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2015 Journal Article pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signaturesPires, Douglas E V, Blundell, Tom L and Ascher, David B (2015). pkCSM: predicting small-molecule pharmacokinetic and toxicity properties using graph-based signatures. Journal of Medicinal Chemistry, 58 (9), 4066-72. doi: 10.1021/acs.jmedchem.5b00104 |
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2015 Journal Article Analysis of HGD gene mutations in patients with Alkaptonuria from the United Kingdom: identification of novel mutationsUsher, Jeannette L, Ascher, David B, Pires, Douglas E V, Milan, Anna M, Blundell, Tom L and Ranganath, Lakshminarayan R (2015). Analysis of HGD gene mutations in patients with Alkaptonuria from the United Kingdom: identification of novel mutations. JIMD Reports, 24, 3-11. doi: 10.1007/8904_2014_380 |
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2015 Journal Article Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in ratsKaminskas, Lisa M., McLeod, Victoria M., Ascher, David B., Ryan, Gemma M., Jones, Seth, Haynes, John M., Trevaskis, Natalie L., Chan, Linda J., Sloan, Erica K., Finnin, Benjamin A., Williamson, Mark, Velkov, Tony, Williams, Elizabeth D., Kelly, Brian D., Owen, David J. and Porter, Christopher J. H. (2015). Methotrexate-conjugated PEGylated dendrimers show differential patterns of deposition and activity in tumor-burdened lymph nodes after intravenous and subcutaneous administration in rats. Molecular Pharmaceutics, 12 (2), 432-443. doi: 10.1021/mp500531e |
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2015 Journal Article PEGylation does not significantly change the initial intravenous or subcutaneous pharmacokinetics or lymphatic exposure of trastuzumab in rats but increases plasma clearance after subcutaneous administrationChan, Linda J., Bulitta, Jürgen B., Ascher, David B., Haynes, John Michael, McLeod, Victoria M., Porter, Christopher J. H., Williams, Charlotte C. and Kaminskas, Lisa M. (2015). PEGylation does not significantly change the initial intravenous or subcutaneous pharmacokinetics or lymphatic exposure of trastuzumab in rats but increases plasma clearance after subcutaneous administration. Molecular Pharmaceutics, 12 (3), 794-809. doi: 10.1021/mp5006189 |
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2015 Journal Article Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptidesHermans, Stefan J, Ascher, David B, Hancock, Nancy C, Holien, Jessica K, Michell, Belinda J, Chai, Siew Yeen, Morton, Craig J and Parker, Michael W (2015). Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides. Protein Science, 24 (2), 190-199. doi: 10.1002/pro.2604 |
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2015 Journal Article Platinum: a database of experimentally measured effects of mutations on structurally defined protein-ligand complexesPires, Douglas E V, Blundell, Tom L and Ascher, David B (2015). Platinum: a database of experimentally measured effects of mutations on structurally defined protein-ligand complexes. Nucleic Acids Research, 43 (D1), D387-D391. doi: 10.1093/nar/gku966 |
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2015 Book Chapter Protein-protein interactions: structures and druggabilityAscher, David B., Jubb, Harry C., Pires, Douglas E. V., Ochi, Takashi, Higueruelo, Alicia and Blundell, Tom L. (2015). Protein-protein interactions: structures and druggability. Multifaceted roles of crystallography in modern drug discovery. (pp. 141-163) Dordrecht, Netherlands: Springer Netherlands. doi: 10.1007/978-94-017-9719-1_12 |
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2014 Journal Article Practical lessons in murine thoracic lymph duct cannulations: Observations in female and male mice across four different strains that impact on cannulatabilityCaliph, Suzanne M., Shackleford, David M., Ascher, David B. and Kaminskas, Lisa M. (2014). Practical lessons in murine thoracic lymph duct cannulations: Observations in female and male mice across four different strains that impact on cannulatability. Journal of Pharmaceutical Sciences, 104 (3), 1207-1209. doi: 10.1002/jps.24312 |
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2014 Journal Article Anti-Aβ antibody target engagement: a response to Siemers et al.Watt, Andrew D, Crespi, Gabriela A N, Down, Russell A, Ascher, David B, Gunn, Adam, Perez, Keyla A, McLean, Catriona A, Villemagne, Victor L, Parker, Michael W, Barnham, Kevin J and Miles, Luke A (2014). Anti-Aβ antibody target engagement: a response to Siemers et al.. Acta Neuropathologica, 128 (4), 611-4. doi: 10.1007/s00401-014-1333-8 |
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2014 Journal Article DUET: a server for predicting effects of mutations on protein stability using an integrated computational approachPires, Douglas E. V., Ascher, David B. and Blundell, Tom L. (2014). DUET: a server for predicting effects of mutations on protein stability using an integrated computational approach. Nucleic Acids Research, 42 (Web Server issue), W314-W319. doi: 10.1093/nar/gku411 |
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2014 Journal Article Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?Watt, Andrew D, Crespi, Gabriela A N, Down, Russell A, Ascher, David B, Gunn, Adam, Perez, Keyla A, McLean, Catriona A, Villemagne, Victor L, Parker, Michael W, Barnham, Kevin J and Miles, Luke A (2014). Do current therapeutic anti-Aβ antibodies for Alzheimer's disease engage the target?. Acta Neuropathologica, 127 (6), 803-810. doi: 10.1007/s00401-014-1290-2 |
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2014 Journal Article Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNAAscher, David B., Wielens, Jerome, Nero, Tracy L., Doughty, Larissa, Morton, Craig J. and Parker, Michael W. (2014). Potent hepatitis C inhibitors bind directly to NS5A and reduce its affinity for RNA. Scientific Reports, 4 (1) 4765. doi: 10.1038/srep04765 |
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2014 Journal Article Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-βCrespi, Gabriela A N, Ascher, David B, Parker, Michael W and Miles, Luke A (2014). Crystallization and preliminary X-ray diffraction analysis of the Fab portion of the Alzheimer's disease immunotherapy candidate bapineuzumab complexed with amyloid-β. Acta Crystallographica. Section F, Structural Biology Communications, 70 (Pt 3), 374-7. doi: 10.1107/S2053230X14001642 |
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2014 Journal Article Structural studies of Streptococcus pyogenes streptolysin O provide insights into the early steps of membrane penetrationFeil, Susanne C, Ascher, David B, Kuiper, Michael J, Tweten, Rodney K and Parker, Michael W (2014). Structural studies of Streptococcus pyogenes streptolysin O provide insights into the early steps of membrane penetration. Journal of Molecular Biology, 426 (4), 785-792. doi: 10.1016/j.jmb.2013.11.020 |
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2014 Journal Article mCSM: predicting the effects of mutations in proteins using graph-based signaturesPires, Douglas E V, Ascher, David B and Blundell, Tom L (2014). mCSM: predicting the effects of mutations in proteins using graph-based signatures. Bioinformatics, 30 (3), 335-42. doi: 10.1093/bioinformatics/btt691 |
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2013 Journal Article PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastasesKaminskas, Lisa M., Ascher, David B., McLeod, Victoria M., Herold, Marco J., Le, Caroline P., Sloan, Erica K. and Porter, Christopher J. H. (2013). PEGylation of interferon α2 improves lymphatic exposure after subcutaneous and intravenous administration and improves antitumour efficacy against lymphatic breast cancer metastases. Journal of Controlled Release, 168 (2), 200-208. doi: 10.1016/j.jconrel.2013.03.006 |
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2013 Journal Article Structure of the N-terminal domain of human thioredoxin-interacting proteinPolekhina, Galina, Ascher, David Benjamin, Kok, Shie Foong, Beckham, Simone, Wilce, Matthew and Waltham, Mark (2013). Structure of the N-terminal domain of human thioredoxin-interacting protein. Acta Crystallographica. Section D: Structural Biology, 69 (Pt 3), 333-344. doi: 10.1107/S0907444912047099 |
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2012 Journal Article Structural approaches to probing metal interaction with proteinsParker, Lorien J, Ascher, David B, Gao, Chen, Miles, Luke A, Harris, Hugh H and Parker, Michael W (2012). Structural approaches to probing metal interaction with proteins. Journal of Inorganic Biochemistry, 115, 138-47. doi: 10.1016/j.jinorgbio.2012.02.015 |
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2012 Journal Article Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2Ascher, David B, Polekhina, Galina and Parker, Michael W (2012). Crystallization and preliminary X-ray diffraction analysis of human endoplasmic reticulum aminopeptidase 2. Acta Crystallographica. Section F: Structural Biology Communications, 68 (Pt 4), 468-71. doi: 10.1107/S1744309112006963 |
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2011 Journal Article Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its ActivationParker, Lorien J., Italiano, Louis C., Morton, Craig J., Hancock, Nancy C., Ascher, David B., Aitken, Jade B., Harris, Hugh H., Campomanes, Pablo, Rothlisberger, Ursula, De Luca, Anastasia, Lo Bello, Mario, Ang, Wee Han, Dyson, Paul J. and Parker, Michael W. (2011). Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation. Chemistry-A European Journal, 17 (28), 7806-7816. doi: 10.1002/chem.201100586 |
