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2024 Journal Article Proteostasis as a fundamental principle of Tau immunotherapyCruz, Esteban, Nisbet, Rebecca M, Padmanabhan, Pranesh, van Waardenberg, Ashley J, Graham, Mark E, Nkajja, Godfrey, Tapaswi, Swara, Connor, Bradley J, Robinson, Phil and Götz, Jürgen (2024). Proteostasis as a fundamental principle of Tau immunotherapy. Brain, 148 (1), 168-184. doi: 10.1093/brain/awae254 |
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2024 Journal Article Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cellsPadmanabhan, Pranesh, Kneynsberg, Andrew, Cruz, Esteban, Briner, Adam and Götz, Jürgen (2024). Single-molecule imaging of Tau reveals how phosphorylation affects its movement and confinement in living cells. Molecular Brain, 17 (1) 7, 7. doi: 10.1186/s13041-024-01078-6 |
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2023 Journal Article Break and accelerator—The mechanics of Tau (and amyloid) toxicityCruz, Esteban, Nisbet, Rebecca M. and Götz, Jürgen (2023). Break and accelerator—The mechanics of Tau (and amyloid) toxicity. Cytoskeleton, 81 (1), 24-29. doi: 10.1002/cm.21781 |
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2022 Journal Article Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasoundChen, Liyu, Cruz, Esteban, Oikari, Lotta E., Padmanabhan, Pranesh, Song, Jae and Götz, Jürgen (2022). Opportunities and challenges in delivering biologics for Alzheimer's disease by low-intensity ultrasound. Advanced Drug Delivery Reviews, 189 114517, 1-18. doi: 10.1016/j.addr.2022.114517 |
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2022 Journal Article Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacyBajracharya, Rinie, Cruz, Esteban, Götz, Jürgen and Nisbet, Rebecca M. (2022). Ultrasound-mediated delivery of novel tau-specific monoclonal antibody enhances brain uptake but not therapeutic efficacy. Journal of Controlled Release, 349, 634-648. doi: 10.1016/j.jconrel.2022.07.026 |
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2022 Journal Article Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletionPadmanabhan, Pranesh, Kneynsberg, Andrew, Cruz, Esteban, Amor, Rumelo, Sibarita, Jean‐Baptiste and Götz, Jürgen (2022). Single‐molecule imaging reveals Tau trapping at nanometer‐sized dynamic hot spots near the plasma membrane that persists after microtubule perturbation and cholesterol depletion. The EMBO Journal, 41 (19) e111265, 1-16. doi: 10.15252/embj.2022111265 |
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2022 Journal Article Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier modelChen, Liyu, Sutharsan, Ratneswary, Lee, Jonathan LF, Cruz, Esteban, Asnicar, Blaise, Palliyaguru, Tishila, Wasielewska, Joanna M, Gaudin, Arnaud, Song, Jae, Leinenga, Gerhard and Götz, Jürgen (2022). Claudin-5 binder enhances focused ultrasound-mediated opening in an in vitro blood-brain barrier model. Theranostics, 12 (5), 1952-1970. doi: 10.7150/thno.65539 |
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2021 Journal Article Glycan profile analysis of engineered trastuzumab with rationally added glycosylation sequons presents significantly increased glycan complexityCruz, Esteban, Sifniotis, Vicki, Sumer-Bayraktar, Zeynep, Reslan, Mouhamad, Wilkinson-White, Lorna, Cordwell, Stuart and Kayser, Veysel (2021). Glycan profile analysis of engineered trastuzumab with rationally added glycosylation sequons presents significantly increased glycan complexity. Pharmaceutics, 13 (11) 1747, 1747. doi: 10.3390/pharmaceutics13111747 |
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2021 Journal Article Therapeutic ultrasound as a treatment modality for physiological and pathological ageing including Alzheimer’s diseaseGötz, Jürgen, Richter-Stretton, Gina and Cruz, Esteban (2021). Therapeutic ultrasound as a treatment modality for physiological and pathological ageing including Alzheimer’s disease. Pharmaceutics, 13 (7) 1002, 1002. doi: 10.3390/pharmaceutics13071002 |
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2021 Book Chapter Drug targets for biologicsLai, Felcia, Hawkins, Bryson A., Cruz, Esteban, Hanrahan, Jane R., Groundwater, Paul W. and Hibbs, David E. (2021). Drug targets for biologics. Biologics, biosimilars, and biobetters: an introduction for pharmacists, physicians, and other health practitioners. (pp. 195-212) edited by Iqbal Ramzan. Hoboken, NJ United States: Wiley. doi: 10.1002/9781119564690.ch5 |
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2020 Journal Article Enhancing the stability of adalimumab by engineering additional glycosylation motifsReslan, Mouhamad, Sifniotis, Vicki, Cruz, Esteban, Sumer-Bayraktar, Zeynep, Cordwell, Stuart and Kayser, Veysel (2020). Enhancing the stability of adalimumab by engineering additional glycosylation motifs. International Journal of Biological Macromolecules, 158, 189-196. doi: 10.1016/j.ijbiomac.2020.04.147 |
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2019 Journal Article Structural biology workflow for the expression and characterization of functional human sodium glucose transporter type 1 in Pichia pastorisSuades, Albert, Alcaraz, Antonio, Cruz, Esteban, Álvarez-Marimon, Elena, Whitelegge, Julian P., Manyosa, Joan, Cladera, Josep and Perálvarez-Marín, Alex (2019). Structural biology workflow for the expression and characterization of functional human sodium glucose transporter type 1 in Pichia pastoris. Scientific Reports, 9 (1) 1203. doi: 10.1038/s41598-018-37445-2 |
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2019 Journal Article Current advancements in addressing key challenges of therapeutic antibody design, manufacture, and formulationSifniotis, Vicki, Cruz, Esteban, Eroglu, Barbaros and Kayser, Veysel (2019). Current advancements in addressing key challenges of therapeutic antibody design, manufacture, and formulation. Antibodies, 8 (2) 36, 36. doi: 10.3390/antib8020036 |
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2019 Journal Article Synthesis and enhanced cellular uptake in vitro of anti-HER2 multifunctional gold nanoparticlesCruz, Esteban and Kayser, Veysel (2019). Synthesis and enhanced cellular uptake in vitro of anti-HER2 multifunctional gold nanoparticles. Cancers, 11 (6) 870, 870. doi: 10.3390/cancers11060870 |
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2019 Journal Article Monoclonal antibody therapy of solid tumors: clinical limitations and novel strategies to enhance treatment efficacyCruz, Esteban and Kayser, Veysel (2019). Monoclonal antibody therapy of solid tumors: clinical limitations and novel strategies to enhance treatment efficacy. Biologics: Targets and Therapy, 13, 33-51. doi: 10.2147/BTT.S166310 |
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2018 Journal Article Demonstration of in vitro host-guest complex formation and safety of para-sulfonatocalix[8]arene as a delivery vehicle for two antibiotic drugsMoussa, Yvonne E., Ong, Yu Qing Elysia, Perry, John D., Cheng, Zhengqi, Kayser, Veysel, Cruz, Esteban, Kim, Ryung Rae, Sciortino, Natasha and Wheate, Nial J. (2018). Demonstration of in vitro host-guest complex formation and safety of para-sulfonatocalix[8]arene as a delivery vehicle for two antibiotic drugs. Journal of Pharmaceutical Sciences, 107 (12), 3105-3111. doi: 10.1016/j.xphs.2018.08.016 |
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2018 Journal Article Site-specific glycosylation profile of influenza A (H1N1) hemagglutinin through tandem mass spectrometryCruz, Esteban, Cain, Joel, Crossett, Ben and Kayser, Veysel (2018). Site-specific glycosylation profile of influenza A (H1N1) hemagglutinin through tandem mass spectrometry. Human Vaccines and Immunotherapeutics, 14 (3), 508-517. doi: 10.1080/21645515.2017.1377871 |
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2017 Journal Article The state-of-play and future of antibody therapeuticsElgundi, Zehra, Reslan, Mouhamad, Cruz, Esteban, Sifniotis, Vicki and Kayser, Veysel (2017). The state-of-play and future of antibody therapeutics. Advanced Drug Delivery Reviews, 122, 2-19. doi: 10.1016/j.addr.2016.11.004 |
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2017 Journal Article Laboratory scale production and purification of a therapeutic antibodyElgundi, Zehra, Sifniotis, Vicki, Reslan, Mouhamad, Cruz, Esteban and Kayser, Veysel (2017). Laboratory scale production and purification of a therapeutic antibody. Journal of Visualized Experiments, 2017 (119) e55153. doi: 10.3791/55153 |
