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2024 Journal Article Prostaglandins in the inflamed central nervous system: potential therapeutic targetsSheremeta, Chynna-Loren, Yarlagadda, Sai, Smythe, Mark L. and Noakes, Peter G. (2024). Prostaglandins in the inflamed central nervous system: potential therapeutic targets. Current Drug Targets, 25 (13), 885-908. doi: 10.2174/0113894501323980240815113851 |
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2024 Journal Article Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarctionRedd, Meredith A, Yoshikawa, Yusuke, Khan, Nemat, Waqar, Maleeha, Saez, Natalie J, Outhwaite, Jennifer E, Russell, Jake S, Hanna, Amy D, Chiu, Han S, Er, Sing Yan, Butcher, Neville J, Mardon, Karine, Fraser, John F, Smythe, Mark L, Rash, Lachlan D, Thomas, Walter G, King, Glenn F, Reichelt, Melissa E and Palpant, Nathan J (2024). Acid-sensing ion channel 1a blockade reduces myocardial injury in rodent models of myocardial infarction. European Heart Journal, 45 (17), 1571-1574. doi: 10.1093/eurheartj/ehad793 |
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2021 Journal Article Hematopoietic prostaglandin D synthase inhibitor PK007 decreases muscle necrosis in DMD mdx model miceYarlagadda, Sai, Kulis, Christina, Noakes, Peter G. and Smythe, Mark L. (2021). Hematopoietic prostaglandin D synthase inhibitor PK007 decreases muscle necrosis in DMD mdx model mice. Life, 11 (9) 994, 994. doi: 10.3390/life11090994 |
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2018 Journal Article PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ productionWerder, Rhiannon B., Lynch, Jason P., Simpson, Jennifer C., Zhang, Vivian, Hodge, Nick H., Poh, Matthew, Forbes-Blom, Elizabeth, Kulis, Christina, Smythe, Mark L., Upham, John W., Spann, Kirsten, Everard, Mark L. and Phipps, Simon (2018). PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production. Science Translational Medicine, 10 (440) eaao0052, eaao0052. doi: 10.1126/scitranslmed.aao0052 |
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2016 Journal Article Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23Barkan, David T., Cheng, Xiao-Li, Celino, Herodion, Tran, Tran T., Bhandari, Ashok, Craik, Charles S., Sali, Andrej and Smythe, Mark L. (2016). Clustering of disulfide-rich peptides provides scaffolds for hit discovery by phage display: application to interleukin-23. BMC Bioinformatics, 17 (481) 481, 481. doi: 10.1186/s12859-016-1350-9 |
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2015 Journal Article Discovery and characterization of a potent interleukin-6 binding peptide with neutralizing activity in vivoRanganath, Sheila, Bhandari, Ashok, Avitahl-Curtis, Nicole, McMahon, Jaimee, Wachtel, Derek, Zhang, Jenny, Leitheiser, Christopher, Bernier, Sylvie G., Liu, Guang, Tran, Tran T., Celino, Herodion, Tobin, Jenny, Jung, Joon, Zhao, Hong, Glen, Katie E., Graul, Chris, Griffin, Aliesha, Schairer, Wayne C., Higgins, Carolyn, Reza, Tammi L., Mowe, Eva, Rivers, Sam, Scott, Sonya, Monreal, Alex, Shea, Courtney, Bourne, Greg, Coons, Casey, Smith, Adaline, Tang, Kim ... Carlson, Kenneth E. (2015). Discovery and characterization of a potent interleukin-6 binding peptide with neutralizing activity in vivo. PLoS One, 10 (11) e0141330, 1-19. doi: 10.1371/journal.pone.0141330 |
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2011 Journal Article Conformational searching using a population-based incremental learning algorithmLong, Stephen M., Tran, Tran T., Adams, Peter, Darwen, Paul and Smythe, M. L. (2011). Conformational searching using a population-based incremental learning algorithm. Journal of Computational Chemistry, 32 (8), 1541-1549. doi: 10.1002/jcc.21732 |
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2011 Journal Article Sigma-class glutathione transferasesFlanagan, Jack U. and Smythe, Mark L. (2011). Sigma-class glutathione transferases. Drug Metabolism Reviews, 43 (2), 194-214. doi: 10.3109/03602532.2011.560157 |
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2010 Journal Article Defining scaffold geometries for interacting with proteins: Geometrical classification of secondary structure linking regionsTran, Tran T., Kulis, Christina, Long, Steven M., Bryant, Darryn, Adams, Peter and Smythe, Mark L. (2010). Defining scaffold geometries for interacting with proteins: Geometrical classification of secondary structure linking regions. Journal of Computer-Aided Molecular Design, 24 (11), 917-934. doi: 10.1007/s10822-010-9384-y |
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2010 Journal Article Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D-2 synthasesChrist, Angelika N., Labzin, Larisa, Bourne, Gregory T., Fukunishi, Hirotada, Weber, Jane E., Sweet, Matthew J., Smythe, Mark L. and Flanagan, Jack U. (2010). Development and characterization of new inhibitors of the human and mouse hematopoietic prostaglandin D-2 synthases. Journal of Medicinal Chemistry, 53 (15), 5536-5548. doi: 10.1021/jm100194a |
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2010 Journal Article Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D-2 synthaseWeber, Jane E., Oakley, Aaron J., Christ, Angelika N., Hayes, John D., Hall, Rhonda, Hume, David A., Board, Philip G., Smythe, Mark L. and Flanagan, Jack U. (2010). Identification and characterisation of new inhibitors for the human hematopoietic prostaglandin D-2 synthase. European Journal of Medicinal Chemistry, 45 (2), 447-454. doi: 10.1016/j.ejmech.2009.10.025 |
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2008 Journal Article Library of biphenyl privileged substructures using a safety-catch linker approachSeverinsen, Rune, Bourne, Gregory T., Tran, Tran T., Ankersen, Michael, Begtrup, Mikael and Smythe, Mark L. (2008). Library of biphenyl privileged substructures using a safety-catch linker approach. Journal of Combinatorial Chemistry, 10 (4), 557-566. doi: 10.1021/cc800006g |
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2008 Journal Article Cyclic tetrapeptides via the ring contraction strategy: Chemical techniques useful for their identificationHorton, D. A., Bourne, G. T., Coughlan, J., Kaiser, S. M., Jacobs, C. M., Jones, A., Ruhmann, A., Turner, J. Y. and Smythe, M. L. (2008). Cyclic tetrapeptides via the ring contraction strategy: Chemical techniques useful for their identification. Organic & Biomolecular Chemistry, 6 (8), 1386-1395. doi: 10.1039/b800464a |
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2006 Journal Article A gradient descent algorithm for minimizing amino acid coupling reactions when synthesizing cyclic-peptide librariesDarwen, PJ, Tran, TT, Bourne, GT, Nielson, JL and Smythe, ML (2006). A gradient descent algorithm for minimizing amino acid coupling reactions when synthesizing cyclic-peptide libraries. Combinatorial Chemistry & High Throughput Screening, 9 (7), 559-563. doi: 10.2174/138620706777935333 |
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2005 Journal Article A convenient method for synthesis of cyclic peptide librariesBourne, Gregory T, Nielson, Jonathon L, Coughlan, Justin F, Darwen, Paul, Campitelli, Marc R, Horton, Douglas A, Rhümann, Andreas, Love, Stephen G, Tran, Tran T and Smythe, Mark L (2005). A convenient method for synthesis of cyclic peptide libraries. Methods in molecular biology (Clifton, N.J.), 298, 151-165. doi: 10.1385/1-59259-877-3:151 |
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2005 Journal Article Intramolecular disulphide bond arrangements in nonhomologous proteinsHartig, Gerald R. S., Tran, Tran T. and Smythe, Mark L. (2005). Intramolecular disulphide bond arrangements in nonhomologous proteins. Protein Science, 14 (2), 474-482. doi: 10.1110/ps.04923305 |
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2005 Journal Article Topological side-chain classification of beta-turns: Ideal motifs for peptidomimetic developmentTran, TT, McKie, J, Meutermans, WDF, Bourne, GT, Andrews, PR and Smythe, ML (2005). Topological side-chain classification of beta-turns: Ideal motifs for peptidomimetic development. Journal of Computer-aided Molecular Design, 19 (8), 551-566. doi: 10.1007/s10822-005-9006-2 |
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2005 Journal Article A versatile synthetic approach to peptidyl privileged structures using a "safety-catch" linkerHorton, Douglas A., Severinsen, Rune, Kofod-Hansen, Mikael, Bourne, Gregorty T. and Smythe, Mark L. (2005). A versatile synthetic approach to peptidyl privileged structures using a "safety-catch" linker. Journal of Combinatorial Chemistry, 7 (3), 421-435. doi: 10.1021/cc049829q |
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2005 Journal Article A safety catch linker for Fmoc-based assembly of constrained cyclic peptidesRavn, J, Bourne, GT and Smythe, ML (2005). A safety catch linker for Fmoc-based assembly of constrained cyclic peptides. Journal of Peptide Science, 11 (9), 572-578. doi: 10.1002/psc.651 |
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2004 Journal Article Increased site 1 affinity improves biopotency of porcine growth hormone - Evidence against diffusion dependent receptor dimerizationWan, Y., McDevitt, A., Shen, B. J., Smythe, M. L. and Waters, M. J. (2004). Increased site 1 affinity improves biopotency of porcine growth hormone - Evidence against diffusion dependent receptor dimerization. Journal of Biological Chemistry, 279 (43), 44775-44784. doi: 10.1074/jbc.M406092200 |
