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2025 Journal Article AAV-mediated inducible co-expression of IL-10 and IL-1RN for ocular inflammatory diseasesMoreira Castro, Brenda Fernanda, Steel, Jason C. and Layton, Christopher J. (2025). AAV-mediated inducible co-expression of IL-10 and IL-1RN for ocular inflammatory diseases. Journal of Drug Delivery Science and Technology, 114 107591, 1-15. doi: 10.1016/j.jddst.2025.107591 |
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2024 Journal Article Nicorandil antiallodynic activity in a model of neuropathic pain is associated with the activation of ATP-dependent potassium channels and opioidergic pathways, and reduced production of cytokines and neutrophils recruitment in paw, sciatic nerve, and dorsal root gangliaBraga, Alysson V., Morais, Marcela Í., Delfino, Darly G. S., Costa, Sarah O. A. M., Barbosa, Bárbara C. M., Rodrigues, Felipe F., Melo, Ivo S. F., Matos, Rafael C., Castro, Brenda F. M., Cunha Júnior, Armando S., Braga, Taniris C., de Fátima, Ângelo, Coelho, Márcio M. and Machado, Renes R. (2024). Nicorandil antiallodynic activity in a model of neuropathic pain is associated with the activation of ATP-dependent potassium channels and opioidergic pathways, and reduced production of cytokines and neutrophils recruitment in paw, sciatic nerve, and dorsal root ganglia. Pharmacological Reports, 76 (5), 1067-1078. doi: 10.1007/s43440-024-00640-2 |
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2024 Journal Article AAV-mediated gene therapies for glaucoma and uveitis: are we there yet?Castro, Brenda, Steel, Jason C. and Layton, Christopher J. (2024). AAV-mediated gene therapies for glaucoma and uveitis: are we there yet?. Expert Reviews in Molecular Medicine, 26 e9, 1-15. doi: 10.1017/erm.2024.4 |
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2023 Journal Article AAV-based strategies for treatment of retinal and choroidal vascular diseases: advances in age-related macular degeneration and diabetic retinopathy therapiesCastro, Brenda F. M., Steel, Jason C. and Layton, Christopher J. (2023). AAV-based strategies for treatment of retinal and choroidal vascular diseases: advances in age-related macular degeneration and diabetic retinopathy therapies. BioDrugs, 38 (1), 73-93. doi: 10.1007/s40259-023-00629-y |
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2022 Journal Article Antiangiogenic potential of small polypeptide sequences: In vivo assays, cytotoxicity, synthetic approaches and influence of C-terminal carboxyamidationCordeiro, Lídia P.B., de Carvalho, Izabella E., Castro, Brenda F.M., Dourado, Lays F.N., Guimarães, Carlos F.C.R., Lula, Ivana S., Fialho, Silvia L., Júnior, Armando da Silva Cunha, Resende, Jarbas M. and Gomes, Elionai C. de L. (2022). Antiangiogenic potential of small polypeptide sequences: In vivo assays, cytotoxicity, synthetic approaches and influence of C-terminal carboxyamidation. Journal of Molecular Structure, 1265 133493, 133493. doi: 10.1016/j.molstruc.2022.133493 |
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2022 Journal Article RI75, a curcumin analogue, inhibits tumor necrosis factor-α and interleukin-6 production and exhibits antiallodynic and antiedematogenic activities in miceCosta, Sarah O. A. M., Rodrigues, Ianny B., Braga, Alysson V., Barbosa, Bárbara C. M., Silva, Roger R. L., Rodrigues, Felipe F., Melo, Ivo S. F., Morais, Marcela Í., Castro, Brenda F. M., Júnior, Armando S. Cunha, Maltarollo, Vinícius G., Oliveira, Renata B., Coelho, Márcio M. and Machado, Renes R. (2022). RI75, a curcumin analogue, inhibits tumor necrosis factor-α and interleukin-6 production and exhibits antiallodynic and antiedematogenic activities in mice. Inflammopharmacology, 30 (2), 505-515. doi: 10.1007/s10787-021-00913-9 |
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2022 Journal Article Low-dose melittin is safe for intravitreal administration and ameliorates inflammation in an experimental model of uveitisMoreira Castro, Brenda Fernanda, Nunes da Silva, Carolina, Barbosa Cordeiro, Lídia Pereira, Pereira de Freitas Cenachi, Sarah, Vasconcelos-Santos, Daniel Vitor, Machado, Renes Resende, Dias Heneine, Luiz Guilherme, Silva, Luciana Maria, Silva-Cunha, Armando and Fialho, Silvia Ligório (2022). Low-dose melittin is safe for intravitreal administration and ameliorates inflammation in an experimental model of uveitis. Current Research in Pharmacology and Drug Discovery, 3 100107, 1-15. doi: 10.1016/j.crphar.2022.100107 |
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2021 Journal Article Intravitreal lupeol: A new potential therapeutic strategy for noninfectious uveitisToledo, Cibele Rodrigues, Paiva, Mayara Rodrigues Brandão, Castro, Brenda Fernanda Moreira, Pereira, Vinicius Viana, Cenachi, Sarah Pereira de Freitas, Vasconcelos-Santos, Daniel Vítor, Fialho, Sílvia Ligório and Silva-Cunha, Armando (2021). Intravitreal lupeol: A new potential therapeutic strategy for noninfectious uveitis. Biomedicine & Pharmacotherapy, 143 112145, 1-9. doi: 10.1016/j.biopha.2021.112145 |
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2020 Journal Article Surface functionalized mesoporous silica nanoparticles for intravitreal application of tacrolimusPaiva, Mayara Rodrigues Brandão, Andrade, Gracielle Ferreira, Dourado, Lays Fernanda Nunes, Castro, Brenda Fernanda Moreira, Fialho, Silvia Ligório, Sousa, Edésia Martins Barros and Silva-Cunha, Armando (2020). Surface functionalized mesoporous silica nanoparticles for intravitreal application of tacrolimus. Journal of Biomaterials Applications, 35 (8), 1019-1033. doi: 10.1177/0885328220977605 |
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2020 Journal Article Positively charged polymeric nanoparticles improve ocular penetration of tacrolimus after topical administrationCastro, Brenda Fernanda Moreira, Fulgêncio, Gustavo de Oliveira, Domingos, Luisa Cangussú, Cotta, Oliver Araújo Lacerda, Silva-Cunha, Armando and Fialho, Silvia Ligório (2020). Positively charged polymeric nanoparticles improve ocular penetration of tacrolimus after topical administration. Journal of Drug Delivery Science and Technology, 60 101912, 1-10. doi: 10.1016/j.jddst.2020.101912 |
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2020 Journal Article Rosmarinic Acid Intravitreal Implants: A New Therapeutic Approach for Ocular NeovascularizationVieira, Lorena Carla, Moreira, Carolina Paula de Souza, Castro, Brenda Fernanda Moreira, Cotta, Oliver Araújo Lacerda, Silva, Luciana Maria, Fulgêncio, Gustavo de Oliveira, Silva-Cunha, Armando and Fialho, Sílvia L. (2020). Rosmarinic Acid Intravitreal Implants: A New Therapeutic Approach for Ocular Neovascularization. Planta Medica, 86 (17), 1286-1297. doi: 10.1055/a-1223-2525 |
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2020 Journal Article Intravitreal thalidomide ameliorates inflammation in a model of experimental uveitis induced by BCGCastro, Brenda Fernanda Moreira, Vieira, Lorena Carla, Vasconcelos-Santos, Daniel Vitor, Cenachi, Sarah Pereira de Freitas, Cotta, Oliver Araújo Lacerda, Guerra, Maria Carolina Andrade, Paiva, Mayara Rodrigues Brandão, Silva, Luciana Maria, Silva-Cunha, Armando and Fialho, Sílvia Ligório (2020). Intravitreal thalidomide ameliorates inflammation in a model of experimental uveitis induced by BCG. International Immunopharmacology, 81 106129, 1-9. doi: 10.1016/j.intimp.2019.106129 |
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2018 Journal Article Permeability and in vivo distribution of poly(Ɛ-caprolactone) nanoparticles loaded with zidovudineMagalhães, Milena C. R. S., Castro, Brenda F. M., de Castro, Whocely V., Barros, Andre L. B., Fernandes, Renata S., Silva-Cunha, Armando and Fialho, Sílvia L. (2018). Permeability and in vivo distribution of poly(Ɛ-caprolactone) nanoparticles loaded with zidovudine. Journal of Nanoparticle Research, 20 (7) 176, 1-14. doi: 10.1007/s11051-018-4280-9 |
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2017 Journal Article Antiangiogenic activity of a bevacizumab-loaded polyurethane device in animal neovascularization modelsFerreira, A.E.R., Castro, B.F.M., Vieira, L.C., Cassali, G.D., Souza, C.M., Fulgêncio, G.O., Ayres, E., Oréfice, R.L., Jorge, R., Silva-Cunha, A. and Fialho, S.L. (2017). Antiangiogenic activity of a bevacizumab-loaded polyurethane device in animal neovascularization models. Journal Français d'Ophtalmologie, 40 (3), 202-208. doi: 10.1016/j.jfo.2016.10.010 |
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2016 Journal Article Safety and in vivo release of fluconazole-loaded implants in rabbits' eyesSilva, Gisele R., Almeida, Ana Paula R., Fernandes-Cunha, Gabriella M., Castro, Brenda F.M., Vieira, Lorena C., Fulgêncio, Gustavo O., Silva-Cunha, Armando and Fialho, Sílvia L. (2016). Safety and in vivo release of fluconazole-loaded implants in rabbits' eyes. Journal of Drug Delivery Science and Technology, 35, 323-326. doi: 10.1016/j.jddst.2016.08.009 |
