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2022

Journal Article

Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study

Urner, Martin, Barnett, Adrian G., Bassi, Gianluigi Li, Brodie, Daniel, Dalton, Heidi J., Ferguson, Niall D., Heinsar, Silver, Hodgson, Carol L., Peek, Giles, Shekar, Kiran, Suen, Jacky Y., Fraser, John F., Fan, Eddy, COVID-19 Critical Care Consortium Investigators and Obonyo, Nchafatso (2022). Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study. BMJ, 377 e068723, e068723. doi: 10.1136/bmj-2021-068723

Venovenous extracorporeal membrane oxygenation in patients with acute covid-19 associated respiratory failure: comparative effectiveness study

2022

Journal Article

Extracorporeal life support organization guidelines for fluid overload, acute kidney injury, and electrolyte management

Bridges, Brian C., Dhar, Archana, Ramanathan, Kollengode, Steflik, Heidi J., Schmidt, Matthieu and Shekar, Kiran (2022). Extracorporeal life support organization guidelines for fluid overload, acute kidney injury, and electrolyte management. ASAIO Journal, 68 (5), 611-618. doi: 10.1097/MAT.0000000000001702

Extracorporeal life support organization guidelines for fluid overload, acute kidney injury, and electrolyte management

2022

Journal Article

Effect of antiplatelet therapy on survival and organ support-free days in critically ill patients with COVID-19: a randomized clinical trial

REMAP-CAP Writing Committee for the REMAP-CAP Investigators, Bradbury, Charlotte A., Lawler, Patrick R., Stanworth, Simon J., McVerry, Bryan J., McQuilten, Zoe, Higgins, Alisa M., Mouncey, Paul R., Al-Beidh, Farah, Rowan, Kathryn M., Berry, Lindsay R., Lorenzi, Elizabeth, Zarychanski, Ryan, Arabi, Yaseen M., Annane, Djillali, Beane, Abi, van Bentum-Puijk, Wilma, Bhimani, Zahra, Bihari, Shailesh, Bonten, Marc J. M., Brunkhorst, Frank M., Buzgau, Adrian, Buxton, Meredith, Carrier, Marc, Cheng, Allen C., Cove, Matthew, Detry, Michelle A., Estcourt, Lise J., Fitzgerald, Mark ... Gordon, Anthony C. (2022). Effect of antiplatelet therapy on survival and organ support-free days in critically ill patients with COVID-19: a randomized clinical trial. JAMA: The Journal of the American Medical Association, 327 (13), 1247. doi: 10.1001/jama.2022.2910

Effect of antiplatelet therapy on survival and organ support-free days in critically ill patients with COVID-19: a randomized clinical trial

2022

Journal Article

The pandemic and the great awakening in the management of acute hypoxaemic respiratory failure

Shekar, Kiran and Ling, Ryan Ruiyang (2022). The pandemic and the great awakening in the management of acute hypoxaemic respiratory failure. The Lancet Respiratory Medicine, 10 (6), 527-529. doi: 10.1016/S2213-2600(22)00051-0

The pandemic and the great awakening in the management of acute hypoxaemic respiratory failure

2022

Journal Article

Population pharmacokinetics and dosing simulations of ceftriaxone in critically ill patients receiving extracorporeal membrane oxygenation (An ASAP ECMO Study)

Cheng, Vesa, Abdul-Aziz, Mohd H., Burrows, Fay, Buscher, Hergen, Cho, Young-Jae, Corley, Amanda, Gilder, Eileen, Kim, Hyung-Sook, Lim, Sung Yoon, McGuinness, Shay, Parke, Rachael, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan A., Fraser, John F., Shekar, Kiran, Roberts, Jason A. and ASAP ECMO Investigators (2022). Population pharmacokinetics and dosing simulations of ceftriaxone in critically ill patients receiving extracorporeal membrane oxygenation (An ASAP ECMO Study). Clinical Pharmacokinetics, 61 (6), 847-856. doi: 10.1007/s40262-021-01106-x

Population pharmacokinetics and dosing simulations of ceftriaxone in critically ill patients receiving extracorporeal membrane oxygenation (An ASAP ECMO Study)

2022

Book Chapter

Pharmacological considerations for analgesia and sedation of ECMO patients

Chew, Joshua, Cheng, Vesa and Shekar, Kiran (2022). Pharmacological considerations for analgesia and sedation of ECMO patients. Extracorporeal Membrane Oxygenation. (pp. 179-190) edited by Marc O. Maybauer. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/med/9780197521304.003.0017

Pharmacological considerations for analgesia and sedation of ECMO patients

2022

Book Chapter

Challenges of antimicrobial therapy in ECMO patients

Cheng, Vesa, Abdul-Aziz, Mohd H. and Shekar, Kiran (2022). Challenges of antimicrobial therapy in ECMO patients. Extracorporeal membrane oxygenation: an interdisciplinary problem-based learning approach. (pp. 191-200) edited by Marc O. Maybauer. Oxford, United Kingdom: Oxford University Press. doi: 10.1093/med/9780197521304.003.0018

Challenges of antimicrobial therapy in ECMO patients

2022

Journal Article

Colorectal surgery in critically unwell patients: a multidisciplinary approach

Subramaniam, Ashwin, Wengritzky, Robert, Skinner, Stewart and Shekar, Kiran (2022). Colorectal surgery in critically unwell patients: a multidisciplinary approach. Clinics in Colon and Rectal Surgery, 35 (03), 244-260. doi: 10.1055/s-0041-1740045

Colorectal surgery in critically unwell patients: a multidisciplinary approach

2022

Journal Article

Is intensive care unit mortality a valid survival outcome measure related to critical illness?

Laupland, Kevin B., Ramanan, Mahesh, Shekar, Kiran, Kirrane, Marianne, Clement, Pierre, Young, Patrick, Edwards, Felicity, Bushell, Rachel and Tabah, Alexis (2022). Is intensive care unit mortality a valid survival outcome measure related to critical illness?. Anaesthesia Critical Care and Pain Medicine, 41 (1) 100996, 100996. doi: 10.1016/j.accpm.2021.100996

Is intensive care unit mortality a valid survival outcome measure related to critical illness?

2022

Journal Article

Frailty and mortality associations in patients with COVID-19: a systematic review and meta-analysis

Subramaniam, Ashwin, Shekar, Kiran, Afroz, Afsana, Ashwin, Sushma, Billah, Baki, Brown, Hamish, Kundi, Harun, Lim, Zheng Jie, Ponnapa Reddy, Mallikarjuna and Curtis, J Randall (2022). Frailty and mortality associations in patients with COVID-19: a systematic review and meta-analysis. Internal Medicine Journal, 52 (5), 724-739. doi: 10.1111/imj.15698

Frailty and mortality associations in patients with COVID-19: a systematic review and meta-analysis

2022

Journal Article

Impact of unacceptable behaviour between healthcare workers on clinical performance and patient outcomes: a systematic review

Guo, Linda, Ryan, Benjamin, Leditschke, Isabel Anne, Haines, Kimberley J, Cook, Katrina, Eriksson, Lars, Olusanya, Olusegun, Selak, Tanya, Shekar, Kiran and Ramanan, Mahesh (2022). Impact of unacceptable behaviour between healthcare workers on clinical performance and patient outcomes: a systematic review. BMJ Quality and Safety, 31 (9) 013955, bmjqs-2021. doi: 10.1136/bmjqs-2021-013955

Impact of unacceptable behaviour between healthcare workers on clinical performance and patient outcomes: a systematic review

2022

Journal Article

Population pharmacokinetics of vancomycin in critically ill adult patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study)

Cheng, Vesa, Abdul-Aziz, Mohd H., Burrows, Fay, Buscher, Hergen, Cho, Young-Jae, Corley, Amanda, Diehl, Arne, Gilder, Eileen, Jakob, Stephan M., Kim, Hyung-Sook, Levkovich, Bianca J., Lim, Sung Yoon, McGuinness, Shay, Parke, Rachael, Pellegrino, Vincent, Que, Yok-Ai, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan A., Zacharias, David, Fraser, John F., Shekar, Kiran, Roberts, Jason A. and on behalf of ASAP ECMO Investigators (2022). Population pharmacokinetics of vancomycin in critically ill adult patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study). Antimicrobial Agents and Chemotherapy, 66 (1) AAC0137721, 1-10. doi: 10.1128/aac.01377-21

Population pharmacokinetics of vancomycin in critically ill adult patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study)

2022

Journal Article

Hyperoxia on venoarterial extracorporeal membrane oxygenation: a modifiable risk?

Joyce, Christopher J., Anderson, Cameron and Shekar, Kiran (2022). Hyperoxia on venoarterial extracorporeal membrane oxygenation: a modifiable risk?. Critical Care Medicine, 50 (1), e99-e100. doi: 10.1097/CCM.0000000000005252

Hyperoxia on venoarterial extracorporeal membrane oxygenation: a modifiable risk?

2022

Journal Article

Characteristics and outcomes of patients with frailty admitted to ICU with Coronavirus disease 2019: An individual patient data meta-analysis

Subramaniam, Ashwin, Anstey, Christopher, Curtis, J Randall, Ashwin, Sushma, Ponnapa Reddy, Mallikarjuna, Aliberti, Márlon Juliano Romero, Avelino-Silva, Thiago Junqueira, Welch, Carly, Koduri, Gouri, Prowle, John R, Wan, Yize I, Laurent, Michaël R, Marengoni, Alessandra, Lim, Jun Pei, Pilcher, David and Shekar, Kiran (2022). Characteristics and outcomes of patients with frailty admitted to ICU with Coronavirus disease 2019: An individual patient data meta-analysis. Critical Care Explorations, 4 (1) e0616, e0616. doi: 10.1097/CCE.0000000000000616

Characteristics and outcomes of patients with frailty admitted to ICU with Coronavirus disease 2019: An individual patient data meta-analysis

2021

Journal Article

Erratum: A systematic review of the incidence and outcomes of in-hospital cardiac arrests in patients with coronavirus disease 2019 (Critical Care Medicine (2019) 49 (901-911) DOI: 10.1097/CCM.0000000000004950)

Lim, Zheng Jie, Reddy, Mallikarjuna Ponnapa, Randall Curtis, J., Afroz, Afsana, Billah, Baki, Hayek, Salim S., Leaf, David E., Miles, Jeremy A., Yuriditsky, Eugene, Jones, Daryl, Shekar, Kiran and Subramaniam, Ashwin (2021). Erratum: A systematic review of the incidence and outcomes of in-hospital cardiac arrests in patients with coronavirus disease 2019 (Critical Care Medicine (2019) 49 (901-911) DOI: 10.1097/CCM.0000000000004950). Critical Care Medicine, 49 (12). doi: 10.1097/CCM.0000000000005384

Erratum: A systematic review of the incidence and outcomes of in-hospital cardiac arrests in patients with coronavirus disease 2019 (Critical Care Medicine (2019) 49 (901-911) DOI: 10.1097/CCM.0000000000004950)

2021

Journal Article

Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis

Ramanathan, Kollengode, Shekar, Kiran, Ling, Ryan Ruiyang, Barbaro, Ryan P., Wong, Suei Nee, Tan, Chuen Seng, Rochwerg, Bram, Fernando, Shannon M., Takeda, Shinhiro, MacLaren, Graeme, Fan, Eddy and Brodie, Daniel (2021). Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis. Critical Care, 25 (1) 211, 211. doi: 10.1186/s13054-021-03634-1

Extracorporeal membrane oxygenation for COVID-19: a systematic review and meta-analysis

2021

Journal Article

Population pharmacokinetics of cefepime in critically ill patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study)

Cheng, Vesa, Abdul-Aziz, Mohd H., Burrows, Fay, Buscher, Hergen, Corley, Amanda, Diehl, Arne, Jakob, Stephan M., Levkovich, Bianca J., Pellegrino, Vincent, Que, Yok-Ai, Reynolds, Claire, Rudham, Sam, Wallis, Steven C., Welch, Susan A., Zacharias, David, Roberts, Jason A., Shekar, Kiran, Fraser, John F. and on behalf ofASAP ECMO Investigators (2021). Population pharmacokinetics of cefepime in critically ill patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study). International Journal of Antimicrobial Agents, 58 (6) 106466, 1-8. doi: 10.1016/j.ijantimicag.2021.106466

Population pharmacokinetics of cefepime in critically ill patients receiving extracorporeal membrane oxygenation (an ASAP ECMO study)

2021

Journal Article

Erratum: Trends in 28-Day mortality of critical care patients with coronavirus disease 2019 in the United Kingdom: A National Cohort Study, March 2020 to January 2021 (Critical Care Medicine (2021) 49 (1895-1900) DOI: 10.1097/CCM.0000000000005184)

Lim, Zheng Jie, Reddy, Mallikarjuna Ponnapa, Randall Curtis, J., Afroz, Afsana, Billah, Baki, Hayek, Salim S., Leaf, David E., Miles, Jeremy A., Yuriditsky, Eugene, Jones, Daryl, Shekar, Kiran and Subramaniam, Ashwin (2021). Erratum: Trends in 28-Day mortality of critical care patients with coronavirus disease 2019 in the United Kingdom: A National Cohort Study, March 2020 to January 2021 (Critical Care Medicine (2021) 49 (1895-1900) DOI: 10.1097/CCM.0000000000005184). Critical Care Medicine, 49 (12). doi: 10.1097/CCM.0000000000005385

Erratum: Trends in 28-Day mortality of critical care patients with coronavirus disease 2019 in the United Kingdom: A National Cohort Study, March 2020 to January 2021 (Critical Care Medicine (2021) 49 (1895-1900) DOI: 10.1097/CCM.0000000000005184)

2021

Journal Article

Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis

Poon, Wynne Hsing, Ramanathan, Kollengode, Ling, Ryan Ruiyang, Yang, Isabelle Xiaorui, Tan, Chuen Seng, Schmidt, Matthieu and Shekar, Kiran (2021). Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis. Critical Care, 25 (1) 292, 292. doi: 10.1186/s13054-021-03723-1

Prone positioning during venovenous extracorporeal membrane oxygenation for acute respiratory distress syndrome: a systematic review and meta-analysis

2021

Journal Article

Reconciling the obesity paradox: obese patients suffer the highest critical illness associated mortality rates

Laupland, Kevin B., Edwards, Felicity, Ramanan, Mahesh, Shekar, Kiran and Tabah, Alexis (2021). Reconciling the obesity paradox: obese patients suffer the highest critical illness associated mortality rates. Journal of Critical Care, 66, 75-77. doi: 10.1016/j.jcrc.2021.08.005

Reconciling the obesity paradox: obese patients suffer the highest critical illness associated mortality rates