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2023 Journal Article Holistic profiling of the venom from the Brazilian wandering spider Phoneutria nigriventer by combining high-throughput ion channel screens with venomicsCardoso, F. C., Walker, A. A., King, G. F. and Gomez, M. V. (2023). Holistic profiling of the venom from the Brazilian wandering spider Phoneutria nigriventer by combining high-throughput ion channel screens with venomics. Frontiers in Molecular Biosciences, 10 1069764, 1-11. doi: 10.3389/fmolb.2023.1069764 |
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2022 Journal Article Holistic profiling of the venom from the lethal spider Phoneutria nigriventer by combining high-throughput ion channel screens with venomicsCardoso, Fernanda C., Walker, Andrew A., King, Glenn F. and Gomez, Marcus V. (2022). Holistic profiling of the venom from the lethal spider Phoneutria nigriventer by combining high-throughput ion channel screens with venomics. doi: 10.1101/2022.11.17.516848 |
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2022 Journal Article The deadly toxin arsenal of the tree-dwelling Australian funnel-web spidersCardoso, Fernanda C., Pineda, Sandy S., Herzig, Volker, Sunagar, Kartik, Shaikh, Naeem Yusuf, Jin, Ai-Hua, King, Glenn F., Alewood, Paul F., Lewis, Richard J. and Dutertre, Sébastien (2022). The deadly toxin arsenal of the tree-dwelling Australian funnel-web spiders. International Journal of Molecular Sciences, 23 (21) 13077, 13077. doi: 10.3390/ijms232113077 |
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2022 Journal Article Venom peptides: a rich combinatorial library for drug developmentCardoso, Fernanda C., Servent, Denis and de Lima, Maria Elena (2022). Venom peptides: a rich combinatorial library for drug development. Frontiers in Molecular Biosciences, 9 924023, 924023. doi: 10.3389/fmolb.2022.924023 |
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2022 Journal Article Inhibition of N-type calcium ion channels by tricyclic antidepressants – experimental and theoretical justification for their use for neuropathic painCardoso, Fernanda C., Schmit, Matthieu, Kuiper, Michael J., Lewis, Richard J., Tuck, Kellie L. and Duggan, Peter J. (2022). Inhibition of N-type calcium ion channels by tricyclic antidepressants – experimental and theoretical justification for their use for neuropathic pain. RSC Medicinal Chemistry, 13 (2), 183-195. doi: 10.1039/d1md00331c |
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2021 Journal Article Voltage-gated sodium channel modulation by a new spider toxin Ssp1a isolated from an Australian theraphosidDongol, Yashad, Choi, Phil M., Wilson, David T., Daly, Norelle L., Cardoso, Fernanda C. and Lewis, Richard J. (2021). Voltage-gated sodium channel modulation by a new spider toxin Ssp1a isolated from an Australian theraphosid. Frontiers in Pharmacology, 12 795455, 795455. doi: 10.3389/fphar.2021.795455 |
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2021 Journal Article Engineering of a spider peptide via conserved structure-function traits optimizes sodium channel inhibition in vitro and anti-nociception in vivoHu, Huiyu, Mawlawi, Saja, Zhao, Tianjiao, Jami, Sina, Deuis, Jennifer R., Vetter, Irina, Lewis, Richard J. and Cardoso, Fernanda C. (2021). Engineering of a spider peptide via conserved structure-function traits optimizes sodium channel inhibition in vitro and anti-nociception in vivo. Frontiers in Molecular Biosciences, 8 742457, 742457. doi: 10.3389/fmolb.2021.742457 |
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2021 Journal Article Pharmacological Inhibition of the Voltage-Gated Sodium Channel Nav1.7 Alleviates Chronic Visceral Pain in a Rodent Model of Irritable Bowel SyndromeJiang, Yan, Castro, Joel, Blomster, Linda V., Agwa, Akello J., Maddern, Jessica, Schober, Gudrun, Herzig, Volker, Chow, Chun Yuen, Cardoso, Fernanda C., Demétrio De Souza França, Paula, Gonzales, Junior, Schroeder, Christina I., Esche, Steffen, Reiner, Thomas, Brierley, Stuart M. and King, Glenn F. (2021). Pharmacological Inhibition of the Voltage-Gated Sodium Channel Nav1.7 Alleviates Chronic Visceral Pain in a Rodent Model of Irritable Bowel Syndrome. ACS Pharmacology & Translational Science, 4 (4) acsptsci.1c00072, 1362-1378. doi: 10.1021/acsptsci.1c00072 |
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2021 Journal Article Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in painHasan, Md. Mahadhi, Ragnarsson, Lotten, Cardoso, Fernanda C. and Lewis, Richard J. (2021). Transfection methods for high-throughput cellular assays of voltage-gated calcium and sodium channels involved in pain. PLOS ONE, 16 (3) e0243645, e0243645. doi: 10.1371/journal.pone.0243645 |
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2021 Journal Article A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndromeCardoso, Fernanda C., Castro, Joel, Grundy, Luke, Schober, Gudrun, Garcia-Caraballo, Sonia, Zhao, Tianjiao, Herzig, Volker, King, Glenn F., Brierley, Stuart M. and Lewis, Richard J. (2021). A spider-venom peptide with multitarget activity on sodium and calcium channels alleviates chronic visceral pain in a model of irritable bowel syndrome. Pain, 162 (2), 569-581. doi: 10.1097/j.pain.0000000000002041 |
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2020 Journal Article Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otencyPeschel, Alicia, Cardoso, Fernanda C., Walker, Andrew A., Durek, Thomas, Stone, M Rhia L., Braga Emidio, Nayara, Dawson, Philip E., Muttenthaler, Markus and King, Glenn F. (2020). Two for the price of one: heterobivalent ligand design targeting two binding sites on voltage-gated sodium channels slows ligand dissociation and enhances otency. Journal of Medicinal Chemistry, 63 (21), 12773-12785. doi: 10.1021/acs.jmedchem.0c01107 |
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2020 Journal Article The neuronal calcium ion channel activity of constrained analogues of MONIRO-1Cardoso, Fernanda C., Marliac, Marie-Adeline, Geoffroy, Chloe, Schmit, Matthieu, Bispat, Anjie, Lewis, Richard J., Tuck, Kellie L. and Duggan, Peter J. (2020). The neuronal calcium ion channel activity of constrained analogues of MONIRO-1. Bioorganic and Medicinal Chemistry, 28 (18) 115655, 115655. doi: 10.1016/j.bmc.2020.115655 |
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2020 Journal Article Characterisation of δ-Conotoxin TxVIA as a mammalian T-type calcium channel modulatorWang, Dan, Himaya, S.W.A., Giacomotto, Jean, Hasan, Md. Mahadhi, Cardoso, Fernanda C., Ragnarsson, Lotten and Lewis, Richard J. (2020). Characterisation of δ-Conotoxin TxVIA as a mammalian T-type calcium channel modulator. Marine Drugs, 18 (7) 343, 1-13. doi: 10.3390/md18070343 |
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2020 Journal Article Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseasesCardoso, Fernanda C (2020). Multi-targeting sodium and calcium channels using venom peptides for the treatment of complex ion channels-related diseases. Biochemical Pharmacology, 181 114107, 114107. doi: 10.1016/j.bcp.2020.114107 |
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2019 Journal Article Spider knottin pharmacology at voltage-gated sodium channels and their potential to modulate pain pathwaysDongol, Yashad, Cardoso, Fernanda C. and Lewis, Richard J. (2019). Spider knottin pharmacology at voltage-gated sodium channels and their potential to modulate pain pathways. Toxins, 11 (11) 10.3390/toxins11110626, 626. doi: 10.3390/toxins11110626 |
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2019 Journal Article Venomic, transcriptomic, and bioactivity analyses of Pamphobeteus verdolaga venom reveal complex disulfide-rich peptides that modulate calcium channelsEstrada-Gomez, Sebastian, Cardoso,Fernanda Caldas, Vargas-Muñoz, Leidy Johana, Quintana-Castillo, Juan Carlos, Gómez, Claudia Marcela Arenas, Pineda, Sandy Steffany and Saldarriaga-Cordoba, Monica Maria (2019). Venomic, transcriptomic, and bioactivity analyses of Pamphobeteus verdolaga venom reveal complex disulfide-rich peptides that modulate calcium channels. Toxins, 11 (9) 496, 496. doi: 10.3390/toxins11090496 |
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2019 Journal Article Multifunctional toxins in snake venoms and therapeutic implications: From pain to hemorrhage and necrosisFerraz, Camila R., Arrahman, Arif, Xie, Chunfang, Casewell, Nicholas R., Lewis, Richard J., Kool, Jeroen and Cardoso, Fernanda C. (2019). Multifunctional toxins in snake venoms and therapeutic implications: From pain to hemorrhage and necrosis. Frontiers in Ecology and Evolution, 7 (JUN) 218. doi: 10.3389/fevo.2019.00218 |
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2019 Journal Article Structure–function and therapeutic potential of spider venom-derived cysteine knot peptides targeting sodium channelsCardoso, Fernanda C. and Lewis, Richard J. (2019). Structure–function and therapeutic potential of spider venom-derived cysteine knot peptides targeting sodium channels. Frontiers in Pharmacology, 10 (APR) 366, 366. doi: 10.3389/fphar.2019.00366 |
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2019 Journal Article ‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET PotencyZiegman, Rebekah , Brust, Andreas , Jha, Prerna , Cardoso, Fernanda C. , Lewis, Richard J. and Alewood, Paul F. (2019). ‘Messy’ Processing of χ-conotoxin MrIA Generates Homologues with Reduced hNET Potency. Marine Drugs, 17 (3) 165, 165. doi: 10.3390/md17030165 |
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2018 Journal Article Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profilingSlagboom, Julien, Otvos, Reka A., Cardoso, Fernanda C., Iyer, Janaki, Visser, Jeroen C., van Doodewaerd, Bjorn R., McCleary, Ryan J.R., Niessen, Wilfried M.A., Somsen, Govert W., Lewis, Richard J., Kini, R. Manjunatha, Smit, August B., Casewell, Nicholas R. and Kool, Jeroen (2018). Neurotoxicity fingerprinting of venoms using on-line microfluidic AChBP profiling. Toxicon, 148, 213-222. doi: 10.1016/j.toxicon.2018.04.022 |
