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2011 Journal Article Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linkerKaminskas, Lisa M., Kelly, Brian D., McLeod, Victoria M., Sberna, Gian, Owen, David J., Boyd, Ben J. and Porter, Christopher J. H. (2011). Characterisation and tumour targeting of PEGylated polylysine dendrimers bearing doxorubicin via a pH labile linker. Journal of Controlled Release, 152 (2), 241-248. doi: 10.1016/j.jconrel.2011.02.005 |
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2011 Journal Article Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated pegylated polylysine dendrimersKaminskas, Lisa M., Kelly, Brian D., McLeod, Victoria M., Sberna, Gian, Boyd, Ben J., Owen, David J. and Porter, Christopher J. H. (2011). Capping methotrexate α-carboxyl groups enhances systemic exposure and retains the cytotoxicity of drug conjugated pegylated polylysine dendrimers. Molecular Pharmaceutics, 8 (2), 338-349. doi: 10.1021/mp1001872 |
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2010 Journal Article Dendrimers enhance delivery of small molecule and biological drugs: Control solubility, half-life, toxicity and targetingOwen, David and Barrett, Paul (2010). Dendrimers enhance delivery of small molecule and biological drugs: Control solubility, half-life, toxicity and targeting. ONdrugDelivery (4), 21-24. |
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2010 Journal Article Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphateKoohang, Ali, Bailey, Jessica L., Coates, Robert M., Erickson, Hans K., Owen, David and Poulter, C. Dale (2010). Enantioselective inhibition of squalene synthase by aziridine analogues of presqualene diphosphate. Journal of Organic Chemistry, 75 (14), 4769-4777. doi: 10.1021/jo100718z |
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2009 Journal Article Total Synthesis of the Potent Anticancer Aglaia Metabolites (-)-Silvestrol and (-)-Episilvestrol and the Active Analogue (-)-4-DesmethoxyepisilvestrolAdams, Tim E., Sous, Mariana El, Hawkins, Bill C., Hirner, Sebastian, Holloway, Georgina, Khoo, Mui Ling, Owen, David J., Paul Savage, G., Seammells, Peter J. and Rizzacasa, Mark A. (2009). Total Synthesis of the Potent Anticancer Aglaia Metabolites (-)-Silvestrol and (-)-Episilvestrol and the Active Analogue (-)-4-Desmethoxyepisilvestrol. Journal of the American Chemical Society, 131 (4), 1607-1616. doi: 10.1021/ja808402e |
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2007 Journal Article Total synthesis of (-)-episilvestrol and (-)-silvestrolEl Sous, Mariana, Khoo, Mui Ling, Holloway, Georgina, Owen, David, Scammells, Peter J. and Rizzacasa, Mark A. (2007). Total synthesis of (-)-episilvestrol and (-)-silvestrol. Angewandte Chemie - International Edition, 46 (41), 7835-7838. doi: 10.1002/anie.200702700 |
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2007 Journal Article Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteriaDavis, Chris B., Hartnell, Regan D., Madge, Paul D., Owen, David J., Thomson, Robin J., Chong, Andrew K.J., Coppel, Ross L. and Von Itzstein, Mark (2007). Synthesis and biological evaluation of galactofuranosyl alkyl thioglycosides as inhibitors of mycobacteria. Carbohydrate Research, 342 (12-13), 1773-1780. doi: 10.1016/j.carres.2007.04.027 |
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2007 Journal Article Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agentsOwen, David J., Davis, Chris B., Hartnell, Regan D., Madge, Paul D., Thomson, Robin J., Chong, Andrew K.J., Coppel, Ross L. and Von Itzstein, Mark (2007). Synthesis and evaluation of galactofuranosyl N,N-dialkyl sulfenamides and sulfonamides as antimycobacterial agents. Bioorganic and Medicinal Chemistry Letters, 17 (8), 2274-2277. doi: 10.1016/j.bmcl.2007.01.068 |
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2003 Journal Article Efficient syntheses of benzothiazepines as antagonists for the mitochondrial sodium-calcium exchanger: Potential therapeutics for type II diabetesPei, Yazhong, Lilly, Michael J., Owen, David J., D'Souza, Lawrence J., Tang, Xiao-Qing, Yu, Jinghua, Nazarbaghi, Ramina, Hunter, Andrew, Anderson, Christen M., Glasco, Susan, Ede, Nicholas J., James, Ian W., Maitra, Uday, Chandrasekaran, S., Moos, Walter H. and Ghosh, Soumitra S. (2003). Efficient syntheses of benzothiazepines as antagonists for the mitochondrial sodium-calcium exchanger: Potential therapeutics for type II diabetes. Journal of Organic Chemistry, 68 (1), 92-103. doi: 10.1021/jo020446t |
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2002 Journal Article A convenient synthesis of C-galactofuranosylic compounds (C-galactofuranosides)Owen, David J., Thomson, Robin J. and Von Itzstein, Mark (2002). A convenient synthesis of C-galactofuranosylic compounds (C-galactofuranosides). Carbohydrate Research, 337 (21-23), 2017-2022. doi: 10.1016/S0008-6215(02)00133-7 |
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2001 Journal Article Synthesis of Functional <i>Ras</i> Lipoproteins and Fluorescent DerivativesKuhn, Karsten, Owen, David J., Bader, Benjamin, Wittinghofer, Alfred, Kuhlmann, Jürgen and Waldmann, Herbert (2001). Synthesis of Functional Ras Lipoproteins and Fluorescent Derivatives. Journal of the American Chemical Society, 123 (6), 1023-1035. doi: 10.1021/ja002723o |
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2000 Journal Article Identification of endogenous gibberellins in strawberry, including the novel gibberellins GA123, GA124 and GA125Blake, Patrick S, Taylor, David R, Crisp, Carol M, Mander, Lewis N and Owen, David J (2000). Identification of endogenous gibberellins in strawberry, including the novel gibberellins GA123, GA124 and GA125. Phytochemistry, 55 (8), 887-890. doi: 10.1016/S0031-9422(00)00237-5 |
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2000 Journal Article Phosphoisoprenoid binding specificity of geranylgeranyltransferase type IIThoma N.H., Iakovenko A., Owen D., Scheidig A.S., Waldmann H., Goody R.S. and Alexandrov K. (2000). Phosphoisoprenoid binding specificity of geranylgeranyltransferase type II. Biochemistry, 39 (39), 12043-12052. doi: 10.1021/bi000835m |
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2000 Journal Article A one-pot synthesis of novel N,N-dialkyl-S-glycosylsulfenamidesOwen, David J. and Von Itzstein, Mark (2000). A one-pot synthesis of novel N,N-dialkyl-S-glycosylsulfenamides. Carbohydrate Research, 328 (3), 287-292. doi: 10.1016/S0008-6215(00)00110-5 |
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2000 Journal Article Bioorganic synthesis of lipid-modified proteins for the study of signal transductionBader, Benjamin, Kuhn, Karsten, Owen, David J., Waldmann, Herbert, Wittinghofer, Alfred and Kuhlmann, Jürgen (2000). Bioorganic synthesis of lipid-modified proteins for the study of signal transduction. Nature, 403 (6766), 223-226. doi: 10.1038/35003249 |
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1999 Journal Article Peptide conjugates as tools for the study of biological signal transductionEisele, Frank, Owen, David J. and Waldmann, Herbert (1999). Peptide conjugates as tools for the study of biological signal transduction. Bioorganic and Medicinal Chemistry, 7 (2), 193-224. doi: 10.1016/S0968-0896(98)00204-1 |
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1999 Journal Article Synthesis and evaluation of aziridine analogues of presqualene diphosphate as squalene synthase inhibitorsKoohang, Ali, Coates, Robert M., Owen, David and Poulter, C. Dale (1999). Synthesis and evaluation of aziridine analogues of presqualene diphosphate as squalene synthase inhibitors. Journal of Organic Chemistry, 64 (1), 6-7. doi: 10.1021/jo981833z |
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1999 Journal Article Chemo-enzymatic synthesis of fluorescent Rab 7 proteins: Tools to study vesicular trafficking in cellsOwen, DJ, Alexandrov, K, Rostkova, E, Scheidig, AJ, Goody, RS and Waldmann, H (1999). Chemo-enzymatic synthesis of fluorescent Rab 7 proteins: Tools to study vesicular trafficking in cells. Angewandte Chemie-International Edition, 38 (4), 509-512. doi: 10.1002/(SICI)1521-3773(19990215)38:43.3.CO;2-V |
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1998 Journal Article Identification of GA113, GA114, GA115 and GA116 and further novel gibberellins in Raphanus sativusNakayama, Massyoshi, Nishijima, Takaaki, Koshioka, Masaji, Yamane, Hisakazu, Owen, David J. and Mander, Lewis N. (1998). Identification of GA113, GA114, GA115 and GA116 and further novel gibberellins in Raphanus sativus. Phytochemistry, 48 (4), 587-593. doi: 10.1016/s0031-9422(98)00035-1 |
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1998 Journal Article Synthesis and confirmation of structure for a new gibberellin, 2β- hydroxy-GA12 (GA110), from spinach and oil palmOwen, David J., Mander, Lewis N., Storey, John M.D., Huntley, Rachael P., Gaskin, Paul, Lenton, John R., Gage, Douglas A. and Zeevaart, Jan A.D. (1998). Synthesis and confirmation of structure for a new gibberellin, 2β- hydroxy-GA12 (GA110), from spinach and oil palm. Phytochemistry, 47 (3), 331-337. doi: 10.1016/S0031-9422(97)00577-3 |
