salomon, Carlos, Lakhani, Sunil R., Fielding, David and Möller, Andreas (2022). Blood-derived extracellular vesicle-associated miR-3182 detects non-small cell lung cancer patients. Cancers, 14 (1) 257, 257. doi: 10.3390/cancers14010257 |
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2021 Journal Article Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detectionFarokhinejad, Fahimeh, Lane, Rebecca E., Lobb, Richard J., Edwardraja, Selvakumar, Wuethrich, Alain, Howard, Christopher B. and Trau, Matt (2021). Generation of nanoyeast single-chain variable fragments as high-avidity biomaterials for dengue virus detection. ACS Biomaterials Science and Engineering, 7 (12) acsbiomaterials.1c01001, 5850-5860. doi: 10.1021/acsbiomaterials.1c01001 |
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2021 Journal Article Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassayLi, Junrong, Wuethrich, Alain, Edwardraja, Selvakumar, Lobb, Richard J., Puttick, Simon, Rose, Stephen, Howard, Christopher B. and Trau, Matt (2021). Amplification-free SARS-CoV-2 detection using nanoyeast-scFv and ultrasensitive plasmonic nanobox-integrated nanomixing microassay. Analytical Chemistry, 93 (29) acs.analchem.1c01657, 10251-10260. doi: 10.1021/acs.analchem.1c01657 |
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2021 Journal Article Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chipWang, Jing, Wuethrich, Alain, Lobb, Richard J., Antaw, Fiach, Sina, Abu Ali Ibn, Lane, Rebecca E., Zhou, Quan, Zieschank, Chloe, Bell, Caroline, Bonazzi, Vanessa F., Aoude, Lauren G., Everitt, Sarah, Yeo, Belinda, Barbour, Andrew P., Möller, Andreas and Trau, Matt (2021). Characterizing the heterogeneity of small extracellular vesicle populations in multiple cancer types via an ultrasensitive chip. ACS Sensors, 6 (9) acssensors.1c00358, 3182-3194. doi: 10.1021/acssensors.1c00358 |
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2021 Journal Article Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistributionLima, Luize G., Ham, Sunyoung, Shin, Hyunku, Chai, Edna P. Z., Lek, Erica S. H., Lobb, Richard J., Müller, Alexandra F., Mathivanan, Suresh, Yeo, Belinda, Choi, Yeonho, Parker, Belinda S. and Möller, Andreas (2021). Tumor microenvironmental cytokines bound to cancer exosomes determine uptake by cytokine receptor-expressing cells and biodistribution. Nature Communications, 12 (1) 3543, 1-12. doi: 10.1038/s41467-021-23946-8 |
