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2025

Journal Article

Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes

Cao, Yuanzhao, Redd, Meredith, Outhwaite, Jennifer, Mizikovsky, Dalia, Shim, Woo Jun, Fang, Chen, Wu, Zhixuan, Daygon, Dara, Stark, Terra, Palfreyman, Robin, Chiu, Han Sheng, Tan, Clarissa, Thomas, Ulrich, Dragicevic, Elena, Sng, Julian, Barrett, Helen, Dorey, Emily, Shah, Sonia, Short, Kirsty and Palpant, Nathan J. (2025). Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes. doi: 10.1101/2025.01.29.635173

Glycaemic variability underlies myocyte dysfunction and myocardial injury risk in diabetes

2024

Journal Article

A community-oriented, data-driven resource to improve protocol design for cardiac modelling from human pluripotent stem cells

Chow, Chris Siu Yeung, Negi, Sumedha, Bao, Shaine, Fang, Chen, Hudson, James, Shim, Woo Jun, Yuanzhao Cao and Palpant, Nathan (2024). A community-oriented, data-driven resource to improve protocol design for cardiac modelling from human pluripotent stem cells. doi: 10.1101/2024.09.04.611313

A community-oriented, data-driven resource to improve protocol design for cardiac modelling from human pluripotent stem cells

2023

Journal Article

New drug targets and preclinical modelling recommendations for treating acute myocardial infarction

Cao, Yuanzhao, Redd, Meredith A., Fang, Chen, Mizikovsky, Dalia, Li, Xichun, Macdonald, Peter S., King, Glenn F. and Palpant, Nathan J. (2023). New drug targets and preclinical modelling recommendations for treating acute myocardial infarction. Heart, Lung and Circulation, 32 (7), 852-869. doi: 10.1016/j.hlc.2022.12.015

New drug targets and preclinical modelling recommendations for treating acute myocardial infarction

2024

Journal Article

Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function

Sinclair, Jane E., Vedelago, Courtney, Ryan, Feargal J., Carney, Meagan, Redd, Meredith A., Lynn, Miriam A., Grubor-Bauk, Branka, Cao, Yuanzhao, Henders, Anjali K., Chew, Keng Yih, Gilroy, Deborah, Greaves, Kim, Labzin, Larisa, Ziser, Laura, Ronacher, Katharina, Wallace, Leanne M., Zhang, Yiwen, Macauslane, Kyle, Ellis, Daniel J., Rao, Sudha, Burr, Lucy, Bain, Amanda, Karawita, Anjana, Schulz, Benjamin L., Li, Junrong, Lynn, David J., Palpant, Nathan, Wuethrich, Alain, Trau, Matt and Short, Kirsty R. (2024). Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function. Nature Microbiology, 9 (12), 1-13. doi: 10.1038/s41564-024-01838-z

Post-acute sequelae of SARS-CoV-2 cardiovascular symptoms are associated with trace-level cytokines that affect cardiomyocyte function

2024

Conference Publication

Preclinical models of Glycaemic variability recapitulate Clinical Cardiovascular outcomes in Diabetes

Cao, Y., Redd, M., Outhwaite, J., Shim, W., Fang, C., Negi, S., Shen, S., Mizikovsky, D., Chiu, H., Tan, C., Thomas, U., Dragicevic, E., Sng, J., Short, K. and Palpant, N. (2024). Preclinical models of Glycaemic variability recapitulate Clinical Cardiovascular outcomes in Diabetes. 72nd Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand, Perth, WA Australia, 1-4 August 2024. Chatswood, NSW Australia: Elsevier. doi: 10.1016/j.hlc.2024.06.332

Preclinical models of Glycaemic variability recapitulate Clinical Cardiovascular outcomes in Diabetes

2024

Journal Article

High-content fluorescence bioassay investigates pore formation, ion channel modulation and cell membrane lysis induced by venoms

Kramer, Simon, Kotapati, Charan, Cao, Yuanzhao, Fry, Bryan G., Palpant, Nathan J., King, Glenn F. and Cardoso, Fernanda C. (2024). High-content fluorescence bioassay investigates pore formation, ion channel modulation and cell membrane lysis induced by venoms. Toxicon: X, 21 100184. doi: 10.1016/j.toxcx.2024.100184

High-content fluorescence bioassay investigates pore formation, ion channel modulation and cell membrane lysis induced by venoms

Featured

2024

Journal Article

Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm

Wu, Zhixuan, Shen, Sophie, Mizikovsky, Dalia, Cao, Yuanzhao, Naval-Sanchez, Marina, Tan, Siew Zhuan, Alvarez, Yanina D., Sun, Yuliangzi, Chen, Xiaoli, Zhao, Qiongyi, Kim, Daniel, Yang, Pengyi, Hill, Timothy A., Jones, Alun, Fairlie, David P., Pébay, Alice, Hewitt, Alex W., Tam, Patrick P.L., White, Melanie D., Nefzger, Christian M. and Palpant, Nathan J. (2024). Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm. Developmental Cell, 59 (6), 705-722.e8. doi: 10.1016/j.devcel.2024.01.019

Wnt dose escalation during the exit from pluripotency identifies tranilast as a regulator of cardiac mesoderm

Featured

2023

Journal Article

HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function

Friedman, Clayton E., Cheetham, Seth W., Negi, Sumedha, Mills, Richard J., Ogawa, Masahito, Redd, Meredith A., Chiu, Han Sheng, Shen, Sophie, Sun, Yuliangzi, Mizikovsky, Dalia, Bouveret, Romaric, Chen, Xiaoli, Voges, Holly K., Paterson, Scott, De Angelis, Jessica E., Andersen, Stacey B., Cao, Yuanzhao, Wu, Yang, Jafrani, Yohaann M.A., Yoon, Sohye, Faulkner, Geoffrey J., Smith, Kelly A., Porrello, Enzo, Harvey, Richard P., Hogan, Benjamin M., Nguyen, Quan, Zeng, Jian, Kikuchi, Kazu, Hudson, James E. and Palpant, Nathan J. (2023). HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function. Developmental Cell, 59 (1), 91-107.e1. doi: 10.1016/j.devcel.2023.11.012

HOPX-associated molecular programs control cardiomyocyte cell states underpinning cardiac structure and function

2023

Conference Publication

Disease modeling utilizing human pluripotent stem cell-derived cardiomyocytes and physiological characterization

Cao, Yuanzhao, Redd, Meredith A., Shim, Woo Jun, Fang, Chen, Chiu, Han, Azofeifa, Daniela Rojas, Thomas, Ulrich, Lemme, Marta, Dragicevic, Elena, Stoelzle-Feix, Sonja and Palpant, Nathan J. (2023). Disease modeling utilizing human pluripotent stem cell-derived cardiomyocytes and physiological characterization. Safety Pharmacology Society Annual Meeting, Brussels, Belgium, 18-21 September 2023. Philadelphia, PA United States: Elsevier. doi: 10.1016/j.vascn.2023.107267

Disease modeling utilizing human pluripotent stem cell-derived cardiomyocytes and physiological characterization

2022

Journal Article

The ins and outs of cellular pH during cardiac ischemia

Cao, Yuanzhao and Palpant, Nathan J. (2022). The ins and outs of cellular pH during cardiac ischemia. Journal of Molecular and Cellular Cardiology, 174, 133-134. doi: 10.1016/j.yjmcc.2022.12.004

The ins and outs of cellular pH during cardiac ischemia

2015

Conference Publication

MnTM-4-PyP protects cortical neurons against oxidative stress via induction of cellular antioxidant responses

Cheng, Kuoyuan, Guo, Fei, Lu, Jiaqi, Cao, Yuanzhao and Xia, Qing (2015). MnTM-4-PyP protects cortical neurons against oxidative stress via induction of cellular antioxidant responses. Joint Meeting of the 20th Biennial Meeting of the International-Society-for-Developmental-Neuroscience / 5th Annual NeuroDevNet Brain Development Conference, Montreal Canada, Jul 19-24, 2014. OXFORD: PERGAMON-ELSEVIER SCIENCE LTD. doi: 10.1016/j.ijdevneu.2015.04.276

MnTM-4-PyP protects cortical neurons against oxidative stress via induction of cellular antioxidant responses

2015

Journal Article

Novel mechanisms for superoxide-scavenging activity of human manganese superoxide dismutase determined by the K68 key acetylation site

Lu, Jiaqi, Cheng, Kuoyuan, Zhang, Bo, Xu, Huan, Cao, Yuanzhao, Guo, Fei, Feng, Xudong and Xia, Qing (2015). Novel mechanisms for superoxide-scavenging activity of human manganese superoxide dismutase determined by the K68 key acetylation site. Free Radical Biology and Medicine, 85, 114-126. doi: 10.1016/j.freeradbiomed.2015.04.011

Novel mechanisms for superoxide-scavenging activity of human manganese superoxide dismutase determined by the K68 key acetylation site

2015

Journal Article

Berberine regulates neurite outgrowth through AMPK-dependent pathways by lowering energy status

Lu, Jiaqi, Cao, Yuanzhao, Cheng, Kuoyuan, Xu, Bo, Wang, Tianchang, Yang, Qi, Yang, Qin, Feng, Xudong and Xia, Qing (2015). Berberine regulates neurite outgrowth through AMPK-dependent pathways by lowering energy status. Experimental Cell Research, 334 (2), 194-206. doi: 10.1016/j.yexcr.2015.04.006

Berberine regulates neurite outgrowth through AMPK-dependent pathways by lowering energy status

2015

Journal Article

MnTM-4-PyP modulates endogenous antioxidant responses and protects primary cortical neurons against oxidative stress

Cheng, Kuo-Yuan, Guo, Fei, Lu, Jia-Qi, Cao, Yuan-Zhao, Wang, Tian-Chang, Yang, Qi and Xia, Qing (2015). MnTM-4-PyP modulates endogenous antioxidant responses and protects primary cortical neurons against oxidative stress. CNS Neuroscience and Therapeutics, 21 (5), 435-445. doi: 10.1111/cns.12373

MnTM-4-PyP modulates endogenous antioxidant responses and protects primary cortical neurons against oxidative stress

2014

Journal Article

AMPK activation regulates neuronal structure in developing hippocampal neurons

Ramamurthy, S., Chang, E., Cao, Y., Zhu, J. and Ronnett, G. V. (2014). AMPK activation regulates neuronal structure in developing hippocampal neurons. Neuroscience, 259, 13-24. doi: 10.1016/j.neuroscience.2013.11.048

AMPK activation regulates neuronal structure in developing hippocampal neurons

2012

Journal Article

Neuroprotection by manganese superoxide dismutase (MnSOD) mimics: antioxidant effect and oxidative stress regulation in acute experimental stroke

Huang, Hai-Feng, Guo, Fei, Cao, Yuan-Zhao, Shi, Wen and Xia, Qing (2012). Neuroprotection by manganese superoxide dismutase (MnSOD) mimics: antioxidant effect and oxidative stress regulation in acute experimental stroke. CNS Neuroscience and Therapeutics, 18 (10), 811-818. doi: 10.1111/j.1755-5949.2012.00380.x

Neuroprotection by manganese superoxide dismutase (MnSOD) mimics: antioxidant effect and oxidative stress regulation in acute experimental stroke