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2017 Journal Article Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD miceReeves, Peta L. S., Rudraraju, Rajeev, Wong, F. Susan, Hamilton-Williams, Emma E. and Steptoe, Raymond J. (2017). Antigen presenting cell-targeted proinsulin expression converts insulin-specific CD8+ T-cell priming to tolerance in autoimmune-prone NOD mice. European Journal of Immunology, 47 (9), 1550-1561. doi: 10.1002/eji.201747089 |
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2017 Journal Article APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD miceReeves, Peta L. S., Rudraraju, Rajeev, Liu, Xiao, Wong, F. Susan, Hamilton-Williams, Emma E. and Steptoe, Raymond J. (2017). APC-targeted proinsulin expression inactivates insulin-specific memory CD8+ T cells in NOD mice. Immunology and Cell Biology, 95 (9), 765-774. doi: 10.1038/icb.2017.48 |
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2016 Journal Article Maintenance of peripheral tolerance to islet antigensHamilton-Williams, Emma E., Bergot, Anne-Sophie, Reeves, Peta L. S and Steptoe, Raymond J. (2016). Maintenance of peripheral tolerance to islet antigens. Journal of Autoimmunity, 72, 118-125. doi: 10.1016/j.jaut.2016.05.009 |
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2016 Journal Article Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic miceJames, Cini R., Buckle, Irina, Muscate, Franziska, Otsuka, Masayuki, Nakao, Mari, Oon, Jack S. H., Steptoe, Raymond J., Thomas, Ranjeny and Hamilton-Williams, Emma E. (2016). Reduced interleukin-2 responsiveness impairs the ability of Treg cells to compete for IL-2 in nonobese diabetic mice. Immunology and Cell Biology, 94 (5), 509-519. doi: 10.1038/icb.2016.7 |
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2015 Journal Article Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetesPang, Dimeng, Irvine, Katharine M., Mehdi, Ahmed M., Thomas, Helen E., Harris, Mark, Hamilton-Williams, Emma E. and Thomas, Ranjeny (2015). Expression profiling pre-diabetic mice to uncover drugs with clinical application to type 1 diabetes. Clinical and Translational Immunology, 4 (8) e41, e41.1-e41.9. doi: 10.1038/cti.2015.17 |
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2013 Journal Article Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexityHamilton-Williams, Emma E., Rainbow, Daniel B., Cheung, Jocelyn, Christensen, Mikkel, Lyons, Paul A., Peterson, Laurence B., Steward, Charles A., Sherman, Linda A. and Wicker, Linda S. (2013). Fine mapping of type 1 diabetes regions Idd9.1 and Idd9.2 reveals genetic complexity. Mammalian Genome, 24 (9-10), 358-375. doi: 10.1007/s00335-013-9466-y |
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2013 Journal Article Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetesLin, Xiaotian, Hamilton-Williams, Emma E., Rainbow, Daniel B., Hunter, Kara M., Dai, Yang D., Cheung, Jocelyn, Peterson, Laurence B., Wicker, Linda S. and Sherman, Linda A. (2013). Genetic interactions among Idd3, Idd5.1, Idd5.2, and Idd5.3 protective loci in the nonobese diabetic mouse model of type 1 diabetes. Journal of Immunology, 190 (7), 3109-3120. doi: 10.4049/jimmunol.1203422 |
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2012 Journal Article PTPN22 alters the development of regulatory T cells in the thymusMaine, Christian J., Hamilton-Williams, Emma E., Cheung, Jocelyn, Stanford, Stephanie M., Bottini, Nunzio, Wicker, Linda S. and Sherman, Linda A. (2012). PTPN22 alters the development of regulatory T cells in the thymus. Journal of Immunology, 188 (11), 5267-5275. doi: 10.4049/jimmunol.1200150 |
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2012 Journal Article Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5Hamilton-Williams, Emma E., Cheung, Jocelyn, Rainbow, Daniel B., Hunter, Kara M., Wicker, Linda S. and Sherman, Linda A. (2012). Cellular mechanisms of restored β-cell tolerance mediated by protective alleles of Idd3 and Idd5. Diabetes, 61 (1), 166-174. doi: 10.2337/db11-0790 |
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2011 Journal Article Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic miceSheng, Huiming, Hassanali, Saleena, Nugent, Courtney, Wen, Li, Hamilton-Williams, Emma, Dias, Peter and Dai, Yang D. (2011). Insulinoma-released exosomes or microparticles are immunostimulatory and can activate autoreactive T cells spontaneously developed in nonobese diabetic mice. Journal of Immunology, 187 (4), 1591-1600. doi: 10.4049/jimmunol.1100231 |
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2010 Journal Article Idd9.2 and Idd9.3 Protective Alleles Function in CD4(+) T-Cells and Nonlymphoid Cells to Prevent Expansion of Pathogenic Islet-Specific CD8(+) T-CellsHamilton-Williams, Emma E., Wong, S.B. Justin, Martinez, Xavier, Rainbow, Daniel B., Hunter, Kara M., Wicker, Linda S. and Sherman, Linda A. (2010). Idd9.2 and Idd9.3 Protective Alleles Function in CD4(+) T-Cells and Nonlymphoid Cells to Prevent Expansion of Pathogenic Islet-Specific CD8(+) T-Cells. Diabetes, 59 (6), 1478-1486. doi: 10.2337/db09-1801 |
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2009 Journal Article Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic miceHamilton-Williams, Emma E., Martinez, Xavier, Clark, Jan, Howlett, Sarah, Hunter, Kara M., Rainbow, Daniel B., Wen, Li, Shlomchik, Mark J., Katz, Jonathan D., Beilhack, Georg F., Wicker, Linda S. and Sherman, Linda A. (2009). Expression of diabetes-associated genes by dendritic cells and CD4 T cells drives the loss of tolerance in nonobese diabetic mice. Journal of Immunology, 183 (3), 1533-1541. doi: 10.4049/jimmunol.0900428 |
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2009 Journal Article Correction to: Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injuryHeymann, Felix, Meyer-Schwesinger, Catherine, Hamilton-Williams, Emma E., Hammerich, Linda, Panzer, Ulf, Kaden, Sylvia, Quaggin, Susan E., Floege, Jurgen, Grone, Hermann-Josef and Kurts, Christian (2009). Correction to: Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. Journal of Clinical Investigation, 119 (7), 2114-2114. doi: 10.1172/JCI38399C1 |
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2009 Journal Article Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injuryHeymann, Felix, Meyer-Schwesinger, Catherine, Hamilton-Williams, Emma E., Hammerich, Linda, Panzer, Ulf, Kaden, Sylvia, Quaggin, Susan E., Floege, Jurgen, Grone, Hermann-Josef and Kurts, Christian (2009). Kidney dendritic cell activation is required for progression of renal disease in a mouse model of glomerular injury. Journal of Clinical Investigation, 119 (5), 1286-1297. doi: 10.1172/JCI38399 |
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2009 Journal Article CD25(+) T-reg specifically suppress auto-Ab generation against pancreatic tissue autoantigensLudwig-Portugall, Isis, Hamilton-Williams, Emma E., Gotot, Janine and Kurts, Christian (2009). CD25(+) T-reg specifically suppress auto-Ab generation against pancreatic tissue autoantigens. European Journal of Immunology, 39 (1), 225-233. doi: 10.1002/eji.200838699 |
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2008 Journal Article Cutting edge: CD25(+) regulatory T cells prevent expansion and induce apoptosis of B cells specific for tissue autoantigensLudwig-Portugall, Isis, Hamilton-Williams, Emma E., Gottschalk, Catherine and Kurts, Christian (2008). Cutting edge: CD25(+) regulatory T cells prevent expansion and induce apoptosis of B cells specific for tissue autoantigens. Journal of Immunology, 181 (7), 4447-4451. doi: 10.4049/jimmunol.181.7.4447 |
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2006 Journal Article Inclusion of Brefeldin A during dendritic cell isolation allows in vitro detection of cross-presented self-antigensBenke, Dirk, Kruger, Thilo, Lang, Andreas, Hamilton-Williams, Emma E. and Kurts, Christian (2006). Inclusion of Brefeldin A during dendritic cell isolation allows in vitro detection of cross-presented self-antigens. Journal of Immunological Methods, 310 (1-2), 12-19. doi: 10.1016/j.jim.2005.10.019 |
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2005 Journal Article Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: In vivo evidence for an immunologic danger signalLang, Andreas, Benke, Dirk, Eitner, Frank, Engel, Daniel, Ehrlich, Svenja, Breloer, Minka, Hamilton-Williams, Emma, Specht, Sabine, Hoerauf, Achim, Floege, Jürgen, von Bonin, Arne and Kurts, Christian (2005). Heat shock protein 60 is released in immune-mediated glomerulonephritis and aggravates disease: In vivo evidence for an immunologic danger signal. Journal of the American Society of Nephrology, 16 (2), 383-391. doi: 10.1681/ASN.2004040276 |
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2005 Journal Article Cutting edge: TLR ligands are not sufficient to break cross-tolerance to self-antigensHamilton-Williams, Emma E., Lang, Andreas, Benke, Dirk, Davey, Gayle M., Wiesmuller, Karl-Heinz and Kurts, Christian (2005). Cutting edge: TLR ligands are not sufficient to break cross-tolerance to self-antigens. Journal of Immunology, 174 (3), 1159-1163. doi: 10.4049/jimmunol.174.3.1159 |
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2004 Journal Article Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritisKruger, T, Benke, D, Eitner, F, Lang, A, Wirtz, M, Hamilton-Williams, EE, Engel, D, Giese, B, Muller-Newen, G, Floege, J and Kurts, C (2004). Identification and functional characterization of dendritic cells in the healthy murine kidney and in experimental glomerulonephritis. Journal of the American Society of Nephrology, 15 (3), 613-621. doi: 10.1097/01.ASN.0000114553.36258.91 |
