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2026 Journal Article Can model-informed precision dosing of beta-lactams in critical care improve clinical outcomes?Oakley, Robert, Ulldemolins, Marta, Hernández Mitre, Maria Patricia, Colmenero, Manuel, Roberts, Natasha, Roberts, Jason, Lipman, Jeffrey and Heffernan, Aaron (2026). Can model-informed precision dosing of beta-lactams in critical care improve clinical outcomes?. Chemotherapy, 1-14. doi: 10.1159/000550822 |
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2024 Journal Article Population pharmacokinetics of piperacillin-tazobactam in the plasma and cerebrospinal fluid of critically ill patientsKumta, Nilesh, Heffernan, Aaron J., Cotta, Menino Osbert, Liu, Xin, Parker, Suzanne, Wallis, Steven, Livermore, Amelia, Starr, Therese, Wong, Wai Tat, Joynt, Gavin M., Lipman, Jeffrey and Roberts, Jason A. (2024). Population pharmacokinetics of piperacillin-tazobactam in the plasma and cerebrospinal fluid of critically ill patients. Antimicrobial Agents and Chemotherapy, 69 (2), e0060124. doi: 10.1128/aac.00601-24 |
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2023 Journal Article The effect of the ABCDE/ABCDEF bundle on delirium, functional outcomes, and quality of life in critically ill patients: A systematic review and meta-analysisSosnowski, Kellie, Lin, Frances, Chaboyer, Wendy, Ranse, Kristen, Heffernan, Aaron and Mitchell, Marion (2023). The effect of the ABCDE/ABCDEF bundle on delirium, functional outcomes, and quality of life in critically ill patients: A systematic review and meta-analysis. International Journal of Nursing Studies, 138 104410, 1-14. doi: 10.1016/j.ijnurstu.2022.104410 |
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2022 Journal Article Evaluation of fosfomycin-sulbactam combination therapy against carbapenem-resistant Acinetobacter baumannii isolates in a hollow-fibre infection modelMohd Sazlly Lim, Sazlyna, Heffernan, Aaron, Naicker, Saiyuri, Wallis, Steven, Roberts, Jason A. and Sime, Fekade Bruck (2022). Evaluation of fosfomycin-sulbactam combination therapy against carbapenem-resistant Acinetobacter baumannii isolates in a hollow-fibre infection model. Antibiotics, 11 (11) 1578, 1-11. doi: 10.3390/antibiotics11111578 |
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2021 Journal Article Dose optimisation of antibiotics used for meningitisHeffernan, Aaron J. and Roberts, Jason A. (2021). Dose optimisation of antibiotics used for meningitis. Current Opinion in Infectious Diseases, 34 (6), 581-590. doi: 10.1097/QCO.0000000000000783 |
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2021 Journal Article Pharmacodynamic evaluation of a single dose versus a 24-hour course of multiple doses of cefazolin for surgical prophylaxisHeffernan, Aaron, Alawie, Jowana, Wallis, Steven C., Naicker, Saiyuri, Adiraju, Santosh, Roberts, Jason A. and Sime, Fekade Bruck (2021). Pharmacodynamic evaluation of a single dose versus a 24-hour course of multiple doses of cefazolin for surgical prophylaxis. Antibiotics, 10 (5) 602, 602. doi: 10.3390/antibiotics10050602 |
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2021 Journal Article Epidemiology of extended-spectrum β-lactamase and metallo-β-lactamase-producing in South AsiaIslam, Kamrul, Heffernan, Aaron J., Naicker, Saiyuri, Henderson, Andrew, Chowdhury, Mohammed Abdul Hassan, Roberts, Jason A. and Sime, Fekade B. (2021). Epidemiology of extended-spectrum β-lactamase and metallo-β-lactamase-producing in South Asia. Future Microbiology, 16 (7) fmb-2020-0193, 521-535. doi: 10.2217/fmb-2020-0193 |
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2021 Journal Article Semi-mechanistic PK/PD modelling of fosfomycin and sulbactam combination against carbapenem-resistant Acinetobacter baumanniiMohd Sazlly Lim, S., Heffernan, A.J., Roberts, J.A. and Sime, F.B. (2021). Semi-mechanistic PK/PD modelling of fosfomycin and sulbactam combination against carbapenem-resistant Acinetobacter baumannii. Antimicrobial Agents and Chemotherapy, 65 (5) e02472-20. doi: 10.1128/aac.02472-20 |
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2021 Journal Article Pharmacodynamics of once- versus twice-daily dosing of nebulized amikacin in an in vitro Hollow-Fiber Infection Model against 3 clinical isolates of Pseudomonas aeruginosaHeffernan, Aaron James, Sime, Fekade Bruck, Naicker, Saiyuri, Andrews, Katherine, Ellwood, David, Guerra-Valero, Yarmarly, Wallis, Steven, Lipman, Jeffrey, Grimwood, Keith and Roberts, Jason Alexander (2021). Pharmacodynamics of once- versus twice-daily dosing of nebulized amikacin in an in vitro Hollow-Fiber Infection Model against 3 clinical isolates of Pseudomonas aeruginosa. Diagnostic microbiology and infectious disease, 100 (2) 115329, 115329. doi: 10.1016/j.diagmicrobio.2021.115329 |
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2020 Journal Article Pharmacodynamic Analysis of Meropenem and Fosfomycin Combination Against Carbapenem-Resistant in Patients with Normal Renal Clearance: Can It Be a Treatment Option?Mohd Sazlly Lim, Sazlyna, Heffernan, Aaron J., Roberts, Jason A. and Sime, Fekade B. (2020). Pharmacodynamic Analysis of Meropenem and Fosfomycin Combination Against Carbapenem-Resistant in Patients with Normal Renal Clearance: Can It Be a Treatment Option?. Microbial drug resistance (Larchmont, N.Y.), 27 (4) mdr.2020.0197, 546-552. doi: 10.1089/mdr.2020.0197 |
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2020 Conference Publication Pharmacodynamic evaluation of intermittent versus prolonged infusion dosing regimens of piperacillin/tazobactam in a hollow-fiber infection model against two susceptible Klebsiella pneumoniae clinical isolatesSumi, Chandra Datta, B.Sime, Fekade, Heffernan, Aaron J., Naicker, Saiyuri, Islam, Kamrul, Cottrell, Kyra, Harris, Patrick N.A. and Roberts, Jason A. (2020). Pharmacodynamic evaluation of intermittent versus prolonged infusion dosing regimens of piperacillin/tazobactam in a hollow-fiber infection model against two susceptible Klebsiella pneumoniae clinical isolates. Federation of Infection Societies Conference 2019, Edinburgh, United Kingdom, 11-14 November 2019. London, United Kingdom: The Microbiology Society. doi: 10.1099/acmi.fis2019.po0103 |
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2018 Journal Article How to optimize antibiotic pharmacokinetic/pharmacodynamics for Gram-negative infections in critically ill patientsHeffernan, Aaron J., Sime, Fekade B., Taccone, Fabio S. and Roberts, Jason A. (2018). How to optimize antibiotic pharmacokinetic/pharmacodynamics for Gram-negative infections in critically ill patients. Current Opinion in Infectious Diseases, 31 (6), 1-565. doi: 10.1097/QCO.0000000000000494 |
