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2014

Conference Publication

Evidence of ECMO induced changes to haemostasis in an ovine model

Foley, S., Fung, L., Simonova, G., Solano, C., Diab, S., Dunster, K., McDonald, C., Shekar, K. and Fraser, J. (2014). Evidence of ECMO induced changes to haemostasis in an ovine model. 38th Australian and New Zealand Scientific Meeting on Intensive Care and the 19th Annual Paediatric and Neonatal intensive Care Conference, Hobart, Australia, October, 2013. Philadelphia, United States: Elsevier. doi: 10.1016/j.aucc.2013.10.057

Evidence of ECMO induced changes to haemostasis in an ovine model

2013

Journal Article

Can optimal drug dosing during ECMO improve outcomes?

Shekar, Kiran, Fraser, John F. and Roberts, Jason A. (2013). Can optimal drug dosing during ECMO improve outcomes?. Intensive Care Medicine, 39 (12), 2237-2237. doi: 10.1007/s00134-013-3080-z

Can optimal drug dosing during ECMO improve outcomes?

2013

Journal Article

To ventilate, oscillate, or cannulate?

Shekar, Kiran, Davies, Andrew R., Mullany, Daniel V., Tiruvoipati, Ravindranath and Fraser, John F. (2013). To ventilate, oscillate, or cannulate?. Journal of Critical Care, 28 (5), 655-662. doi: 10.1016/j.jcrc.2013.04.009

To ventilate, oscillate, or cannulate?

2013

Journal Article

Stored blood transfusion induces transient pulmonary arterial hypertension without impairing coagulation in an ovine model of nontraumatic haemorrhage

Fung, Y. L., Tung, J. P., Foley, S. R., Simonova, G., Thom, O., Staib, A., Collier, J., Dunster, K. R., Solano, C., Shekar, K., Chew, M. S. and Fraser, J. F. (2013). Stored blood transfusion induces transient pulmonary arterial hypertension without impairing coagulation in an ovine model of nontraumatic haemorrhage. Vox Sanguinis, 105 (2), 150-158. doi: 10.1111/vox.12032

Stored blood transfusion induces transient pulmonary arterial hypertension without impairing coagulation in an ovine model of nontraumatic haemorrhage

2013

Journal Article

Depletion of myocardial glucose is observed during endotoxaemic but not haemorrhagic shock in a porcine model

Chew M. S., Shekar K., Brand B. A., Norin C. and Barnett A. G. (2013). Depletion of myocardial glucose is observed during endotoxaemic but not haemorrhagic shock in a porcine model. Critical Care, 17 (4) R164. doi: 10.1186/cc12843

Depletion of myocardial glucose is observed during endotoxaemic but not haemorrhagic shock in a porcine model

2013

Journal Article

Is hyperoxaemia helping or hurting patients during extracorporeal membrane oxygenation? Review of a complex problem

Hayes, R. A., Shekar, K. and Fraser, J. F. (2013). Is hyperoxaemia helping or hurting patients during extracorporeal membrane oxygenation? Review of a complex problem. Perfusion, 28 (3), 184-193. doi: 10.1177/0267659112473172

Is hyperoxaemia helping or hurting patients during extracorporeal membrane oxygenation? Review of a complex problem

2013

Journal Article

The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation

Shekar, Kiran, Roberts, Jason A., Smith, Maree T., Fung, Yoke L. and Fraser, John F. (2013). The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation. BMC Anesthesiology, 13 (1) 7, 7.1-7.10. doi: 10.1186/1471-2253-13-7

The ECMO PK Project: an incremental research approach to advance understanding of the pharmacokinetic alterations and improve patient outcomes during extracorporeal membrane oxygenation

2013

Journal Article

Single-centre experience of donation after cardiac death

Kumar, Raj, Shekar, Kiran and Fraser, John F. (2013). Single-centre experience of donation after cardiac death. Medical Journal of Australia, 198 (2), 87-88. doi: 10.5694/mja12.11502

Single-centre experience of donation after cardiac death

2013

Journal Article

Hyperoxic damage and the need for optimised oxygenation practices

Hayes, Rylan A., Shekar, Kiran and Fraser, John F. (2013). Hyperoxic damage and the need for optimised oxygenation practices. Critical Care, 17 (4) 441, 441. doi: 10.1186/cc12802

Hyperoxic damage and the need for optimised oxygenation practices

2013

Conference Publication

The impact of continuous flow from venovenous extracorporeal membrane oxygenation cannulae on tricuspid valve geometry and function

Platts, D., Diab, S., MacDonald, M., Chemonges, S., Dunster, K., Shekar, K., Burstow, D., Mullany, D. and Fraser, D. (2013). The impact of continuous flow from venovenous extracorporeal membrane oxygenation cannulae on tricuspid valve geometry and function. 2013 ANZSCTS Annual Scientific Meeting, Darwin, NT Australia, 22 - 25 August 2013. Chatswood, NSW Australia: Elsevier Australia. doi: 10.1016/j.hlc.2013.05.474

The impact of continuous flow from venovenous extracorporeal membrane oxygenation cannulae on tricuspid valve geometry and function

2013

Conference Publication

Feasibility of a novel echocardiographic imaging technique, intracatheter echocardiography, to guide venovenous extracorporeal membrane oxygenation cannulae placement in a validated ovine model

Platts, D., Hilton, A., Diab, S., MacDonald, C., Tunbridge, M., Chemonges, S., Dunster, K., Shekar, K., Burstow, D. and Fraser, J. (2013). Feasibility of a novel echocardiographic imaging technique, intracatheter echocardiography, to guide venovenous extracorporeal membrane oxygenation cannulae placement in a validated ovine model. CSANZ 2013: 61st Annual Scientific Meeting of the Cardiac Society of Australia and New Zealand; in conjunction with the 37th Annual Scientific Meeting of the International Society for Heart Research, Gold Coast, QLD, Australia, 8-11 August, 2013. Chatswood, NSW, Australia: Elsevier Australia. doi: 10.1016/j.hlc.2013.05.429

Feasibility of a novel echocardiographic imaging technique, intracatheter echocardiography, to guide venovenous extracorporeal membrane oxygenation cannulae placement in a validated ovine model

2012

Journal Article

Drotrecogin alfa (activated) falls amid continuing enthusiasm to normalise physiology in ICU patients

Shekar, Kiran and Fraser, John F. (2012). Drotrecogin alfa (activated) falls amid continuing enthusiasm to normalise physiology in ICU patients. Critical Care and Resuscitation, 14 (4), 324-324. doi: 10.1016/s1441-2772(23)01775-1

Drotrecogin alfa (activated) falls amid continuing enthusiasm to normalise physiology in ICU patients

2012

Journal Article

Massive bilateral pulmonary emboli, paradoxical embolus and the knot of life

Platts, David, Shekar, Kiran, Senz, Ainslie and Thomson, Bruce (2012). Massive bilateral pulmonary emboli, paradoxical embolus and the knot of life. European Heart Journal, 33 (24), 3077-3077. doi: 10.1093/eurheart/ehs256

Massive bilateral pulmonary emboli, paradoxical embolus and the knot of life

2012

Journal Article

ASAP ECMO: antibiotic, sedative and analgesic pharmacokinetics during extracorporeal membrane oxygenation: a multi-centre study to optimise drug therapy during ECMO

Shekar, Kiran, Roberts, Jason A., Welsh, Susan, Buscher, Hergen, Rudham, Sam, Burrows, Fay, Ghassabian, Sussan, Wallis, Steven C., Levkovich, Bianca, Pellegrino, Vin, McGuiness, Shay, Parke, Rachael, Gilder, Eileen, Barnett, Adrian G., Walsham, James, Mullany, Daniel V., Fung, Yoke L., Smith, Maree T. and Fraser, John F. (2012). ASAP ECMO: antibiotic, sedative and analgesic pharmacokinetics during extracorporeal membrane oxygenation: a multi-centre study to optimise drug therapy during ECMO. BMC Anesthesiology, 12 (1) 29, 29.1-29.9. doi: 10.1186/1471-2253-12-29

ASAP ECMO: antibiotic, sedative and analgesic pharmacokinetics during extracorporeal membrane oxygenation: a multi-centre study to optimise drug therapy during ECMO

2012

Journal Article

Sedation during extracorporeal membrane oxygenation-why more is less

Shekar, K., Roberts, J. A., Ghassabian, S., Mullany, D. V., Ziegenfuss, M., Smith, M. T., Fung, Y. L. and Fraser, J. F. (2012). Sedation during extracorporeal membrane oxygenation-why more is less. Anaesthesia and Intensive Care, 40 (6), 1067-1069.

Sedation during extracorporeal membrane oxygenation-why more is less

2012

Journal Article

Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?

Shekar, Kiran, Roberts, Jason A., Ghassabian, Sussan, Mullany, Daniel V., Wallis, Steven C., Smith, Maree T. and Fraser, John F. (2012). Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?. Journal of Antimicrobial Chemotherapy, 68 (3), 726-727. doi: 10.1093/jac/dks435

Altered antibiotic pharmacokinetics during extracorporeal membrane oxygenation: cause for concern?

2012

Journal Article

Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation

Shekar, Kiran, Roberts, Jason A., McDonald, Charles I., Fisquet, Stephanie, Barnett, Adrian G., Mullany, Daniel V., Ghassabian, Sussan, Wallis, Steven C., Fung, Yoke L., Smith, Maree T. and Fraser, John F. (2012). Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation. Critical Care, 16 (5) R194, R194.1-R194.7. doi: 10.1186/cc11679

Sequestration of drugs in the circuit may lead to therapeutic failure during extracorporeal membrane oxygenation

2012

Journal Article

High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS

Ghassabian, Sussan, Moosavi, Seyed Mojtaba, Valero, Yarmarly Guerra, Shekar, Kiran, Fraser, John F. and Smith, Maree T. (2012). High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS. Journal of Chromatography B, 903, 126-133. doi: 10.1016/j.jchromb.2012.07.005

High-throughput assay for simultaneous quantification of the plasma concentrations of morphine, fentanyl, midazolam and their major metabolites using automated SPE coupled to LC-MS/MS

2012

Journal Article

Outcomes of the first 30 cases of an adult extracorporeal membrane oxygenation program: strategies to manage the "learning curve" and implications for intensive care unit risk adjustment models

Mullany, Daniel V., Bull, Taressa N., Hunt, William, Shekar, Kiran, Thomson, Bruce, Fraser, John F. and Ziegenfuss, Marc (2012). Outcomes of the first 30 cases of an adult extracorporeal membrane oxygenation program: strategies to manage the "learning curve" and implications for intensive care unit risk adjustment models. Critical Care and Resuscitation, 14 (2), 119-29.

Outcomes of the first 30 cases of an adult extracorporeal membrane oxygenation program: strategies to manage the "learning curve" and implications for intensive care unit risk adjustment models

2012

Journal Article

Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions

Shekar, Kiran, Fung, Yoke L., Diab, Sara, Mullany, Daniel V., McDonald, Charles I., Dunster, Kimble R., Fisquet, Stephanie, Platts, David G., Stewart, David, Wallis, Steven C., Smith, Maree T., Roberts, Jason A. and Fraser, John F. (2012). Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions. Critical Care and Resuscitation, 14 (2), 105-111.

Development of simulated and ovine models of extracorporeal life support to improve understanding of circuit-host interactions