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2025 Journal Article Inhibition of the NLRP3 inflammasome using MCC950 reduces vincristine‐induced adverse effects in an acute lymphoblastic leukemia patient‐derived xenograft modelStarobova, Hana, McCalmont, Hannah, Shatunova, Svetlana, Tay, Nicolette, Smith, Christopher M., Robertson, Avril, Winkler, Ingrid, Lock, Richard B. and Vetter, Irina (2025). Inhibition of the NLRP3 inflammasome using MCC950 reduces vincristine‐induced adverse effects in an acute lymphoblastic leukemia patient‐derived xenograft model. HemaSphere, 9 (3) e70092, 3. doi: 10.1002/hem3.70092 |
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2025 Journal Article A comprehensive protocol for simplified mouse DRG fixation, processing and F4/80 immunohistochemistry: Overcoming common challengesTay, Nicolette, Alshammari, Ammar, Kaur, Simranpreet, Pettit, Allison, Mu, Erica, Reid, Anna, Winkler, Ingrid, Vetter, Irina and Starobova, Hana (2025). A comprehensive protocol for simplified mouse DRG fixation, processing and F4/80 immunohistochemistry: Overcoming common challenges. Journal of Neuroscience Methods, 418 110434, 110434. doi: 10.1016/j.jneumeth.2025.110434 |
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2024 Conference Publication Antibody drug conjugate (ADC) payload-induced IL1 suggests potential for anti-IL1RAP therapy combination for enhanced treatment efficacy and prevention of neuropathyGyllenback, Elin Jaensson, Shatunova, Svetlana, Rydberg-Millrud, Camilla, Grönberg, Caitríona, Vetter, Irina, Starobova, Hana and Liberg, David (2024). Antibody drug conjugate (ADC) payload-induced IL1 suggests potential for anti-IL1RAP therapy combination for enhanced treatment efficacy and prevention of neuropathy. SITC 39th Annual Meeting (SITC 2024), Houston, TX United States, 6-10 November 2024. London, United Kingdom: BMJ Group. doi: 10.1136/jitc-2024-sitc2024.1303 |
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2024 Journal Article The role of the neuronal microenvironment in sensory function and pain pathophysiologyStarobova, Hana, Alshammari, Ammar, Winkler, Ingrid G. and Vetter, Irina (2024). The role of the neuronal microenvironment in sensory function and pain pathophysiology. Journal of Neurochemistry, 168 (11), 3620-3643. doi: 10.1111/jnc.15724 |
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2024 Journal Article The role of the gut microbiome in neuroinflammation and chemotherapy-induced peripheral neuropathyShatunova, Svetlana, Aktar, Rubina, Peiris, Madusha, Lee, Jia Yu Peppermint, Vetter, Irina and Starobova, Hana (2024). The role of the gut microbiome in neuroinflammation and chemotherapy-induced peripheral neuropathy. European Journal of Pharmacology, 979 176818, 1-16. doi: 10.1016/j.ejphar.2024.176818 |
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2024 Conference Publication Impact on chemotherapy induced peripheral neuropathy of nadunolimab, a first-in-class monoclonal antibody against IL1RAP, in patients with pancreatic cancer, with supportive mouse model dataVan Cutsem, Eric, Ochsenreither, Sebastian, Collignon, Joelle, Eefsen, Rikke Lovendahl, Ivanauskas, Audrius, Shatunova, Svetlana, Vetter, Irina, Gyllenback, Elin Jaensson, Skoog, Petter, Losic, Nedjad, Tersago, Dominique and Starobova, Hana (2024). Impact on chemotherapy induced peripheral neuropathy of nadunolimab, a first-in-class monoclonal antibody against IL1RAP, in patients with pancreatic cancer, with supportive mouse model data. 2024 ASCO Annual Meeting Gastrointestinal Cancer—Gastroesophageal, Pancreatic, and Hepatobiliary, Chicago, IL, United States, 31 May - 4 June 2024. Alexandria, VA, United States: American Society of Clinical Oncology. |
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2024 Conference Publication Impact on chemotherapy induced peripheral neuropathy of nadunolimab, a first-in-class monoclonal antibody against IL1RAP, in patients with pancreatic cancer, with supportive mouse model dataVan Cutsem, Eric, Ochsenreither, Sebastian, Collignon, Joelle, Eefsen, Rikke Løvendahl, Ivanauskas, Audrius, Shatunova, Svetlana, Vetter, Irina, Gyllenbäck, Elin Jaensson, Skoog, Petter, Losic, Nedjad, Tersago, Dominique and Starobova, Hana (2024). Impact on chemotherapy induced peripheral neuropathy of nadunolimab, a first-in-class monoclonal antibody against IL1RAP, in patients with pancreatic cancer, with supportive mouse model data. 2024 ASCO Annual Meeting, Chicago, IL United States, 31 May - 4 June 2024. Alexandria, VA United States: American Society of Clinical Oncology. doi: 10.1200/jco.2024.42.16_suppl.4148 |
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2022 Journal Article Chemotherapy-induced peripheral neuropathy in children and adolescent cancer patientsTay, Nicolette, Laakso, E-Liisa, Schweitzer, Daniel, Endersby, Raelene, Vetter, Irina and Starobova, Hana (2022). Chemotherapy-induced peripheral neuropathy in children and adolescent cancer patients. Frontiers in Molecular Biosciences, 9 1015746, 1015746. doi: 10.3389/fmolb.2022.1015746 |
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2022 Journal Article A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signallingStables, Jennifer, Green, Emma K., Sehgal, Anuj, Patkar, Omkar L., Keshvari, Sahar, Taylor, Isis, Ashcroft, Maisie E., Grabert, Kathleen, Wollscheid-Lengeling, Evi, Szymkowiak, Stefan, McColl, Barry W., Adamson, Antony, Humphreys, Neil E., Mueller, Werner, Starobova, Hana, Vetter, Irina, Shabestari, Sepideh Kiani, Blurton-Jones, Matthew M., Summers, Kim M., Irvine, Katharine M., Pridans, Clare and Hume, David A. (2022). A kinase-dead Csf1r mutation associated with adult-onset leukoencephalopathy has a dominant inhibitory impact on CSF1R signalling. Development, 149 (8) dev200237. doi: 10.1242/dev.200237 |
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2022 Journal Article A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammalsEagles, David A., Saez, Natalie J., Krishnarjuna, Bankala, Bradford, Julia J., Chin, Yanni K.-Y., Starobova, Hana, Mueller, Alexander, Reichelt, Melissa E., Undheim, Eivind A. B., Norton, Raymond S., Thomas, Walter G., Vetter, Irina, King, Glenn F. and Robinson, Samuel D. (2022). A peptide toxin in ant venom mimics vertebrate EGF-like hormones to cause long-lasting hypersensitivity in mammals. Proceedings of the National Academy of Sciences, 119 (7) e2112630119. doi: 10.1073/pnas.2112630119 |
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2022 Journal Article Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spiderFinol-Urdaneta, Rocio K., Ziegman, Rebekah, Dekan, Zoltan, McArthur, Jeffrey R., Heitmann, Stewart, Luna-Ramirez, Karen, Tae, Han-Shen, Mueller, Alexander, Starobova, Hana, Chin, Yanni K.-Y., Wingerd, Joshua S., Undheim, Eivind A. B., Cristofori-Armstrong, Ben, Hill, Adam P., Herzig, Volker, King, Glenn F., Vetter, Irina, Rash, Lachlan D., Adams, David J. and Alewood, Paul F. (2022). Multitarget nociceptor sensitization by a promiscuous peptide from the venom of the King Baboon spider. Proceedings of the National Academy of Sciences, 119 (5) e2110932119. doi: 10.1073/pnas.2110932119 |
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2021 Journal Article Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β releaseStarobova, Hana, Monteleone, Mercedes, Adolphe, Christelle, Batoon, Lena, Sandrock, Cheyenne J., Tay, Bryan, Deuis, Jennifer R., Smith, Alexandra V., Mueller, Alexander, Nadar, Evelyn Israel, Lawrence, Grace Pamo, Mayor, Amanda, Tolson, Elissa, Levesque, Jean-Pierre, Pettit, Allison R., Wainwright, Brandon J., Schroder, Kate and Vetter, Irina (2021). Vincristine-induced peripheral neuropathy is driven by canonical NLRP3 activation and IL-1β release. Journal of Experimental Medicine, 218 (5) e20201452. doi: 10.1084/jem.20201452 |
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2021 Conference Publication Subcutaneous analgesic actions and mode of action of binding of ω-conotoxins at Cav2.2Hasan, Mahadhi, Abraham, Nikita, Cardoso, Fernanda C., Ragnarsson, Lotten, Starobova, Hana, Mueller, Alexander, Vetter, Irina and Lewis, Richard J. (2021). Subcutaneous analgesic actions and mode of action of binding of ω-conotoxins at Cav2.2. Venom to Drugs, Daydream Island, QLD Australia, 15 - 19 March 2021. |
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2021 Journal Article Subcutaneous ω-conotoxins alleviate mechanical pain in rodent models of acute peripheral neuropathyHasan, Md. Mahadhi, Starobova, Hana, Mueller, Alexander, Vetter, Irina and Lewis, Richard J. (2021). Subcutaneous ω-conotoxins alleviate mechanical pain in rodent models of acute peripheral neuropathy. Marine Drugs, 19 (2) 106, 1-15. doi: 10.3390/md19020106 |
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2021 Journal Article Small cyclic sodium channel inhibitorsPeigneur, Steve, da Costa Oliveira, Cristina, de Sousa Fonseca, Flávia Cristina, McMahon, Kirsten L., Mueller, Alexander, Cheneval, Olivier, Cristina Nogueira Freitas, Ana, Starobova, Hana, Dimitri Gama Duarte, Igor, Craik, David J., Vetter, Irina, de Lima, Maria Elena, Schroeder, Christina I. and Tytgat, Jan (2021). Small cyclic sodium channel inhibitors. Biochemical Pharmacology, 183 114291, 114291. doi: 10.1016/j.bcp.2020.114291 |
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2020 Journal Article The NLRP3 inflammasome: role and therapeutic potential in pain treatmentStarobova, Hana, Nadar, Evelyn Israel and Vetter, Irina (2020). The NLRP3 inflammasome: role and therapeutic potential in pain treatment. Frontiers in Physiology, 11 1016, 1016. doi: 10.3389/fphys.2020.01016 |
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2020 Other Outputs Novel therapeutic targets for the treatment of vincristine induced peripheral neuropathyStarobova, Hana (2020). Novel therapeutic targets for the treatment of vincristine induced peripheral neuropathy. PhD Thesis, Institute for Molecular Bioscience, The University of Queensland. doi: 10.14264/uql.2020.972 |
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2020 Journal Article Mapping the molecular surface of the analgesic NaV1.7-selective peptide Pn3a reveals residues essential for membrane and channel interactionsMueller, Alexander, Dekan, Zoltan, Kaas, Quentin, Agwa, Akello J., Starobova, Hana, Alewood, Paul F., Schroeder, Christina I., Mobli, Mehdi, Deuis, Jennifer R. and Vetter, Irina (2020). Mapping the molecular surface of the analgesic NaV1.7-selective peptide Pn3a reveals residues essential for membrane and channel interactions. ACS Pharmacology and Translational Science. doi: 10.1021/acsptsci.0c00002 |
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2019 Journal Article Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofenMueller, Alexander, Starobova, Hana, Morgan, Michael, Dekan, Zoltan, Cheneval, Olivier, Schroeder, Christina I., Alewood, Paul F., Deuis, Jennifer R. and Vetter, Irina (2019). Antiallodynic effects of the selective NaV1.7 inhibitor Pn3a in a mouse model of acute postsurgical pain: evidence for analgesic synergy with opioids and baclofen. Pain, 160 (8), 1766-1780. doi: 10.1097/j.pain.0000000000001567 |
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2019 Journal Article Minocycline prevents the development of mechanical allodynia in mouse models of vincristine-induced peripheral neuropathyStarobova, H., Mueller, A., Allavena, R., Lohman, R. J., Sweet, M. J. and Vetter, I. (2019). Minocycline prevents the development of mechanical allodynia in mouse models of vincristine-induced peripheral neuropathy. Frontiers in Neuroscience, 13 (JUN) 653, 653. doi: 10.3389/fnins.2019.00653 |
